A genome-wide association study of the human metabolome in a community-based cohort

Cell Metabolism

Volumn 18, Issue 1, 2013, Pages 130-143

  Rhee, Eugene P ^a,b   Ho, Jennifer E ^c   Chen, Ming Huei ^c,d   Shen, Dongxiao ^a   Cheng, Susan ^c,e   Larson, Martin G ^c,f   Ghorbani, Anahita ^a   Shi, Xu ^a   Helenius, Iiro T ^a   O'Donnell, Christopher J ^a,c,g   Souza, Amanda L ^b   Deik, Amy ^b   Pierce, Kerry A ^b   Bullock, Kevin ^b   Walford, Geoffrey A ^a   Vasan, Ramachandran S ^c   Florez, Jose C ^a,b   Clish, Clary ^b   Yeh, J R Joanna ^a   Wang, Thomas J ^h   Gerszten, Robert E ^a,b   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f Boston University   (United States)

^g NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^h VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; EMBRYO; FEMALE; GENE CLUSTER; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HUMAN; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLOME; NONHUMAN; OBSERVATIONAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; UREA CYCLE;

AGED; CHOLESTEROL ESTERS; COHORT STUDIES; CONSUMER PARTICIPATION; FEMALE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MASSACHUSETTS; METABOLOME; MIDDLE AGED; TRANSAMINASES; TRIGLYCERIDES;

EID: 84879867981     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.06.013     Document Type: Article

References (73)

1. S. Abhary, K.P. Burdon, A. Kuot, S. Javadiyan, M.J. Whiting, N. Kasmeridis, N. Petrovsky, and J.E. Craig Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes PLoS ONE 5 2010 e9462
2. J. Adamski Genome-wide association studies with metabolomics Genome Med 4 2012 34
3. L. Almasy, and J. Blangero Multipoint quantitative-trait linkage analysis in general pedigrees Am. J. Hum. Genet. 62 1998 1198 1211
4. N.L. Beer, N.D. Tribble, L.J. McCulloch, C. Roos, P.R. Johnson, M. Orho-Melander, and A.L. Gloyn The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver Hum. Mol. Genet. 18 2009 4081 4088
5. C. Bellenguez, S. Bevan, A. Gschwendtner, C.C. Spencer, A.I. Burgess, M. Pirinen, C.A. Jackson, M. Traylor, A. Strange, Z. Su International Stroke Genetics Consortium (ISGC) Wellcome Trust Case Control Consortium 2 (WTCCC2) Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke Nat. Genet. 44 2012 328 333
6. J.C. Chambers, W. Zhang, G.M. Lord, P. van der Harst, D.A. Lawlor, J.S. Sehmi, D.P. Gale, M.N. Wass, K.R. Ahmadi, and S.J. Bakker Genetic loci influencing kidney function and chronic kidney disease Nat. Genet. 42 2010 373 375
7. M.H. Chen, and Q. Yang GWAF: an R package for genome-wide association analyses with family data Bioinformatics 26 2010 580 581
8. J.S. Danik, G. Paré, D.I. Chasman, R.Y. Zee, D.J. Kwiatkowski, A. Parker, J.P. Miletich, and P.M. Ridker Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study Circ Cardiovasc Genet 2 2009 134 141
9. A. Dehghan, J. Dupuis, M. Barbalic, J.C. Bis, G. Eiriksdottir, C. Lu, N. Pellikka, H. Wallaschofski, J. Kettunen, and P. Henneman Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels Circulation 123 2011 731 738
10. A. Demirkan, C.M. van Duijn, P. Ugocsai, A. Isaacs, P.P. Pramstaller, G. Liebisch, J.F. Wilson, A. Johansson, I. Rudan, Y.S. Aulchenko DIAGRAM Consortium CARDIoGRAM Consortium CHARGE Consortium EUROSPAN consortium Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations PLoS Genet. 8 2012 e1002490
11. J. Dupuis, C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo, A.U. Jackson, E. Wheeler, N.L. Glazer, N. Bouatia-Naji, A.L. Gloyn DIAGRAM Consortium GIANT Consortium Global BPgen Consortium Anders Hamsten on behalf of Procardis Consortium MAGIC investigators New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat. Genet. 42 2010 105 116
12. M. Eijgelsheim, C. Newton-Cheh, N. Sotoodehnia, P.I. de Bakker, M. Müller, A.C. Morrison, A.V. Smith, A. Isaacs, S. Sanna, and M. Dörr Genome-wide association analysis identifies multiple loci related to resting heart rate Hum. Mol. Genet. 19 2010 3885 3894
13. P.T. Ellinor, K.L. Lunetta, C.M. Albert, N.L. Glazer, M.D. Ritchie, A.V. Smith, D.E. Arking, M. Müller-Nurasyid, B.P. Krijthe, and S.A. Lubitz Meta-analysis identifies six new susceptibility loci for atrial fibrillation Nat. Genet. 44 2012 670 675
14. K. Estrada, U. Styrkarsdottir, E. Evangelou, Y.H. Hsu, E.L. Duncan, E.E. Ntzani, L. Oei, O.M. Albagha, N. Amin, and J.P. Kemp Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture Nat. Genet. 44 2012 491 501
15. L. Feliubadaló, M. Font, J. Purroy, F. Rousaud, X. Estivill, V. Nunes, E. Golomb, M. Centola, I. Aksentijevich, Y. Kreiss International Cystinuria Consortium Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT Nat. Genet. 23 1999 52 57
16. O.L. Francone, E.L. Gong, D.S. Ng, C.J. Fielding, and E.M. Rubin Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism J. Clin. Invest. 96 1995 1440 1448
17. A. Franke, D.P. McGovern, J.C. Barrett, K. Wang, G.L. Radford-Smith, T. Ahmad, C.W. Lees, T. Balschun, J. Lee, and R. Roberts Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Nat. Genet. 42 2010 1118 1125
18. H. Fröhlich, K.M. Boini, G. Seebohm, N. Strutz-Seebohm, O.N. Ureche, M. Föller, M. Eichenmüller, E. Shumilina, G. Pathare, and A.K. Singh Hypothyroidism of gene-targeted mice lacking Kcnq1 Pflugers Arch. 461 2011 45 52
19. J. Frohlich, R. McLeod, P.H. Pritchard, J. Fesmire, and W. McConathy Plasma lipoprotein abnormalities in heterozygotes for familial lecithin:cholesterol acyltransferase deficiency Metabolism 37 1988 3 8
20. C. Gieger, L. Geistlinger, E. Altmaier, M. Hrabé de Angelis, F. Kronenberg, T. Meitinger, H.-W. Mewes, H.-E. Wichmann, K.M. Weinberger, and J. Adamski Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum PLoS Genet. 4 2008 e1000282
21. C. Gieger, A. Radhakrishnan, A. Cvejic, W. Tang, E. Porcu, G. Pistis, J. Serbanovic-Canic, U. Elling, A.H. Goodall, and Y. Labrune New gene functions in megakaryopoiesis and platelet formation Nature 480 2011 201 208
22. D.J. Gottlieb, G.T. O'Connor, and J.B. Wilk Genome-wide association of sleep and circadian phenotypes BMC Med. Genet. 8 Suppl 1 2007 S9
23. A.A. Hicks, P.P. Pramstaller, A. Johansson, V. Vitart, I. Rudan, P. Ugocsai, Y. Aulchenko, C.S. Franklin, G. Liebisch, and J. Erdmann Genetic determinants of circulating sphingolipid concentrations in European populations PLoS Genet. 5 2009 e1000672
24. B.E. Himes, G.M. Hunninghake, J.W. Baurley, N.M. Rafaels, P. Sleiman, D.P. Strachan, J.B. Wilk, S.A. Willis-Owen, B. Klanderman, and J. Lasky-Su Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene Am. J. Hum. Genet. 84 2009 581 593
25. X. Hu, D. Atzler, X. Xu, P. Zhang, H. Guo, Z. Lu, J. Fassett, E. Schwedhelm, R.H. Böger, R.J. Bache, and Y. Chen Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine Arterioscler. Thromb. Vasc. Biol. 31 2011 1540 1546
26. T. Illig, C. Gieger, G. Zhai, W. Römisch-Margl, R. Wang-Sattler, C. Prehn, E. Altmaier, G. Kastenmüller, B.S. Kato, and H.-W. Mewes A genome-wide perspective of genetic variation in human metabolism Nat. Genet. 42 2010 137 141
27. M. Imboden, E. Bouzigon, I. Curjuric, A. Ramasamy, A. Kumar, D.B. Hancock, J.B. Wilk, J.M. Vonk, G.A. Thun, and V. Siroux Genome-wide association study of lung function decline in adults with and without asthma J. Allergy Clin. Immunol. 129 2012 1218 1228
28. A.D. Johnson, M. Kavousi, A.V. Smith, M.H. Chen, A. Dehghan, T. Aspelund, J.P. Lin, C.M. van Duijn, T.B. Harris, and L.A. Cupples Genome-wide association meta-analysis for total serum bilirubin levels Hum. Mol. Genet. 18 2009 2700 2710
29. Y. Kamatani, K. Matsuda, Y. Okada, M. Kubo, N. Hosono, Y. Daigo, Y. Nakamura, and N. Kamatani Genome-wide association study of hematological and biochemical traits in a Japanese population Nat. Genet. 42 2010 210 215
30. W.B. Kannel, M. Feinleib, P.M. McNamara, R.J. Garrison, and W.P. Castelli An investigation of coronary heart disease in families. The Framingham offspring study Am. J. Epidemiol. 110 1979 281 290
31. J. Kettunen, T. Tukiainen, A.P. Sarin, A. Ortega-Alonso, E. Tikkanen, L.P. Lyytikäinen, A.J. Kangas, P. Soininen, P. Würtz, and K. Silander Genome-wide association study identifies multiple loci influencing human serum metabolite levels Nat. Genet. 44 2012 269 276
32. Y.J. Kim, M.J. Go, C. Hu, C.B. Hong, Y.K. Kim, J.Y. Lee, J.Y. Hwang, J.H. Oh, D.J. Kim, N.H. Kim MAGIC consortium Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits Nat. Genet. 43 2011 990 995
33. M. Kolz, T. Johnson, S. Sanna, A. Teumer, V. Vitart, M. Perola, M. Mangino, E. Albrecht, C. Wallace, M. Farrall EUROSPAN Consortium ENGAGE Consortium PROCARDIS Consortium KORA Study WTCCC Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations PLoS Genet. 5 2009 e1000504
34. A. Kotronen, V.R. Velagapudi, L. Yetukuri, J. Westerbacka, R. Bergholm, K. Ekroos, J. Makkonen, M.-R. Taskinen, M. Oresic, and H. Yki-Järvinen Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations Diabetologia 52 2009 684 690
35. A. Köttgen, C. Pattaro, C.A. Böger, C. Fuchsberger, M. Olden, N.L. Glazer, A. Parsa, X. Gao, Q. Yang, and A.V. Smith New loci associated with kidney function and chronic kidney disease Nat. Genet. 42 2010 376 384
36. K. Kristiansson, M. Perola, E. Tikkanen, J. Kettunen, I. Surakka, A.S. Havulinna, A. Stancáková, C. Barnes, E. Widen, and E. Kajantie Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits Circ Cardiovasc Genet 5 2012 242 249
37. L.A. Lange, D.C. Croteau-Chonka, A.F. Marvelle, L. Qin, K.J. Gaulton, C.W. Kuzawa, T.W. McDade, Y. Wang, Y. Li, and S. Levy Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults Hum. Mol. Genet. 19 2010 2050 2058
38. R.N. Lemaitre, T. Tanaka, W. Tang, A. Manichaikul, M. Foy, E.K. Kabagambe, J.A. Nettleton, I.B. King, L.C. Weng, and S. Bhattacharya Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium PLoS Genet. 7 2011 e1002193
39. A.S. Levey, J.P. Bosch, J.B. Lewis, T. Greene, N. Rogers, D. Roth Modification of Diet in Renal Disease Study Group A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation Ann. Intern. Med. 130 1999 461 470
40. Y. Li, C.J. Willer, J. Ding, P. Scheet, and G.R. Abecasis MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes Genet. Epidemiol. 34 2010 816 834
41. E. Link, S. Parish, J. Armitage, L. Bowman, S. Heath, F. Matsuda, I. Gut, M. Lathrop, R. Collins SEARCH Collaborative Group SLCO1B1 variants and statin-induced myopathy - a genomewide study N. Engl. J. Med. 359 2008 789 799
42. C. Mora, J. Chillarón, M.J. Calonge, J. Forgo, X. Testar, V. Nunes, H. Murer, A. Zorzano, and M. Palacín The rBAT gene is responsible for L-cystine uptake via the b0,(+)-like amino acid transport system in a "renal proximal tubular" cell line (OK cells) J. Biol. Chem. 271 1996 10569 10576
43. B.M. Neale, J. Fagerness, R. Reynolds, L. Sobrin, M. Parker, S. Raychaudhuri, P.L. Tan, E.C. Oh, J.E. Merriam, and E. Souied Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC) Proc. Natl. Acad. Sci. USA 107 2010 7395 7400
44. D.S. Ng, O.L. Francone, T.M. Forte, J. Zhang, M. Haghpassand, and E.M. Rubin Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I J. Biol. Chem. 272 1997 15777 15781
45. D.S. Ng, C. Xie, G.F. Maguire, X. Zhu, F. Ugwu, E. Lam, and P.W. Connelly Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance J. Biol. Chem. 279 2004 7636 7642
46. M. Orho-Melander, O. Melander, C. Guiducci, P. Perez-Martinez, D. Corella, C. Roos, R. Tewhey, M.J. Rieder, J. Hall, and G. Abecasis Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations Diabetes 57 2008 3112 3121
47. - uptake FASEB J. 26 2012 3252 3259
48. E.P. Rhee, S. Cheng, M.G. Larson, G.A. Walford, G.D. Lewis, E. McCabe, E. Yang, L. Farrell, C.S. Fox, and C.J. O'Donnell Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans J. Clin. Invest. 121 2011 1402 1411
49. E.P. Rhee, and R.E. Gerszten Metabolomics and cardiovascular biomarker discovery Clin. Chem. 58 2012 139 147
50. E.P. Rhee, C.B. Clish, A. Ghorbani, M.G. Larson, S. Elmariah, E. McCabe, Q. Yang, S. Cheng, K. Pierce, and A. Deik A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction J. Am. Soc. Nephrol. 2013
51. P.M. Ridker, G. Pare, A. Parker, R.Y. Zee, J.S. Danik, J.E. Buring, D. Kwiatkowski, N.R. Cook, J.P. Miletich, and D.I. Chasman Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study Am. J. Hum. Genet. 82 2008 1185 1192
52. S. Sanna, F. Busonero, A. Maschio, P.F. McArdle, G. Usala, M. Dei, S. Lai, A. Mulas, M.G. Piras, and L. Perseu Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia Hum. Mol. Genet. 18 2009 2711 2718
53. R. Saxena, M.F. Hivert, C. Langenberg, T. Tanaka, J.S. Pankow, P. Vollenweider, V. Lyssenko, N. Bouatia-Naji, J. Dupuis, A.U. Jackson GIANT consortium MAGIC investigators Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat. Genet. 42 2010 142 148
54. R.B. Schnabel, K.L. Lunetta, M.G. Larson, J. Dupuis, I. Lipinska, J. Rong, M.H. Chen, Z. Zhao, J.F. Yamamoto, and J.B. Meigs The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations Circ Cardiovasc Genet 2 2009 229 237
55. H. Schunkert, I.R. König, S. Kathiresan, M.P. Reilly, T.L. Assimes, H. Holm, M. Preuss, A.F. Stewart, M. Barbalic, C. Gieger Cardiogenics CARDIoGRAM Consortium Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Nat. Genet. 43 2011 333 338
56. S.H. Shah, E.R. Hauser, J.R. Bain, M.J. Muehlbauer, C. Haynes, R.D. Stevens, B.R. Wenner, Z.E. Dowdy, C.B. Granger, and G.S. Ginsburg High heritability of metabolomic profiles in families burdened with premature cardiovascular disease Mol. Syst. Biol. 5 2009 258
57. H. Song, L. Zhu, C.M. Picardo, G. Maguire, V. Leung, P.W. Connelly, and D.S. Ng Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism Am. J. Physiol. Endocrinol. Metab. 290 2006 E17 E25
58. Q. Song, J.W. Cole, J.R. O'Connell, O.C. Stine, M. Gallagher, W.H. Giles, B.D. Mitchell, M.A. Wozniak, B.J. Stern, and J.D. Sorkin Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study Hum. Mol. Genet. 15 2006 2468 2478
59. K. Suhre, and C. Gieger Genetic variation in metabolic phenotypes: study designs and applications Nat. Rev. Genet. 13 2012 759 769
60. K. Suhre, S.-Y. Shin, A.-K. Petersen, R.P. Mohney, D. Meredith, B. Wägele, E. Altmaier, P. Deloukas, J. Erdmann, E. Grundberg CARDIoGRAM Human metabolic individuality in biomedical and pharmaceutical research Nature 477 2011 54 60
61. K. Suhre, H. Wallaschofski, J. Raffler, N. Friedrich, R. Haring, K. Michael, C. Wasner, A. Krebs, F. Kronenberg, and D. Chang A genome-wide association study of metabolic traits in human urine Nat. Genet. 43 2011 565 569
62. T.M. Teslovich, K. Musunuru, A.V. Smith, A.C. Edmondson, I.M. Stylianou, M. Koseki, J.P. Pirruccello, S. Ripatti, D.I. Chasman, and C.J. Willer Biological, clinical and population relevance of 95 loci for blood lipids Nature 466 2010 707 713
63. T.M. Therneau, P.M. Grambsch, and V.S. Pankratz Penalized survival models and frailty J. Comput. Graph. Statist. 12 2003 156 175
64. T. Tukiainen, J. Kettunen, A.J. Kangas, L.P. Lyytikäinen, P. Soininen, A.P. Sarin, E. Tikkanen, P.F. O'Reilly, M.J. Savolainen, and K. Kaski Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci Hum. Mol. Genet. 21 2012 1444 1455
65. H. Unoki, A. Takahashi, T. Kawaguchi, K. Hara, M. Horikoshi, G. Andersen, D.P. Ng, J. Holmkvist, K. Borch-Johnsen, and T. Jørgensen SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations Nat. Genet. 40 2008 1098 1102
66. P. Vallance, R.M. Palmer, and S. Moncada The role of induction of nitric oxide synthesis in the altered responses of jugular veins from endotoxaemic rabbits Br. J. Pharmacol. 106 1992 459 463
67. T.J. Wang, M.G. Larson, D. Levy, E.J. Benjamin, D. Corey, E.P. Leip, and R.S. Vasan Heritability and genetic linkage of plasma natriuretic peptide levels Circulation 108 2003 13 16
68. T.J. Wang, M.G. Larson, R.S. Vasan, S. Cheng, E.P. Rhee, E. McCabe, G.D. Lewis, C.S. Fox, P.F. Jacques, and C. Fernandez Metabolite profiles and the risk of developing diabetes Nat. Med. 17 2011 448 453
69. D.M. Waterworth, S.L. Ricketts, K. Song, L. Chen, J.H. Zhao, S. Ripatti, Y.S. Aulchenko, W. Zhang, X. Yuan, N. Lim Wellcome Trust Case Control Consortium Genetic variants influencing circulating lipid levels and risk of coronary artery disease Arterioscler. Thromb. Vasc. Biol. 30 2010 2264 2276
70. J.B. Wilk, T.H. Chen, D.J. Gottlieb, R.E. Walter, M.W. Nagle, B.J. Brandler, R.H. Myers, I.B. Borecki, E.K. Silverman, S.T. Weiss, and G.T. O'Connor A genome-wide association study of pulmonary function measures in the Framingham Heart Study PLoS Genet. 5 2009 e1000429
71. C. Wu, Z. Hu, Z. He, W. Jia, F. Wang, Y. Zhou, Z. Liu, Q. Zhan, Y. Liu, and D. Yu Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations Nat. Genet. 43 2011 679 684
72. Q. Yang, A. Köttgen, A. Dehghan, A.V. Smith, N.L. Glazer, M.H. Chen, D.I. Chasman, T. Aspelund, G. Eiriksdottir, and T.B. Harris Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors Circ Cardiovasc Genet 3 2010 523 530
73. K. Yasuda, K. Miyake, Y. Horikawa, K. Hara, H. Osawa, H. Furuta, Y. Hirota, H. Mori, A. Jonsson, and Y. Sato Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus Nat. Genet. 40 2008 1092 1097