Modulation of the gut microbiota by nutrients with prebiotic properties: Consequences for host health in the context of obesity and metabolic syndrome

Microbial Cell Factories

Volumn 10, Issue SUPPL. 1, 2011, Pages

  Delzenne, Nathalie M ^a   Neyrinck, Audrey M ^a   Cani, Patrice D ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ADENOSINE TRIPHOSPHATASE; ALKALINE PHOSPHATASE; ARABINOXYLAN; BUTYRIC ACID; CARBOHYDRATE; FASTING INDUCED ADIPOSE FACTOR; FATTY ACID; FRUCTAN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; GALACTOSE OLIGOSACCHARIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LACTULOSE; LIPOPOLYSACCHARIDE; LIPOPROTEIN LIPASE; PEPTIDE YY; PREBIOTIC AGENT; PROBIOTIC AGENT; PROPIONIC ACID; SHORT CHAIN FATTY ACID; TRACE ELEMENT; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; XYLOOLIGOSACCHARIDE;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; AGE; ARTICLE; BACTERIUM DETECTION; BACTEROIDES; BACTEROIDES THETAIOTAOMICRON; BIFIDOBACTERIUM; BIFIDOBACTERIUM ADOLESCENTIS; BIFIDOBACTERIUM ANIMALIS; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM BREVE; BIFIDOBACTERIUM CATENULATUM; BODY FAT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CELL SIZE; CLOSTRIDIUM; COLON; DIABETES MELLITUS; DIABETIC PATIENT; DIET; ENDOCRINE FUNCTION; ENERGY METABOLISM; ENTEROBACTERIACEAE; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; ENZYME INHIBITION; ETHNICITY; FAECALIBACTERIUM PRAUSNITZII; FIRMICUTES; FOLLOW UP; GAMMAPROTEOBACTERIA; GENDER; GENE EXPRESSION; GENETIC ASSOCIATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HOMEOSTASIS; HUMAN; IMMUNITY; IMMUNOMODULATION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTESTINE FLORA; JEJUNUM; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS GASSERI; LACTOBACILLUS PARACASEI; LACTOBACILLUS PLANTARUM; LACTOBACILLUS RHAMNOSUS; LIVER DISEASE; METABOLIC DISORDER; METABOLIC SYNDROME X; METHANOBREVIBACTER SMITHII; MICROBIAL COMMUNITY; MORBID OBESITY; MUSCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRIENT; OBESITY; PREGNANCY; PREVOTELLA; PREVOTELLACEAE; PROTEIN EXPRESSION; PROTEOBACTERIA; RANDOMIZED CONTROLLED TRIAL (TOPIC); ROUX Y ANASTOMOSIS; RUMINOCOCCUS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STOMACH BYPASS; WAIST CIRCUMFERENCE; WEIGHT GAIN; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE; ANIMAL; DIET THERAPY; DRUG EFFECT; GASTROINTESTINAL TRACT; IMMUNE SYSTEM; METABOLISM; MICROBIOLOGY; NUTRITIONAL STATUS; PHYSIOLOGY; REVIEW;

ANIMALIA;

ANIMALS; GASTROINTESTINAL TRACT; HUMANS; IMMUNE SYSTEM; METABOLIC SYNDROME X; NUTRITIONAL STATUS; OBESITY; PREBIOTICS;

EID: 80052225187     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-10-S1-S10     Document Type: Article

References (85)

1. World health organization - Obesity and overweight - Fact sheet N°311 - Updated March 2011. , http://www.who.int/mediacentre/factsheets/fs311/en/index.html
2. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006, 444:860-867. 10.1038/nature05485, 17167474.
3. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645. 10.1161/CIRCULATIONAHA.109.192644, 19805654.
4. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, Cao J, Wang B, Liang H, Zheng H, Xie Y, Tap J, Lepage P, Bertalan M, Batto JM, Hansen T, Le PD, Linneberg A, Nielsen HB, Pelletier E, Renault P, Sicheritz-Ponten T, Turner K, Zhu H, Yu C, Li S, Jian M, Zhou Y, Li Y, Zhang X, Li S, Qin N, Yang H, Wang J, Brunak S, Dore J, Guarner F, Kristiansen K, Pedersen O, Parkhill J, Weissenbach J, Bork P, Ehrlich SD, Wang J. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464:59-65. 10.1038/nature08821, 20203603.
5. Diamant M, Blaak EE, de Vos WM. Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?. Obes Rev 2010,
6. Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 2009, 1:6ra 14.
7. Caesar R, Fak F, Backhed F. Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. J Intern Med 2010, 268:320-328. 10.1111/j.1365-2796.2010.02270.x, 21050286.
8. Cani PD, Delzenne NM. The gut microbiome as therapeutic target. Pharmacol Ther 2011, 130:202-212. 10.1016/j.pharmthera.2011.01.012, 21295072.
9. Delzenne NM, Cani PD. Nutritional modulation of gut microbiota in the context of obesity and insulin resistance: Potential interest of prebiotics. International Dairy Journal 2010, 20:277-280.
10. Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol 2010, 26:5-11. 10.1097/MOG.0b013e328333d751, 19901833.
11. Jia W, Li H, Zhao L, Nicholson JK. Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov 2008, 7:123-129. 10.1038/nrd2505, 18239669.
12. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 2009, 9:313-323. 10.1038/nri2515, 19343057.
13. Neish AS. Microbes in gastrointestinal health and disease. Gastroenterology 2009, 136:65-80. 10.1053/j.gastro.2008.10.080, 2892787, 19026645.
14. Hsiao WW, Fraser-Liggett CM. Human Microbiome Project--paving the way to a better understanding of ourselves and our microbes. Drug Discov Today 2009, 14:331-333. 10.1016/j.drudis.2009.03.001, 19340927.
15. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature 2007, 449:804-810. 10.1038/nature06244, 17943116.
16. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 2005, 102:11070-11075. 10.1073/pnas.0504978102, 1176910, 16033867.
17. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006, 444:1022-1023. 10.1038/4441022a, 17183309.
18. Armougom F, Henry M, Vialettes B, Raccah D, Raoult D. Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PLoS One 2009, 4:e7125. 10.1371/journal.pone.0007125, 2742902, 19774074.
19. Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, Louis P, Flint HJ. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond) 2008, 32:1720-1724.
20. Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y, Parameswaran P, Crowell MD, Wing R, Rittmann BE, Krajmalnik-Brown R. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci U S A 2009, 106:2365-2370. 10.1073/pnas.0812600106, 2629490, 19164560.
21. Hoyles L, McCartney AL. What do we mean when we refer to Bacteroidetes populations in the human gastrointestinal microbiota?. FEMS Microbiol Lett 2009, 299:175-183. 10.1111/j.1574-6968.2009.01741.x, 19694813.
22. Arumugam M, Raes J, Pelletier E, Le PD, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Dore J, Consortium M, Weissenbach J, Ehrlich SD, Bork P, Antolin M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de GM, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le RK, Maguin E, Merieux A, Melo MR, M'rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G. Enterotypes of the human gut microbiome. Nature 2011,
23. Kalliomaki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 2008, 87:534-538.
24. Lundell AC, Adlerberth I, Lindberg E, Karlsson H, Ekberg S, Aberg N, Saalman R, Hock B, Steinkasserer A, Hesselmar B, Wold AE, Rudin A. Increased levels of circulating soluble CD14 but not CD83 in infants are associated with early intestinal colonization with Staphylococcus aureus. Clin Exp Allergy 2007, 37:62-71. 10.1111/j.1365-2222.2006.02625.x, 17210043.
25. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmee E, Cousin B, Sulpice T, Chamontin B, Ferrieres J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-1772. 10.2337/db06-1491, 17456850.
26. Collado MC, Isolauri E, Laitinen K, Salminen S. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 2008, 88:894-899.
27. Wu X, Ma C, Han L, Nawaz M, Gao F, Zhang X, Yu P, Zhao C, Li L, Zhou A, Wang J, Moore JE, Millar BC, Xu J. Molecular characterisation of the faecal microbiota in patients with type II diabetes. Curr Microbiol 2010, 61:69-78. 10.1007/s00284-010-9582-9, 20087741.
28. Santacruz A, Marcos A, Warnberg J, Marti A, Martin-Matillas M, Campoy C, Moreno LA, Veiga O, Redondo-Figuero C, Garagorri JM, Azcona C, Delgado M, Garcia-Fuentes M, Collado MC, Sanz Y. Interplay between weight loss and gut microbiota composition in overweight adolescents. Obesity (Silver Spring) 2009, 17:1906-1915.
29. Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, Mariat D, Corthier G, Dore J, Henegar C, Rizkalla S, Clement K. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 2010, 59:3049-3057. 10.2337/db10-0253, 20876719.
30. Boesten RJ, de Vos WM. Interactomics in the human intestine: Lactobacilli and Bifidobacteria make a difference. J Clin Gastroenterol 2008, 42:S163-S167.
31. Boesten RJ, Schuren FH, de Vos WM. A Bifidobacterium mixed-species microarray for high resolution discrimination between intestinal bifidobacteria. J Microbiol Methods 2009, 76:269-277. 10.1016/j.mimet.2008.12.006, 19141304.
32. Turroni F, Marchesi JR, Foroni E, Gueimonde M, Shanahan F, Margolles A, van SD, Ventura M. Microbiomic analysis of the bifidobacterial population in the human distal gut. ISME J 2009, 3:745-751. 10.1038/ismej.2009.19, 19295640.
33. Kadooka Y, Sato M, Imaizumi K, Ogawa A, Ikuyama K, Akai Y, Okano M, Kagoshima M, Tsuchida T. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr 2010, 64:636-643. 10.1038/ejcn.2010.19, 20216555.
34. Andreasen AS, Larsen N, Pedersen-Skovsgaard T, Berg RM, Moller K, Svendsen KD, Jakobsen M, Pedersen BK. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr 2010, 104:1831-1838. 10.1017/S0007114510002874, 20815975.
35. Luoto R, Laitinen K, Nermes M, Isolauri E. Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr 2010, 103:1792-1799. 10.1017/S0007114509993898, 20128938.
36. Takemura N, Okubo T, Sonoyama K. Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. Exp Biol Med (Maywood ) 2010, 235:849-856.
37. Aronsson L, Huang Y, Parini P, Korach-Andre M, Hakansson J, Gustafsson JA, Pettersson S, Arulampalam V, Rafter J. Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLoS One 2010, 5:pii-e13087. 2953488, 20967294.
38. Karlsson CL, Molin G, Fak F, Johansson Hagslatt ML, Jakesevic M, Hakansson A, Jeppsson B, Westrom B, Ahrne S. Effects on weight gain and gut microbiota in rats given bacterial supplements and a high-energy-dense diet from fetal life through to 6 months of age. Br J Nutr 2011, 1-9.
39. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031. 10.1038/nature05414, 17183312.
40. Turnbaugh PJ, Backhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 2008, 3:213-223. 10.1016/j.chom.2008.02.015, 18407065.
41. Tilg H, Moschen AR, Kaser A. Obesity and the microbiota. Gastroenterology 2009, 136:1476-1483. 10.1053/j.gastro.2009.03.030, 19327360.
42. Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010, 328:228-231. 10.1126/science.1179721, 20203013.
43. Backhed F, Crawford PA. Coordinated regulation of the metabolome and lipidome at the host-microbial interface. Biochim Biophys Acta 2010, 1801:240-245. 2823845, 19782151.
44. Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr 2011,
45. Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001, 291:881-884. 10.1126/science.291.5505.881, 11157169.
46. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004, 101:15718-15723. 10.1073/pnas.0407076101, 524219, 15505215.
47. Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 2007, 104:979-984. 10.1073/pnas.0605374104, 1764762, 17210919.
48. Fleissner CK, Huebel N, bd El-Bary MM, Loh G, Klaus S, Blaut M. Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br J Nutr 2010, 104:919-929. 10.1017/S0007114510001303, 20441670.
49. Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007, 50:2374-2383. 10.1007/s00125-007-0791-0, 17823788.
50. Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen YY, Knight R, Ahima RS, Bushman F, Wu GD. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 2009, 137:1716-1724. 10.1053/j.gastro.2009.08.042, 2770164, 19706296.
51. de LG, de La Serre CB, Raybould HE. Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin. Physiol Behav 2011,
52. Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One 2010, 5:e12191. 10.1371/journal.pone.0012191, 2922379, 20808947.
53. Le PE, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van DJ, Parmentier M, Detheux M. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003, 278:25481-25489. 10.1074/jbc.M301403200, 12711604.
54. Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 2008, 105:16767-16772. 10.1073/pnas.0808567105, 2569967, 18931303.
55. Hong YH, Nishimura Y, Hishikawa D, Tsuzuki H, Miyahara H, Gotoh C, Choi KC, Feng DD, Chen C, Lee HG, Katoh K, Roh SG, Sasaki S. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology 2005, 146:5092-5099. 10.1210/en.2005-0545, 16123168.
56. Cani PD, Delzenne NM. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 2009, 15:1546-1558. 10.2174/138161209788168164, 19442172.
57. Neyrinck AM, Delzenne NM. Potential interest of gut microbial changes induced by non-digestible carbohydrates of wheat in the management of obesity and related disorders. Curr Opin Clin Nutr Metab Care 2010, 13:722-728. 10.1097/MCO.0b013e32833ec3fb, 20823777.
58. Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco MJ, Leotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A. Prebiotic effects: metabolic and health benefits. Br J Nutr 2010, 104(Suppl 2):S1-63.
59. Abrams SA, Griffin IJ, Hawthorne KM, Ellis KJ. Effect of prebiotic supplementation and calcium intake on body mass index. J Pediatr 2007, 151:293-298. 10.1016/j.jpeds.2007.03.043, 17719942.
60. Genta S, Cabrera W, Habib N, Pons J, Carillo IM, Grau A, Sanchez S. Yacon syrup: beneficial effects on obesity and insulin resistance in humans. Clin Nutr 2009, 28:182-187. 10.1016/j.clnu.2009.01.013, 19254816.
61. Parnell JA, Reimer RA. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults1. Am J Clin Nutr 2009, 89:1751-1759. 10.3945/ajcn.2009.27465, 19386741.
62. Cani PD, Lecourt E, Dewulf EM, Sohet FM, Pachikian BD, Naslain D, De BF, Neyrinck AM, Delzenne NM. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr 2009, 90:1236-1243. 10.3945/ajcn.2009.28095, 19776140.
63. Cani PD, Delzenne NM. Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol 2009, 9:737-743. 10.1016/j.coph.2009.06.016, 19628432.
64. Delzenne NM, Cani PD, Neyrinck AM. Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data. J Nutr 2007, 137:2547S-2551S.
65. Cani PD, Delzenne NM. Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care 2007, 10:729-734. 10.1097/MCO.0b013e3282efdebb, 18089955.
66. Cani PD, Knauf C, Iglesias MA, Drucker DJ, Delzenne NM, Burcelin R. Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like Peptide 1 receptor. Diabetes 2006, 55:1484-1490. 10.2337/db05-1360, 16644709.
67. Cani PD, Possemiers S, Van de WT, Guiot Y, Everard A, Rottier O, Geurts L, Naslain D, Neyrinck A, Lambert DM, Muccioli GG, Delzenne NM. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009, 58:1091-1103. 10.1136/gut.2008.165886, 2702831, 19240062.
68. Muccioli GG, Naslain D, Backhed F, Reigstad CS, Lambert DM, Delzenne NM, Cani PD. The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol 2010, 6:392. 2925525, 20664638.
69. Reigstad CS, Lunden GO, Felin J, Backhed F. Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota. PLoS One 2009, 4:e5842. 10.1371/journal.pone.0005842, 2688757, 19513118.
70. Waldram A, Holmes E, Wang Y, Rantalainen M, Wilson ID, Tuohy KM, McCartney AL, Gibson GR, Nicholson JK. Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents. J Proteome Res 2009, 8:2361-2375. 10.1021/pr8009885, 19275195.
71. Wang Z, Xiao G, Yao Y, Guo S, Lu K, Sheng Z. The role of bifidobacteria in gut barrier function after thermal injury in rats. J Trauma 2006, 61:650-657. 10.1097/01.ta.0000196574.70614.27, 16967002.
72. Griffiths EA, Duffy LC, Schanbacher FL, Qiao H, Dryja D, Leavens A, Rossman J, Rich G, Dirienzo D, Ogra PL. In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice. Dig Dis Sci 2004, 49:579-589.
73. Wang ZT, Yao YM, Xiao GX, Sheng ZY. Risk factors of development of gut-derived bacterial translocation in thermally injured rats. World J Gastroenterol 2004, 10:1619-1624.
74. Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, Rowland IR. Effects of fermentation products of pro- and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer 2005, 51:102-109. 10.1207/s15327914nc5101_14, 15749636.
75. Ruan X, Shi H, Xia G, Xiao Y, Dong J, Ming F, Wang S. Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation. Nutrition 2007, 23:754-761. 10.1016/j.nut.2007.07.002, 17706400.
76. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008, 57:1470-1481. 10.2337/db07-1403, 18305141.
77. Martinez I, Kim J, Duffy PR, Schlegel VL, Walter J. Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects. PLoS One 2010, 5:e15046. 10.1371/journal.pone.0015046, 2993935, 21151493.
78. Dewulf EM, Cani PD, Neyrinck AM, Possemiers S, Holle AV, Muccioli GG, Deldicque L, Bindels LB, Pachikian BD, Sohet FM, Mignolet E, Francaux M, Larondelle Y, Delzenne NM. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARgamma-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. J Nutr Biochem 2011, 22:712-722. 10.1016/j.jnutbio.2010.05.009, 21115338.
79. van BP, Troost F, van der MC, Hooiveld G, Boekschoten M, Brummer RJ, Kleerebezem M. Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways. Proc Natl Acad Sci U S A 2011, 108(Suppl 1):4562-4569.
80. Devine DA, Marsh PD. Prospects for the development of probiotics and prebiotics for oral applications. J Oral Microbiol 2009, 1:1. doi:10.3402/jom.v1i0.1949.
81. Ohlrich EJ, Cullinan MP, Leichter JW. Diabetes, periodontitis, and the subgingival microbiota. J Oral Microbiol 2010, 2. doi:10.3402/jom.v2i0.5818.
82. Wall R, Ross RP, Shanahan F, O'Mahony L, O'Mahony C, Coakley M, Hart O, Lawlor P, Quigley EM, Kiely B, Fitzgerald GF, Stanton C. Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues. Am J Clin Nutr 2009, 89:1393-1401. 10.3945/ajcn.2008.27023, 19357220.
83. Pachikian BD, Neyrinck AM, Deldicque L, de Backer FC, Catry E, Dewulf EM, Sohet FM, Bindels LB, Everard A, Francaux M, Guiot Y, Cani PD, Delzenne NM. Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. J Nutr 2010, 140:509-514. 10.3945/jn.109.117374, 20089787.
84. Claus SP, Ellero SL, Berger B, Krause L, Bruttin A, Molina J, Paris A, Want EJ, de WI, Cloarec O, Richards SE, Wang Y, Dumas ME, Ross A, Rezzi S, Kochhar S, Van BP, Lindon JC, Holmes E, Nicholson JK. Colonization-induced host-gut microbial metabolic interaction. MBio 2011, 2:pii-e00271-10.
85. He Q, Ren P, Kong X, Wu Y, Wu G, Li P, Hao F, Tang H, Blachier F, Yin Y. Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach. J Nutr Biochem 2011,