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Volumn 6, Issue 2, 2015, Pages 189-197

Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: Mechanisms of actions and potential effects on metabolic syndrome

Author keywords

4 hydroxyisoleucine; Botanicals; Diosgenin; Fat cells; Fenugreek; Insulin action

Indexed keywords

4-HYDROXYISOLEUCINE; BIOLOGICAL MARKER; DIOSGENIN; FENUGREEK SEED MEAL; ISOLEUCINE; PLANT EXTRACT;

EID: 84943238922     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.114.007807     Document Type: Review
Times cited : (118)

References (93)
  • 1
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 2
    • 82955233927 scopus 로고    scopus 로고
    • The International Diabetes Federation diabetes atlas methodology for estimating global and national prevalence of diabetes in adults
    • Guariguata L, Whiting D, Weil C, Unwin N. The International Diabetes Federation diabetes atlas methodology for estimating global and national prevalence of diabetes in adults. Diabetes Res Clin Pract 2011;94:322-32.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 322-332
    • Guariguata, L.1    Whiting, D.2    Weil, C.3    Unwin, N.4
  • 3
    • 79960614571 scopus 로고    scopus 로고
    • National diabetes fact sheet: National estimates and general information on diabetes and pre-diabetes in the United States
    • Atlanta (GA): US Department of Health and Human Services, CDC
    • CDC. National diabetes fact sheet: National estimates and general information on diabetes and pre-diabetes in the United States. Atlanta (GA): US Department of Health and Human Services, CDC; 2011.
    • (2011)
  • 4
    • 1942436069 scopus 로고    scopus 로고
    • Role of selected Indian plants in management of type 2 diabetes: a review
    • Saxena A, Vikram NK. Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med 2004;10:369-78.
    • (2004) J Altern Complement Med , vol.10 , pp. 369-378
    • Saxena, A.1    Vikram, N.K.2
  • 5
    • 47649122375 scopus 로고    scopus 로고
    • Review of selected Chinese herbal medicines in the treatment of type 2 diabetes
    • Wang E, Wylie-Rosett J. Review of selected Chinese herbal medicines in the treatment of type 2 diabetes. Diabetes Educ 2008;34:645-54.
    • (2008) Diabetes Educ , vol.34 , pp. 645-654
    • Wang, E.1    Wylie-Rosett, J.2
  • 6
    • 84879346612 scopus 로고    scopus 로고
    • Traditional Indian medicines used for the management of diabetes mellitus
    • Rizvi SI, Mishra N. Traditional Indian medicines used for the management of diabetes mellitus. J Diabetes Res 2013;3013:712092.
    • (2013) J Diabetes Res , vol.3013 , pp. 712092
    • Rizvi, S.I.1    Mishra, N.2
  • 7
    • 84878699348 scopus 로고    scopus 로고
    • Treating type 2 diabetes mellitus with traditional Chinese and Indian medicinal herbs
    • Wang Z, Wang J, Chan P. Treating type 2 diabetes mellitus with traditional Chinese and Indian medicinal herbs. Evid Based Complement Alternat Med 2013;2013:343594.
    • (2013) Evid Based Complement Alternat Med , vol.2013 , pp. 343594
    • Wang, Z.1    Wang, J.2    Chan, P.3
  • 8
    • 84891782445 scopus 로고    scopus 로고
    • Pharmacological effects of Trigonella foenumgraecum L. in health and disease
    • Yadav UC, Baquer NZ. Pharmacological effects of Trigonella foenumgraecum L. in health and disease. Pharm Biol 2014;52:243-54.
    • (2014) Pharm Biol , vol.52 , pp. 243-254
    • Yadav, U.C.1    Baquer, N.Z.2
  • 11
    • 70350437252 scopus 로고    scopus 로고
    • American roulette-contaminated dietary supplements
    • Cohen PA. American roulette-contaminated dietary supplements. N Engl J Med 2009;361:1523-5.
    • (2009) N Engl J Med , vol.361 , pp. 1523-1525
    • Cohen, P.A.1
  • 12
    • 84897535273 scopus 로고    scopus 로고
    • Hazards of hindsight-monitoring the safety of nutritional supplements
    • Cohen PA. Hazards of hindsight-monitoring the safety of nutritional supplements. N Engl J Med 2014;370:1277-80.
    • (2014) N Engl J Med , vol.370 , pp. 1277-1280
    • Cohen, P.A.1
  • 13
    • 84867567251 scopus 로고    scopus 로고
    • Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma
    • Das S, Dey KK, Dey G, Pal I, Majumder A. MaitiChoudhury S, Kundu SC, Mandal M. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma. PLoS ONE 2012;7:e46641.
    • (2012) PLoS ONE , vol.7
    • Das, S.1    Dey, K.K.2    Dey, G.3    Pal, I.4    Majumder, A.5    MaitiChoudhury, S.6    Kundu, S.C.7    Mandal, M.8
  • 15
    • 84905016365 scopus 로고    scopus 로고
    • Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats
    • Kalailingam P, Kannaian B, Tamilmani E, Kaliaperumal R. Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats. Phytomedicine 2014;21:1154-61.
    • (2014) Phytomedicine , vol.21 , pp. 1154-1161
    • Kalailingam, P.1    Kannaian, B.2    Tamilmani, E.3    Kaliaperumal, R.4
  • 16
    • 84864996142 scopus 로고    scopus 로고
    • Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats
    • Pari L, Monisha P, Jalaludeen AM. Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats. Eur J Pharmacol 2012;691:143-50.
    • (2012) Eur J Pharmacol , vol.691 , pp. 143-150
    • Pari, L.1    Monisha, P.2    Jalaludeen, A.M.3
  • 18
    • 37649008319 scopus 로고    scopus 로고
    • Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats
    • Son IS, Kim JH, Sohn HY, Son KH, Kim JS, Kwon CS. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats. Biosci Biotechnol Biochem 2007;71:3063-71.
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 3063-3071
    • Son, I.S.1    Kim, J.H.2    Sohn, H.Y.3    Son, K.H.4    Kim, J.S.5    Kwon, C.S.6
  • 20
    • 70450222919 scopus 로고    scopus 로고
    • Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H. Wright in rodents
    • Qin Y, Wu X, Huang W, Gong G, Li D, He Y, Zhao Y. Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H. Wright in rodents. J Ethnopharmacol 2009;126:543-50.
    • (2009) J Ethnopharmacol , vol.126 , pp. 543-550
    • Qin, Y.1    Wu, X.2    Huang, W.3    Gong, G.4    Li, D.5    He, Y.6    Zhao, Y.7
  • 21
    • 84907594292 scopus 로고    scopus 로고
    • Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARgamma activity in type 2 diabetic rats
    • Tharaheswari M, Jayachandra Reddy N, Kumar R, Varshney KC, Kannan M, Sudha Rani S. Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARgamma activity in type 2 diabetic rats. Mol Cell Biochem 2014;396:161-74.
    • (2014) Mol Cell Biochem , vol.396 , pp. 161-174
    • Tharaheswari, M.1    Jayachandra Reddy, N.2    Kumar, R.3    Varshney, K.C.4    Kannan, M.5    Sudha Rani, S.6
  • 22
    • 84912533012 scopus 로고    scopus 로고
    • Modulatory effects of diosgenin on attenuating the key enzymes activities of carbohydrate metabolism and glycogen content in streptozotocin-induced diabetic rats
    • Saravanan G, Ponmurugan P, Deepa MA, Senthilkumar B. Modulatory effects of diosgenin on attenuating the key enzymes activities of carbohydrate metabolism and glycogen content in streptozotocin-induced diabetic rats. Can J Diabetes 2014;38:409-14.
    • (2014) Can J Diabetes , vol.38 , pp. 409-414
    • Saravanan, G.1    Ponmurugan, P.2    Deepa, M.A.3    Senthilkumar, B.4
  • 24
    • 78349261237 scopus 로고    scopus 로고
    • Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues
    • Uemura T, Hirai S, Mizoguchi N, Goto T, Lee J-Y, Taketani K, Nakano Y, Shono J, Hoshino S, Tsuge N, et al. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res 2010;54:1596-608.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 1596-1608
    • Uemura, T.1    Hirai, S.2    Mizoguchi, N.3    Goto, T.4    Lee, J.-Y.5    Taketani, K.6    Nakano, Y.7    Shono, J.8    Hoshino, S.9    Tsuge, N.10
  • 26
    • 26244456414 scopus 로고    scopus 로고
    • ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity
    • Wang H, Kouri G, Wollheim CB. ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. J Cell Sci 2005;118:3905-15.
    • (2005) J Cell Sci , vol.118 , pp. 3905-3915
    • Wang, H.1    Kouri, G.2    Wollheim, C.B.3
  • 27
    • 84887625928 scopus 로고    scopus 로고
    • Ectopic fat and cardiometabolic and vascular risk
    • Lim S, Meigs JB. Ectopic fat and cardiometabolic and vascular risk. Int J Cardiol 2013;169:166-76.
    • (2013) Int J Cardiol , vol.169 , pp. 166-176
    • Lim, S.1    Meigs, J.B.2
  • 30
    • 84901480586 scopus 로고    scopus 로고
    • Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease
    • Byrne CD, Targher G. Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease. Arterioscler Thromb Vasc Biol 2014;34:1155-61.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1155-1161
    • Byrne, C.D.1    Targher, G.2
  • 31
    • 84906936828 scopus 로고    scopus 로고
    • Links between ectopic fat and vascular disease in humans
    • Lim S, Meigs JB. Links between ectopic fat and vascular disease in humans. Arterioscler Thromb Vasc Biol 2014;34:1820-6.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1820-1826
    • Lim, S.1    Meigs, J.B.2
  • 32
    • 84887064874 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
    • Huang YY, Gusdon AM, Qu S. Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies. Lipids Health Dis 2013;12:171.
    • (2013) Lipids Health Dis , vol.12 , pp. 171
    • Huang, Y.Y.1    Gusdon, A.M.2    Qu, S.3
  • 33
    • 84888022758 scopus 로고    scopus 로고
    • Obesity-associated nonalcoholic fatty liver disease
    • Yilmaz Y, Younossi ZM. Obesity-associated nonalcoholic fatty liver disease. Clin Liver Dis 2014;18:19-31.
    • (2014) Clin Liver Dis , vol.18 , pp. 19-31
    • Yilmaz, Y.1    Younossi, Z.M.2
  • 34
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002;109:1125-31.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 35
    • 0036164154 scopus 로고    scopus 로고
    • BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
    • Edwards PA, Kast HR, Anisfeld AM. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J Lipid Res 2002;43:2-12.
    • (2002) J Lipid Res , vol.43 , pp. 2-12
    • Edwards, P.A.1    Kast, H.R.2    Anisfeld, A.M.3
  • 36
    • 78650498453 scopus 로고    scopus 로고
    • Diosgenin, the main aglycon of fenugreek, inhibits LXR alpha activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice
    • Uemura T, Goto T, Kang MS, Mizoguchi N, Hirai S, Lee JY, Nakano Y, Shono J, Hoshino S, Taketani K, et al. Diosgenin, the main aglycon of fenugreek, inhibits LXR alpha activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr 2011;141:17-23.
    • (2011) J Nutr , vol.141 , pp. 17-23
    • Uemura, T.1    Goto, T.2    Kang, M.S.3    Mizoguchi, N.4    Hirai, S.5    Lee, J.Y.6    Nakano, Y.7    Shono, J.8    Hoshino, S.9    Taketani, K.10
  • 37
    • 84871536826 scopus 로고    scopus 로고
    • Adipose tissue biology and cardiomyopathy: translational implications
    • Turer AT, Hill JA, Elmquist JK, Scherer PE. Adipose tissue biology and cardiomyopathy: translational implications. Circ Res 2012;111:1565-77.
    • (2012) Circ Res , vol.111 , pp. 1565-1577
    • Turer, A.T.1    Hill, J.A.2    Elmquist, J.K.3    Scherer, P.E.4
  • 38
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell 2014;156:20-44.
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 39
    • 84866133825 scopus 로고    scopus 로고
    • Adiponectin: mechanistic insights and clinical implications
    • Turer AT, Scherer PE. Adiponectin: mechanistic insights and clinical implications. Diabetologia 2012;55:2319-26.
    • (2012) Diabetologia , vol.55 , pp. 2319-2326
    • Turer, A.T.1    Scherer, P.E.2
  • 40
    • 84897114276 scopus 로고    scopus 로고
    • Adipokines-removing road blocks to obesity and diabetes therapy
    • Bluher M. Adipokines-removing road blocks to obesity and diabetes therapy. Mol Metab 2014;3:230-40.
    • (2014) Mol Metab , vol.3 , pp. 230-240
    • Bluher, M.1
  • 41
    • 84907321291 scopus 로고    scopus 로고
    • The role of adipose tissue immune cells in obesity and low-grade inflammation
    • Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol 2014;222:R113-27.
    • (2014) J Endocrinol , vol.222 , pp. R113-R127
    • Mraz, M.1    Haluzik, M.2
  • 42
    • 0031589638 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma: a key regulator of adipogenesis and systemic insulin sensitivity
    • Spiegelman BM. Peroxisome proliferator-activated receptor gamma: a key regulator of adipogenesis and systemic insulin sensitivity. Eur J Med Res 1997;2:457-64.
    • (1997) Eur J Med Res , vol.2 , pp. 457-464
    • Spiegelman, B.M.1
  • 43
    • 84860375795 scopus 로고    scopus 로고
    • Thiazolidinediones and PPARgamma agonists: time for a reassessment
    • Cariou B, Charbonnel B, Staels B. Thiazolidinediones and PPARgamma agonists: time for a reassessment. Trends Endocrinol Metab 2012;23:205-15.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 205-215
    • Cariou, B.1    Charbonnel, B.2    Staels, B.3
  • 46
    • 79960496099 scopus 로고    scopus 로고
    • Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver
    • Tang W, Jia L, Ma Y, Xie P, Haywood J, Dawson PA, Li J, Yu L. Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver. Biochim Biophys Acta 2011;1811:549-55.
    • (2011) Biochim Biophys Acta , vol.1811 , pp. 549-555
    • Tang, W.1    Jia, L.2    Ma, Y.3    Xie, P.4    Haywood, J.5    Dawson, P.A.6    Li, J.7    Yu, L.8
  • 47
    • 77950955510 scopus 로고    scopus 로고
    • Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression
    • Feng D, Ohlsson L, Duan RD. Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression. Lipids Health Dis 2010;9:40.
    • (2010) Lipids Health Dis , vol.9 , pp. 40
    • Feng, D.1    Ohlsson, L.2    Duan, R.D.3
  • 48
    • 84864763990 scopus 로고    scopus 로고
    • Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKbeta and IRS-1 pathways
    • Liu K, Zhao W, Gao X, Huang F, Kou J, Liu B. Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKbeta and IRS-1 pathways. Atherosclerosis 2012;223:350-8.
    • (2012) Atherosclerosis , vol.223 , pp. 350-358
    • Liu, K.1    Zhao, W.2    Gao, X.3    Huang, F.4    Kou, J.5    Liu, B.6
  • 49
    • 84889083532 scopus 로고    scopus 로고
    • Diosgenin improves vascular function by increasing aortic eNOS expression, normalize dyslipidemia and ACE activity in chronic renal failure rats
    • Manivannan J, Balamurugan E, Silambarasan T, Raja B. Diosgenin improves vascular function by increasing aortic eNOS expression, normalize dyslipidemia and ACE activity in chronic renal failure rats. Mol Cell Biochem 2013;384:113-20.
    • (2013) Mol Cell Biochem , vol.384 , pp. 113-120
    • Manivannan, J.1    Balamurugan, E.2    Silambarasan, T.3    Raja, B.4
  • 50
    • 84901809247 scopus 로고    scopus 로고
    • Diosgenin interferes coronary vasoconstriction and inhibits osteochondrogenic transdifferentiation of aortic VSMC in CRF rats
    • Manivannan J, Shanthakumar J, Arunagiri P, Raja B, Balamurugan E. Diosgenin interferes coronary vasoconstriction and inhibits osteochondrogenic transdifferentiation of aortic VSMC in CRF rats. Biochimie 2014;102:183-7.
    • (2014) Biochimie , vol.102 , pp. 183-187
    • Manivannan, J.1    Shanthakumar, J.2    Arunagiri, P.3    Raja, B.4    Balamurugan, E.5
  • 51
    • 84879422546 scopus 로고    scopus 로고
    • Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats
    • Salimeh A, Mohammadi M, Rashidi B. Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats. J Physiol Biochem 2013;69:255-65.
    • (2013) J Physiol Biochem , vol.69 , pp. 255-265
    • Salimeh, A.1    Mohammadi, M.2    Rashidi, B.3
  • 52
    • 84906569212 scopus 로고    scopus 로고
    • Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats
    • Ahmed LA, Obaid AA, Zaki HF, Agha AM. Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats. Eur J Pharmacol 2014;740:379-87.
    • (2014) Eur J Pharmacol , vol.740 , pp. 379-387
    • Ahmed, L.A.1    Obaid, A.A.2    Zaki, H.F.3    Agha, A.M.4
  • 53
    • 84921921407 scopus 로고    scopus 로고
    • Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel
    • Badalzadeh R, Yousefi B, Majidinia M, Ebrahimi H. Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel. J Physiol Sci 2014;64:393-400.
    • (2014) J Physiol Sci , vol.64 , pp. 393-400
    • Badalzadeh, R.1    Yousefi, B.2    Majidinia, M.3    Ebrahimi, H.4
  • 54
    • 84904640729 scopus 로고    scopus 로고
    • Diosgenin attenuates inflammatory response induced by myocardial reperfusion injury: role of mitochondrial ATP-sensitive potassium channels
    • Ebrahimi H, Badalzadeh R, Mohammadi M, Yousefi B. Diosgenin attenuates inflammatory response induced by myocardial reperfusion injury: role of mitochondrial ATP-sensitive potassium channels. J Physiol Biochem 2014;70:425-32.
    • (2014) J Physiol Biochem , vol.70 , pp. 425-432
    • Ebrahimi, H.1    Badalzadeh, R.2    Mohammadi, M.3    Yousefi, B.4
  • 56
    • 49549166736 scopus 로고
    • 4-Hydroxyisoleucine from seed of Trigonella-Foenum-Graecum
    • Fowden L, Pratt HM, Smith A. 4-Hydroxyisoleucine from seed of Trigonella-Foenum-Graecum. Phytochemistry 1973;12:1707-11.
    • (1973) Phytochemistry , vol.12 , pp. 1707-1711
    • Fowden, L.1    Pratt, H.M.2    Smith, A.3
  • 58
    • 0001573264 scopus 로고
    • Changes in growth, proteins and free amino acids of developing seed and pod of fenugreek
    • Sauvaire Y, Girardon P, Baccou JC, Risterucci AM. Changes in growth, proteins and free amino acids of developing seed and pod of fenugreek. Phytochemistry 1984;23:479-86.
    • (1984) Phytochemistry , vol.23 , pp. 479-486
    • Sauvaire, Y.1    Girardon, P.2    Baccou, J.C.3    Risterucci, A.M.4
  • 63
    • 58149523225 scopus 로고    scopus 로고
    • The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats
    • Haeri MR, Izaddoost M, Ardekani MRS, Nobar MR, White KN. The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats. Phytother Res 2009;23:61-4.
    • (2009) Phytother Res , vol.23 , pp. 61-64
    • Haeri, M.R.1    Izaddoost, M.2    Ardekani, M.R.S.3    Nobar, M.R.4    White, K.N.5
  • 64
    • 76949092020 scopus 로고    scopus 로고
    • Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice
    • Singh AB, Tamarkar AK, Narender T, Srivastava AK. Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice. Nat Prod Res 2010;24:258-65.
    • (2010) Nat Prod Res , vol.24 , pp. 258-265
    • Singh, A.B.1    Tamarkar, A.K.2    Narender, T.3    Srivastava, A.K.4
  • 65
    • 84860606932 scopus 로고    scopus 로고
    • Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats
    • Haeri MR, Limaki HK, White CJ, White KN. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine 2012;19:571-4.
    • (2012) Phytomedicine , vol.19 , pp. 571-574
    • Haeri, M.R.1    Limaki, H.K.2    White, C.J.3    White, K.N.4
  • 66
    • 84870251086 scopus 로고    scopus 로고
    • 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway
    • Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya P, Srivastava AK, Narender T, Tamrakar AK. 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway. Eur J Nutr 2012;51:893-8.
    • (2012) Eur J Nutr , vol.51 , pp. 893-898
    • Jaiswal, N.1    Maurya, C.K.2    Venkateswarlu, K.3    Sukanya, P.4    Srivastava, A.K.5    Narender, T.6    Tamrakar, A.K.7
  • 67
    • 84906492099 scopus 로고    scopus 로고
    • 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells
    • Maurya CK, Singh R, Jaiswal N, Venkateswarlu K, Narender T, Tamrakar AK. 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells. Mol Cell Endocrinol 2014;395:51-60.
    • (2014) Mol Cell Endocrinol , vol.395 , pp. 51-60
    • Maurya, C.K.1    Singh, R.2    Jaiswal, N.3    Venkateswarlu, K.4    Narender, T.5    Tamrakar, A.K.6
  • 69
    • 0024515411 scopus 로고
    • Symptomatic hypoglycemia in NIDDM patients treated with oral hypoglycemic agents
    • Jennings AM,Wilson RM,Ward JD. Symptomatic hypoglycemia in NIDDM patients treated with oral hypoglycemic agents. Diabetes Care 1989;12:203-8.
    • (1989) Diabetes Care , vol.12 , pp. 203-208
    • Jennings, A.M.1    Wilson, R.M.2    Ward, J.D.3
  • 70
    • 84878759344 scopus 로고    scopus 로고
    • Dietary fiber and the glycemic index: a background paper for the Nordic Nutrition Recommendations 2012
    • Overby NC, Sonestedt E, Laaksonen DE, Birgisdottir BE. Dietary fiber and the glycemic index: a background paper for the Nordic Nutrition Recommendations 2012. Food Nutr Res 2013;57.
    • (2013) Food Nutr Res , pp. 57
    • Overby, N.C.1    Sonestedt, E.2    Laaksonen, D.E.3    Birgisdottir, B.E.4
  • 71
    • 84888877682 scopus 로고    scopus 로고
    • Fiber intake and glycemic control in patients with type 2 diabetes mellitus: a systematic review with meta-analysis of randomized controlled trials
    • Silva FM, Kramer CK, de Almeida JC, Steemburgo T, Gross JL, Azevedo MJ. Fiber intake and glycemic control in patients with type 2 diabetes mellitus: a systematic review with meta-analysis of randomized controlled trials. Nutr Rev 2013;71:790-801.
    • (2013) Nutr Rev , vol.71 , pp. 790-801
    • Silva, F.M.1    Kramer, C.K.2    de Almeida, J.C.3    Steemburgo, T.4    Gross, J.L.5    Azevedo, M.J.6
  • 72
    • 83455194630 scopus 로고    scopus 로고
    • The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia
    • Roberts KT. The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia. J Med Food 2011;14:1485-9.
    • (2011) J Med Food , vol.14 , pp. 1485-1489
    • Roberts, K.T.1
  • 73
    • 84901269722 scopus 로고    scopus 로고
    • Fenugreek seed extract inhibit fat accumulation and ameliorates dyslipidemia in high fat diet-induced obese rats
    • Kumar P, Bhandari U, Jamadagni S. Fenugreek seed extract inhibit fat accumulation and ameliorates dyslipidemia in high fat diet-induced obese rats. Biomed Res Int 2014;2014:606021.
    • (2014) Biomed Res Int , vol.2014 , pp. 606021
    • Kumar, P.1    Bhandari, U.2    Jamadagni, S.3
  • 74
    • 61649121296 scopus 로고    scopus 로고
    • New proposals on "hyperentanglement" of galactomannans: solution viscosity of fenugreek gum under neutral and alkaline conditions
    • Doyle JP, Lyons G, Morris ER. New proposals on "hyperentanglement" of galactomannans: solution viscosity of fenugreek gum under neutral and alkaline conditions. Food Hydrocoll 2009;23:1501-10.
    • (2009) Food Hydrocoll , vol.23 , pp. 1501-1510
    • Doyle, J.P.1    Lyons, G.2    Morris, E.R.3
  • 75
    • 34047254102 scopus 로고    scopus 로고
    • Soluble dietary fibre fraction of Trigonella foenumgraecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action
    • Hannan JMA, Ali L, Rokeya B, Khaleque J, Akhter M, Flatt PR, Abdel-Wahab YHA. Soluble dietary fibre fraction of Trigonella foenumgraecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr 2007;97:514-21.
    • (2007) Br J Nutr , vol.97 , pp. 514-521
    • Hannan, J.M.A.1    Ali, L.2    Rokeya, B.3    Khaleque, J.4    Akhter, M.5    Flatt, P.R.6    Abdel-Wahab, Y.H.A.7
  • 76
    • 58649121283 scopus 로고    scopus 로고
    • In vitro intestinal glucose uptake is inhibited by galactomannan from Canadian fenugreek seed (Trigonella foenum graecum L) in genetically lean and obese rats
    • Srichamroen A, Thomson AB, Field CJ, Basu TK. In vitro intestinal glucose uptake is inhibited by galactomannan from Canadian fenugreek seed (Trigonella foenum graecum L) in genetically lean and obese rats. Nutr Res 2009;29:49-54.
    • (2009) Nutr Res , vol.29 , pp. 49-54
    • Srichamroen, A.1    Thomson, A.B.2    Field, C.J.3    Basu, T.K.4
  • 77
    • 77956214430 scopus 로고    scopus 로고
    • Inhibitory effect of fenugreek galactomannan on digestive enzymes related to diabetes, hyperlipidemia, and liver-kidney dysfunctions
    • Hamden K, Jaouadi B, Carreau S, Bejar S, Elfeki A. Inhibitory effect of fenugreek galactomannan on digestive enzymes related to diabetes, hyperlipidemia, and liver-kidney dysfunctions. Biotechnol Bioprocess Eng 2010;15:407-13.
    • (2010) Biotechnol Bioprocess Eng , vol.15 , pp. 407-413
    • Hamden, K.1    Jaouadi, B.2    Carreau, S.3    Bejar, S.4    Elfeki, A.5
  • 78
    • 81555198139 scopus 로고    scopus 로고
    • Hypolipidemic effect of soluble dietary fiber (galactomannan) isolated from fenugreek seeds in WNIN (GR-Ob) obese rats
    • Ramulu P, Giridharan NV, Udayasekhararao P. Hypolipidemic effect of soluble dietary fiber (galactomannan) isolated from fenugreek seeds in WNIN (GR-Ob) obese rats. J Med Plants Res 2011;5:4804-13.
    • (2011) J Med Plants Res , vol.5 , pp. 4804-4813
    • Ramulu, P.1    Giridharan, N.V.2    Udayasekhararao, P.3
  • 79
    • 23944493588 scopus 로고    scopus 로고
    • Dietary fiber: how did we get where we are?
    • Eastwood M, Kritchevsky D. Dietary fiber: how did we get where we are? Annu Rev Nutr 2005;25:1-8.
    • (2005) Annu Rev Nutr , vol.25 , pp. 1-8
    • Eastwood, M.1    Kritchevsky, D.2
  • 80
    • 51849156461 scopus 로고    scopus 로고
    • Biochemical and molecular investigation of two Korean patients with glycogen storage disease type III
    • Oh S-H, Park H-D, Ki C-S, Choe Y-H, Lee S-Y. Biochemical and molecular investigation of two Korean patients with glycogen storage disease type III. Clin Chem Lab Med 2008;46:1245-9.
    • (2008) Clin Chem Lab Med , vol.46 , pp. 1245-1249
    • Oh, S.-H.1    Park, H.-D.2    Ki, C.-S.3    Choe, Y.-H.4    Lee, S.-Y.5
  • 81
    • 77956192532 scopus 로고    scopus 로고
    • Enhancement of anti-tumorigenic polysaccharide production, adhesion, and branch formation of bifidobacterium bifidum BGN4 by phytic acid
    • Ku S, You HJ, Ji GE. Enhancement of anti-tumorigenic polysaccharide production, adhesion, and branch formation of bifidobacterium bifidum BGN4 by phytic acid. Food Sci Biotechnol 2009;18:749-54.
    • (2009) Food Sci Biotechnol , vol.18 , pp. 749-754
    • Ku, S.1    You, H.J.2    Ji, G.E.3
  • 82
    • 67449116102 scopus 로고    scopus 로고
    • Diphlorethohy-droxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice
    • Heo SJ, Hwang JY, Choi JI, Han JS, Kim HJ, Jeon YJ. Diphlorethohy-droxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur J Pharmacol 2009;615:252-6.
    • (2009) Eur J Pharmacol , vol.615 , pp. 252-256
    • Heo, S.J.1    Hwang, J.Y.2    Choi, J.I.3    Han, J.S.4    Kim, H.J.5    Jeon, Y.J.6
  • 83
    • 0042668433 scopus 로고    scopus 로고
    • Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats
    • Hannan JM, Rokeya B, Faruque O, Nahar N, Mosihuzzaman M, Azad Khan AK, Ali L. Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats. J Ethnopharmacol 2003;88:73-7.
    • (2003) J Ethnopharmacol , vol.88 , pp. 73-77
    • Hannan, J.M.1    Rokeya, B.2    Faruque, O.3    Nahar, N.4    Mosihuzzaman, M.5    Azad Khan, A.K.6    Ali, L.7
  • 84
    • 33947496078 scopus 로고    scopus 로고
    • Hypolipidaemic effect of chemically different mucilages in rats: a comparative study
    • Boban PT, Nambisan B, Sudhakaran PR. Hypolipidaemic effect of chemically different mucilages in rats: a comparative study. Br J Nutr 2006;96:1021-9.
    • (2006) Br J Nutr , vol.96 , pp. 1021-1029
    • Boban, P.T.1    Nambisan, B.2    Sudhakaran, P.R.3
  • 85
    • 33846701894 scopus 로고    scopus 로고
    • A fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats
    • Venkatesan N, Devaraj SN, Devaraj H. A fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats. Mol Cell Biochem 2007;294:145-53.
    • (2007) Mol Cell Biochem , vol.294 , pp. 145-153
    • Venkatesan, N.1    Devaraj, S.N.2    Devaraj, H.3
  • 86
    • 58649109446 scopus 로고    scopus 로고
    • The modifying effects of galactomannan from Canadian-grown fenugreek (Trigonella foenumgraecum L.) on the glycemic and lipidemic status in rats
    • Srichamroen A, Field CJ, Thomson AB, Basu TK. The modifying effects of galactomannan from Canadian-grown fenugreek (Trigonella foenumgraecum L.) on the glycemic and lipidemic status in rats. J Clin Biochem Nutr 2008;43:167-74.
    • (2008) J Clin Biochem Nutr , vol.43 , pp. 167-174
    • Srichamroen, A.1    Field, C.J.2    Thomson, A.B.3    Basu, T.K.4
  • 87
    • 84892468157 scopus 로고    scopus 로고
    • Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials
    • Neelakantan N, Narayanan M, de Souza RJ, van Dam RM. Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J 2014;13:7.
    • (2014) Nutr J , vol.13 , pp. 7
    • Neelakantan, N.1    Narayanan, M.2    de Souza, R.J.3    van Dam, R.M.4
  • 90
    • 84900988344 scopus 로고    scopus 로고
    • Elucidating the interactions between the human gut microbiota and its host through metabolic modeling
    • Shoaie S, Nielsen J. Elucidating the interactions between the human gut microbiota and its host through metabolic modeling. Front Genet 2014;5:86.
    • (2014) Front Genet , vol.5 , pp. 86
    • Shoaie, S.1    Nielsen, J.2


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