Pyrene is a novel constitutive androstane receptor (CAR) activator and causes hepatotoxicity by CAR

Toxicological Sciences

Volumn 147, Issue 2, 2015, Pages 436-445

  Zhang, Xiao Jie ^a   Shi, Zhe ^a   Lyv, Jing Xi ^a   He, Xuyan ^a   Englert, Neal A ^b   Zhang, Shu Yun ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Hepatotoxicity; Nuclear receptor CAR; Pyrene

Indexed keywords

1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; ALANINE AMINOTRANSFERASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; CYTOCHROME P450 2B10; CYTOCHROME P450 2B6; CYTOCHROME P450 3A11; GLUTATHIONE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M3; PYRENE; SULFOTRANSFERASE 1A1; UNCLASSIFIED DRUG; CELL RECEPTOR; PYRENE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DISEASE ACTIVITY; ENZYME ACTIVITY; GENE EXPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL; LIVER HYPERTROPHY; LIVER METABOLISM; LIVER TOXICITY; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ACTIVE TRANSPORT; AGONISTS; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; ENZYMOLOGY; LIVER; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ALANINE TRANSAMINASE; ANIMALS; BLOTTING, WESTERN; CYTOCHROME P-450 CYP2B6; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; HEP G2 CELLS; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; PYRENES; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84943452664     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv142     Document Type: Article

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