Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells

Biochemical Pharmacology

Volumn 98, Issue 1, 2015, Pages 190-202

  Li, Daochuan ^a   MacKowiak, Bryan ^a   Brayman, Timothy G ^b   Mitchell, Michael ^b   Zhang, Lei ^c   Huang, Shiew Mei ^c   Wang, Hongbing ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Sigma Life Science   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

CAR; CITCO; Gene knockout; HepaRG; Phenobarbital; RNA seq

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; DRUG METABOLIZING ENZYME; GENOMIC DNA; PHENOBARBITAL; RNA; TRANSCRIPTOME; 6-(4-CHLOROPHENYL)IMIDAZO(2,1-B)(1,3)THIAZOLE-5-CARBALDEHYDE O-(3,4-DICHLOROBENZYL)OXIME; AMINO ACID RECEPTOR BLOCKING AGENT; CELL RECEPTOR; OXIME; THIAZOLE DERIVATIVE;

ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE INACTIVATION; GENETIC ASSOCIATION; GENETIC CODE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; UPREGULATION; WILD TYPE; AGONISTS; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; PHYSIOLOGY;

EXCITATORY AMINO ACID ANTAGONISTS; GENE DELETION; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; OXIMES; PHENOBARBITAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; THIAZOLES; TRANSCRIPTOME;

EID: 84943450204     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.08.087     Document Type: Article

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