Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway

Molecular Cancer Therapeutics

Volumn 6, Issue 6, 2007, Pages 1840-1850

  Ke, Ning ^a   Sundaram, Roshni ^a   Liu, Guohong ^a   Chionis, John ^a   Fan, Wufang ^a   Rogers, Cheryl ^a   Awad, Tarif ^b   Grifman, Mirta ^a   Yu, Dehua ^a   Wong Staal, Flossie ^a   Li, Qi Xiang ^a  

^a Immusol Inc   (United States)

^b Thermo Fisher Scientific   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR 56; GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANOIKIS; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER TISSUE; CARCINOGENESIS; CELL ADHESION; CELL LINE; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MELANOMA CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR REGRESSION;

ANIMALS; BASE SEQUENCE; CELL ADHESION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA PRIMERS; GENE EXPRESSION PROFILING; GENE SILENCING; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34250693661     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0066     Document Type: Article

References (22)

1. Bewick MA, Lafrenie RM. Adhesion dependent signalling in the tumour microenvironment: the future of drug targetting. Curr Pharm Des 2006;12:2833-48.
2. Syrigos KN, Karayiannakis AJ. Adhesion molecules as targets for the treatment of neoplastic diseases. Curr Pharm Des 2006;12:2849-61.
3. Bjarnadottir TK, Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004;84:23-33.
4. Zendman AJ, Cornelissen IM, Weidle UH, Ruiter DJ, van Muijen GN. TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential. FEBS Lett 1999;446:292-8.
5. Liu M, Parker RM, Darby K, et al. GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics 1999;55:296-305.
6. Shashidhar S, Lorente G, Nagavarapu U, et al. GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion. Oncogene 2005;24:1673-82.
7. Piao X, Hill RS, Bodell A, et al. G protein-coupled receptor-dependent development of human frontal cortex. Science 2004;303:2033-6.
8. Xu L, Begum S, Hearn JD, Hynes RO. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci U S A 2006;103:9023-8.
9. Boylan MO, Athanassiou M, Houle B, Wang Y, Zarbl H. Activation of tumor suppressor genes in nontumorigenic revertants of the HeLa cervical carcinoma cell line. Cell Growth Differ 1996;7:725-35.
10. Ke N, Claassen G, Yu DH, et al. Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis. Cancer Res 2004;64:8208-12.
11. Ke N, Albers A, Claassen G, et al. One-week 96-well soft agar growth assay for cancer target validation. Biotechniques 2004;36:826-8, 830, 832-3.
12. Ke N, Zhou D, Chatterton JE, et al. A new inducible RNAi xenograft model for assessing the staged tumor response to mTOR silencing. Exp Cell Res 2006;312:2726-34.
13. Claassen G, Ke N, Yu DH, et al. Comprehensive assessment of cell growth properties affected by various agents using an integrated and non-subjective approach. Preclinica 2004;2:435-9.
14. Yu DH, Fan W, Liu G, et al. PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. Exp Cell Res 2006;312:865-76.
15. Li QX, Tan P, Ke N, Wong-Staal F. Ribozyme technology for cancer gene target identification and validation. Adv Cancer Res 2007;96:103-43.
16. Welch PJ, Marcusson EG, Li QX, et al. Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. Genomics 2000;66:274-83.
17. Fiucci G, Ravid D, Reich R, Liscovitch M. Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 2002;21:2365-75.
18. Resh MD. Fyn, a Src family tyrosine kinase. Int J Biochem Cell Biol 1998;30:1159-62.
19. Takayama T, Mogi Y, Kogawa K, et al. A role for the fyn oncogene in metastasis of methylcholanthrene-induced fibrosarcoma A cells. Int J Cancer 1993;54:875-9.
20. Hynes RO. Cell adhesion: old and new questions. Trends Cell Biol 1999;9:M33-7.
21. Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 2004;4:937-47.
22. Little KD, Hemler ME, Stipp CS. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Gα q/11 association. Mol Biol Cell 2004;15:2375-87.