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Volumn 30, Issue 10, 2015, Pages 1656-1664

Obesity - A disease with many aetiologies disguised in the same oversized phenotype: Has the overeating theory failed?

Author keywords

epigenome; gut microbiota; insulin resistance; mitochondria; obesity

Indexed keywords

FRUCTOSE; GLUCOSE; TRANSCRIPTION FACTOR NRF2; TRIACYLGLYCEROL;

EID: 84943428908     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfu338     Document Type: Review
Times cited : (29)

References (100)
  • 2
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013 a systematic analysis for the global burden of disease study 2013
    • Ng M, Fleming T, RobinsonMet al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384: 766-781
    • (2014) Lancet , vol.384 , pp. 766-781
    • Ng, M.1    Fleming, T.2    Robinson, M.3
  • 4
    • 84876099677 scopus 로고    scopus 로고
    • Metabolic inflammation: Connecting obesity and insulin resistance
    • Dali-Youcef N, Mecili M, Ricci R, et al. Metabolic inflammation: connecting obesity and insulin resistance. Ann Med 2013; 45: 242-253
    • (2013) Ann Med , vol.45 , pp. 242-253
    • Dali-Youcef, N.1    Mecili, M.2    Ricci, R.3
  • 5
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard JI, Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 2013; 339: 172-177
    • (2013) Science , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 7
    • 84874233416 scopus 로고    scopus 로고
    • Dietary patterns, calories, and kidney disease
    • Kramer H. Dietary patterns, calories, and kidney disease. Adv Chronic Kidney Dis 2013; 20: 135-140
    • (2013) Adv Chronic Kidney Dis , vol.20 , pp. 135-140
    • Kramer, H.1
  • 8
    • 84870987975 scopus 로고    scopus 로고
    • Treat obesity as physiology, not physics
    • Taube G. Treat obesity as physiology, not physics. Nature 2012; 492: 155
    • (2012) Nature , vol.492 , pp. 155
    • Taube, G.1
  • 9
    • 84887409757 scopus 로고    scopus 로고
    • Worldwide relation between the number of mcdonald's restaurants and the prevalence of obesity
    • Alhéritière A, Montois S, Galinski M, et al. Worldwide relation between the number of McDonald's restaurants and the prevalence of obesity. J Intern Med 2013; 274: 610-611
    • (2013) J Intern Med , vol.274 , pp. 610-611
    • Alhéritière, A.1    Montois, S.2    Galinski, M.3
  • 10
    • 84868665312 scopus 로고    scopus 로고
    • Physical inactivity: Associated diseases and disorders
    • Knight JA. Physical inactivity: associated diseases and disorders. Ann Clin Lab Sci 2012; 42: 320-337
    • (2012) Ann Clin Lab Sci , vol.42 , pp. 320-337
    • Knight, J.A.1
  • 11
    • 84863985439 scopus 로고    scopus 로고
    • Anorexia nervosa and obesity are associated with opposite brain reward response
    • Frank GK, Reynolds JR, Shott ME, et al. Anorexia nervosa and obesity are associated with opposite brain reward response. Neuropsychopharmacology 2012; 37: 2031-2046
    • (2012) Neuropsychopharmacology , vol.37 , pp. 2031-2046
    • Frank, G.K.1    Reynolds, J.R.2    Shott, M.E.3
  • 13
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444: 1022-1023
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3
  • 14
    • 39649110585 scopus 로고    scopus 로고
    • Could viruses contribute to the worldwide epidemic of obesity?
    • Atkinson RL. Could viruses contribute to the worldwide epidemic of obesity?. Int J Pediatr Obes 2008; 3: 37-43
    • (2008) Int J Pediatr Obes , vol.3 , pp. 37-43
    • Atkinson, R.L.1
  • 15
    • 80051784027 scopus 로고    scopus 로고
    • Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake
    • Roncal-Jimenez CA, Lanaspa MA, Rivard CJ, et al. Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism 2011; 60: 1259-1270
    • (2011) Metabolism , vol.60 , pp. 1259-1270
    • Roncal-Jimenez, C.A.1    Lanaspa, M.A.2    Rivard, C.J.3
  • 16
    • 84984930218 scopus 로고    scopus 로고
    • Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome
    • Lanaspa MA, Ishimoto T, Li N, et al. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun 2013; 4: 2434
    • (2013) Nat Commun , vol.4 , pp. 2434
    • Lanaspa, M.A.1    Ishimoto, T.2    Li, N.3
  • 17
    • 0033816441 scopus 로고    scopus 로고
    • Can anyone successfully control their weight? Findings of a three year community-based study of men and women
    • Crawford D, Jeffery RW, French SA. Can anyone successfully control their weight?. Findings of a three year community-based study of men and women. Int J Obes Relat Metab Disord 2000; 24: 1107-1110
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 1107-1110
    • Crawford, D.1    Jeffery, R.W.2    French, S.A.3
  • 18
    • 84874524849 scopus 로고    scopus 로고
    • The relationship of sugar to populationlevel diabetes prevalence: An econometric analysis of repeated cross-sectional data
    • Basu S, Yoffe P, Hills N, et al. The relationship of sugar to populationlevel diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS ONE 2013; 8: e57973
    • (2013) Plos One , vol.8 , pp. e57973
    • Basu, S.1    Yoffe, P.2    Hills, N.3
  • 19
    • 36849090797 scopus 로고    scopus 로고
    • Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients
    • Trirogoff ML, Shintani A, Himmelfarb J, et al. Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients. Am J Clin Nutr 2007; 86: 1642-1648
    • (2007) Am J Clin Nutr , vol.86 , pp. 1642-1648
    • Trirogoff, M.L.1    Shintani, A.2    Himmelfarb, J.3
  • 20
    • 84905438166 scopus 로고    scopus 로고
    • Validation of insulin sensitivity surrogate indices and prediction of clinical outcomes in individuals with and without impaired renal function
    • Jia T, Huang X, Qureshi AR, et al. Validation of insulin sensitivity surrogate indices and prediction of clinical outcomes in individuals with and without impaired renal function. Kidney Int 2014; 86: 383-391
    • (2014) Kidney Int , vol.86 , pp. 383-391
    • Jia, T.1    Huang, X.2    Qureshi, A.R.3
  • 21
    • 84865976689 scopus 로고    scopus 로고
    • Are there still healthy obese patients?
    • Blüher M. Are there still healthy obese patients?. Curr Opin Endocrinol Diabetes 2012; 19: 341-346
    • (2012) Curr Opin Endocrinol Diabetes , vol.19 , pp. 341-346
    • Blüher, M.1
  • 22
    • 84857686899 scopus 로고    scopus 로고
    • Insulin-sensitive obesity in humans-a "favorable fat' phenotype?
    • Samocha-Bonet D, Chisholm DJ, Tonks K, et al. Insulin-sensitive obesity in humans-a "favorable fat' phenotype?. Trends Endocrinol Metab 2012; 23: 116-124
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 116-124
    • Samocha-Bonet, D.1    Chisholm, D.J.2    Tonks, K.3
  • 23
    • 77953612080 scopus 로고    scopus 로고
    • Gluteofemoral body fat as a determinat of metabolic health
    • Manolopoulos KN, Karpe F, Frayn KN. Gluteofemoral body fat as a determinat of metabolic health. Int J Obes (Lond) 2010; 34: 949-959
    • (2010) Int J Obes (Lond , vol.34 , pp. 949-959
    • Manolopoulos, K.N.1    Karpe, F.2    Frayn, K.N.3
  • 24
    • 80053018598 scopus 로고    scopus 로고
    • Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals
    • Voulgari C, Tentolouris N, Dilaveris P, et al. Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol 2011; 58: 1343-1350
    • (2011) J Am Coll Cardiol , vol.58 , pp. 1343-1350
    • Voulgari, C.1    Tentolouris, N.2    Dilaveris, P.3
  • 25
    • 84863416895 scopus 로고    scopus 로고
    • Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1
    • Asterholm IW, Mundy DI, Weng J, et al. Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Cell Metab 2012; 15: 171-185
    • (2012) Cell Metab , vol.15 , pp. 171-185
    • Asterholm, I.W.1    Mundy, D.I.2    Weng, J.3
  • 26
    • 84878290380 scopus 로고    scopus 로고
    • Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology
    • Johnson RJ, Stenvinkel P, Martin SL, et al. Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity 2013; 21: 659-664
    • (2013) Obesity , vol.21 , pp. 659-664
    • Johnson, R.J.1    Stenvinkel, P.2    Martin, S.L.3
  • 27
    • 84873410195 scopus 로고    scopus 로고
    • Hibernating bears (ursidae): Metabolic magicians of definite interest for the nephrologist
    • Stenvinkel P, Jani AH, Johnson RJ. Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist. Kidney Int 2013; 83: 207-212
    • (2013) Kidney Int , vol.83 , pp. 207-212
    • Stenvinkel, P.1    Jani, A.H.2    Johnson, R.J.3
  • 28
    • 84883625178 scopus 로고    scopus 로고
    • Metabolic changes in summer active and anuric hibernating free-ranging brown bears (ursus arctos
    • Stenvinkel P, Fröbert O, Anderstam B, et al. Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos) PLoS ONE 2013; 8: e72934
    • (2013) Plos One , vol.8 , pp. e72934
    • Stenvinkel, P.1    Fröbert, O.2    Anderstam, B.3
  • 29
    • 84862224614 scopus 로고    scopus 로고
    • Brown bears (ursus arctos) seem resistant to atherosclerosis despite highly elevated plasma lipids during hibernation and active state
    • Arinell K, Sahdo B, Evans AL, et al. Brown bears (Ursus arctos) seem resistant to atherosclerosis despite highly elevated plasma lipids during hibernation and active state. Clin Transl Sci 2012; 5: 269-272
    • (2012) Clin Transl Sci , vol.5 , pp. 269-272
    • Arinell, K.1    Sahdo, B.2    Evans, A.L.3
  • 30
    • 84905732123 scopus 로고    scopus 로고
    • Grizzly bears exhibit augmented insulin sensitivity while obese prior to a reversible insulin resistance during hibernation
    • Nelson OL, Jansen HT, Galbreath E, et al. Grizzly bears exhibit augmented insulin sensitivity while obese prior to a reversible insulin resistance during hibernation. Cell Metab 2014; 20: 376-382
    • (2014) Cell Metab , vol.20 , pp. 376-382
    • Nelson, O.L.1    Jansen, H.T.2    Galbreath, E.3
  • 32
    • 49449098216 scopus 로고    scopus 로고
    • Dietary fructose consumption among us children and adults: The third national health and nutrition examination survey
    • Vos MB, Kimmons JE, Gillespie C, et al. Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J Med 2008; 9: 160
    • (2008) Medscape J Med , vol.9 , pp. 160
    • Vos, M.B.1    Kimmons, J.E.2    Gillespie, C.3
  • 33
    • 84943414625 scopus 로고    scopus 로고
    • Sweden: Statistik från jordbruksverket
    • Consumption of food 1960-2006. Sweden: Statistik från jordbruksverket. 2009
    • (2009) Consumption of Food 1960-2006
  • 34
    • 60549110854 scopus 로고    scopus 로고
    • Hypo thesis: Could excessive fructose intake and uric acid cause type 2 diabetes?
    • Johnson RJ, Perez-Pozo SE, Sautin YY, et al. Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?. Endocr Rev 2009; 30: 96-116
    • (2009) Endocr Rev , vol.30 , pp. 96-116
    • Johnson, R.J.1    Perez-Pozo, S.E.2    Sautin, Y.Y.3
  • 35
    • 84880131754 scopus 로고    scopus 로고
    • Adverse metabolic effects of dietary fructose: Results from the recent epidemiological, clinical and mechanistic studies
    • Stanhope KL, Schwarz JM, Havel P. Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical and mechanistic studies. Curr Opin Lipidol 2013; 24: 198-206
    • (2013) Curr Opin Lipidol , vol.24 , pp. 198-206
    • Stanhope, K.L.1    Schwarz, J.M.2    Havel, P.3
  • 36
    • 33645560926 scopus 로고    scopus 로고
    • A causal role for uric acid in fructose-induced metabolic syndrome
    • Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006; 290: F625-F631
    • (2006) Am J Physiol Renal Physiol , vol.290 , pp. F625-F631
    • Nakagawa, T.1    Hu, H.2    Zharikov, S.3
  • 37
    • 66449093225 scopus 로고    scopus 로고
    • Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    • Stanhope KL, Schwarz JM, Keim NL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009; 119: 1322-1334
    • (2009) J Clin Invest , vol.119 , pp. 1322-1334
    • Stanhope, K.L.1    Schwarz, J.M.2    Keim, N.L.3
  • 38
    • 84880222926 scopus 로고    scopus 로고
    • Fructose: It salcohol without the buzz
    • Lustig RH. Fructose: it s alcohol without the buzz. Adv Nutr 2013; 4: 226-235
    • (2013) Adv Nutr , vol.4 , pp. 226-235
    • Lustig, R.H.1
  • 39
    • 0032962915 scopus 로고    scopus 로고
    • Fatty acid oxidation affects food intake by altering hepatic energy status
    • Friedman MI, Harris RB, Ramirez I, et al. Fatty acid oxidation affects food intake by altering hepatic energy status. Am J Physiol 1999; 276: R1046-R1053
    • (1999) Am J Physiol , vol.276 , pp. R1046-R1053
    • Friedman, M.I.1    Harris, R.B.2    Ramirez, I.3
  • 40
    • 55849114189 scopus 로고    scopus 로고
    • Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding
    • Shapiro A, Mu W, Roncal C, et al. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol 2008; 295: R1370-R1375
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295 , pp. R1370-R1375
    • Shapiro, A.1    Mu, W.2    Roncal, C.3
  • 41
    • 63149108459 scopus 로고    scopus 로고
    • Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain
    • Lane MD, Cha SH. Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain. Biochem Biophys Res Commun 2009; 382: 1-5
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 1-5
    • Lane, M.D.1    Cha, S.H.2
  • 42
    • 84856627182 scopus 로고    scopus 로고
    • Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women
    • Cox CL, Stanhope KL, Schwarz JM, et al. Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women. Eur J Clin Nutr 2012; 66: 201-208
    • (2012) Eur J Clin Nutr , vol.66 , pp. 201-208
    • Cox, C.L.1    Stanhope, K.L.2    Schwarz, J.M.3
  • 43
    • 84893875963 scopus 로고    scopus 로고
    • Added sugar intake and cardiovascular diseases mortality among US adults
    • Yang Q, Zhang Z, Gregg EW, et al. Added sugar intake and cardiovascular diseases mortality among US adults. JAMA Intern Med 2014; 174: 516-524
    • (2014) Jama Intern Med , vol.174 , pp. 516-524
    • Yang, Q.1    Zhang, Z.2    Gregg, E.W.3
  • 44
    • 0036291466 scopus 로고    scopus 로고
    • Glycemic index, glycemic load, and risk of type 2 diabetes
    • Willett W, Manson J, Liu S. Glycemic index, glycemic load, and risk of type 2 diabetes. Am J Clin Nutr 2002; 76: 274S-280S
    • (2002) Am J Clin Nutr , vol.76 , pp. 274S-280S
    • Willett, W.1    Manson, J.2    Liu, S.3
  • 45
    • 21944452085 scopus 로고    scopus 로고
    • Risk of overweight and obesity among semivegetarian, lactovegetarian, and vegan women
    • Newby PK, Tucker KL, Wolk A. Risk of overweight and obesity among semivegetarian, lactovegetarian, and vegan women. Am J Clin Nutr 2005; 81: 1267-1274
    • (2005) Am J Clin Nutr , vol.81 , pp. 1267-1274
    • Newby, P.K.1    Tucker, K.L.2    Wolk, A.3
  • 46
    • 84891760409 scopus 로고    scopus 로고
    • Sugar, uric acid, and the etiology of diabetes and obesity
    • Johnson RJ, Nakagawa T, Sanchez-Lozada LG, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 2013; 62: 3307-3315
    • (2013) Diabetes , vol.62 , pp. 3307-3315
    • Johnson, R.J.1    Nakagawa, T.2    Sanchez-Lozada, L.G.3
  • 47
    • 84869996114 scopus 로고    scopus 로고
    • Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: Potential role in fructose-dependent and -independent fatty liver
    • Lanaspa MA, Sanchez-Lozada LG, Choi YJ, et al. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem 2012; 287: 40732-40744
    • (2012) J Biol Chem , vol.287 , pp. 40732-40744
    • Lanaspa, M.A.1    Sanchez-Lozada, L.G.2    Choi, Y.J.3
  • 48
    • 50449095362 scopus 로고    scopus 로고
    • Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: A randomized trial
    • Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 2008; 300: 924-932
    • (2008) Jama , vol.300 , pp. 924-932
    • Feig, D.I.1    Soletsky, B.2    Johnson, R.J.3
  • 49
    • 0028983567 scopus 로고
    • The influence of dairy products on plasma uric acid in women
    • Ghadirian P, Shatenstein B, Verdy M, et al. The influence of dairy products on plasma uric acid in women. Eur J Epidemiol 1995; 11: 275-281
    • (1995) Eur J Epidemiol , vol.11 , pp. 275-281
    • Ghadirian, P.1    Shatenstein, B.2    Verdy, M.3
  • 50
    • 70349566593 scopus 로고
    • Diabetes mellitus: A thrifty genotype rendered detrimental by progress?
    • Neel JV. Diabetes Mellitus: a thrifty genotype rendered detrimental by progress?. Am J Hum Genet 1962; 14: 353-362
    • (1962) Am J Hum Genet , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 51
    • 79951690860 scopus 로고    scopus 로고
    • Theodore e woodward award the evolution of obesity: Insights from the mid-miocene
    • Johnson RJ, Andrews P, Benner SA, et al. Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene. Trans Am Clin Climatol Assos 2010; 121: 295-305
    • (2010) Trans Am Clin Climatol Assos , vol.121 , pp. 295-305
    • Johnson, R.J.1    Andrews, P.2    Benner, S.A.3
  • 52
    • 34147125312 scopus 로고    scopus 로고
    • Defective mitochondrial biogenesis: A hallmark of the high cardiovascular risk in the metabolic syndrome?
    • Nisoli E, Clementi E, Carruba MO, et al. Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome?. Circ Res 2007; 100: 795-806
    • (2007) Circ Res , vol.100 , pp. 795-806
    • Nisoli, E.1    Clementi, E.2    Carruba, M.O.3
  • 53
    • 73249137594 scopus 로고    scopus 로고
    • Mitochondrial function and insulin resistance in overweight and normal-weight children
    • Fleischman A, Kron M, Systrom DM, et al. Mitochondrial function and insulin resistance in overweight and normal-weight children. J Clin Endocrinol Metab 2009; 94: 4923-4930
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4923-4930
    • Fleischman, A.1    Kron, M.2    Systrom, D.M.3
  • 54
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Morino K, Petersen KF, Dufour S, et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 2005; 115: 3587-3593
    • (2005) J Clin Invest , vol.115 , pp. 3587-3593
    • Morino, K.1    Petersen, K.F.2    Dufour, S.3
  • 55
    • 84875078504 scopus 로고    scopus 로고
    • Modulation of adipose tissue inflammation by bioactive food compounds
    • Siriwardhana N, Kalupahana NS, Cekanova M, et al. Modulation of adipose tissue inflammation by bioactive food compounds. J Nutr Biochem 2013; 24: 613-623
    • (2013) J Nutr Biochem , vol.24 , pp. 613-623
    • Siriwardhana, N.1    Kalupahana, N.S.2    Cekanova, M.3
  • 56
    • 84889564987 scopus 로고    scopus 로고
    • Novel insights of dietary polyphenols and obesity
    • Wang S, Moustaid-Moussa N, Chen L, et al. Novel insights of dietary polyphenols and obesity. J Nutr Biochem 2014; 25: 1-18
    • (2014) J Nutr Biochem , vol.25 , pp. 1-18
    • Wang, S.1    Moustaid-Moussa, N.2    Chen, L.3
  • 57
    • 84880349078 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol in obesity and type 2 diabetes: New avenues for health benefits?
    • Timmers S, Hesselink MK, Schrauwen P. Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?. Ann NY Acad Sci 2012; 1290: 83-89
    • (2012) Ann NY Acad Sci , vol.1290 , pp. 83-89
    • Timmers, S.1    Hesselink, M.K.2    Schrauwen, P.3
  • 58
    • 84885148256 scopus 로고    scopus 로고
    • Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet
    • Jimenez-Gomez Y, Mattison JA, Pearson KJ, et al. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab 2013; 18: 533-545
    • (2013) Cell Metab , vol.18 , pp. 533-545
    • Jimenez-Gomez, Y.1    Mattison, J.A.2    Pearson, K.J.3
  • 59
    • 84943416899 scopus 로고    scopus 로고
    • Can resveratrol help to maintain metabolic health?
    • Schrauwen P, Timmers S. Can resveratrol help to maintain metabolic health?. Proc Nutr Soc 2014; 14: 1-7
    • (2014) Proc Nutr Soc , vol.14 , pp. 1-7
    • Schrauwen, P.1    Timmers, S.2
  • 60
    • 84865188577 scopus 로고    scopus 로고
    • The fiber and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose in healthy human volunteers
    • Linderborg KM, Järvinen R, Lehtonen HM, et al. The fiber and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose in healthy human volunteers. Nutr Res 2012; 32: 471-478
    • (2012) Nutr Res , vol.32 , pp. 471-478
    • Linderborg, K.M.1    Järvinen, R.2    Lehtonen, H.M.3
  • 61
    • 84893832238 scopus 로고    scopus 로고
    • Evaluation of beneficial metabolic effects of berries in high-fat fed c57bl/6j mice
    • Heyman L, Axling U, Blanco N, et al. Evaluation of beneficial metabolic effects of berries in high-fat fed C57BL/6J mice. J Nutr Metab 2014; 2014: 403041
    • (2014) J Nutr Metab , vol.2014 , pp. 403041
    • Heyman, L.1    Axling, U.2    Blanco, N.3
  • 62
    • 84860591093 scopus 로고    scopus 로고
    • Effect of blueberry polyphenols on 3T3-F442A preadipocyte differentiation
    • Moghe SS, Juma S, Imrhan V, et al. Effect of blueberry polyphenols on 3T3-F442A preadipocyte differentiation. J Med Food 2012; 15: 448-452
    • (2012) J Med Food , vol.15 , pp. 448-452
    • Moghe, S.S.1    Juma, S.2    Imrhan, V.3
  • 63
    • 84865345184 scopus 로고    scopus 로고
    • Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women
    • Törrönen R, Kolehmainen M, Sarkkinen E, et al. Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Am J Clin Nutr 2012; 96: 527-533
    • (2012) Am J Clin Nutr , vol.96 , pp. 527-533
    • Törrönen, R.1    Kolehmainen, M.2    Sarkkinen, E.3
  • 64
    • 84867043672 scopus 로고    scopus 로고
    • Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome
    • Kolehmainen M, Mykkänen O, Kirjavainen PV, et al. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res 2012; 56: 1501-1510
    • (2012) Mol Nutr Food Res , vol.56 , pp. 1501-1510
    • Kolehmainen, M.1    Mykkänen, O.2    Kirjavainen, P.V.3
  • 65
    • 84878417938 scopus 로고    scopus 로고
    • Nut intake and adiposity: Meta-analysis of clinical trials
    • Flores-Mateo G, Rojas-Rueda D, Basora J, et al. Nut intake and adiposity: meta-analysis of clinical trials. Am J Clin Nutr 2013; 97: 1346-1355
    • (2013) Am J Clin Nutr , vol.97 , pp. 1346-1355
    • Flores-Mateo, G.1    Rojas-Rueda, D.2    Basora, J.3
  • 66
    • 84891128348 scopus 로고    scopus 로고
    • Effects of pistachio nuts on body composition, metabolic, inflammatory and oxidative stress parameters in Asian Indians with metabolic syndrome: A 24-wk, randomized control trial
    • Gulati S, Misra A, Pandey RM, et al. Effects of pistachio nuts on body composition, metabolic, inflammatory and oxidative stress parameters in Asian Indians with metabolic syndrome: a 24-wk, randomized control trial. Nutrition 2014; 30: 192-197
    • (2014) Nutrition , vol.30 , pp. 192-197
    • Gulati, S.1    Misra, A.2    Pandey, R.M.3
  • 67
    • 84878246396 scopus 로고    scopus 로고
    • Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia
    • Berryman CE, Grieger JA, West SG, et al. Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia. J Nutr 2013; 143: 788-794
    • (2013) J Nutr , vol.143 , pp. 788-794
    • Berryman, C.E.1    Grieger, J.A.2    West, S.G.3
  • 68
    • 84896923023 scopus 로고    scopus 로고
    • Tree nuts are inversely associated with metabolic syndrome and obesity: The adventist health study-2
    • Jaceldo-Siegl K, Haddad E, Oda K, et al. Tree nuts are inversely associated with metabolic syndrome and obesity: the adventist health study-2. PLoS ONE 2014; 9: e85133
    • (2014) Plos One , vol.9 , pp. e85133
    • Jaceldo-Siegl, K.1    Haddad, E.2    Oda, K.3
  • 69
    • 84872255925 scopus 로고    scopus 로고
    • Nutritional antioxidants and their applications in cardiometabolic diseases
    • Soory M. Nutritional antioxidants and their applications in cardiometabolic diseases. Infect Disord Drug Targets 2012; 12: 388-401
    • (2012) Infect Disord Drug Targets , vol.12 , pp. 388-401
    • Soory, M.1
  • 70
    • 84879433832 scopus 로고    scopus 로고
    • Emerging role of Nrf2 in adipocytes and adipose biology
    • Schneider KS, Chan JY. Emerging role of Nrf2 in adipocytes and adipose biology. Adv Nutr 2013; 4: 62-66
    • (2013) Adv Nutr , vol.4 , pp. 62-66
    • Schneider, K.S.1    Chan, J.Y.2
  • 71
    • 70349140473 scopus 로고    scopus 로고
    • Role of nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid cddo-imidazolide
    • Shin S, Wakabayashi J, Yates MS, et al. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide. Eur J Pharmacol 2009; 620: 138-144
    • (2009) Eur J Pharmacol , vol.620 , pp. 138-144
    • Shin, S.1    Wakabayashi, J.2    Yates, M.S.3
  • 72
    • 84890946148 scopus 로고    scopus 로고
    • Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease
    • de Zeeuw D, Akizawa T, Audhya P, et al. Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. N Engl J Med 2013; 369: 2492-2503
    • (2013) N Engl J Med , vol.369 , pp. 2492-2503
    • De Zeeuw, D.1    Akizawa, T.2    Audhya, P.3
  • 73
    • 84879688547 scopus 로고    scopus 로고
    • Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2
    • Cardozo LF, Pedruzzi LM, Stenvinkel P, et al. Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2. Biochimie 2013; 95: 1525-1533
    • (2013) Biochimie , vol.95 , pp. 1525-1533
    • Cardozo, L.F.1    Pedruzzi, L.M.2    Stenvinkel, P.3
  • 75
    • 0038513515 scopus 로고    scopus 로고
    • Diet and body mass index in 38000 epic-oxford meat-eaters, fish-eaters, vegetarians and vegans
    • Spencer EA, Appleby PN, Davey GK, et al. Diet and body mass index in 38000 EPIC-Oxford meat-eaters, fish-eaters, vegetarians and vegans. Int J Obes Relat Metab Disord 2003; 27: 728-734
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 728-734
    • Spencer, E.A.1    Appleby, P.N.2    Davey, G.K.3
  • 76
    • 84889582897 scopus 로고    scopus 로고
    • Omega-3 fatty acids: A review of the effects on adiponectin and leptin and potential implications for obesity management
    • Gray B, Steyn F, Davies PS, et al. Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management. Eur J Clin Nutr 2013; 67: 1234-1242
    • (2013) Eur J Clin Nutr , vol.67 , pp. 1234-1242
    • Gray, B.1    Steyn, F.2    Davies, P.S.3
  • 77
    • 84865646777 scopus 로고    scopus 로고
    • Preservation of metabolic flexibility in skeletal muscle by a combined use of n-3 pufa and rosiglitazone in dietary obese mice
    • Horakova O, Medrikova D, van Schothorst EM, et al. Preservation of metabolic flexibility in skeletal muscle by a combined use of n-3 PUFA and rosiglitazone in dietary obese mice. PLoS ONE 2012; 7: e43764
    • (2012) Plos One , vol.7 , pp. e43764
    • Horakova, O.1    Medrikova, D.2    Van Schothorst, E.M.3
  • 78
    • 84889099226 scopus 로고    scopus 로고
    • Genetic and epigenetic control of metabolic health
    • Schwenk RW, Vogel H, Schürmann A. Genetic and epigenetic control of metabolic health. Mol Met 2013; 2: 337-347
    • (2013) Mol Met , vol.2 , pp. 337-347
    • Schwenk, R.W.1    Vogel, H.2    Schürmann, A.3
  • 79
    • 84899813785 scopus 로고    scopus 로고
    • How can genetics and epigenetics help the nephrologist improve the diagnosis and treatment of chronic kidney disease patients?
    • Witasp A, Ekström T, Schalling M, et al. How can genetics and epigenetics help the nephrologist improve the diagnosis and treatment of chronic kidney disease patients?. Nephrol Dial Transplant 2014; 29: 972-980
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 972-980
    • Witasp, A.1    Ekström, T.2    Schalling, M.3
  • 80
    • 78650291801 scopus 로고    scopus 로고
    • Obesity related methylation changes in DNA of peripheral blood leukocytes
    • Wang X, Zhu H, Snieder H, et al. Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med 2010; 8: 87
    • (2010) BMC Med , vol.8 , pp. 87
    • Wang, X.1    Zhu, H.2    Snieder, H.3
  • 81
    • 55949137722 scopus 로고    scopus 로고
    • Persistent epigenetic differences associated with prenatal exposure to famine in humans
    • Heijmans BT, Tobi EW, Stein AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA 2008; 105: 17046-17049
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17046-17049
    • Heijmans, B.T.1    Tobi, E.W.2    Stein, A.D.3
  • 82
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: Targets for early nutritional effects on epigenetic gene regulation
    • Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003; 23: 5293-5300
    • (2003) Mol Cell Biol , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 83
    • 33645633542 scopus 로고    scopus 로고
    • Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome
    • Dolinoy DC, Weidman JR, Waterland RA, et al. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 2006; 114: 567-572
    • (2006) Environ Health Perspect , vol.114 , pp. 567-572
    • Dolinoy, D.C.1    Weidman, J.R.2    Waterland, R.A.3
  • 84
    • 77952859811 scopus 로고    scopus 로고
    • High-fat diet leads to a decreased methylation of the mc4r gene in the obese bfmi and the lean b6 mouse lines
    • Widiker S, Karst S, Wagener A, et al. High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines. J Appl Genet 2010; 51: 193-197
    • (2010) J Appl Genet , vol.51 , pp. 193-197
    • Widiker, S.1    Karst, S.2    Wagener, A.3
  • 85
    • 84858055958 scopus 로고    scopus 로고
    • Acute exercise remodels promoter methylation in human skeletal muscle
    • Barrès R, Yan J, Egan B, et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab 2012; 15: 405-411
    • (2012) Cell Metab , vol.15 , pp. 405-411
    • Barrès, R.1    Yan, J.2    Egan, B.3
  • 86
    • 84879931169 scopus 로고    scopus 로고
    • Differential methylation in glucoregulatory genes of offspring born before vs after maternal gastrointestinal bypass surgery
    • Guénard F, Deshaies Y, Cianflone K, et al. Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Proc Natl Acad Sci USA 2013; 110: 11439-11444
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 11439-11444
    • Guénard, F.1    Deshaies, Y.2    Cianflone, K.3
  • 87
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice
    • 6ra14
    • Turnbaugh PJ, Ridaura VK, Faith JJ, et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 2009; 1: 6ra14
    • (2009) Sci Transl Med , vol.1
    • Turnbaugh, P.J.1    Ridaura, V.K.2    Faith, J.J.3
  • 88
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura V, Faith J, Rey F, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013; 341: 1241214
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.1    Faith, J.2    Rey, F.3
  • 89
    • 73949137604 scopus 로고    scopus 로고
    • Microbiota and SCFA in lean and overweight healthy subjects
    • Schwiertz A, Taras D, Schäfer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010; 18: 190-195
    • (2010) Obesity (Silver Spring , vol.18 , pp. 190-195
    • Schwiertz, A.1    Taras, D.2    Schäfer, K.3
  • 90
    • 84859587827 scopus 로고    scopus 로고
    • Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms
    • Lin HV, Frassetto A, Kowalik EJ, et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS ONE 2012; 7: e35240
    • (2012) Plos One , vol.7 , pp. e35240
    • Lin, H.V.1    Frassetto, A.2    Kowalik, E.J.3
  • 91
    • 84892874108 scopus 로고    scopus 로고
    • Effects of short chain fatty acid producing bacteria on epigenetic regulation of ffar3 in type 2 diabetes and obesity
    • Remely M, Aumueller E, Merold C, et al. Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. Gene 2014; 537: 85-92
    • (2014) Gene , vol.537 , pp. 85-92
    • Remely, M.1    Aumueller, E.2    Merold, C.3
  • 92
    • 80052225187 scopus 로고    scopus 로고
    • Modulation of the gut microbiota by nutrients with prebiotic properties: Consequences for host health in the context of obesity and metabolic syndrome
    • Delzenne NM, Neyrinck AM, Cani PD. Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact 2011; 10: S10
    • (2011) Microb Cell Fact , vol.10 , pp. S10
    • Delzenne, N.M.1    Neyrinck, A.M.2    Cani, P.D.3
  • 93
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011; 472: 57-63
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3
  • 94
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of l-carnitin, a nutrient in red meat, promotes atherosclerosis
    • Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of l-carnitin, a nutrient in red meat, promotes atherosclerosis. Nature Med 2013; 19: 576-585
    • (2013) Nature Med , vol.19 , pp. 576-585
    • Koeth, R.A.1    Wang, Z.2    Levison, B.S.3
  • 95
    • 84884370038 scopus 로고    scopus 로고
    • Related actions of probiotics and antibiotics on gut microbiota and weight modification
    • Angelakis E, Merhej V, Raoult D. Related actions of probiotics and antibiotics on gut microbiota and weight modification. Lancet Infect Dis 2013; 13: 889-899
    • (2013) Lancet Infect Dis , vol.13 , pp. 889-899
    • Angelakis, E.1    Merhej, V.2    Raoult, D.3
  • 96
    • 84872116197 scopus 로고    scopus 로고
    • Infant antibiotic exposures and earlylife body mass
    • Trasande L, Blustein J, Liu M, et al. Infant antibiotic exposures and earlylife body mass. Int J Obesity 2013; 37: 16-23
    • (2013) Int J Obesity , vol.37 , pp. 16-23
    • Trasande, L.1    Blustein, J.2    Liu, M.3
  • 97
    • 84908325271 scopus 로고    scopus 로고
    • Artificial sweeteners induce glucose intolerance by altering the gut microbiota
    • Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 2014; 514: 181-186
    • (2014) Nature , vol.514 , pp. 181-186
    • Suez, J.1    Korem, T.2    Zeevi, D.3
  • 98
    • 14744283479 scopus 로고    scopus 로고
    • Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids
    • Atkinson RL, Dhurandhar NV, Allison DB, et al. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes (Lond) 2005; 29: 281-286
    • (2005) Int J Obes (Lond , vol.29 , pp. 281-286
    • Atkinson, R.L.1    Dhurandhar, N.V.2    Allison, D.B.3
  • 99
    • 84901805653 scopus 로고    scopus 로고
    • Increasing adiposity consequence or cause of overeating?
    • Ludwig DS, Friedman MI. Increasing adiposity. Consequence or cause of overeating?. JAMA 2014; 311: 2167-2168
    • (2014) Jama , vol.311 , pp. 2167-2168
    • Ludwig, D.S.1    Friedman, M.I.2
  • 100
    • 84907377132 scopus 로고    scopus 로고
    • MicroRNA-378 controls classical brown fat expansion to counteract obesity
    • Pan D, Mao C, Quattrochi B, et al. MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun 2014; 22: 4725
    • (2014) Nat Commun , vol.22 , pp. 4725
    • Pan, D.1    Mao, C.2    Quattrochi, B.3


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