메뉴 건너뛰기




Volumn 12, Issue 2, 2014, Pages 1066-1101

Marketed marine natural products in the pharmaceutical and cosmeceutical industries: Tips for success

Author keywords

Biodiscovery; Challenges; Cosmeceuticals; Marine natural products; Market; Pharmaceuticals; Success

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; ANTINEOPLASTIC AGENT; ASG 5ME; BRENTUXIMAB VEDOTIN; CARRAGEENAN; CARRAGELOSE; COSMETIC; CYTARABINE; DEHYDRODIDEMNIN B; ELISIDEPSIN; ERIBULIN; EXOPOLYSACCHARIDE; GLEMBATUMUMAB VEDOTIN; KAHALALIDE F; LURBINECTEDIN; NATURAL PRODUCT; OMEGA 3 ACID ETHYL ESTER; OMEGA CONOTOXIN MVIIA; PLINABULIN; PM 00104; PM 060184; PRIAL; SALINOSPORAMIDE A; SOBLIDOTIN; SQUALAMINE; TALTOBULIN; TASIDOTIN; TRABECTEDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIDARABINE; VORSETUZUMAB MAFODOTIN; ZALYPSIS;

EID: 84896732066     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12021066     Document Type: Review
Times cited : (431)

References (128)
  • 2
    • 84878280763 scopus 로고    scopus 로고
    • A historical overview of natural products in drug discovery
    • Dias, D.A.; Urban, S.; Roessner, U. A historical overview of natural products in drug discovery. Metabolites 2012, 2, 303-336.
    • (2012) Metabolites , vol.2 , pp. 303-336
    • Dias, D.A.1    Urban, S.2    Roessner, U.3
  • 3
    • 80055018013 scopus 로고    scopus 로고
    • Natural products and Pharma 2011: Strategic changes spur new opportunities
    • Carter, G.T. Natural products and Pharma 2011: Strategic changes spur new opportunities. Nat. Prod. Rep. 2011, 28, 1783-1789.
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 1783-1789
    • Carter, G.T.1
  • 4
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335.
    • (2012) J. Nat. Prod. , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 6
    • 84856406381 scopus 로고    scopus 로고
    • Lessons from the past and charting the future of marine natural products drug discovery and chemical biology
    • Gerwick, W.H.; Moore, B.S. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem. Biol. 2012, 19, 85-98.
    • (2012) Chem. Biol. , vol.19 , pp. 85-98
    • Gerwick, W.H.1    Moore, B.S.2
  • 7
    • 84856034997 scopus 로고    scopus 로고
    • Trends in the discovery of new marine natural products from invertebrates over the last two decades - Where and what are we bioprospecting?
    • Leal, M.C.; Puga, J.; Serodio, J.; Gomes, N.C.M.; Calado, R. Trends in the discovery of new marine natural products from invertebrates over the last two decades - Where and what are we bioprospecting? PLoS One 2012, 7, e30580.
    • (2012) PLoS One , vol.7
    • Leal, M.C.1    Puga, J.2    Serodio, J.3    Gomes, N.C.M.4    Calado, R.5
  • 10
    • 78049442273 scopus 로고    scopus 로고
    • Immense essence of excellence: Marine microbial bioactive compounds
    • Bhatnagar, I.; Kim, S.K. Immense essence of excellence: Marine microbial bioactive compounds. Mar. Drugs 2010, 8, 2673-2701.
    • (2010) Mar. Drugs , vol.8 , pp. 2673-2701
    • Bhatnagar, I.1    Kim, S.K.2
  • 11
    • 78349305358 scopus 로고    scopus 로고
    • The expanding role of marine microbes in pharmaceutical development
    • Waters, A.L.; Hill, R.T.; Place, A.R.; Hamann, M.T. The expanding role of marine microbes in pharmaceutical development. Curr. Opin. Biotechnol. 2010, 21, 780-786.
    • (2010) Curr. Opin. Biotechnol. , vol.21 , pp. 780-786
    • Waters, A.L.1    Hill, R.T.2    Place, A.R.3    Hamann, M.T.4
  • 12
    • 77952495893 scopus 로고    scopus 로고
    • Development of novel drugs from marine surface associated microorganisms
    • Penesyan, A.; Kjelleberg, S.; Egan, S. Development of novel drugs from marine surface associated microorganisms. Mar. Drugs 2010, 8, 438-459.
    • (2010) Mar. Drugs , vol.8 , pp. 438-459
    • Penesyan, A.1    Kjelleberg, S.2    Egan, S.3
  • 13
    • 61449113023 scopus 로고    scopus 로고
    • Metabolites from symbiotic bacteria
    • Piel, J. Metabolites from symbiotic bacteria. Nat. Prod. Rep. 2009, 26, 338-362.
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 338-362
    • Piel, J.1
  • 15
    • 19644393308 scopus 로고    scopus 로고
    • Bioactive microbial metabolites
    • Berdy, J. Bioactive microbial metabolites. J. Antibiot. 2005, 58, 1-26.
    • (2005) J. Antibiot. , vol.58 , pp. 1-26
    • Berdy, J.1
  • 16
    • 33847029508 scopus 로고    scopus 로고
    • Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina
    • Sudek, S.; Lopanik, N.B.; Waggoner, L.E.; Hildebrand, M.; Anderson, C.; Liu, H.; Patel, A.; Sherman, D.H.; Haygood, M.G. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J. Nat. Prod. 2007, 70, 67-74.
    • (2007) J. Nat. Prod. , vol.70 , pp. 67-74
    • Sudek, S.1    Lopanik, N.B.2    Waggoner, L.E.3    Hildebrand, M.4    Anderson, C.5    Liu, H.6    Patel, A.7    Sherman, D.H.8    Haygood, M.G.9
  • 18
    • 79960802666 scopus 로고    scopus 로고
    • Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer
    • Schumacher, M.; Kelkel, M.; Dicato, M.; Diederich, M. Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer. Biotechnol. Adv. 2011, 29, 531-547.
    • (2011) Biotechnol. Adv. , vol.29 , pp. 531-547
    • Schumacher, M.1    Kelkel, M.2    Dicato, M.3    Diederich, M.4
  • 19
    • 80053203292 scopus 로고    scopus 로고
    • Natural products: An evolving role in future drug discovery
    • Mishra, B.B.; Tiwari, V.K. Natural products: An evolving role in future drug discovery. Eur. J. Med. Chem. 2011, 46, 4769-4807.
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 4769-4807
    • Mishra, B.B.1    Tiwari, V.K.2
  • 20
  • 22
    • 84873115218 scopus 로고    scopus 로고
    • Beneficial effects of marine algal compounds in cosmeceuticals
    • Thomas, N.V.; Kim, S.-K. Beneficial effects of marine algal compounds in cosmeceuticals. Mar. Drugs 2013, 11, 146-164.
    • (2013) Mar. Drugs , vol.11 , pp. 146-164
    • Thomas, N.V.1    Kim, S.-K.2
  • 23
    • 84873157312 scopus 로고    scopus 로고
    • Bioactivity and applications of sulphated polysaccharides from marine microalgae
    • Raposo, M.F.; de Morais, R.M.; Bernardo de Morais, A.M. Bioactivity and applications of sulphated polysaccharides from marine microalgae. Mar. Drugs 2013, 11, 233-252.
    • (2013) Mar. Drugs , vol.11 , pp. 233-252
    • Raposo, M.F.1    De Morais, R.M.2    Bernardo De Morais, A.M.3
  • 24
    • 40449087392 scopus 로고    scopus 로고
    • Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient
    • Kim, Y.H.; Chung, C.B.; Kim, J.G.; Ko, K.I.; Park, S.H.; Kim, J.H.; Eom, S.Y.; Kim, Y.S.; Hwang, Y.I.; Kim, K.H. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient. Biosci. Biotechnol. Biochem. 2008, 72, 303-311.
    • (2008) Biosci. Biotechnol. Biochem. , vol.72 , pp. 303-311
    • Kim, Y.H.1    Chung, C.B.2    Kim, J.G.3    Ko, K.I.4    Park, S.H.5    Kim, J.H.6    Eom, S.Y.7    Kim, Y.S.8    Hwang, Y.I.9    Kim, K.H.10
  • 25
    • 85111441699 scopus 로고    scopus 로고
    • Pichan, drugs and cosmetics from the sea
    • Kijjoa, A.S. Pichan, drugs and cosmetics from the sea. Mar. Drugs 2004, 2, 73-74.
    • (2004) Mar. Drugs , vol.2 , pp. 73-74
    • Kijjoa, A.S.1
  • 26
    • 79960844742 scopus 로고    scopus 로고
    • Bio-mining the microbial treasures of the ocean: New natural products
    • Imhoff, J.F.; Labes, A.; Wiese, J. Bio-mining the microbial treasures of the ocean: New natural products. Biotechnol. Adv. 2011, 29, 468-482.
    • (2011) Biotechnol. Adv. , vol.29 , pp. 468-482
    • Imhoff, J.F.1    Labes, A.2    Wiese, J.3
  • 27
    • 67349092463 scopus 로고    scopus 로고
    • Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action
    • Mayer, A.M.S.; Rodriguez, A.D.; Berlinck, R.G.S.; Hamann, M.T. Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Biochim. Biophys. Acta 2009, 1790, 283-308.
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 283-308
    • Mayer, A.M.S.1    Rodriguez, A.D.2    Berlinck, R.G.S.3    Hamann, M.T.4
  • 28
    • 2942565810 scopus 로고    scopus 로고
    • Natural products and combinatorial chemistry: Back to the future
    • Ortholand, J.Y.; Ganesan, A. Natural products and combinatorial chemistry: Back to the future. Curr. Opin. Chem. Biol. 2004, 8, 271-280.
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 271-280
    • Ortholand, J.Y.1    Ganesan, A.2
  • 29
    • 70149117263 scopus 로고    scopus 로고
    • Natural products as a foundation for drug discovery
    • Beutler, J.A. Natural products as a foundation for drug discovery. Curr. Protoc. Pharmacol. 2009, 46, 9.11.1-9.11.21.
    • (2009) Curr. Protoc. Pharmacol. , vol.46
    • Beutler, J.A.1
  • 30
    • 80055020580 scopus 로고    scopus 로고
    • Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants
    • Radjasa, O.K.; Vaske, Y.M.; Navarro, G.; Vervoort, H.C.; Tenney, K.; Linington, R.G.; Crews, P. Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants. Bioorg. Med. Chem. 2011, 19, 6658-6674.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 6658-6674
    • Radjasa, O.K.1    Vaske, Y.M.2    Navarro, G.3    Vervoort, H.C.4    Tenney, K.5    Linington, R.G.6    Crews, P.7
  • 31
    • 67649491097 scopus 로고    scopus 로고
    • A renaissance in marine pharmacology: From preclinical curiosity to clinical reality
    • Glaser, K.B.; Mayer, A.M.S. A renaissance in marine pharmacology: From preclinical curiosity to clinical reality. Biochem. Pharmacol. 2009, 78, 440-448.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 440-448
    • Glaser, K.B.1    Mayer, A.M.S.2
  • 32
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery
    • Koehn, F.E.; Carter, G.T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 2005, 4, 206-220.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2
  • 33
    • 0036180639 scopus 로고    scopus 로고
    • Choosing the best pulse sequences, acquisition parameters, postacquisition processing strategies, and probes for natural product structure elucidation by NMR spectroscopy
    • Reynolds, W.F.; Enriquez, R.G. Choosing the best pulse sequences, acquisition parameters, postacquisition processing strategies, and probes for natural product structure elucidation by NMR spectroscopy. J. Nat. Prod. 2002, 65, 221-244.
    • (2002) J. Nat. Prod. , vol.65 , pp. 221-244
    • Reynolds, W.F.1    Enriquez, R.G.2
  • 34
    • 33644767089 scopus 로고    scopus 로고
    • Recent developments in antibacterial drug discovery: Microbe-derived natural products - From collection to the clinic
    • Leeds, J.A.; Schmitt, E.K.; Krastel, P. Recent developments in antibacterial drug discovery: Microbe-derived natural products - From collection to the clinic. Expert Opin. Investig. Drugs 2006, 15, 211-226.
    • (2006) Expert Opin. Investig. Drugs , vol.15 , pp. 211-226
    • Leeds, J.A.1    Schmitt, E.K.2    Krastel, P.3
  • 35
    • 34250220631 scopus 로고    scopus 로고
    • Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules
    • Brady, S.F. Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules. Nat. Protoc. 2007, 2, 1297-1305.
    • (2007) Nat. Protoc. , vol.2 , pp. 1297-1305
    • Brady, S.F.1
  • 36
    • 26944493400 scopus 로고    scopus 로고
    • Metagenomics-based drug discovery and marine microbial diversity
    • Li, X.; Qin, L. Metagenomics-based drug discovery and marine microbial diversity. Trends Biotechnol. 2005, 23, 539-543.
    • (2005) Trends Biotechnol. , vol.23 , pp. 539-543
    • Li, X.1    Qin, L.2
  • 37
    • 35349020474 scopus 로고    scopus 로고
    • Natural product drug discovery: The times have never been better
    • Galm, U.; Shen, B. Natural product drug discovery: The times have never been better. Chem. Biol. 2007, 14, 1098-1104.
    • (2007) Chem. Biol. , vol.14 , pp. 1098-1104
    • Galm, U.1    Shen, B.2
  • 38
    • 58849113668 scopus 로고    scopus 로고
    • Beyond the hapmap genotypic data: Prospects of deep resequencing projects
    • doi:10.2174/157489308785909232
    • Zhang, W.; Dolan, M.E. Beyond the hapmap genotypic data: Prospects of deep resequencing projects. Curr. Bioinform. 2008, 3, 178; doi:10.2174/ 157489308785909232.
    • (2008) Curr. Bioinform. , vol.3 , pp. 178
    • Zhang, W.1    Dolan, M.E.2
  • 39
    • 33751103661 scopus 로고    scopus 로고
    • Combinatorial biosynthesis in symbiotic bacteria
    • Piel, J. Combinatorial biosynthesis in symbiotic bacteria. Nat. Chem. Biol. 2006, 2, 661-662.
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 661-662
    • Piel, J.1
  • 40
    • 84896709341 scopus 로고    scopus 로고
    • Marine pharmacology and the marine pharmaceuticals pipeline
    • Mayer, A.M.S.; Glaser, K.B. Marine pharmacology and the marine pharmaceuticals pipeline. FASEB J. 2013, 27, 1167.7.
    • (2013) FASEB J. , vol.27
    • Mayer, A.M.S.1    Glaser, K.B.2
  • 41
    • 4344650390 scopus 로고    scopus 로고
    • Marine natural products and related compounds in clinical and advanced preclinical trials
    • Newman, D.J.; Cragg, G.M. Marine natural products and related compounds in clinical and advanced preclinical trials. J. Nat. Prod. 2004, 67, 1216-1238.
    • (2004) J. Nat. Prod. , vol.67 , pp. 1216-1238
    • Newman, D.J.1    Cragg, G.M.2
  • 43
    • 84876488980 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • BCC Research. Available online: http://www.bccresearch.com/pressroom/phm/ global-market-marine-derived-drugs-reach-nearly-$8.6-billion-2016 (accessed on 25 November 2013).
    • BCC Research
  • 44
    • 84896738053 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • Freedonia Group. Available online: http://www.freedoniagroup.com/ FreedoniaStudyIndex.aspx (accessed on 25 November 2013).
  • 45
    • 84896715022 scopus 로고    scopus 로고
    • Available online: (acessed on 25 November 2013)
    • EurOcean. Available online: http://www.eurocean.org/np4/2502.html (acessed on 25 November 2013).
  • 46
    • 33751156706 scopus 로고
    • Supply Issues Complicate Trek of Chemicals from the Sea to Market
    • Rouhi, A.M. Supply Issues Complicate Trek of Chemicals from the Sea to Market. Chem. Eng. News 1995, 73, 42-44.
    • (1995) Chem. Eng. News , vol.73 , pp. 42-44
    • Rouhi, A.M.1
  • 47
    • 84865495556 scopus 로고    scopus 로고
    • Bioprospecting of marine invertebrates for new natural products - A chemical and zoogeographical perspective
    • Leal, M.C.; Madeira, C.; Brandão, C.A.; Puga, J.; Calado, R. Bioprospecting of marine invertebrates for new natural products - A chemical and zoogeographical perspective. Molecules 2012, 17, 9842-9854.
    • (2012) Molecules , vol.17 , pp. 9842-9854
    • Leal, M.C.1    Madeira, C.2    Brandão, C.A.3    Puga, J.4    Calado, R.5
  • 48
    • 79952283235 scopus 로고    scopus 로고
    • Culturability and secondary metabolite diversity of extreme microbes: Expanding contribution of deep sea and deep-sea vent microbes to natural product discovery
    • Pettit, R.K. Culturability and secondary metabolite diversity of extreme microbes: Expanding contribution of deep sea and deep-sea vent microbes to natural product discovery. Mar. Biotechnol. 2011, 13, 1-11.
    • (2011) Mar. Biotechnol. , vol.13 , pp. 1-11
    • Pettit, R.K.1
  • 49
    • 80052498659 scopus 로고    scopus 로고
    • Marine natural products: A new wave of drugs?
    • Montaser, R.; Luesch, H. Marine natural products: A new wave of drugs? Future Med. Chem. 2011, 3, 1475-1489.
    • (2011) Future Med. Chem. , vol.3 , pp. 1475-1489
    • Montaser, R.1    Luesch, H.2
  • 50
    • 84896704356 scopus 로고    scopus 로고
    • Marine Natural Products Biotechnology
    • Available online: (accessed on 25 November 2013)
    • Hill, R.T. Marine Natural Products Biotechnology. In Biotechnology; Volume 9. Available online: http://www.eolss.net/sample-chapters/c17/e6-58-08- 05.pdf (accessed on 25 November 2013).
    • Biotechnology , vol.9
    • Hill, R.T.1
  • 51
    • 84872827945 scopus 로고    scopus 로고
    • The impact of the United Nations Convention on Biological Diversity on natural products research
    • Cragg, G.M.; Katz, F.; David, J.N.A.; Rosenthal, J. The impact of the United Nations Convention on Biological Diversity on natural products research. Nat. Prod. Rep. 2012, 29, 1407-1423.
    • (2012) Nat. Prod. Rep. , vol.29 , pp. 1407-1423
    • Cragg, G.M.1    Katz, F.2    David, J.N.A.3    Rosenthal, J.4
  • 52
    • 33746611586 scopus 로고    scopus 로고
    • European marine biodiversity inventory and taxonomic resources: State of the art and gaps in knowledge
    • Costello, M.J.; Bouchet, P.; Emblow, C.S.; Legakis, A. European marine biodiversity inventory and taxonomic resources: State of the art and gaps in knowledge. Mar. Ecol. Prog. Ser. 2006, 316, 257-268.
    • (2006) Mar. Ecol. Prog. Ser. , vol.316 , pp. 257-268
    • Costello, M.J.1    Bouchet, P.2    Emblow, C.S.3    Legakis, A.4
  • 53
    • 84871400384 scopus 로고    scopus 로고
    • Is coarse taxonomy sufficient for detecting macroinvertebrate patterns in floodplain lakes?
    • Jianga, X.; Xionga, J.; Songa, Z.; Morsed, J.C.; Jonese, F.C.; Xie, Z. Is coarse taxonomy sufficient for detecting macroinvertebrate patterns in floodplain lakes? Ecol. Indic. 2013, 27, 48-55.
    • (2013) Ecol. Indic. , vol.27 , pp. 48-55
    • Jianga, X.1    Xionga, J.2    Songa, Z.3    Morsed, J.C.4    Jonese, F.C.5    Xie, Z.6
  • 55
    • 12844283957 scopus 로고    scopus 로고
    • High-throughput drug discovery: What can we exulect from HTS?
    • Gribbon, P.; Sewing, A. High-throughput drug discovery: What can we exulect from HTS? Drug Discov. Today 2005, 10, 17-22.
    • (2005) Drug Discov. Today , vol.10 , pp. 17-22
    • Gribbon, P.1    Sewing, A.2
  • 56
    • 79953240916 scopus 로고    scopus 로고
    • Modern natural products drug discovery and its relevance to biodiversity conservation
    • Kingston, D.G.I. Modern natural products drug discovery and its relevance to biodiversity conservation. J. Nat. Prod. 2011, 74, 496-511.
    • (2011) J. Nat. Prod. , vol.74 , pp. 496-511
    • Kingston, D.G.I.1
  • 58
    • 80054978605 scopus 로고    scopus 로고
    • Survey of marine natural product structure revisions: A synergy of spectroscopy and chemical synthesis
    • Suyama, T.L.; Gerwick, W.H.; McPhail, K.L. Survey of marine natural product structure revisions: A synergy of spectroscopy and chemical synthesis. Bioorg. Med. Chem. 2011, 19, 6675-6701.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 6675-6701
    • Suyama, T.L.1    Gerwick, W.H.2    McPhail, K.L.3
  • 59
    • 70349769976 scopus 로고    scopus 로고
    • Structural revisions of natural products by total synthesis
    • Maier, M.E. Structural revisions of natural products by total synthesis. Nat. Prod. Rep. 2009, 26, 1105-1124.
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 1105-1124
    • Maier, M.E.1
  • 60
    • 84877873492 scopus 로고    scopus 로고
    • New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources
    • Michel, T.; Halabalaki, M.; Skaltsounis, A.L. New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources. Planta Med. 2013, 79, 514-532.
    • (2013) Planta Med. , vol.79 , pp. 514-532
    • Michel, T.1    Halabalaki, M.2    Skaltsounis, A.L.3
  • 61
    • 48349131278 scopus 로고    scopus 로고
    • Available online: (acessed on 20 November 2013)
    • AntiBase 2012, The Natural Compound Identifier. Available online: http://www.wiley-vch.de/stmdata/antibase.php (acessed on 20 November 2013).
    • AntiBase 2012, the Natural Compound Identifier
  • 62
    • 8744240590 scopus 로고    scopus 로고
    • Christchurch, New Zealand. Available online: (accessed on 20 November 2013)
    • MarinLit Database™, 2012, University of Canterbury, Christchurch, New Zealand. Available online: http://www.chem.canterbury.ac.nz/marinlit/ marinlit.shtml (accessed on 20 November 2013).
    • (2012) MarinLit Database™
  • 64
    • 36549043394 scopus 로고    scopus 로고
    • NAPROC-13: A database for the dereplication of natural product mixtures in bioassay-guided protocols
    • Lopez-Perez, J.L.; Theron, R.; del Olmo, E.; Diaz, D. NAPROC-13: A database for the dereplication of natural product mixtures in bioassay-guided protocols. Bioinformatics 2007, 23, 3256-3257.
    • (2007) Bioinformatics , vol.23 , pp. 3256-3257
    • Lopez-Perez, J.L.1    Theron, R.2    Del Olmo, E.3    Diaz, D.4
  • 68
    • 24944547571 scopus 로고    scopus 로고
    • Why drugs fail - A study on side effects in new chemical entities
    • Schuster, D.; Laggner, C.; Langer, T. Why drugs fail - A study on side effects in new chemical entities. Curr. Pharm. Des. 2005, 11, 3545-3559.
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 3545-3559
    • Schuster, D.1    Laggner, C.2    Langer, T.3
  • 69
    • 84871989429 scopus 로고    scopus 로고
    • A historical perspective on the development of the cytarabine (7 days) and daunorubicin (3 days) treatment regimen for acute myelogenous leukemia: 2013 the 40th anniversary of 7 + 3
    • Lichtman, M.A. A historical perspective on the development of the cytarabine (7 days) and daunorubicin (3 days) treatment regimen for acute myelogenous leukemia: 2013 the 40th anniversary of 7 + 3. Blood Cells Mol. Dis. 2013, 50, 119-130.
    • (2013) Blood Cells Mol. Dis. , vol.50 , pp. 119-130
    • Lichtman, M.A.1
  • 70
    • 0021261895 scopus 로고
    • Antiviral agents from a gorgonian, eunicella-cavolini
    • Cimino, G.; Derosa, S.; Destefano, S. Antiviral agents from a gorgonian, eunicella-cavolini. Experientia 1984, 40, 339-340.
    • (1984) Experientia , vol.40 , pp. 339-340
    • Cimino, G.1    Derosa, S.2    Destefano, S.3
  • 71
    • 78649937348 scopus 로고    scopus 로고
    • Development of cytarabine prodrugs and delivery systems for leukemia treatment
    • Chhikara, B.S.; Parang, K. Development of cytarabine prodrugs and delivery systems for leukemia treatment. Expert Opin. Drug Deliv. 2010, 7, 1399-1414.
    • (2010) Expert Opin. Drug Deliv. , vol.7 , pp. 1399-1414
    • Chhikara, B.S.1    Parang, K.2
  • 72
    • 69749110108 scopus 로고    scopus 로고
    • Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine
    • Kripp, M.; Hofheinz, R.D. Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine. Int. J. Nanomed. 2008, 3, 397-401.
    • (2008) Int. J. Nanomed. , vol.3 , pp. 397-401
    • Kripp, M.1    Hofheinz, R.D.2
  • 73
    • 84896706642 scopus 로고    scopus 로고
    • Available online: (accessed on 1 November 2013)
    • National Cancer Institute, Clinical Trials (PDQ®). Available online: http://www.cancer.gov/clinicaltrials/search/results?protocolsearchid=6532271 (accessed on 1 November 2013).
    • Clinical Trials (PDQ®)
  • 78
    • 0002224261 scopus 로고    scopus 로고
    • ω-Conotoxin MVIIA: From Marine Snail Venom to Analgesic Drug
    • Karger: Basel, Switzerland; New York, NY, USA
    • Oliveira, B.M. ω-Conotoxin MVIIA: From Marine Snail Venom to Analgesic Drug. In Drugs from the Sea; Karger: Basel, Switzerland; New York, NY, USA, 2000.
    • (2000) Drugs from the Sea
    • Oliveira, B.M.1
  • 79
    • 84890020560 scopus 로고    scopus 로고
    • Industrial natural product chemistry for drug discovery and development
    • Bauer, A.; Bronstrup, M. Industrial natural product chemistry for drug discovery and development. Nat. Prod. Rep. 2013, 31, 35-60.
    • (2013) Nat. Prod. Rep. , vol.31 , pp. 35-60
    • Bauer, A.1    Bronstrup, M.2
  • 80
  • 81
    • 84896699243 scopus 로고    scopus 로고
    • Elan Corporation: Dublin, Ireland
    • Elan 2010 Annual Report; Elan Corporation: Dublin, Ireland, 2010.
    • (2010) Elan 2010 Annual Report
  • 82
    • 33845992556 scopus 로고    scopus 로고
    • Conus peptides: Biodiversity-based discovery and exogenomics
    • Olivera, B.M. Conus peptides: Biodiversity-based discovery and exogenomics. J. Biol. Chem. 2006, 281, 31173-31177.
    • (2006) J. Biol. Chem. , vol.281 , pp. 31173-31177
    • Olivera, B.M.1
  • 83
    • 84896695810 scopus 로고    scopus 로고
    • Available online: (accessed on 1 November 2013)
    • Vemomics for Health. Available online: http://www.venomics.eu/ (accessed on 1 November 2013).
    • Vemomics for Health
  • 84
    • 84867902225 scopus 로고    scopus 로고
    • Titrating lovaza from 4 to 8 to 12 grams/day in patients with primary hypertriglyceridemia who had triglyceride levels >500 mg/dL despite conventional triglyceride lowering therapy
    • Glueck, C.J.; Khan, N.; Riaz, M.; Padda, J.; Khan, Z.; Wang, P. Titrating lovaza from 4 to 8 to 12 grams/day in patients with primary hypertriglyceridemia who had triglyceride levels >500 mg/dL despite conventional triglyceride lowering therapy. Lipids Health Dis. 2012, 11, 143.
    • (2012) Lipids Health Dis. , vol.11 , pp. 143
    • Glueck, C.J.1    Khan, N.2    Riaz, M.3    Padda, J.4    Khan, Z.5    Wang, P.6
  • 85
    • 73349122930 scopus 로고    scopus 로고
    • A® (prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemia
    • A® (prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemia. Adv. Ther. 2009, 26, 675-690.
    • (2009) Adv. Ther. , vol.26 , pp. 675-690
    • Rupp, H.1
  • 86
    • 45349107588 scopus 로고    scopus 로고
    • Omega-3-acid ethyl esters (lovaza) for severe hypertriglyceridemia
    • Koski, R.R. Omega-3-acid ethyl esters (lovaza) for severe hypertriglyceridemia. Pharm. Ter. 2008, 33, 271-303.
    • (2008) Pharm. Ter. , vol.33 , pp. 271-303
    • Koski, R.R.1
  • 87
    • 77955505177 scopus 로고    scopus 로고
    • A review of trabectedin (ET-743): A unique mechanism of action
    • D'Incalci, M.; Galmarini, C.M. A review of trabectedin (ET-743): A unique mechanism of action. Mol. Cancer Ther. 2010, 9, 2157-2163.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2157-2163
    • D'Incalci, M.1    Galmarini, C.M.2
  • 88
    • 84867525162 scopus 로고    scopus 로고
    • Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer
    • Monk, B.J.; Dalton, H.; Benjamin, I.; Tanovic, A. Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer. Curr. Pharm. Des. 2012, 18, 3754-3769.
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 3754-3769
    • Monk, B.J.1    Dalton, H.2    Benjamin, I.3    Tanovic, A.4
  • 89
    • 61549104994 scopus 로고    scopus 로고
    • Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem
    • Cuevas, C.; Francesch, A. Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem. Nat. Prod. Rep. 2009, 26, 322-337.
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 322-337
    • Cuevas, C.1    Francesch, A.2
  • 90
    • 84896695862 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • PharmaMar. Annual report 2011. Available online: http://www.pharmamar. com/pdf/EN-memoria2012.pdf (accessed on 25 November 2013).
    • PharmaMar. Annual Report 2011
  • 95
    • 77956682296 scopus 로고    scopus 로고
    • Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: A randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold
    • Eccles, R.; Meier, C.; Jawad, M.; Weinmullner, R.; Grassauer, A.; Prieschl-Grassauer, E. Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: A randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. Respir. Res. 2010, 11, 108.
    • (2010) Respir. Res. , vol.11 , pp. 108
    • Eccles, R.1    Meier, C.2    Jawad, M.3    Weinmullner, R.4    Grassauer, A.5    Prieschl-Grassauer, E.6
  • 96
    • 84896705726 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • Euromonitor. Available online: http://www.euromonitor.com/skin-care (accessed on 25 November 2013).
  • 97
    • 33750360173 scopus 로고    scopus 로고
    • Exopolysaccharides from marine bacteria
    • Chi, Z.; Fang, Y. Exopolysaccharides from marine bacteria. J. Ocean Univ. China 2005, 4, 67-74.
    • (2005) J. Ocean Univ. China , vol.4 , pp. 67-74
    • Chi, Z.1    Fang, Y.2
  • 98
    • 24144476682 scopus 로고    scopus 로고
    • Bacterial exopolysaccharides from extreme marine environments with special consideration of the southern ocean, sea ice, and deep-sea hydrothermal vents: A review
    • Nichols, C.A.; Guezennec, J.; Bowman, J.P. Bacterial exopolysaccharides from extreme marine environments with special consideration of the southern ocean, sea ice, and deep-sea hydrothermal vents: A review. Mar. Biotechnol. 2005, 7, 253-271.
    • (2005) Mar. Biotechnol. , vol.7 , pp. 253-271
    • Nichols, C.A.1    Guezennec, J.2    Bowman, J.P.3
  • 99
    • 0028134864 scopus 로고
    • Production and characterization of an exopolysaccharide excreted by a deep-sea hydrothermal vent bacterium isolated from the polychaete annelid alvinella pompejana
    • Vincent, P.; Pignet, P.; Talmont, F.; Bozzi, L.; Fournet, B.; Guezennec, J.; Jeanthon, C.; Prieur, D. Production and characterization of an exopolysaccharide excreted by a deep-sea hydrothermal vent bacterium isolated from the polychaete annelid alvinella pompejana. Appl. Environ. Microbiol. 1994, 60, 4134-4141.
    • (1994) Appl. Environ. Microbiol. , vol.60 , pp. 4134-4141
    • Vincent, P.1    Pignet, P.2    Talmont, F.3    Bozzi, L.4    Fournet, B.5    Guezennec, J.6    Jeanthon, C.7    Prieur, D.8
  • 100
    • 0030023234 scopus 로고    scopus 로고
    • Description of a new polymer-secreting bacterium from a deep-sea hydrothermal vent, Alteromonas macleodii subsp. Fijiensis, and preliminary characterization of the polymer
    • Raguenes, G.; Pignet, P.; Gauthier, G.; Peres, A.; Christen, R.; Rougeaux, H.; Barbier, G.; Guezennec, J. Description of a new polymer-secreting bacterium from a deep-sea hydrothermal vent, Alteromonas macleodii subsp. fijiensis, and preliminary characterization of the polymer. Appl. Environ. Microbiol. 1996, 62, 67-73.
    • (1996) Appl. Environ. Microbiol. , vol.62 , pp. 67-73
    • Raguenes, G.1    Pignet, P.2    Gauthier, G.3    Peres, A.4    Christen, R.5    Rougeaux, H.6    Barbier, G.7    Guezennec, J.8
  • 101
    • 0042278367 scopus 로고    scopus 로고
    • Vibrio diabolicus sp. Nov., a new polysaccharide-secreting organism isolated from a deep-sea hydrothermal vent polychaete annelid, Alvinella pompejana
    • Raguenes, G.; Christen, R.; Guezennec, J.; Pignet, P.; Barbier, G. Vibrio diabolicus sp. nov., a new polysaccharide-secreting organism isolated from a deep-sea hydrothermal vent polychaete annelid, Alvinella pompejana. Int. J. Syst. Bacteriol. 1997, 47, 989-995.
    • (1997) Int. J. Syst. Bacteriol. , vol.47 , pp. 989-995
    • Raguenes, G.1    Christen, R.2    Guezennec, J.3    Pignet, P.4    Barbier, G.5
  • 103
    • 0032977183 scopus 로고    scopus 로고
    • Structural determination of the exopolysaccharide of Pseudoalteromonas strain HYD 721 isolated from a deep-sea hydrothermal vent
    • Rougeaux, H.; Guezennec, J.; Carlson, R.W.; Kervarec, N.; Pichon, R.; Talaga, P. Structural determination of the exopolysaccharide of Pseudoalteromonas strain HYD 721 isolated from a deep-sea hydrothermal vent. Carbohydr. Res. 1999, 315, 273-285.
    • (1999) Carbohydr. Res. , vol.315 , pp. 273-285
    • Rougeaux, H.1    Guezennec, J.2    Carlson, R.W.3    Kervarec, N.4    Pichon, R.5    Talaga, P.6
  • 104
    • 0036360349 scopus 로고    scopus 로고
    • A novel polymer produced by a bacterium isolated from a deep-sea hydrothermal vent polychaete annelid
    • Cambon-Bonavita, M.A.; Raguenes, G.; Jean, J.; Vincent, P.; Guezennec, J. A novel polymer produced by a bacterium isolated from a deep-sea hydrothermal vent polychaete annelid. J. Appl. Microbiol. 2002, 93, 310-315.
    • (2002) J. Appl. Microbiol. , vol.93 , pp. 310-315
    • Cambon-Bonavita, M.A.1    Raguenes, G.2    Jean, J.3    Vincent, P.4    Guezennec, J.5
  • 105
    • 0029586274 scopus 로고
    • Structure, function and immunochemistry of bacterial exopolysaccharides
    • Weiner, R.; Langille, S.; Quintero, E. Structure, function and immunochemistry of bacterial exopolysaccharides. J. Ind. Microbiol. 1995, 15, 339-346.
    • (1995) J. Ind. Microbiol. , vol.15 , pp. 339-346
    • Weiner, R.1    Langille, S.2    Quintero, E.3
  • 106
    • 0001120015 scopus 로고
    • Alvinella pompejana gen. sp. nov., aberrant Ampharetidae from East Pacific Rise hydrothermal vents
    • Desbruyeres, D.; Laubier, L. Alvinella pompejana gen. sp. nov., aberrant Ampharetidae from East Pacific Rise hydrothermal vents. Oceanol. Acta 1980, 3, 326-274.
    • (1980) Oceanol. Acta , vol.3 , pp. 326-1274
    • Desbruyeres, D.1    Laubier, L.2
  • 108
    • 84864142928 scopus 로고    scopus 로고
    • The applications and functions of new exopolysaccharide "Deepsane" from the deepest oceans
    • Thibodeau, A.; Takeoka, A. The applications and functions of new exopolysaccharide "Deepsane" from the deepest oceans. Fragr. J. 2006, 34, 61-68.
    • (2006) Fragr. J. , vol.34 , pp. 61-68
    • Thibodeau, A.1    Takeoka, A.2
  • 109
    • 0027034136 scopus 로고
    • Phospholipase A2 inhibitors from marine organisms
    • Potts, B.C.; Faulkner, D.J.; Jacobs, R.S. Phospholipase A2 inhibitors from marine organisms. J. Nat. Prod. 1992, 55, 1701-1717.
    • (1992) J. Nat. Prod. , vol.55 , pp. 1701-1717
    • Potts, B.C.1    Faulkner, D.J.2    Jacobs, R.S.3
  • 110
    • 84885082014 scopus 로고    scopus 로고
    • Cyclodextrin formulation of the marine natural product pseudopterosin A uncovers optimal pharmacodynamics in proliferation studies of human umbilical vein endothelial cells
    • Day, D.R.; Jabaiah, S.; Jacobs, R.S.; Little, R.D. Cyclodextrin formulation of the marine natural product pseudopterosin A uncovers optimal pharmacodynamics in proliferation studies of human umbilical vein endothelial cells. Mar. Drugs 2013, 11, 3258-3271.
    • (2013) Mar. Drugs , vol.11 , pp. 3258-3271
    • Day, D.R.1    Jabaiah, S.2    Jacobs, R.S.3    Little, R.D.4
  • 111
    • 0142197761 scopus 로고    scopus 로고
    • Betting on natural products for cures
    • Rouhi, A.M. Betting on natural products for cures. Chem. Eng. News 2003, 81, 93-103.
    • (2003) Chem. Eng. News , vol.81 , pp. 93-103
    • Rouhi, A.M.1
  • 112
    • 84896737322 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • Lipotec. Available online: http://www.lipotec.com (accessed on 25 November 2013).
  • 115
    • 84878323101 scopus 로고    scopus 로고
    • Photoprotective bioactivity present in a unique marine bacteria collection from Portuguese deep sea hydrothermal vents
    • Martins, A.; Tenreiro, T.; Andrade, G.; Gadanho, M.; Chaves, S.; Abrantes, M.; Calado, P.; Tenreiro, R.; Vieira, H. Photoprotective bioactivity present in a unique marine bacteria collection from Portuguese deep sea hydrothermal vents. Mar. Drugs 2013, 11, 1506-1523.
    • (2013) Mar. Drugs , vol.11 , pp. 1506-1523
    • Martins, A.1    Tenreiro, T.2    Andrade, G.3    Gadanho, M.4    Chaves, S.5    Abrantes, M.6    Calado, P.7    Tenreiro, R.8    Vieira, H.9
  • 116
    • 84896704883 scopus 로고    scopus 로고
    • Available online: (accessed on 1 November 2013)
    • RefirMAR™ by BIOALVO. Available online: http://www.bioalvo.com/ products/products-bioactive-ingredients/refirmar (accessed on 1 November 2013).
    • RefirMAR™ by BIOALVO
  • 117
    • 78650598342 scopus 로고    scopus 로고
    • A review on microalgae, a versatile source for sustainable energy and materials
    • Satyanarayana, K.G.; Mariano, A.B.; Vargas, J.V.C. A review on microalgae, a versatile source for sustainable energy and materials. Int. J. Energy Res. 2011, 35, 291-311.
    • (2011) Int. J. Energy Res. , vol.35 , pp. 291-311
    • Satyanarayana, K.G.1    Mariano, A.B.2    Vargas, J.V.C.3
  • 118
    • 33748469323 scopus 로고    scopus 로고
    • Manufacturing microalgae for skin care
    • Stolz, P.; Obermayer, B. Manufacturing microalgae for skin care. Cosmet. Toilet. 2005, 120, 99-106.
    • (2005) Cosmet. Toilet. , vol.120 , pp. 99-106
    • Stolz, P.1    Obermayer, B.2
  • 119
    • 84896725711 scopus 로고    scopus 로고
    • Website. Available online: (accessed on 25 November 2013)
    • CODIF Website. Available online: http://www.codif-recherche-et nature.com/en/s06-catalogue/s06p02-fiche.php?prod=56 (accessed on 25 November 2013).
  • 120
    • 84896718314 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • An Unlimite Mine of Innovation. Available online: http://greensea.fr/en/ active-ingredients (accessed on 25 November 2013).
    • An Unlimite Mine of Innovation
  • 121
    • 84896708526 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • Patented Breakthrough Ingredient. Available online: http://www.algenist. com/why-algenist/patented-breakthrough-ingredient (accessed on 25 November 2013).
    • Patented Breakthrough Ingredient
  • 122
    • 84896695132 scopus 로고    scopus 로고
    • Available online: (accessed on 25 November 2013)
    • Frutarom. Available online: http://www.frutarom.com/FrutaromNew/index.asp (accessed on 25 November 2013).
  • 123
    • 24944536715 scopus 로고    scopus 로고
    • Isolation and characterization of collagen from brown backed toadfish (Lagocephalus gloveri) skin
    • Senaratne, L.S.; Park, P.J.; Kim, S.K. Isolation and characterization of collagen from brown backed toadfish (Lagocephalus gloveri) skin. Bioresour. Technol. 2006, 97, 191-197.
    • (2006) Bioresour. Technol. , vol.97 , pp. 191-197
    • Senaratne, L.S.1    Park, P.J.2    Kim, S.K.3
  • 124
    • 0034237675 scopus 로고    scopus 로고
    • Strategies for discovering drugs from previously unexplored natural products
    • Alan, H. Strategies for discovering drugs from previously unexplored natural products. Drug Discov. Today 2000, 5, 294-300.
    • (2000) Drug Discov. Today , vol.5 , pp. 294-300
    • Alan, H.1
  • 125
    • 46749090589 scopus 로고    scopus 로고
    • Pre-fractionated microbial samples-The second generation natural products library at Wyeth
    • Wagenaar, M.M. Pre-fractionated microbial samples-The second generation natural products library at Wyeth. Molecules 2008, 13, 1406-1426.
    • (2008) Molecules , vol.13 , pp. 1406-1426
    • Wagenaar, M.M.1
  • 126
    • 84893493312 scopus 로고    scopus 로고
    • DNA assembly techniques for next generation combinatorial biosynthesis of natural products
    • Cobb, R.E.; Ning, J.C.; Zhao, H. DNA assembly techniques for next generation combinatorial biosynthesis of natural products. J. Ind. Microbiol. Biotechnol. 2014, 41, 469-477.
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 469-477
    • Cobb, R.E.1    Ning, J.C.2    Zhao, H.3
  • 127
    • 81355135430 scopus 로고    scopus 로고
    • Combinatorial biosynthesis in plants: A (p)review on its potential and future exploitation
    • Pollier, J.; Moses, T.; Goossens, A. Combinatorial biosynthesis in plants: A (p)review on its potential and future exploitation. Nat. Prod. Rep. 2011, 28, 1897-1916.
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 1897-1916
    • Pollier, J.1    Moses, T.2    Goossens, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.