Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways

Atherosclerosis

Volumn 223, Issue 2, 2012, Pages 350-358

  Liu, Kang ^a   Zhao, Wenwen ^a   Gao, Xuejiao ^a   Huang, Fang ^a   Kou, Junping ^a   Liu, Baolin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Diosgenin; Endothelial cells; Endothelial dysfunction; Inflammation; Insulin resistance

Indexed keywords

DIOSGENIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; PALMITIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; SALICYLIC ACID; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELLS, CULTURED; DIOSGENIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; I-KAPPA B KINASE; INFLAMMATION MEDIATORS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INTERLEUKIN-6; MICROSCOPY, FLUORESCENCE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PALMITIC ACID; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SALICYLIC ACID; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION;

EID: 84864763990     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.06.012     Document Type: Article

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