Diosgenin attenuates inflammatory response induced by myocardial reperfusion injury: Role of mitochondrial ATP-sensitive potassium channels

Journal of Physiology and Biochemistry

Volumn 70, Issue 2, 2014, Pages 425-432

  Ebrahimi, Hadi ^a   Badalzadeh, Reza ^a,b   Mohammadi, Mustafa ^b   Yousefi, Bahman ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diosgenin; Inflammation; KATP channel; Reperfusion injury

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CREMOPHOR; DIOSGENIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; TUMOR NECROSIS FACTOR ALPHA; ADENOSINE TRIPHOSPHATE; POTASSIUM CHANNEL;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INFLAMMATION; ISOLATED HEART; MALE; MEDIATOR RELEASE; NONHUMAN; RAT; REPERFUSION INJURY; SPECTROPHOTOMETRY; SUPERNATANT; WISTAR RAT; ANIMAL; COMPLICATION; ENZYMOLOGY; HEART MITOCHONDRION; METABOLISM; PHYSIOLOGY;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; DIOSGENIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; MALE; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; POTASSIUM CHANNELS; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904640729     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-014-0320-9     Document Type: Article

References (30)

1. + channel reduces apoptosis of spleenmononuclear cells induced by hyperlipidemia. Lipid Health Dis 12(87):1-9
2. Badalzadeh R, Mohammadi M, Najafi M, Ahmadiasl N, Farajnia S, Ebrahimi H (2012) The additive effects of ischemic postconditioning and cyclosporine-A on nitric oxide activity and functions of diabetic myocardium injured by ischemia/ reperfusion. J Cardiovasc Pharmacol Ther 17(2):181-189
3. Bonvini RF, Hendiri T, Camenzind E (2005) Inflammatory response post-myocardial infarction and reperfusion: a new therapeutic target? Eur Heart J Suppl 7(Supplement I):I27-I36 (Pubitemid 43051637)
4. Bulua AC, Simon A, Maddipati R, Pelletier M, Park M, Kim KY, Sack MN, Kastner DL, Siege RM (2011) Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). JEM 208(3):519-533
5. + channels are redox-sensitive pathways that control reactive oxygen species production. Free Radical Biol Med 42(7):1039-1048
6. Gonga G, Qinb Y, Huanga W, Zhouc S, Wub X, Yangc X, Yinlan Z, Li D (2010) Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis. Chem Biol Interact 184:366-375
7. Halestrap A, Clarke SJ, Khaliulin I (2007) The role of mitochondria in protection of the heart by preconditioning. Biochimica Biophysica Acta 1767:1007-1031 (Pubitemid 47101788)
8. Hirai S, Uemura T, Mizoguchi N, J-Y L, Taketani K, Nakano Y, Hoshino S, Tsuge N, Narukami T, Yu R, Takahashi N, Kawada T (2010) Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages. Mol Nutr Food Res 54:797-804
9. Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS (2007) Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization. Am J Physiol Heart Circ Physiol 293:H1107-H1114 (Pubitemid 47254211)
10. Jayachandran KS, Vasanthi HR, Rajamanickam GV (2009) Antilipoperoxidative and membrane stabilizing effect of diosgenin, in experimentally induced myocardial infarction. Mol Cell Biochem 327:203-210
11. Jiang WL, Fu FH, Xu BM, Tian JW, Zhu HB, Hou J (2010) Cardioprotection with forsythoside B in rat myocardial ischemia-reperfusion injury: relation to inflammation response. Phytomedicine 17:635-639
12. Jung DH, Park HJ, Byun HE, Park YM, Kim TW, Kim BO, UmSH, Pyo S (2010) Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation. Int Immunopharmacol 10:1047-1054
13. Kim TH, Lee SM (2010) The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem Toxicol 48:1516-1520
14. Leger DY, Liagre B, Beneytout JL (2006) Role of MAPKs and NF-κB in diosgenin-induced megakaryocytic differentiation and subsequent apoptosis in HEL cells. Int J Oncol 28(1):201-207
15. Lísias K, Dias G, Azevedo Correia ND, Gonçalves PK, Barbosa-Filho JM, Marques KV, Araújo IG, Silva DF, Guedes DN, Anjos NM, Bendhack LM, Medeiros IA (2007) Mechanisms involved in the vasodilator effect induced by diosgenin in rat superior mesenteric artery. Eur J Pharmacol 574:172-178 (Pubitemid 47575525)
16. Lutz J, Thürme K, Heemann U (2010) Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation. J Inflam 7:27
17. Ma A, Qi S, Chen H (2008) Antioxidant therapy for prevention of inflammation, ischemic reperfusion injuries and allograft rejection. Cardiovasc Hematol Agents Med Chem 6:20-43 (Pubitemid 351247874)
18. McAnuff MA, Harding WW, Omoruyi FO, Jacobs H, Morrison EY, Asemota HN (2005) Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, dioscorea polygonoides. Food Chem Toxicol 43:1667-1672 (Pubitemid 41265897)
19. McCully J, Levitsky S (2003) The mitochondrial K-ATP channel and cardioprotection. Ann Thorac Surg 75:S667-S673
20. Nossuli TO, Lakshminarayanan V, Baumgarten G, Taffet E, Ballantyne CM, Michae LH, Entman ML (2000) A chronic mouse model of myocardial ischemia-reperfusion: essential in cytokine studies. Am J Physiol Heart Circ Physiol 278:H1049-H1055 (Pubitemid 30235479)
21. Pari L,Monisha P,MedJalaludeen A (2012) Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats. Eur J Pharmacol 691:143-150
22. Perrelli MG, Pagliaro P, Penna C (2011) Ischemia/reperfusion injury and cardioprotective mechanisms: role of mitochondria and reactive oxygen species. World J Cardiol 3(6):186-200
23. Piper HM, Meuter K, Schäfer C (2003) Cellular mechanisms of ischemia-reperfusion injury. Ann Thorac Surg 75:644-648
24. Sanada S, Komuro I, Kitakaze M (2011) Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures. Am J Physiol Heart Circ Physiol 301:H1723-H1741
25. Schmidt MR, Smerup M, Konstantinov IE, Shimizu M, Li J, CheungM, White PA, Kristiansen SB, Sorensen K, Dzavik V, Redington AN, Kharbanda RK (2007) Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic preconditioning. Am J Physiol Heart Circ Physiol 292:H1883-H1890 (Pubitemid 46572412)
26. Son IS, Kim JH, SohnHY, Son KH, KimJS, Kwon CS (2007) Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (dioscorea spp.) on high-cholesterol fed rats. Biosci Biotechnol Biochem 7:3063-3071
27. Song J-X, Ma L, Kou JP, Yang YB (2012) Diosgenin reduces leukocytes adhesion and migration linked with inhibition of intercellular adhesion molecule-1 expression and NF-κB p65 activation in endothelial cells. Chin J NatMed 10(2):0142-0149
28. Turer AT, Hill JA (2010) Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol 106(3):360-368
29. Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB (2010) Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins 2:2428-2466
30. Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121-1135