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Volumn 19, Issue 2, 2014, Pages 228-234

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid

(24)  Luykx, J J a,b   Bakker, S C a   Lentjes, E b   Neeleman, M a   Strengman, E b   Mentink, L a,b   Deyoung, J c   De Jong, S c   Sul, J H d   Eskin, E d,e   Van Eijk, K b   Van Setten, J b   Buizer Voskamp, J E a   Cantor, R M e   Lu, A e   Van Amerongen, M f   Van Dongen, E P A g   Keijzers, P h   Kappen, T b   Borgdorff, P i   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; DNA; GLUTAMATE RECEPTOR; MESSENGER RNA; MONOAMINE; SEROTONIN; 5 HYDROXYINDOLEACETIC ACID; DOPAMINE; HOMOVANILLIC ACID; PHOSPHODIESTERASE; PHOSPHODIESTERASE 9A; UNCLASSIFIED DRUG;

EID: 84893658006     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2012.183     Document Type: Article
Times cited : (43)

References (67)
  • 1
    • 0038670579 scopus 로고    scopus 로고
    • The human phenome project
    • Freimer N, Sabatti C. The human phenome project. Nat Genet 2003; 34: 15-21.
    • (2003) Nat Genet , vol.34 , pp. 15-21
    • Freimer, N.1    Sabatti, C.2
  • 3
    • 79957489903 scopus 로고    scopus 로고
    • TMEM132D, a new candidate for anxiety phenotypes: Evidence from human and mouse studies
    • Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S et al. TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol Psychiatry 2011; 16: 647-663.
    • (2011) Mol Psychiatry , vol.16 , pp. 647-663
    • Erhardt, A.1    Czibere, L.2    Roeske, D.3    Lucae, S.4    Unschuld, P.G.5    Ripke, S.6
  • 4
    • 84855360075 scopus 로고    scopus 로고
    • Genome-wide association study of major depressive disorder: New results, metaanalysis, and lessons learned
    • Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR et al. Genome-wide association study of major depressive disorder: new results, metaanalysis, and lessons learned. Mol Psychiatry 2012; 17: 36-48.
    • (2012) Mol Psychiatry , vol.17 , pp. 36-48
    • Wray, N.R.1    Pergadia, M.L.2    Blackwood, D.H.3    Penninx, B.W.4    Gordon, S.D.5    Nyholt, D.R.6
  • 8
    • 0037308528 scopus 로고    scopus 로고
    • Genes for schizophrenia? Recent findings and their pathophysiological implications
    • Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 2003; 361: 417-419.
    • (2003) Lancet , vol.361 , pp. 417-419
    • Harrison, P.J.1    Owen, M.J.2
  • 9
    • 42449129221 scopus 로고    scopus 로고
    • Clinical utility of monoamine neurotransmitter metabolite analysis in cerebrospinal fluid
    • Hyland K. Clinical utility of monoamine neurotransmitter metabolite analysis in cerebrospinal fluid. Clin Chem 2008; 54: 633-641.
    • (2008) Clin Chem , vol.54 , pp. 633-641
    • Hyland, K.1
  • 11
    • 79960352475 scopus 로고    scopus 로고
    • The monoamine neurotransmitter disorders: An expanding range of neurological syndromes
    • Kurian MA, Gissen P, Smith M, Heales Jr. S, Clayton PT. The monoamine neurotransmitter disorders: an expanding range of neurological syndromes. Lancet Neurol 2011; 10: 721-733.
    • (2011) Lancet Neurol , vol.10 , pp. 721-733
    • Kurian, M.A.1    Gissen, P.2    Smith, M.3    Heales, Jr.S.4    Clayton, P.T.5
  • 12
    • 0029842899 scopus 로고    scopus 로고
    • Neurotransmitters in CSF of idiopathic adult-onset dystonia: Reduced 5-HIAA levels as evidence of impaired serotonergic metabolism
    • Naumann M, Gotz M, Reiners K, Lange KW, Riederer P. Neurotransmitters in CSF of idiopathic adult-onset dystonia: reduced 5-HIAA levels as evidence of impaired serotonergic metabolism. J Neural Transm 1996; 103: 1083-1091.
    • (1996) J Neural Transm , vol.103 , pp. 1083-1091
    • Naumann, M.1    Gotz, M.2    Reiners, K.3    Lange, K.W.4    Riederer, P.5
  • 13
    • 0036081162 scopus 로고    scopus 로고
    • Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia
    • Assmann B, Kohler M, Hoffmann GF, Heales S, Surtees R. Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia. Pediat Res 2002; 52: 91-94.
    • (2002) Pediat Res , vol.52 , pp. 91-94
    • Assmann, B.1    Kohler, M.2    Hoffmann, G.F.3    Heales, S.4    Surtees, R.5
  • 14
    • 35649001487 scopus 로고    scopus 로고
    • A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species
    • Freimer NB, Service SK, Ophoff RA, Jasinska AJ, McKee K, Villeneuve A et al. A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species. Proc Natl Acad Sci USA 2007; 104: 15811-15816.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15811-15816
    • Freimer, N.B.1    Service, S.K.2    Ophoff, R.A.3    Jasinska, A.J.4    McKee, K.5    Villeneuve, A.6
  • 15
    • 0027268035 scopus 로고
    • Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta)
    • Higley JD, Thompson WW, Champoux M, Goldman D, Hasert MF, Kraemer GW et al. Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta). Arch Gen Psychiatry 1993; 50: 615-623.
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 615-623
    • Higley, J.D.1    Thompson, W.W.2    Champoux, M.3    Goldman, D.4    Hasert, M.F.5    Kraemer, G.W.6
  • 16
    • 1642378729 scopus 로고    scopus 로고
    • Genetics of monoamine metabolites in baboons: Overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid
    • Rogers J, Martin LJ, Comuzzie AG, Mann JJ, Manuck SB, Leland M et al. Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid. Biol Psychiatry 2004; 55: 739-744.
    • (2004) Biol Psychiatry , vol.55 , pp. 739-744
    • Rogers, J.1    Martin, L.J.2    Comuzzie, A.G.3    Mann, J.J.4    Manuck, S.B.5    Leland, M.6
  • 17
    • 33748040737 scopus 로고    scopus 로고
    • A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index
    • Ducci F, Newman TK, Funt S, Brown GL, Virkkunen M, Goldman D. A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index. Mol Psychiatry 2006; 11: 858-866.
    • (2006) Mol Psychiatry , vol.11 , pp. 858-866
    • Ducci, F.1    Newman, T.K.2    Funt, S.3    Brown, G.L.4    Virkkunen, M.5    Goldman, D.6
  • 18
    • 0342424722 scopus 로고    scopus 로고
    • A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    • Jonsson EG, Norton N, Gustavsson JP, Oreland L, Owen MJ, Sedvall GC. A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers. J Psychiatr Res 2000; 34: 239-244.
    • (2000) J Psychiatr Res , vol.34 , pp. 239-244
    • Jonsson, E.G.1    Norton, N.2    Gustavsson, J.P.3    Oreland, L.4    Owen, M.J.5    Sedvall, G.C.6
  • 19
    • 2642537654 scopus 로고    scopus 로고
    • Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    • Jonsson EG, Bah J, Melke J, Abou Jamra R, Schumacher J, Westberg L et al. Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers. BMC Psychiatry 2004; 4: 4.
    • (2004) BMC Psychiatry , vol.4 , pp. 4
    • Jonsson, E.G.1    Bah, J.2    Melke, J.3    Abou Jamra, R.4    Schumacher, J.5    Westberg, L.6
  • 20
    • 34548687990 scopus 로고    scopus 로고
    • Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression
    • Kishida I, Aklillu E, Kawanishi C, Bertilsson L, Agren H. Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression. Neuropsychopharmacology 2007; 32: 2143-2151.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2143-2151
    • Kishida, I.1    Aklillu, E.2    Kawanishi, C.3    Bertilsson, L.4    Agren, H.5
  • 22
    • 84856462859 scopus 로고    scopus 로고
    • Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid
    • Luykx JJ, Bakker SC, Lentjes E, Boks MP, van Geloven N, Eijkemans MJ et al. Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid. PLoS One 2012; 7: e30497.
    • (2012) PLoS One , vol.7
    • Luykx, J.J.1    Bakker, S.C.2    Lentjes, E.3    Boks, M.P.4    Van Geloven, N.5    Eijkemans, M.J.6
  • 25
  • 26
    • 35348817330 scopus 로고    scopus 로고
    • Rapid and accurate haplotype phasing and missingdata inference for whole-genome association studies by use of localized haplotype clustering
    • Browning SR, Browning BL. Rapid and accurate haplotype phasing and missingdata inference for whole-genome association studies by use of localized haplotype clustering. Am J Hum Genet 2007; 81: 1084-1097.
    • (2007) Am J Hum Genet , vol.81 , pp. 1084-1097
    • Browning, S.R.1    Browning, B.L.2
  • 27
    • 84864417548 scopus 로고    scopus 로고
    • Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
    • Howie BFC, Stephens M, Marchini J, Abecasis GR. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet 2012; 44: 955-9.
    • (2012) Nat Genet , vol.44 , pp. 955-959
    • Howie, B.F.C.1    Stephens, M.2    Marchini, J.3    Abecasis, G.R.4
  • 28
    • 78649508578 scopus 로고    scopus 로고
    • MaCH: Using sequence and genotype data to estimate haplotypes and unobserved genotypes
    • Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 2010; 34: 816-834.
    • (2010) Genet Epidemiol , vol.34 , pp. 816-834
    • Li, Y.1    Willer, C.J.2    Ding, J.3    Scheet, P.4    Abecasis, G.R.5
  • 29
    • 0016833666 scopus 로고
    • Concentrations of monoamine metabolites in human lumbar and cisternal cerebrospinal fluid
    • Johansson B, Roos BE. Concentrations of monoamine metabolites in human lumbar and cisternal cerebrospinal fluid. Acta Neurol Scand 1975; 52: 137-144.
    • (1975) Acta Neurol Scand , vol.52 , pp. 137-144
    • Johansson, B.1    Roos, B.E.2
  • 30
    • 0028627789 scopus 로고
    • CSF concentration gradients of monoamine metabolites in patients with hydrocephalus
    • Malm J, Kristensen B, Ekstedt J, Wester P. CSF concentration gradients of monoamine metabolites in patients with hydrocephalus. J Neurol Neurosurg Psychiatry 1994; 57: 1026-1033.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 1026-1033
    • Malm, J.1    Kristensen, B.2    Ekstedt, J.3    Wester, P.4
  • 31
    • 42249087793 scopus 로고    scopus 로고
    • Estimation of significance thresholds for genomewide association scans
    • Dudbridge F, Gusnanto A. Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 2008; 32: 227-234.
    • (2008) Genet Epidemiol , vol.32 , pp. 227-234
    • Dudbridge, F.1    Gusnanto, A.2
  • 32
    • 12244264435 scopus 로고    scopus 로고
    • Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits
    • Purcell S, Cherny SS, Sham PC. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003; 19: 149-150.
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 33
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: A pipeline for processing illumina microarray
    • Du P, Kibbe WA, Lin SM. lumi: a pipeline for processing Illumina microarray. Bioinformatics 2008; 24: 1547-1548.
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 34
    • 39149111937 scopus 로고    scopus 로고
    • Model-based variance-stabilizing transformation for Illumina microarray data
    • Lin SM, Du P, Huber W, Kibbe WA. Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res 2008; 36: e11.
    • (2008) Nucleic Acids Res , vol.36
    • Lin, S.M.1    Du, P.2    Huber, W.3    Kibbe, W.A.4
  • 35
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article 3
    • Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article 3.
    • (2004) Stat Appl Genet Mol Biol , vol.3
    • Smyth, G.K.1
  • 36
    • 33644872577 scopus 로고    scopus 로고
    • Limma: Linear models for microarray data
    • R Gentleman, V Carey, S Dudoit, R Irizarry, W Huber (eds) Springer: New York
    • Smyth GK. Limma: linear models for microarray data. In: R Gentleman, V Carey, S Dudoit, R Irizarry, W Huber (eds). Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Springer: New York, 2005, pp 397-420.
    • (2005) Bioinformatics and Computational Biology Solutions Using R and Bioconductor. , pp. 397-420
    • Smyth, G.K.1
  • 37
    • 84863455522 scopus 로고    scopus 로고
    • Prediction of serotonin transporter promoter polymorphism genotypes from single nucleotide polymorphism arrays using machine learning methods
    • Lu AT, Bakker S, Janson E, Cichon S, Cantor RM, Ophoff RA. Prediction of serotonin transporter promoter polymorphism genotypes from single nucleotide polymorphism arrays using machine learning methods. Psychiatr Genet 2012; 22: 182-188.
    • (2012) Psychiatr Genet , vol.22 , pp. 182-188
    • Lu, A.T.1    Bakker, S.2    Janson, E.3    Cichon, S.4    Cantor, R.M.5    Ophoff, R.A.6
  • 38
    • 46749136096 scopus 로고    scopus 로고
    • Mutations in human monoamine-related neurotransmitter pathway genes
    • Haavik J, Blau N, Thony B. Mutations in human monoamine-related neurotransmitter pathway genes. Hum Mutat 2008; 29: 891-902.
    • (2008) Hum Mutat , vol.29 , pp. 891-902
    • Haavik, J.1    Blau, N.2    Thony, B.3
  • 40
    • 84859991527 scopus 로고    scopus 로고
    • Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo
    • Kleiman RJ, Chapin DS, Christoffersen C, Freeman J, Fonseca KR, Geoghegan KF et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther 2012; 341: 396-409.
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 396-409
    • Kleiman, R.J.1    Chapin, D.S.2    Christoffersen, C.3    Freeman, J.4    Fonseca, K.R.5    Geoghegan, K.F.6
  • 41
    • 0026453393 scopus 로고
    • Molecular cloning and functional expression of a brain-specific somatostatin receptor
    • Bruno JF, Xu Y, Song J, Berelowitz M. Molecular cloning and functional expression of a brain-specific somatostatin receptor. Proc Natl Acad Sci USA 1992; 89: 11151-11155.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11151-11155
    • Bruno, J.F.1    Xu, Y.2    Song, J.3    Berelowitz, M.4
  • 42
    • 42749095376 scopus 로고    scopus 로고
    • Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    • Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci 2008; 31: 234-242.
    • (2008) Trends Neurosci , vol.31 , pp. 234-242
    • Lisman, J.E.1    Coyle, J.T.2    Green, R.W.3    Javitt, D.C.4    Benes, F.M.5    Heckers, S.6
  • 43
    • 79955473843 scopus 로고    scopus 로고
    • Genome-wide association study of bipolar i disorder in the Han Chinese population
    • Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC et al. Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry 2011; 16: 548-556.
    • (2011) Mol Psychiatry , vol.16 , pp. 548-556
    • Lee, M.T.1    Chen, C.H.2    Lee, C.S.3    Chen, C.C.4    Chong, M.Y.5    Ouyang, W.C.6
  • 45
    • 67349182343 scopus 로고    scopus 로고
    • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
    • Glessner JT, Wang K, Cai G, Korvatska O, Kim CE, Wood S et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 2009; 459: 569-573.
    • (2009) Nature , vol.459 , pp. 569-573
    • Glessner, J.T.1    Wang, K.2    Cai, G.3    Korvatska, O.4    Kim, C.E.5    Wood, S.6
  • 49
    • 0029979454 scopus 로고    scopus 로고
    • Cyclic nucleotide-gated ion channels: An extended family with diverse functions
    • Finn JT, Grunwald ME, Yau KW. Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Annu Rev Physiol 1996; 58: 395-426.
    • (1996) Annu Rev Physiol , vol.58 , pp. 395-426
    • Finn, J.T.1    Grunwald, M.E.2    Yau, K.W.3
  • 50
    • 33746629480 scopus 로고    scopus 로고
    • Phosphodiesterases in the CNS: Targets for drug development
    • Menniti FS, Faraci WS, Schmidt CJ. Phosphodiesterases in the CNS: targets for drug development. Nat Rev Drug Discov 2006; 5: 660-670.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 660-670
    • Menniti, F.S.1    Faraci, W.S.2    Schmidt, C.J.3
  • 51
    • 70350347177 scopus 로고    scopus 로고
    • Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampus
    • Reierson GW, Mastronardi CA, Licinio J, Wong ML. Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampus. Neurosci Lett 2009; 466: 149-153.
    • (2009) Neurosci Lett , vol.466 , pp. 149-153
    • Reierson, G.W.1    Mastronardi, C.A.2    Licinio, J.3    Wong, M.L.4
  • 52
    • 0033556178 scopus 로고    scopus 로고
    • Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms
    • Takahashi M, Terwilliger R, Lane C, Mezes PS, Conti M, Duman RS. Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms. Neurosci 1999; 19: 610-618.
    • (1999) Neurosci , vol.19 , pp. 610-618
    • Takahashi, M.1    Terwilliger, R.2    Lane, C.3    Mezes, P.S.4    Conti, M.5    Duman, R.S.6
  • 54
    • 33750061011 scopus 로고    scopus 로고
    • Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
    • Wong ML, Whelan F, Deloukas P, Whittaker P, Delgado M, Cantor RM et al. Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc Natl Acad Sci USA 2006; 103: 15124-15129.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15124-15129
    • Wong, M.L.1    Whelan, F.2    Deloukas, P.3    Whittaker, P.4    Delgado, M.5    Cantor, R.M.6
  • 57
    • 0035889980 scopus 로고    scopus 로고
    • Expression of cGMP-specific phosphodiesterase 9A mRNA in the rat brain
    • Andreeva SG, Dikkes P, Epstein PM, Rosenberg PA. Expression of cGMP-specific phosphodiesterase 9A mRNA in the rat brain. J Neurosci 2001; 21: 9068-9076.
    • (2001) J Neurosci , vol.21 , pp. 9068-9076
    • Andreeva, S.G.1    Dikkes, P.2    Epstein, P.M.3    Rosenberg, P.A.4
  • 58
    • 27844464469 scopus 로고    scopus 로고
    • Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line
    • Wunder F, Tersteegen A, Rebmann A, Erb C, Fahrig T, Hendrix M. Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line. Mol Pharmacol 2005; 68: 1775-1781.
    • (2005) Mol Pharmacol , vol.68 , pp. 1775-1781
    • Wunder, F.1    Tersteegen, A.2    Rebmann, A.3    Erb, C.4    Fahrig, T.5    Hendrix, M.6
  • 59
    • 73249130591 scopus 로고    scopus 로고
    • Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy
    • Verhoest PR, Proulx-Lafrance C, Corman M, Chenard L, Helal CJ, Hou X et al. Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy. J Med Chem 2009; 52: 7946-7949.
    • (2009) J Med Chem , vol.52 , pp. 7946-7949
    • Verhoest, P.R.1    Proulx-Lafrance, C.2    Corman, M.3    Chenard, L.4    Helal, C.J.5    Hou, X.6
  • 60
    • 79959999316 scopus 로고    scopus 로고
    • The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4- methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H- py ran-4-yl)-1,5- dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
    • Hutson PH, Finger EN, Magliaro BC, Smith SM, Converso A, Sanderson PE et al. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4- methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H- py ran-4-yl)-1,5- dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. Neuropharmacology 2011; 61: 665-676.
    • (2011) Neuropharmacology , vol.61 , pp. 665-676
    • Hutson, P.H.1    Finger, E.N.2    Magliaro, B.C.3    Smith, S.M.4    Converso, A.5    Sanderson, P.E.6
  • 61
    • 79957607662 scopus 로고    scopus 로고
    • Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
    • Small KS, Hedman AK, Grundberg E, Nica AC, Thorleifsson G, Kong A et al. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet 2011; 43: 561-564.
    • (2011) Nat Genet , vol.43 , pp. 561-564
    • Small, K.S.1    Hedman, A.K.2    Grundberg, E.3    Nica, A.C.4    Thorleifsson, G.5    Kong, A.6
  • 63
    • 74849111621 scopus 로고    scopus 로고
    • Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders
    • Glinskii AB, Ma J, Ma S, Grant D, Lim CU, Sell S et al. Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders. Cell Cycle 2009; 8: 3925-3942.
    • (2009) Cell Cycle , vol.8 , pp. 3925-3942
    • Glinskii, A.B.1    Ma, J.2    Ma, S.3    Grant, D.4    Lim, C.U.5    Sell, S.6
  • 65
    • 78650315006 scopus 로고    scopus 로고
    • Systems level studies of mammalian metabolomes: The roles of mass spectrometry and nuclear magnetic resonance spectroscopy
    • Dunn WB, Broadhurst DI, Atherton HJ, Goodacre R, Griffin JL. Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem Soc Rev 2011; 40: 387-426.
    • (2011) Chem Soc Rev , vol.40 , pp. 387-426
    • Dunn, W.B.1    Broadhurst, D.I.2    Atherton, H.J.3    Goodacre, R.4    Griffin, J.L.5
  • 66
    • 78651249842 scopus 로고    scopus 로고
    • Symptomatic pulmonary embolism after outpatient arthroscopic procedures of the knee: The incidence and risk factors in 418,323 arthroscopies
    • Hetsroni I, Lyman S, Do H, Mann G, Marx RG. Symptomatic pulmonary embolism after outpatient arthroscopic procedures of the knee: the incidence and risk factors in 418,323 arthroscopies. J Bone Joint Surg Br 2011; 93: 47-51.
    • (2011) J Bone Joint Surg Br , vol.93 , pp. 47-51
    • Hetsroni, I.1    Lyman, S.2    Do, H.3    Mann, G.4    Marx, R.G.5
  • 67
    • 82855165185 scopus 로고    scopus 로고
    • Region and state specific glutamate downregulation in major depressive disorder: A meta-analysis of (1)H-MRS findings
    • Luykx JJ, Laban KG, van den Heuvel MP, Boks MP, Mandl RC, Kahn RS et al. Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of (1)H-MRS findings. Neurosci Biobehav Rev 2012; 36: 198-205.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 198-205
    • Luykx, J.J.1    Laban, K.G.2    Van Den Heuvel, M.P.3    Boks, M.P.4    Mandl, R.C.5    Kahn, R.S.6


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