Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches

Pharmaceutical Research

Volumn 30, Issue 2, 2013, Pages 489-501

  Lynch, Caitlin ^a   Pan, Yongmei ^a   Li, Linhao ^a   Ferguson, Stephen S ^b   Xia, Menghang ^c   Swaan, Peter W ^a   Wang, Hongbing ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Life Technologies Corp   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CAR; CYP2B6; hepatocytes; induction; pharmacophore

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B6;

ARTICLE; CARCINOGENESIS; DRUG APPROVAL; FOOD AND DRUG ADMINISTRATION; GENE TARGETING; HOMEOSTASIS; LIGAND BINDING; MATHEMATICAL MODEL; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; DATABASES, PHARMACEUTICAL; DRUG DISCOVERY; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; MOLECULAR DOCKING SIMULATION; OXIDOREDUCTASES, N-DEMETHYLATING; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84873433884     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0895-1     Document Type: Article

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