메뉴 건너뛰기




Volumn 14, Issue , 2015, Pages 91-98

Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer

Author keywords

Antitumor activity; Breast cancer; Brown seaweed; Fucoidan; Fucoxanthin; Phloroglucinol

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CAROTENOID; CYTOTOXIC AGENT; FUCOIDIN; FUCOXANTHIN; PHLOROGLUCINOL; PHLOROTANNIN; POLYPHENOL DERIVATIVE; POLYSACCHARIDE; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84942853309     PISSN: 18743900     EISSN: 18767486     Source Type: Journal    
DOI: 10.1016/j.phytol.2015.09.007     Document Type: Review
Times cited : (158)

References (115)
  • 1
    • 84875542642 scopus 로고    scopus 로고
    • Gene expression alterations in doxorubicin resistant MCF7 breast cancer cell line
    • S. AbuHammad, and M. Zihlif Gene expression alterations in doxorubicin resistant MCF7 breast cancer cell line Genomics 101 2013 213 220
    • (2013) Genomics , vol.101 , pp. 213-220
    • AbuHammad, S.1    Zihlif, M.2
  • 2
    • 84908017574 scopus 로고    scopus 로고
    • Pharmaceutical, cosmeceutical, and traditional applications of marine carbohydrates
    • A.B. Ahmed, M. Adel, P. Karimi, and M. Peidayesh Pharmaceutical, cosmeceutical, and traditional applications of marine carbohydrates Adv. Food Nutr. Res. 73 2014 197 220
    • (2014) Adv. Food Nutr. Res. , vol.73 , pp. 197-220
    • Ahmed, A.B.1    Adel, M.2    Karimi, P.3    Peidayesh, M.4
  • 3
    • 11144297712 scopus 로고    scopus 로고
    • Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways
    • Y. Aisa, Y. Miyakawa, T. Nakazato, H. Shibata, K. Saito, Y. Ikeda, and M. Kizaki Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways Am. J. Hematol. 78 2005 7 14
    • (2005) Am. J. Hematol. , vol.78 , pp. 7-14
    • Aisa, Y.1    Miyakawa, Y.2    Nakazato, T.3    Shibata, H.4    Saito, K.5    Ikeda, Y.6    Kizaki, M.7
  • 5
    • 84873827141 scopus 로고    scopus 로고
    • FLX Pyrosequencing analysis of the effects of the brown-algal fermentable polysaccharides alginate and laminaran on rat cecal microbiotas
    • C. An, T. Kuda, T. Yazaki, H. Takahashi, and B. Kimura FLX Pyrosequencing analysis of the effects of the brown-algal fermentable polysaccharides alginate and laminaran on rat cecal microbiotas Appl. Environ. Microbiol. 79 2013 860 866
    • (2013) Appl. Environ. Microbiol. , vol.79 , pp. 860-866
    • An, C.1    Kuda, T.2    Yazaki, T.3    Takahashi, H.4    Kimura, B.5
  • 7
    • 84873725975 scopus 로고    scopus 로고
    • In vitro antioxidant properties of crude extracts and compounds from brown algae
    • E.M. Balboa, E. Conde, A. Moure, E. Falqué, and H. Domínguez In vitro antioxidant properties of crude extracts and compounds from brown algae Food Chem. 138 2013 1764 1785
    • (2013) Food Chem. , vol.138 , pp. 1764-1785
    • Balboa, E.M.1    Conde, E.2    Moure, A.3    Falqué, E.4    Domínguez, H.5
  • 8
    • 84889259777 scopus 로고    scopus 로고
    • Simultaneous extraction and depolymerization of fucoidan from sargassum muticum in aqueous media
    • E.M. Balboa, S. Rivas, A. Moure, H. Domínguez, and J.C. Parajó Simultaneous extraction and depolymerization of fucoidan from sargassum muticum in aqueous media Mar. Drugs 11 2013 4612 4627
    • (2013) Mar. Drugs , vol.11 , pp. 4612-4627
    • Balboa, E.M.1    Rivas, S.2    Moure, A.3    Domínguez, H.4    Parajó, J.C.5
  • 10
    • 84907221224 scopus 로고    scopus 로고
    • Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades
    • S. Chen, Y. Zhao, Y. Zhang, and D. Zhang Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades PLoS One 9 2014 e108157
    • (2014) PLoS One , vol.9 , pp. e108157
    • Chen, S.1    Zhao, Y.2    Zhang, Y.3    Zhang, D.4
  • 11
    • 41249097555 scopus 로고    scopus 로고
    • Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium
    • S.L. Crockett, E.M. Wenzig, O. Kunert, and R. Bauer Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium Phytochem. Lett. 1 2008 37 43
    • (2008) Phytochem. Lett. , vol.1 , pp. 37-43
    • Crockett, S.L.1    Wenzig, E.M.2    Kunert, O.3    Bauer, R.4
  • 14
    • 1442315196 scopus 로고    scopus 로고
    • Anti-allergic agents from natural sources (4): Anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae)
    • A. Daikonya, S. Katsuki, J.B. Wu, and S. Kitanaka Anti-allergic agents from natural sources (4): anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae) Chem. Pharm. Bull. (Tokyo) 50 2002 1566 1569
    • (2002) Chem. Pharm. Bull. (Tokyo) , vol.50 , pp. 1566-1569
    • Daikonya, A.1    Katsuki, S.2    Wu, J.B.3    Kitanaka, S.4
  • 15
    • 84928329477 scopus 로고    scopus 로고
    • Marine extremophiles: A source of hydrolases for biotechnological applications
    • G.Z.L. Dalmaso, D. Ferreira, and A.B. Vermelho Marine extremophiles: a source of hydrolases for biotechnological applications Mar. Drugs 13 2015 1925 1965
    • (2015) Mar. Drugs , vol.13 , pp. 1925-1965
    • Dalmaso, G.Z.L.1    Ferreira, D.2    Vermelho, A.B.3
  • 17
    • 84906544769 scopus 로고    scopus 로고
    • Cisplatin in cancer therapy: Molecular mechanisms of action
    • S. Dasari, and P.B. Tchounwou Cisplatin in cancer therapy: molecular mechanisms of action Eur. J. Pharmacol. 740 2014 364 378
    • (2014) Eur. J. Pharmacol. , vol.740 , pp. 364-378
    • Dasari, S.1    Tchounwou, P.B.2
  • 18
    • 17144363256 scopus 로고    scopus 로고
    • Understanding breast cancer risk - Where do we stand in 2005?
    • R.G. Dumitrescu, and I. Cotarla Understanding breast cancer risk - where do we stand in 2005? J. Cell. Mol. Med. 9 2005 208 221
    • (2005) J. Cell. Mol. Med. , vol.9 , pp. 208-221
    • Dumitrescu, R.G.1    Cotarla, I.2
  • 19
    • 84865222831 scopus 로고    scopus 로고
    • Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters
    • S.Y. Eid, M.Z. El-Readi, and M. Wink Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters Phytomedicine 19 2012 977 987
    • (2012) Phytomedicine , vol.19 , pp. 977-987
    • Eid, S.Y.1    El-Readi, M.Z.2    Wink, M.3
  • 21
    • 84880732227 scopus 로고    scopus 로고
    • In vitro antibacterial activity and synergistic antibiotic effects of phlorotannins isolated from Eisenia bicyclis against methicillin-resistant Staphylococcus aureus
    • S.H. Eom, D.H. Kim, S.H. Lee, N.Y. Yoon, J.H. Kim, T.H. Kim, Y.H. Chung, S.B. Kim, Y.M. Kim, H.W. Kim, and et al. In vitro antibacterial activity and synergistic antibiotic effects of phlorotannins isolated from Eisenia bicyclis against methicillin-resistant Staphylococcus aureus Phytother. Res. 27 2013 1260 1264
    • (2013) Phytother. Res. , vol.27 , pp. 1260-1264
    • Eom, S.H.1    Kim, D.H.2    Lee, S.H.3    Yoon, N.Y.4    Kim, J.H.5    Kim, T.H.6    Chung, Y.H.7    Kim, S.B.8    Kim, Y.M.9    Kim, H.W.10
  • 23
    • 84899446067 scopus 로고    scopus 로고
    • Efficacy and safety of parecoxib/phloroglucinol combination therapy versus parecoxib monotherapy for acute renal colic: A randomized, double-blind clinical trial
    • W. Fu, J. Yao, Q. Li, Y. Wang, X. Wu, Z. Zhou, W.B. Li, and J.A. Yan Efficacy and safety of parecoxib/phloroglucinol combination therapy versus parecoxib monotherapy for acute renal colic: a randomized, double-blind clinical trial Cell Biochem. Biophys. 69 2014 157 161
    • (2014) Cell Biochem. Biophys. , vol.69 , pp. 157-161
    • Fu, W.1    Yao, J.2    Li, Q.3    Wang, Y.4    Wu, X.5    Zhou, Z.6    Li, W.B.7    Yan, J.A.8
  • 24
    • 84864390238 scopus 로고    scopus 로고
    • Green tea: An effective synergist with anticancer drugs for tertiary cancer prevention
    • H. Fujiki, and M. Suganuma Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention Cancer Lett. 324 2012 119 125
    • (2012) Cancer Lett. , vol.324 , pp. 119-125
    • Fujiki, H.1    Suganuma, M.2
  • 25
    • 84867093355 scopus 로고    scopus 로고
    • Fucoxanthin content and antioxidant properties of Undaria pinnatifida
    • A. Fung, N. Hamid, and J. Lu Fucoxanthin content and antioxidant properties of Undaria pinnatifida Food Chem. 136 2013 1055 1062
    • (2013) Food Chem. , vol.136 , pp. 1055-1062
    • Fung, A.1    Hamid, N.2    Lu, J.3
  • 26
    • 84928411843 scopus 로고    scopus 로고
    • Anti-obesity activity of the marine carotenoid fucoxanthin
    • M.A. Gammone, and N. D'Orazio Anti-obesity activity of the marine carotenoid fucoxanthin Mar. Drugs 13 2015 2196 2214
    • (2015) Mar. Drugs , vol.13 , pp. 2196-2214
    • Gammone, M.A.1    D'Orazio, N.2
  • 27
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • M.M. Gottesman Mechanisms of cancer drug resistance Annu. Rev. Med. 53 2002 615 627
    • (2002) Annu. Rev. Med. , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 28
    • 79957648857 scopus 로고    scopus 로고
    • Bioactive potential and possible health effects of edible brown seaweeds
    • S. Gupta, and N. Abu-Ghannam Bioactive potential and possible health effects of edible brown seaweeds Trends iFood Sc. Technol. 22 2011 315 326
    • (2011) Trends IFood Sc. Technol. , vol.22 , pp. 315-326
    • Gupta, S.1    Abu-Ghannam, N.2
  • 29
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 30
    • 20544460150 scopus 로고    scopus 로고
    • Antioxidant activities of enzymatic extracts from brown seaweeds
    • S.J. Heo, E.J. Park, K.W. Lee, and Y.J. Jeon Antioxidant activities of enzymatic extracts from brown seaweeds Bioresour. Technol. 96 2005 1613 1623
    • (2005) Bioresour. Technol. , vol.96 , pp. 1613-1623
    • Heo, S.J.1    Park, E.J.2    Lee, K.W.3    Jeon, Y.J.4
  • 31
    • 84864153426 scopus 로고    scopus 로고
    • Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage
    • S.J. Heo, W.J. Yoon, K.N. Kim, C. Oh, Y.U. Choi, K.T. Yoon, D.H. Kang, Z.J. Qian, I.W. Choi, and W.K. Jung Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage Food Chem. Toxicol. 50 2012 3336 3342
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 3336-3342
    • Heo, S.J.1    Yoon, W.J.2    Kim, K.N.3    Oh, C.4    Choi, Y.U.5    Yoon, K.T.6    Kang, D.H.7    Qian, Z.J.8    Choi, I.W.9    Jung, W.K.10
  • 32
    • 79958758613 scopus 로고    scopus 로고
    • Bioactive compounds in seaweed: Functional food applications and legislation
    • S. Holdt, and S. Kraan Bioactive compounds in seaweed: functional food applications and legislation J. Appl. Phycol. 23 2011 543 597
    • (2011) J. Appl. Phycol. , vol.23 , pp. 543-597
    • Holdt, S.1    Kraan, S.2
  • 33
    • 84938878427 scopus 로고    scopus 로고
    • Quality of life in patients with breast cancer and their rehabilitation needs
    • C. Hong-li, W. Xiao-chun, W. Jiang-bin, Z. Jing-bo, and W. Yao Quality of life in patients with breast cancer and their rehabilitation needs Pak. J. Med. Sci. 30 2014 126 130
    • (2014) Pak. J. Med. Sci. , vol.30 , pp. 126-130
    • Hong-Li, C.1    Xiao-Chun, W.2    Jiang-Bin, W.3    Jing-Bo, Z.4    Yao, W.5
  • 34
    • 84875935094 scopus 로고    scopus 로고
    • Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFbeta receptor degradation in breast cancer
    • H.Y. Hsu, T.Y. Lin, P.A. Hwang, L.M. Tseng, R.H. Chen, S.M. Tsao, and J. Hsu Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFbeta receptor degradation in breast cancer Carcinogenesis 34 2013 874 884
    • (2013) Carcinogenesis , vol.34 , pp. 874-884
    • Hsu, H.Y.1    Lin, T.Y.2    Hwang, P.A.3    Tseng, L.M.4    Chen, R.H.5    Tsao, S.M.6    Hsu, J.7
  • 37
    • 79551626046 scopus 로고    scopus 로고
    • Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer
    • M. Ikeguchi, M. Yamamoto, Y. Arai, Y. Maeta, K. Ashida, K. Katano, Y. Miki, and T. Kimura Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer Oncol. Lett. 2 2011 319 322
    • (2011) Oncol. Lett. , vol.2 , pp. 319-322
    • Ikeguchi, M.1    Yamamoto, M.2    Arai, Y.3    Maeta, Y.4    Ashida, K.5    Katano, K.6    Miki, Y.7    Kimura, T.8
  • 39
    • 77953121878 scopus 로고    scopus 로고
    • Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: A comparative study on ascophyllan and fucoidan
    • Z. Jiang, T. Okimura, T. Yokose, Y. Yamasaki, K. Yamaguchi, and T. Oda Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: a comparative study on ascophyllan and fucoidan J. Biosci. Bioeng. 110 2010 113 117
    • (2010) J. Biosci. Bioeng. , vol.110 , pp. 113-117
    • Jiang, Z.1    Okimura, T.2    Yokose, T.3    Yamasaki, Y.4    Yamaguchi, K.5    Oda, T.6
  • 40
    • 84875103424 scopus 로고    scopus 로고
    • Cell survival and apoptosis signaling as therapeutic target for cancer: Marine bioactive compounds
    • S. Kalimuthu, and K. Se-Kwon Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds Int. J. Mol. Sci. 14 2013 2334 2354
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 2334-2354
    • Kalimuthu, S.1    Se-Kwon, K.2
  • 42
    • 77952314064 scopus 로고    scopus 로고
    • Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo
    • K.A. Kang, R. Zhang, S. Chae, S.J. Lee, J. Kim, J. Kim, J. Jeong, J. Lee, T. Shin, N.H. Lee, and et al. Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo Chem. Biol. Interact. 185 2010 215 226
    • (2010) Chem. Biol. Interact. , vol.185 , pp. 215-226
    • Kang, K.A.1    Zhang, R.2    Chae, S.3    Lee, S.J.4    Kim, J.5    Kim, J.6    Jeong, J.7    Lee, J.8    Shin, T.9    Lee, N.H.10
  • 43
    • 85003220345 scopus 로고    scopus 로고
    • Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines
    • G.J. Kapadia, G.S. Rao, C. Ramachandran, A. Iida, N. Suzuki, and H. Tokuda Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines J. Complement. Integr. Med. 10 2013
    • (2013) J. Complement. Integr. Med. , vol.10
    • Kapadia, G.J.1    Rao, G.S.2    Ramachandran, C.3    Iida, A.4    Suzuki, N.5    Tokuda, H.6
  • 45
    • 77956338890 scopus 로고    scopus 로고
    • Effect of phloroglucinol on oxidative stress and inflammation
    • M.M. Kim, and S.K. Kim Effect of phloroglucinol on oxidative stress and inflammation Food Chem. Toxicol. 48 2010 2925 2933
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 2925-2933
    • Kim, M.M.1    Kim, S.K.2
  • 46
    • 84923229083 scopus 로고    scopus 로고
    • Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition
    • R.K. Kim, Y. Suh, K.C. Yoo, Y.H. Cui, E. Hwang, H.J. Kim, J.S. Kang, M.J. Kim, Y.Y. Lee, and S.J. Lee Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition Cancer Sci. 106 2015 94 101
    • (2015) Cancer Sci. , vol.106 , pp. 94-101
    • Kim, R.K.1    Suh, Y.2    Yoo, K.C.3    Cui, Y.H.4    Hwang, E.5    Kim, H.J.6    Kang, J.S.7    Kim, M.J.8    Lee, Y.Y.9    Lee, S.J.10
  • 47
    • 84887140160 scopus 로고    scopus 로고
    • Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin
    • T.H. Kim, Y.J. Shin, A.J. Won, B.M. Lee, W.S. Choi, J.H. Jung, H.Y. Chung, and H.S. Kim Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin Bioch. Biophys. Acta (BBA) - Gen. Subj. 1840 2014 615 625
    • (2014) Bioch. Biophys. Acta (BBA) - Gen. Subj. , vol.1840 , pp. 615-625
    • Kim, T.H.1    Shin, Y.J.2    Won, A.J.3    Lee, B.M.4    Choi, W.S.5    Jung, J.H.6    Chung, H.Y.7    Kim, H.S.8
  • 48
    • 67349194659 scopus 로고    scopus 로고
    • Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells
    • C.-S. Kong, J.-A. Kim, N.-Y. Yoon, and S.-K. Kim Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells Food Chem. Toxicol. 47 2009 1653 1658
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 1653-1658
    • Kong, C.-S.1    Kim, J.-A.2    Yoon, N.-Y.3    Kim, S.-K.4
  • 49
    • 31344463235 scopus 로고    scopus 로고
    • Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells
    • I. Konishi, M. Hosokawa, T. Sashima, H. Kobayashi, and K. Miyashita Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells Comp. Biochem. Physiol. C Toxicol. Pharmacol. 142 2006 53 59
    • (2006) Comp. Biochem. Physiol. C Toxicol. Pharmacol. , vol.142 , pp. 53-59
    • Konishi, I.1    Hosokawa, M.2    Sashima, T.3    Kobayashi, H.4    Miyashita, K.5
  • 50
    • 18844385479 scopus 로고    scopus 로고
    • Antiproliferative effect of neoxanthin and fucoxanthin on cultured cells
    • E. Kotake-Nara, T. Sugawara, and A. Nagao Antiproliferative effect of neoxanthin and fucoxanthin on cultured cells Fish Sci. 71 2005 459 461
    • (2005) Fish Sci. , vol.71 , pp. 459-461
    • Kotake-Nara, E.1    Sugawara, T.2    Nagao, A.3
  • 51
    • 0037437728 scopus 로고    scopus 로고
    • Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities
    • S. Koyanagi, N. Tanigawa, H. Nakagawa, S. Soeda, and H. Shimeno Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities Biochem. Pharmacol. 65 2003 173 179
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 173-179
    • Koyanagi, S.1    Tanigawa, N.2    Nakagawa, H.3    Soeda, S.4    Shimeno, H.5
  • 52
    • 28544439691 scopus 로고    scopus 로고
    • Carotenoid actions and their relation to health and disease
    • N.I. Krinsky, and E.J. Johnson Carotenoid actions and their relation to health and disease Mol. Aspects Med. 26 2005 459 516
    • (2005) Mol. Aspects Med. , vol.26 , pp. 459-516
    • Krinsky, N.I.1    Johnson, E.J.2
  • 53
    • 84892419887 scopus 로고    scopus 로고
    • Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms
    • S.R. Kumar, M. Hosokawa, and K. Miyashita Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms Mar. Drugs 11 2013 5130 5147
    • (2013) Mar. Drugs , vol.11 , pp. 5130-5147
    • Kumar, S.R.1    Hosokawa, M.2    Miyashita, K.3
  • 54
    • 84896717589 scopus 로고    scopus 로고
    • Fucoidan as a marine anticancer agent in preclinical development
    • J.-Y. Kwak Fucoidan as a marine anticancer agent in preclinical development Mar. Drugs 12 2014 851 870
    • (2014) Mar. Drugs , vol.12 , pp. 851-870
    • Kwak, J.-Y.1
  • 55
    • 50949098274 scopus 로고    scopus 로고
    • Fucoidan: Structure and Bioactivity
    • B. Li, F. Lu, X. Wei, and R. Zhao Fucoidan: Structure and Bioactivity Molecules 13 2008 1671 1695
    • (2008) Molecules , vol.13 , pp. 1671-1695
    • Li, B.1    Lu, F.2    Wei, X.3    Zhao, R.4
  • 56
    • 80055007725 scopus 로고    scopus 로고
    • Phlorotannins as bioactive agents from brown algae
    • Y.-X. Li, I. Wijesekara, Y. Li, and S.-K. Kim Phlorotannins as bioactive agents from brown algae Process Biochem. 46 2011 2219 2224
    • (2011) Process Biochem. , vol.46 , pp. 2219-2224
    • Li, Y.-X.1    Wijesekara, I.2    Li, Y.3    Kim, S.-K.4
  • 57
    • 84873174521 scopus 로고    scopus 로고
    • Fucoxanthin enhances cisplatin-induced cytotoxicity via NFκB-mediated pathway and downregulates DNA repair gene expression in human hepatoma HepG2Cells
    • C.-L. Liu, Y.-P. Lim, and M.-L. Hu Fucoxanthin enhances cisplatin-induced cytotoxicity via NFκB-mediated pathway and downregulates dna repair gene expression in human hepatoma HepG2Cells Mar. Drugs 11 2013 50 66
    • (2013) Mar. Drugs , vol.11 , pp. 50-66
    • Liu, C.-L.1    Lim, Y.-P.2    Hu, M.-L.3
  • 58
    • 84875960694 scopus 로고    scopus 로고
    • Fucoidan from New Zealand Undaria pinnatifida: Monthly variations and determination of antioxidant activities
    • W. Mak, N. Hamid, T. Liu, J. Lu, and W.L. White Fucoidan from New Zealand Undaria pinnatifida: monthly variations and determination of antioxidant activities Carbohydr. Polym. 95 2013 606 614
    • (2013) Carbohydr. Polym. , vol.95 , pp. 606-614
    • Mak, W.1    Hamid, N.2    Liu, T.3    Lu, J.4    White, W.L.5
  • 59
    • 84896732066 scopus 로고    scopus 로고
    • Marketed marine natural products in the pharmaceutical and cosmeceutical industries: Tips for success
    • A. Martins, H. Vieira, H. Gaspar, and S. Santos Marketed marine natural products in the pharmaceutical and cosmeceutical industries: tips for success Mar. Drugs 12 2014 1066 1101
    • (2014) Mar. Drugs , vol.12 , pp. 1066-1101
    • Martins, A.1    Vieira, H.2    Gaspar, H.3    Santos, S.4
  • 62
    • 0029945201 scopus 로고    scopus 로고
    • Beta-carotene, carotenoids, and disease prevention in humans
    • S.T. Mayne Beta-carotene, carotenoids, and disease prevention in humans FASEB J. 10 1996 690 701
    • (1996) FASEB J. , vol.10 , pp. 690-701
    • Mayne, S.T.1
  • 63
    • 84879990532 scopus 로고    scopus 로고
    • Biosynthetic pathway and health benefits of fucoxanthin, an algae-specific Xanthophyll in brown seaweeds
    • K. Mikami, and M. Hosokawa Biosynthetic pathway and health benefits of fucoxanthin, an algae-specific Xanthophyll in brown seaweeds Int. J. Mol. Sci. 14 2013 13763 13781
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 13763-13781
    • Mikami, K.1    Hosokawa, M.2
  • 64
  • 66
    • 67651160371 scopus 로고    scopus 로고
    • Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines
    • Y. Nakazawa, T. Sashima, M. Hosokawa, and K. Miyashita Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines J. Funct. Foods 1 2009 88 97
    • (2009) J. Funct. Foods , vol.1 , pp. 88-97
    • Nakazawa, Y.1    Sashima, T.2    Hosokawa, M.3    Miyashita, K.4
  • 68
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • C.K. Osborne Tamoxifen in the treatment of breast cancer N. Engl. J. Med. 339 1998 1609 1618
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1609-1618
    • Osborne, C.K.1
  • 69
    • 33746589549 scopus 로고    scopus 로고
    • Phloroglucinol compounds of natural origin
    • I. Pal Singh, and S.B. Bharate Phloroglucinol compounds of natural origin Nat. Prod. Rep. 23 2006 558 591
    • (2006) Nat. Prod. Rep. , vol.23 , pp. 558-591
    • Pal Singh, I.1    Bharate, S.B.2
  • 70
    • 80054921621 scopus 로고    scopus 로고
    • Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health
    • J. Peng, J.-P. Yuan, C.-F. Wu, and J.-H. Wang Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health Mar. Drugs 9 2011 1806 1828
    • (2011) Mar. Drugs , vol.9 , pp. 1806-1828
    • Peng, J.1    Yuan, J.-P.2    Wu, C.-F.3    Wang, J.-H.4
  • 71
    • 0032437869 scopus 로고    scopus 로고
    • Paclitaxel in breast cancer
    • E.A. Perez Paclitaxel in breast cancer Oncologist 3 1998 373 389
    • (1998) Oncologist , vol.3 , pp. 373-389
    • Perez, E.A.1
  • 72
    • 68349154203 scopus 로고    scopus 로고
    • Light-dependent regulation of carotenoid biosynthesis in plants
    • L. Pizarro, and C. Stange Light-dependent regulation of carotenoid biosynthesis in plants Cienc. Invest. Agrar. 36 2009 143 162
    • (2009) Cienc. Invest. Agrar. , vol.36 , pp. 143-162
    • Pizarro, L.1    Stange, C.2
  • 73
    • 84889768148 scopus 로고    scopus 로고
    • Cancer preventive efficacy of marine carotenoid fucoxanthin: Cell cycle arrest and apoptosis
    • T. Rengarajan, P. Rajendran, N. Nandakumar, M. Balasubramanian, and I. Nishigaki Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis Nutrients 5 2013 4978 4989
    • (2013) Nutrients , vol.5 , pp. 4978-4989
    • Rengarajan, T.1    Rajendran, P.2    Nandakumar, N.3    Balasubramanian, M.4    Nishigaki, I.5
  • 74
    • 77955415856 scopus 로고    scopus 로고
    • Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris
    • L.-E. Rioux, S.L. Turgeon, and M. Beaulieu Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris Phytochemistry 71 2010 1586 1595
    • (2010) Phytochemistry , vol.71 , pp. 1586-1595
    • Rioux, L.-E.1    Turgeon, S.L.2    Beaulieu, M.3
  • 75
    • 84903541432 scopus 로고    scopus 로고
    • Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway
    • A. Rwigemera, J. Mamelona, and L. Martin Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway Cell Biol. Toxicol. 30 2014 157 167
    • (2014) Cell Biol. Toxicol. , vol.30 , pp. 157-167
    • Rwigemera, A.1    Mamelona, J.2    Martin, L.3
  • 76
    • 84920482331 scopus 로고    scopus 로고
    • Comparative effects between fucoxanthinol and its precursor fucoxanthin on viability and apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231
    • A. Rwigemera, J. Mamelona, and L.J. Martin Comparative effects between fucoxanthinol and its precursor fucoxanthin on viability and apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231 Anticancer Re.s 35 2015 207 219
    • (2015) Anticancer Re.s , vol.35 , pp. 207-219
    • Rwigemera, A.1    Mamelona, J.2    Martin, L.J.3
  • 77
    • 35548992780 scopus 로고    scopus 로고
    • Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites
    • N.M. Sachindra, E. Sato, H. Maeda, M. Hosokawa, Y. Niwano, M. Kohno, and K. Miyashita Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites J. Agric. Food Chem. 55 2007 8516 8522
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 8516-8522
    • Sachindra, N.M.1    Sato, E.2    Maeda, H.3    Hosokawa, M.4    Niwano, Y.5    Kohno, M.6    Miyashita, K.7
  • 78
    • 84855604916 scopus 로고    scopus 로고
    • The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes
    • S.N. Saldanha, and T.O. Tollefsbol The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes J. Oncol. 2012 2012 23
    • (2012) J. Oncol. , vol.2012 , pp. 23
    • Saldanha, S.N.1    Tollefsbol, T.O.2
  • 79
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
    • C. Scheel, and R.A. Weinberg Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links Semin. Cancer Biol. 22 2012 396 403
    • (2012) Semin. Cancer Biol. , vol.22 , pp. 396-403
    • Scheel, C.1    Weinberg, R.A.2
  • 80
    • 34249952126 scopus 로고    scopus 로고
    • Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein
    • Z. Shi, Y.J. Liang, Z.S. Chen, X.H. Wang, Y. Ding, L.M. Chen, and L.W. Fu Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein Oncol. Rep. 17 2007 969 976
    • (2007) Oncol. Rep. , vol.17 , pp. 969-976
    • Shi, Z.1    Liang, Y.J.2    Chen, Z.S.3    Wang, X.H.4    Ding, Y.5    Chen, L.M.6    Fu, L.W.7
  • 82
    • 77649095023 scopus 로고    scopus 로고
    • Phloroglucinol compounds of natural origin: Synthetic aspects
    • I.P. Singh, J. Sidana, S.B. Bharate, and W.J. Foley Phloroglucinol compounds of natural origin: synthetic aspects Nat. Prod. Rep. 27 2010 393 416
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 393-416
    • Singh, I.P.1    Sidana, J.2    Bharate, S.B.3    Foley, W.J.4
  • 83
    • 79955114649 scopus 로고    scopus 로고
    • Anticancer drugs from marine flora: An overview
    • N. Sithranga Boopathy, and K. Kathiresan Anticancer drugs from marine flora: an overview J. Oncol. 2010 2010
    • (2010) J. Oncol. , vol.2010
    • Sithranga Boopathy, N.1    Kathiresan, K.2
  • 84
    • 8744287436 scopus 로고    scopus 로고
    • Medicinal and pharmaceutical uses of seaweed natural products: A review
    • A. Smit Medicinal and pharmaceutical uses of seaweed natural products: a review J. Appl. Phycol. 16 2004 245 262
    • (2004) J. Appl. Phycol. , vol.16 , pp. 245-262
    • Smit, A.1
  • 87
    • 81255188020 scopus 로고    scopus 로고
    • Immunomodulation and antitumor activities of different-molecular-weight polysaccharides from Porphyridium cruentum
    • L. Sun, L. Wang, and Y. Zhou Immunomodulation and antitumor activities of different-molecular-weight polysaccharides from Porphyridium cruentum Carbohydr. Polym. 87 2012 1206 1210
    • (2012) Carbohydr. Polym. , vol.87 , pp. 1206-1210
    • Sun, L.1    Wang, L.2    Zhou, Y.3
  • 88
    • 84942845155 scopus 로고    scopus 로고
    • Carotenoids in algae: Distributions, biosyntheses and functions
    • S. Takaichi Carotenoids in algae: distributions, biosyntheses and functions Biosci. Biotechnol. Biochem. 70 2011 2807 2811
    • (2011) Biosci. Biotechnol. Biochem. , vol.70 , pp. 2807-2811
    • Takaichi, S.1
  • 89
    • 1342306726 scopus 로고    scopus 로고
    • The role of carotenoids in the prevention of human pathologies
    • H. Tapiero, D.M. Townsend, and K.D. Tew The role of carotenoids in the prevention of human pathologies Biomed. Pharmacother. 58 2004 100 110
    • (2004) Biomed. Pharmacother. , vol.58 , pp. 100-110
    • Tapiero, H.1    Townsend, D.M.2    Tew, K.D.3
  • 90
    • 84877615964 scopus 로고    scopus 로고
    • The consumption of seaweed as a protective factor in the etiology of breast cancer: Proof of principle
    • J. Teas, S. Vena, D.L. Cone, and M. Irhimeh The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle J. Appl. Phycol. 25 2013 771 779
    • (2013) J. Appl. Phycol. , vol.25 , pp. 771-779
    • Teas, J.1    Vena, S.2    Cone, D.L.3    Irhimeh, M.4
  • 91
    • 84856413433 scopus 로고    scopus 로고
    • Parallel evolution under chemotherapy pressure in 29 breast cancer cell lines results in dissimilar mechanisms of resistance
    • B. Tegze, Z. Szallasi, I. Haltrich, Z. Penzvalto, Z. Toth, I. Liko, and B. Gyorffy Parallel evolution under chemotherapy pressure in 29 breast cancer cell lines results in dissimilar mechanisms of resistance PloS One 7 2012 e30804
    • (2012) PloS One , vol.7 , pp. e30804
    • Tegze, B.1    Szallasi, Z.2    Haltrich, I.3    Penzvalto, Z.4    Toth, Z.5    Liko, I.6    Gyorffy, B.7
  • 92
    • 78650737833 scopus 로고    scopus 로고
    • Singlet molecular oxygen-quenching activity of carotenoids: Relevance to protection of the skin from photoaging
    • J. Terao, Y. Minami, and N. Bando Singlet molecular oxygen-quenching activity of carotenoids: relevance to protection of the skin from photoaging J. Clin. Biochem. Nutr. 48 2011 57 62
    • (2011) J. Clin. Biochem. Nutr. , vol.48 , pp. 57-62
    • Terao, J.1    Minami, Y.2    Bando, N.3
  • 94
    • 0037648896 scopus 로고    scopus 로고
    • Molecular targeting therapy of cancer: Drug resistance, apoptosis and survival signal
    • T. Tsuruo, M. Naito, A. Tomida, N. Fujita, T. Mashima, H. Sakamoto, and N. Haga Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal Cancer Sci. 94 2003 15 21
    • (2003) Cancer Sci. , vol.94 , pp. 15-21
    • Tsuruo, T.1    Naito, M.2    Tomida, A.3    Fujita, N.4    Mashima, T.5    Sakamoto, H.6    Haga, N.7
  • 95
    • 79955086761 scopus 로고    scopus 로고
    • Bio-prospecting of a few brown seaweeds for their cytotoxic and antioxidant activities
    • R.C. Vinayak, A.S. Sabu, and A. Chatterji Bio-prospecting of a few brown seaweeds for their cytotoxic and antioxidant activities Evid.-Based Complement. Altern. Med. 2011 2011 9
    • (2011) Evid.-Based Complement. Altern. Med. , vol.2011 , pp. 9
    • Vinayak, R.C.1    Sabu, A.S.2    Chatterji, A.3
  • 96
    • 81455158705 scopus 로고    scopus 로고
    • Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: Isolation, structural characteristics, and antitumor activity
    • O.S. Vishchuk, S.P. Ermakova, and T.N. Zvyagintseva Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity Carbohydr. Res. 346 17 2011 2769 2776
    • (2011) Carbohydr. Res. , vol.346 , Issue.17 , pp. 2769-2776
    • Vishchuk, O.S.1    Ermakova, S.P.2    Zvyagintseva, T.N.3
  • 97
    • 78650638887 scopus 로고    scopus 로고
    • Potential anti-HIV agents from marine resources: An overview
    • T.-S. Vo, and S.-K. Kim Potential anti-HIV agents from marine resources: an overview Mar. Drugs 8 2010 2871 2892
    • (2010) Mar. Drugs , vol.8 , pp. 2871-2892
    • Vo, T.-S.1    Kim, S.-K.2
  • 98
    • 84871143693 scopus 로고    scopus 로고
    • Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl
    • G. Wang, J. Zhang, L. Liu, S. Sharma, and Q. Dong Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl PloS One 7 2012 e51764
    • (2012) PloS One , vol.7 , pp. e51764
    • Wang, G.1    Zhang, J.2    Liu, L.3    Sharma, S.4    Dong, Q.5
  • 99
    • 84871799778 scopus 로고    scopus 로고
    • The antiviral activities and mechanisms of marine polysaccharides: An overview
    • W. Wang, S.-X. Wang, and H.-S. Guan The antiviral activities and mechanisms of marine polysaccharides: an overview Mar. Drugs 10 2012 2795 2816
    • (2012) Mar. Drugs , vol.10 , pp. 2795-2816
    • Wang, W.1    Wang, S.-X.2    Guan, H.-S.3
  • 101
    • 78650155374 scopus 로고    scopus 로고
    • Phlorotannins from Ecklonia cava (Phaeophyceae): Biological activities and potential health benefits
    • I. Wijesekara, N.Y. Yoon, and S.K. Kim Phlorotannins from Ecklonia cava (Phaeophyceae): biological activities and potential health benefits Biofactors 36 2010 408 414
    • (2010) Biofactors , vol.36 , pp. 408-414
    • Wijesekara, I.1    Yoon, N.Y.2    Kim, S.K.3
  • 102
    • 84855987713 scopus 로고    scopus 로고
    • Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review
    • W.A.J.P. Wijesinghe, and Y.-J. Jeon Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: a review Carbohydr. Polym. 88 2012 13 20
    • (2012) Carbohydr. Polym. , vol.88 , pp. 13-20
    • Wijesinghe, W.A.J.P.1    Jeon, Y.-J.2
  • 103
    • 0028054039 scopus 로고
    • Immunomodulatory and anti-tumour polysaccharides from medicinal plants
    • C.K. Wong, K.N. Leung, K.P. Fung, and Y.M. Choy Immunomodulatory and anti-tumour polysaccharides from medicinal plants J. Int. Med. Res. 22 1994 299 312
    • (1994) J. Int. Med. Res. , vol.22 , pp. 299-312
    • Wong, C.K.1    Leung, K.N.2    Fung, K.P.3    Choy, Y.M.4
  • 104
    • 84879352014 scopus 로고    scopus 로고
    • Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells
    • G.-S. Wu, J.-J. Lu, J.-J. Guo, M.-Q. Huang, L. Gan, X.-P. Chen, and Y.-T. Wang Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells Pharmacol. Rep. 65 2013 453 459
    • (2013) Pharmacol. Rep. , vol.65 , pp. 453-459
    • Wu, G.-S.1    Lu, J.-J.2    Guo, J.-J.3    Huang, M.-Q.4    Gan, L.5    Chen, X.-P.6    Wang, Y.-T.7
  • 105
    • 84876117537 scopus 로고    scopus 로고
    • Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/beta-catenin signaling
    • M. Xue, Y. Ge, J. Zhang, Y. Liu, Q. Wang, L. Hou, and Z. Zheng Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/beta-catenin signaling Nutr. Cancer 65 2013 460 468
    • (2013) Nutr. Cancer , vol.65 , pp. 460-468
    • Xue, M.1    Ge, Y.2    Zhang, J.3    Liu, Y.4    Wang, Q.5    Hou, L.6    Zheng, Z.7
  • 106
    • 84865175152 scopus 로고    scopus 로고
    • Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo
    • M. Xue, Y. Ge, J. Zhang, Q. Wang, L. Hou, Y. Liu, L. Sun, and Q. Li Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo PloS One 7 2012 e43483
    • (2012) PloS One , vol.7 , pp. e43483
    • Xue, M.1    Ge, Y.2    Zhang, J.3    Wang, Q.4    Hou, L.5    Liu, Y.6    Sun, L.7    Li, Q.8
  • 107
    • 70349319640 scopus 로고    scopus 로고
    • Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells
    • Y. Yamasaki-Miyamoto, M. Yamasaki, H. Tachibana, and K. Yamada Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells J. Agric. Food Chem. 57 2009 8677 8682
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 8677-8682
    • Yamasaki-Miyamoto, Y.1    Yamasaki, M.2    Tachibana, H.3    Yamada, K.4
  • 108
    • 0033094880 scopus 로고    scopus 로고
    • Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed
    • X. Yan, Y. Chuda, M. Suzuki, and T. Nagata Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed Biosci. Biotechnol. Biochem. 63 1999 605 607
    • (1999) Biosci. Biotechnol. Biochem. , vol.63 , pp. 605-607
    • Yan, X.1    Chuda, Y.2    Suzuki, M.3    Nagata, T.4
  • 109
    • 33744939692 scopus 로고    scopus 로고
    • Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds
    • Y.V. Yuan, and N.A. Walsh Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds Food Chem. Toxicol. 44 2006 1144 1150
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 1144-1150
    • Yuan, Y.V.1    Walsh, N.A.2
  • 110
    • 84864508008 scopus 로고    scopus 로고
    • Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway
    • Y. Zhang, M. Luo, Y. Zu, Y. Fu, C. Gu, W. Wang, L. Yao, and T. Efferth Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway Chem. Biol. Interact. 199 2012 129 136
    • (2012) Chem. Biol. Interact. , vol.199 , pp. 129-136
    • Zhang, Y.1    Luo, M.2    Zu, Y.3    Fu, Y.4    Gu, C.5    Wang, W.6    Yao, L.7    Efferth, T.8
  • 111
    • 80855135589 scopus 로고    scopus 로고
    • Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways
    • Z. Zhang, K. Teruya, H. Eto, and S. Shirahata Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways PloS One 6 2011 e27441
    • (2011) PloS One , vol.6 , pp. e27441
    • Zhang, Z.1    Teruya, K.2    Eto, H.3    Shirahata, S.4
  • 112
    • 84875446913 scopus 로고    scopus 로고
    • Induction of apoptosis by low-molecular-weight fucoidan through calcium- and caspase-dependent mitochondrial pathways in MDA-MB-231 breast cancer cells
    • Z. Zhang, K. Teruya, H. Eto, and S. Shirahata Induction of apoptosis by low-molecular-weight fucoidan through calcium- and caspase-dependent mitochondrial pathways in MDA-MB-231 breast cancer cells Biosci. Biotechnol. Biochem. 77 2013 235 242
    • (2013) Biosci. Biotechnol. Biochem. , vol.77 , pp. 235-242
    • Zhang, Z.1    Teruya, K.2    Eto, H.3    Shirahata, S.4
  • 113
    • 84873205267 scopus 로고    scopus 로고
    • Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells
    • Z. Zhang, K. Teruya, T. Yoshida, H. Eto, and S. Shirahata Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells Mar. Drugs 11 2013 81 98
    • (2013) Mar. Drugs , vol.11 , pp. 81-98
    • Zhang, Z.1    Teruya, K.2    Yoshida, T.3    Eto, H.4    Shirahata, S.5
  • 114
    • 84881045264 scopus 로고    scopus 로고
    • Fucoxanthin protects cultured human keratinocytes against oxidative stress by blocking free radicals and inhibiting apoptosis
    • J. Zheng, M.J. Piao, Y.S. Keum, H.S. Kim, and J.W. Hyun Fucoxanthin protects cultured human keratinocytes against oxidative stress by blocking free radicals and inhibiting apoptosis Biomol. Ther. (Seoul) 21 2013 270 276
    • (2013) Biomol. Ther. (Seoul) , vol.21 , pp. 270-276
    • Zheng, J.1    Piao, M.J.2    Keum, Y.S.3    Kim, H.S.4    Hyun, J.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.