메뉴 건너뛰기




Volumn 13, Issue 4, 2015, Pages 2196-2214

Anti-obesity activity of the marine carotenoid fucoxanthin

Author keywords

Fucoxanthin; Functional food; Metabolism; Nutrition; Obesity

Indexed keywords

AMAROUCIAXANTHIN A; AMITRIPTYLINE; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; CARBAMAZEPINE; CAROTENOID; CLOZAPINE; CYTOKINE; DOCOSAHEXAENOIC ACID; FUCOXANTHIN; FUCOXANTHINOL; GLUCOSE; LEPTIN; LITHIUM SALT; NEUROLEPTIC AGENT; OLANZAPINE; STEROID; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; VALPROIC ACID; ANTIOBESITY AGENT; ANTIOXIDANT; NONSTEROID ANTIINFLAMMATORY AGENT; XANTHOPHYLL;

EID: 84928411843     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13042196     Document Type: Review
Times cited : (245)

References (67)
  • 2
    • 84862792585 scopus 로고    scopus 로고
    • A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum
    • Kim, S.M.; Jung, Y.H.; Kwon, O.; Cha, K.H.; Um, B.H. A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Appl. Biochem. Biotechnol. 2012, 166, 1843-1855.
    • (2012) Appl. Biochem. Biotechnol. , vol.166 , pp. 1843-1855
    • Kim, S.M.1    Jung, Y.H.2    Kwon, O.3    Cha, K.H.4    Um, B.H.5
  • 3
    • 34948878515 scopus 로고    scopus 로고
    • Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice
    • Maeda, H.; Hosokawa, M.; Sashima, T.; Miyashita, K. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. J. Agric. Food Chem. 2007, 55, 7701-7706.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 7701-7706
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Miyashita, K.4
  • 4
    • 77954385541 scopus 로고    scopus 로고
    • Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice
    • Woo, M.N.; Jeon, S.M.; Kim, H.J.; Lee, M.K.; Shin, S.K.; Shin, Y.C.; Park, Y.B.; Choi, M.S. Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice. Chem. Biol. Interact. 2010, 186, 316-322.
    • (2010) Chem. Biol. Interact. , vol.186 , pp. 316-322
    • Woo, M.N.1    Jeon, S.M.2    Kim, H.J.3    Lee, M.K.4    Shin, S.K.5    Shin, Y.C.6    Park, Y.B.7    Choi, M.S.8
  • 5
    • 74049106642 scopus 로고    scopus 로고
    • Comparative effects of β-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats
    • Sangeetha, R.K.; Bhaskar, N.; Baskaran, V. Comparative effects of β-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats. Mol. Cell. Biochem. 2009, 331, 59-67.
    • (2009) Mol. Cell. Biochem. , vol.331 , pp. 59-67
    • Sangeetha, R.K.1    Bhaskar, N.2    Baskaran, V.3
  • 6
    • 3042742915 scopus 로고    scopus 로고
    • Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(κ)B kinase-dependent NF-κB activation
    • Lee, S.J.; Bai, S.K.; Lee, K.S.; Namkoong, S.; Na, H.J.; Ha, K.S; Han, J.A.; Yim, S.V.; Chang, K.; Kwon, Y.G.; et al. Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(κ)B kinase-dependent NF-κB activation. Mol. Cells 2003, 16, 97-105.
    • (2003) Mol. Cells , vol.16 , pp. 97-105
    • Lee, S.J.1    Bai, S.K.2    Lee, K.S.3    Namkoong, S.4    Na, H.J.5    Ha, K.S.6    Han, J.A.7    Yim, S.V.8    Chang, K.9    Kwon, Y.G.10
  • 8
    • 43049168941 scopus 로고    scopus 로고
    • Biologic activity of carotenoids related to distinct membrane physicochemical interactions
    • McNulty, H.; Jacob, R.F.; Mason, R.P. Biologic activity of carotenoids related to distinct membrane physicochemical interactions. Am. J. Cardiol. 2008, 101, 20D-29D.
    • (2008) Am. J. Cardiol. , vol.101 , pp. 20D-29D
    • McNulty, H.1    Jacob, R.F.2    Mason, R.P.3
  • 9
    • 34547666796 scopus 로고    scopus 로고
    • A review of the interaction among dietary antioxidants and reactive oxygen species
    • Seifried, H.E.; Anderson, D.E.; Fisher, E.I.; Milner, J.A. A review of the interaction among dietary antioxidants and reactive oxygen species. J. Nutr. Biochem. 2007, 18, 567-579.
    • (2007) J. Nutr. Biochem. , vol.18 , pp. 567-579
    • Seifried, H.E.1    Anderson, D.E.2    Fisher, E.I.3    Milner, J.A.4
  • 10
    • 77949330371 scopus 로고    scopus 로고
    • Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro
    • Hu, T.; Liu, D.; Chen, Y.; Wu, J.; Wang, S. Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro. Int. J. Biol. Macromol. 2010, 46, 193-198.
    • (2010) Int. J. Biol. Macromol. , vol.46 , pp. 193-198
    • Hu, T.1    Liu, D.2    Chen, Y.3    Wu, J.4    Wang, S.5
  • 11
    • 73449119904 scopus 로고    scopus 로고
    • Bioavailability and metabolism of fucoxanthin in rats: Structural characterization of metabolites by LC-MS (APCI)
    • Sangeetha, R.K.; Bhaskar, N.; Divakar, S.; Baskaran, V. Bioavailability and metabolism of fucoxanthin in rats: Structural characterization of metabolites by LC-MS (APCI). Mol. Cell. Biochem. 2010, 333, 299-310.
    • (2010) Mol. Cell. Biochem. , vol.333 , pp. 299-310
    • Sangeetha, R.K.1    Bhaskar, N.2    Divakar, S.3    Baskaran, V.4
  • 12
    • 40949104695 scopus 로고    scopus 로고
    • Growth inhibition of human hepatic carcinoma Hep-G2 cells by fucoxanthin is associated with down-regulation of cyclin D
    • Das, S.K.; Hashimoto, T.; Kanazawa, K. Growth inhibition of human hepatic carcinoma Hep-G2 cells by fucoxanthin is associated with down-regulation of cyclin D. Biochim. Biophys. Acta 2008, 1780, 743-749.
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 743-749
    • Das, S.K.1    Hashimoto, T.2    Kanazawa, K.3
  • 13
    • 0842304213 scopus 로고    scopus 로고
    • Biotransformation of fucoxanthinol in amarouciaxanthin A in mice and Hep-G2 cells: Formation and cytotoxicity of fucoxanthin metabolites
    • Asai, A.; Sugawara, T.; Ono, H.; Nagao, A. Biotransformation of fucoxanthinol in amarouciaxanthin A in mice and Hep-G2 cells: Formation and cytotoxicity of fucoxanthin metabolites. Drug Metab. Dispos. 2004, 32, 205-211.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 205-211
    • Asai, A.1    Sugawara, T.2    Ono, H.3    Nagao, A.4
  • 14
  • 15
    • 84922495868 scopus 로고    scopus 로고
    • Carotenoids: Potential allies of cardiovascular health?
    • Gammone, M.A.; Riccioni, G.; D'Orazio, N. Carotenoids: Potential allies of cardiovascular health? Food Nutr. Res. 2015, 59, 26762.
    • (2015) Food Nutr. Res. , vol.59 , pp. 26762
    • Gammone, M.A.1    Riccioni, G.2    D'Orazio, N.3
  • 16
    • 52949126022 scopus 로고    scopus 로고
    • Low bioavailability of dietary epoxy-xanthophylls in humans
    • Asai, A.; Yonekura, L.; Nagao, A. Low bioavailability of dietary epoxy-xanthophylls in humans. Br. J. Nutr. 2008, 100, 273-277.
    • (2008) Br. J. Nutr. , vol.100 , pp. 273-277
    • Asai, A.1    Yonekura, L.2    Nagao, A.3
  • 17
    • 84863129378 scopus 로고    scopus 로고
    • Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats
    • Hu, X.; Li, Y.; Li, C.; Fu, Y.; Cai, F.; Chen, Q.; Li, D. Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats. Arch. Biochem. Biophys. 2012, 519, 59-65.
    • (2012) Arch. Biochem. Biophys. , vol.519 , pp. 59-65
    • Hu, X.1    Li, Y.2    Li, C.3    Fu, Y.4    Cai, F.5    Chen, Q.6    Li, D.7
  • 18
    • 23944509003 scopus 로고    scopus 로고
    • Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery
    • Tong, L. Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery. Cell. Mol. Life Sci. 2005, 62, 1784-1803.
    • (2005) Cell. Mol. Life Sci. , vol.62 , pp. 1784-1803
    • Tong, L.1
  • 19
    • 84865836821 scopus 로고    scopus 로고
    • Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A(y) mice
    • Beppu, F.; Hosokawa, M.; Niwano, Y.; Miyashita, K. Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A(y) mice. Lipids Health Dis. 2012, 11, 112.
    • (2012) Lipids Health Dis. , vol.11 , pp. 112
    • Beppu, F.1    Hosokawa, M.2    Niwano, Y.3    Miyashita, K.4
  • 21
    • 84880574008 scopus 로고    scopus 로고
    • Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A(y) mice
    • Beppu, F.; Hosokawa, M.; Yim, M.J.; Shinoda, T.; Miyashita, K. Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A(y) mice. Lipids 2013, 48, 449-455.
    • (2013) Lipids , vol.48 , pp. 449-455
    • Beppu, F.1    Hosokawa, M.2    Yim, M.J.3    Shinoda, T.4    Miyashita, K.5
  • 23
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: Master regulators of lipid homeostasis
    • Eberlé, D.; Hegarty, B.; Bossard, P.; Ferré, P.; Foufelle, F. SREBP transcription factors: Master regulators of lipid homeostasis. Biochimie 2004, 86, 839-848.
    • (2004) Biochimie , vol.86 , pp. 839-848
    • Eberlé, D.1    Hegarty, B.2    Bossard, P.3    Ferré, P.4    Foufelle, F.5
  • 24
    • 77957302090 scopus 로고    scopus 로고
    • Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c
    • Ferré, P.; Foufelle F. Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes. Metab. 2010, 12, 83-92.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 83-92
    • Ferré, P.1    Foufelle, F.2
  • 25
    • 0344739627 scopus 로고    scopus 로고
    • Role of lipases, lecithin: Cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus
    • DeVries, R.; Borggreve, S.E.; Dullaart, R.P. Role of lipases, lecithin: Cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus. Clin. Lab. 2004, 49, 601-613.
    • (2004) Clin. Lab. , vol.49 , pp. 601-613
    • DeVries, R.1    Borggreve, S.E.2    Dullaart, R.P.3
  • 26
    • 0036896836 scopus 로고    scopus 로고
    • Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
    • Rasmussen, B.B.; Holmbäck, U.C.; Volpi, E.; Morio-Liondore, B.; Paddon-Jones, D.; Wolfe, R.R. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J. Clin. Invest. 2002, 110, 1687-1693.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1687-1693
    • Rasmussen, B.B.1    Holmbäck, U.C.2    Volpi, E.3    Morio-Liondore, B.4    Paddon-Jones, D.5    Wolfe, R.R.6
  • 27
    • 73649136846 scopus 로고    scopus 로고
    • Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditionsin a murine model
    • Maeda, H.; Hosokawa, M.; Sashima, T.; Murakami-Funayama K.; Miyashita, K. Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditionsin a murine model. Mol. Med. Rep. 2009, 2, 897-902.
    • (2009) Mol. Med. Rep. , vol.2 , pp. 897-902
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Murakami-Funayama, K.4    Miyashita, K.5
  • 28
    • 84859376820 scopus 로고    scopus 로고
    • Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase
    • Kang, S.I.; Shin, H.S.; Kim, H.M.; Yoon, S.A.; Kang, S.W.; Kim, J.H.; Ko, H.C.; Kim, S.J. Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. J. Agric. Food Chem. 2012, 60, 3389-3395.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 3389-3395
    • Kang, S.I.1    Shin, H.S.2    Kim, H.M.3    Yoon, S.A.4    Kang, S.W.5    Kim, J.H.6    Ko, H.C.7    Kim, S.J.8
  • 29
    • 0034535853 scopus 로고    scopus 로고
    • Adipocyte differentiation and gene expression
    • Ntambi, J.M.; Kim, Y.C. Adipocyte differentiation and gene expression. J. Nutr. 2000, 12, 3122-3126.
    • (2000) J. Nutr. , vol.12 , pp. 3122-3126
    • Ntambi, J.M.1    Kim, Y.C.2
  • 30
    • 79959210671 scopus 로고    scopus 로고
    • Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes
    • Kang, S.I.; Ko, H.C.; Shin, H.S.; Kim, H.M.; Hong, Y.S.; Lee, N.H.; Kim, S.J. Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes. Biochem. Biophys. Res. Commun. 2011, 409, 769-777.
    • (2011) Biochem. Biophys. Res. Commun. , vol.409 , pp. 769-777
    • Kang, S.I.1    Ko, H.C.2    Shin, H.S.3    Kim, H.M.4    Hong, Y.S.5    Lee, N.H.6    Kim, S.J.7
  • 31
    • 33748173403 scopus 로고    scopus 로고
    • Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells
    • Maeda, H.; Hosokawa, M.; Sashima, T.; Takahashi, N.; Kawada, T.; Miyashita, K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Intern. J. Mol. Med. 2006, 18, 147-152.
    • (2006) Intern. J. Mol. Med. , vol.18 , pp. 147-152
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Takahashi, N.4    Kawada, T.5    Miyashita, K.6
  • 32
    • 79952153349 scopus 로고    scopus 로고
    • Suppressive effects of amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPAR-γ and C/EBPr mRNA expression
    • Yim, M.J.; Hosokawa, M.; Mizushina, Y.; Yoshida, H.; Saito, Y.; Miyashita, K. Suppressive effects of amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPAR-γ and C/EBPr mRNA expression. J. Agric. Food Chem. 2011, 59, 1646-1652.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 1646-1652
    • Yim, M.J.1    Hosokawa, M.2    Mizushina, Y.3    Yoshida, H.4    Saito, Y.5    Miyashita, K.6
  • 34
    • 84901474586 scopus 로고    scopus 로고
    • Marine bioactives and potential application in sports
    • Gammone, M.A.; Gemello, E.; Riccioni, G.; D'Orazio, N. Marine bioactives and potential application in sports. Mar. Drugs 2014, 12, 2357-2382.
    • (2014) Mar. Drugs , vol.12 , pp. 2357-2382
    • Gammone, M.A.1    Gemello, E.2    Riccioni, G.3    D'Orazio, N.4
  • 35
    • 19444376373 scopus 로고    scopus 로고
    • Fucoxanthin from edible seaweed Undaria pinnatifida, shows anti-obesity effect through UCP1 expression in white adipose tissues
    • Maeda, H.; Hosokawa, M.; Sashima, T.; Funayama, K.; Miyashita, K. Fucoxanthin from edible seaweed Undaria pinnatifida, shows anti-obesity effect through UCP1 expression in white adipose tissues. Biochem. Biophys. Res. Commun. 2005, 332, 392-397.
    • (2005) Biochem. Biophys. Res. Commun. , vol.332 , pp. 392-397
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Funayama, K.4    Miyashita, K.5
  • 36
    • 73349138274 scopus 로고    scopus 로고
    • The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
    • Abidov, M.; Ramazanov, Z.; Seifulla, R.; Grachev, S. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabet. Obes. Metable 2010, 12, 72-81.
    • (2010) Diabet. Obes. Metable , vol.12 , pp. 72-81
    • Abidov, M.1    Ramazanov, Z.2    Seifulla, R.3    Grachev, S.4
  • 37
    • 0035716609 scopus 로고    scopus 로고
    • Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women
    • Heilbronn, L.K.; Noakes, M.; Clifton, M.P. Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women. Atheroscler. Thromb. Vasc. Biol. 2001, 21, 968-970.
    • (2001) Atheroscler. Thromb. Vasc. Biol. , vol.21 , pp. 968-970
    • Heilbronn, L.K.1    Noakes, M.2    Clifton, M.P.3
  • 39
    • 79957896666 scopus 로고    scopus 로고
    • Sixteen years and counting: An update on leptin in energy balance
    • Gautron, L.; Elmquist, J.K. Sixteen years and counting: An update on leptin in energy balance. J. Clin. Invest. 2011, 121, 2087-2093.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2087-2093
    • Gautron, L.1    Elmquist, J.K.2
  • 40
    • 84907683590 scopus 로고    scopus 로고
    • New pharmacological perspectives for the leptin receptor in the treatment of obesity
    • Roujeau, C.; Jockers, R.; Dam, J. New pharmacological perspectives for the leptin receptor in the treatment of obesity. Front Endocrinol. 2014, 13, 5-167.
    • (2014) Front Endocrinol. , vol.13 , pp. 5-167
    • Roujeau, C.1    Jockers, R.2    Dam, J.3
  • 41
    • 79952453920 scopus 로고    scopus 로고
    • Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice
    • Park, H.J.; Lee, M.K.; Park, Y.B.; Shin, Y.C.; Choi, M.S. Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice. Food Chem. Toxicol. 2011, 49, 727-733.
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 727-733
    • Park, H.J.1    Lee, M.K.2    Park, Y.B.3    Shin, Y.C.4    Choi, M.S.5
  • 42
    • 84867287664 scopus 로고    scopus 로고
    • Circadian rhythm of leptin, orexin and ghrelin
    • Tsujino, N.; Sakurai T. Circadian rhythm of leptin, orexin and ghrelin. Nihon Rinsho 2012, 70, 1121-1125.
    • (2012) Nihon Rinsho , vol.70 , pp. 1121-1125
    • Tsujino, N.1    Sakurai, T.2
  • 43
    • 33745059329 scopus 로고    scopus 로고
    • Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis
    • Sakurai, T. Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis. CNS Neurol. Disord. Drug Targets 2006, 5, 313-325.
    • (2006) CNS Neurol. Disord. Drug Targets , vol.5 , pp. 313-325
    • Sakurai, T.1
  • 46
    • 34447332251 scopus 로고    scopus 로고
    • Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice
    • Tsukui, T.; Konno, K.; Hosokawa, M.; Maeda, H.; Sashima, T.; Miyashita, K. Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice. J. Agric. Food Chem. 2007, 55, 5025-5029.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 5025-5029
    • Tsukui, T.1    Konno, K.2    Hosokawa, M.3    Maeda, H.4    Sashima, T.5    Miyashita, K.6
  • 47
    • 67651097613 scopus 로고    scopus 로고
    • Enhancement of hepatic docosahexaenoic acid and arachidonic acid contents in C57BL/6J mice by dietary fucoxanthin
    • Tsukui, T.; Baba, T.; Hosokawa, M.; Sashima, T.; Miyashita, K. Enhancement of hepatic docosahexaenoic acid and arachidonic acid contents in C57BL/6J mice by dietary fucoxanthin. Fish. Sci. 2009, 75, 261-263.
    • (2009) Fish. Sci. , vol.75 , pp. 261-263
    • Tsukui, T.1    Baba, T.2    Hosokawa, M.3    Sashima, T.4    Miyashita, K.5
  • 49
    • 77649216380 scopus 로고    scopus 로고
    • Review article: Omega-3 fatty acids-A promising novel therapy for non-alcoholic fatty liver disease
    • Masterton, G.S.; Plevris, J.N.; Hayes, P.C. Review article: Omega-3 fatty acids-A promising novel therapy for non-alcoholic fatty liver disease. Aliment. Pharmacol. Ther. 2010, 31, 679-692.
    • (2010) Aliment. Pharmacol. Ther. , vol.31 , pp. 679-692
    • Masterton, G.S.1    Plevris, J.N.2    Hayes, P.C.3
  • 50
    • 15444366991 scopus 로고    scopus 로고
    • Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    • Dandona, P.; Aljada, A.; Chaudhuri, A.; Mohanty, P.; Garg, R. Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005, 111, 1448-1454.
    • (2005) Circulation , vol.111 , pp. 1448-1454
    • Dandona, P.1    Aljada, A.2    Chaudhuri, A.3    Mohanty, P.4    Garg, R.5
  • 51
    • 84860629862 scopus 로고    scopus 로고
    • Marine bioactives: Pharmacological properties and potential applications against inflammatory diseases
    • D'Orazio, N.; Gammone, M.A.; Gemello, E., DeGirolamo, M.; Cusenza, S.; Riccioni, G. Marine bioactives: Pharmacological properties and potential applications against inflammatory diseases. Mar. Drugs 2012, 10, 812-833.
    • (2012) Mar. Drugs , vol.10 , pp. 812-833
    • D'Orazio, N.1    Gammone, M.A.2    Gemello, E.3    DeGirolamo, M.4    Cusenza, S.5    Riccioni, G.6
  • 52
    • 84891596020 scopus 로고    scopus 로고
    • Antioxidant effects of fucoxanthin rich powder in rats fed with high fat diet
    • Ha, A.W.; Na, S.J.; Kim, W.K. Antioxidant effects of fucoxanthin rich powder in rats fed with high fat diet. Nutr. Res. Pract. 2013, 7, 475-480.
    • (2013) Nutr. Res. Pract. , vol.7 , pp. 475-480
    • Ha, A.W.1    Na, S.J.2    Kim, W.K.3
  • 53
    • 80054942205 scopus 로고    scopus 로고
    • Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity
    • Liu, C.L.; Chiu, Y.T.; Hu, M.L. Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity. J. Agric. Food Chem. 2011, 59, 11344-11351.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 11344-11351
    • Liu, C.L.1    Chiu, Y.T.2    Hu, M.L.3
  • 54
  • 55
    • 77956181267 scopus 로고    scopus 로고
    • Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway
    • Kim, K.N.; Heo, S.J.; Kang, S.M.; Ahn, G.; Jeon, Y.J. Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway. Toxicol. Vitro 2010, 24, 1648-1654.
    • (2010) Toxicol. Vitro , vol.24 , pp. 1648-1654
    • Kim, K.N.1    Heo, S.J.2    Kang, S.M.3    Ahn, G.4    Jeon, Y.J.5
  • 56
    • 78049236040 scopus 로고    scopus 로고
    • Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages
    • Kim, K.N.; Heo, S.J.; Yoon, W.J.; Kang, S.M.; Ahn, G.; Yi, T.H.; Jeon, Y.J. Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages. Eur. J. Pharmacol. 2010, 649, 369-375.
    • (2010) Eur. J. Pharmacol. , vol.649 , pp. 369-375
    • Kim, K.N.1    Heo, S.J.2    Yoon, W.J.3    Kang, S.M.4    Ahn, G.5    Yi, T.H.6    Jeon, Y.J.7
  • 57
    • 70350488922 scopus 로고    scopus 로고
    • Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptor
    • Sakai, S.; Sugawara, T.; Matsubara, K.; Hirata, T. Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptor. J. Biol. Chem. 2009, 284, 28172-28179.
    • (2009) J. Biol. Chem. , vol.284 , pp. 28172-28179
    • Sakai, S.1    Sugawara, T.2    Matsubara, K.3    Hirata, T.4
  • 59
    • 77951927411 scopus 로고    scopus 로고
    • The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes
    • Jia, J.J.; Tian, Y.B.; Cao, Z.H.; Tao, L.L.; Zhang, X.; Gao, S.Z. The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes. Mol. Biol. Rep. 2010, 37, 1513-1522.
    • (2010) Mol. Biol. Rep. , vol.37 , pp. 1513-1522
    • Jia, J.J.1    Tian, Y.B.2    Cao, Z.H.3    Tao, L.L.4    Zhang, X.5    Gao, S.Z.6
  • 60
    • 0029843407 scopus 로고    scopus 로고
    • Additive effect of A→G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the β3-adrenergic receptor gene on weight gain in morbid obesity
    • Clément, K.; Ruiz, J.; Cassard-Doulcier, A.M.; Bouillaud, F.; Ricquier, D.; Basdevant, A.; Guy-Grand, B.; Froguel, P. Additive effect of A→G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the β3-adrenergic receptor gene on weight gain in morbid obesity. Int. J. Obes. Relat. Metab. Disord . 1996, 20, 1062-1066.
    • (1996) Int. J. Obes. Relat. Metab. Disord , vol.20 , pp. 1062-1066
    • Clément, K.1    Ruiz, J.2    Cassard-Doulcier, A.M.3    Bouillaud, F.4    Ricquier, D.5    Basdevant, A.6    Guy-Grand, B.7    Froguel, P.8
  • 61
    • 0032452431 scopus 로고    scopus 로고
    • Additive effects of the mutations in the β3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women
    • Fogelholm, M.; Valve, R.; Kukkonen-Harjula, K.; Nenonen, A.; Hakkarainen, V.; Laakso, M. Additive effects of the mutations in the β3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women. J. Clin. Endocrinol. Metab. 1998, 83, 4246-4250.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 4246-4250
    • Fogelholm, M.1    Valve, R.2    Kukkonen-Harjula, K.3    Nenonen, A.4    Hakkarainen, V.5    Laakso, M.6
  • 62
    • 0033192479 scopus 로고    scopus 로고
    • Frequency and significance of the A→G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort
    • Schäffler, A.; Palitzsch, K.D.; Watzlawek, E.; Drobnik, W.; Schwer, H.; Schölmerich, J. Frequency and significance of the A→G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort. Eur. J. Clin. Invest. 1999, 29, 770-779.
    • (1999) Eur. J. Clin. Invest. , vol.29 , pp. 770-779
    • Schäffler, A.1    Palitzsch, K.D.2    Watzlawek, E.3    Drobnik, W.4    Schwer, H.5    Schölmerich, J.6
  • 65
    • 0025740492 scopus 로고
    • Weight gain, increased appetite, and excessive food intake induced by carbamazepine
    • Lamp, Y.; Eshel, Y.; Rapaport, A.; Sarova-Pinhas, I. Weight gain, increased appetite, and excessive food intake induced by carbamazepine. Clin. Neuropharmacol. 1991, 14, 251-255.
    • (1991) Clin. Neuropharmacol. , vol.14 , pp. 251-255
    • Lamp, Y.1    Eshel, Y.2    Rapaport, A.3    Sarova-Pinhas, I.4
  • 66
    • 84872161044 scopus 로고    scopus 로고
    • The gut microbiota, obesity and insulin resistance
    • Shen, J.; Obin, M.S.; Zhao, L. The gut microbiota, obesity and insulin resistance. Mol. Aspects Med. 2013, 34, 39-58.
    • (2013) Mol. Aspects Med. , vol.34 , pp. 39-58
    • Shen, J.1    Obin, M.S.2    Zhao, L.3
  • 67
    • 84883193357 scopus 로고    scopus 로고
    • The role of gut microbiota in the pathogenesis of obesity and diabetes
    • Stachowicz, N.; Kiersztan, A. The role of gut microbiota in the pathogenesis of obesity and diabetes. Postepy Hig. Med. Dosw. 2013, 67, 288-303.
    • (2013) Postepy Hig. Med. Dosw. , vol.67 , pp. 288-303
    • Stachowicz, N.1    Kiersztan, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.