Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

Oncology Letters

Volumn 2, Issue 2, 2011, Pages 319-322

  Ikeguchi, Masahide ^a   Yamamoto, Manabu ^a   Arai, Yosuke ^a   Maeta, Yoshihiko ^a   Ashida, Keigo ^a   Katano, Kuniyuki ^a   Miki, Yasunari ^b   Kimura, Takayuki ^b  

^a TOTTORI UNIVERSITY   (Japan)

^b Marine Products Kimuraya Co Ltd   (Japan)

Author keywords

Chemotherapy; Colorectal cancer; Fatigue; Fucoidan

Indexed keywords

FLUOROURACIL; FOLINIC ACID; FUCOIDIN; IRINOTECAN; OXALIPLATIN;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; COLORECTAL CANCER; CONTINUOUS INFUSION; DIARRHEA; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; LEUKOPENIA; LIVER DYSFUNCTION; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; PERIPHERAL NEUROPATHY; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RECURRENT CANCER; STOMATITIS; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 79551626046     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.254     Document Type: Article

References (21)

1. Goldgerg RM, Sargent DJ, Morton RF, et al: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22: 23-30, 2004.
2. Tournigand C, Andre T, Achille E, et al: FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GER-COR study. J Clin Oncol 22: 229-237, 2004.
3. Japanese Society for Cancer of the Colon and Rectum: Guidelines for Management of Colon Cancer (for Physicians, version 2005) Kanehara & Co., Ltd., Tokyo, 2005.
4. Lee CK, Park KK, Hwang JK, Lee SK and Chung WY: Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice. Phytother Res 23: 999-1005, 2009.
5. Block KI, Koch AC, Mead MN, Tothy PK, Newman RA and Gyllenhaal C: Impact of antioxidant supplementation on chemo- therapeutic toxicity: A systematic review of the evidence from randomized controlled trials. Int J Cancer 123: 1227-1239, 2008.
6. Eussen S, Klungel O, Garssen J, et al: Support of drug therapy using functional foods and dietary supplements: focus on statin therapy. Br J Nutr 103: 1260-1277, 2010.
7. Hayashi S, Itoh A, Isoda K, Kondoh M, Kawase M and Yagi K: Fucoidan partly prevents CCl4-induced liver fibrosis. Eur J Pharmacol 580: 380-384, 2008.
8. Yamasaki-Miyamoto Y, Yamasaki M, Tachibana H and Yamada K: Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells. J Agric Food Chem 57: 8677-8682, 2009.
9. Saitoh Y, Nagai Y and Miwa N: Fucoidan-Vitamin C complex suppresses tumor invasion through the basement membrane, with scarce injuries to normal or tumor cells, via decreases in oxidative stress and matrix metalloproteinases. Int J Oncol 35: 1183-1189, 2009.
10. Sugimoto S, Katano K, Kanazawa A, et al: Multicenter safety study of, mFOLFOX6 for unresectable advanced/recurrent colorectal cancer in elderly patients. J Exp Clin Cancer Res 28: 109, 2009.
11. Therasse P, Arbuck SG, Eisenhauer E, et al: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92: 205-216, 2000.
12. Lévi F, Misset JL, Brienza S, et al: A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxali- platin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer. Cancer 69: 893-900, 1992.
13. Choi JI, Raghavendran HRB, Sung NY, et al: Effect of fucoidan on aspirin-induced stomach ulceration in rats. Chem Biol Interact 183: 249-254, 2010.
14. Del Bigio MR, Yan HJ, Campbell TM and Peeling J: Effect of fucoidan treatment on collagenase-induced intracerebral hemorrhage in rats. Neurol Res 21: 415-419, 1999.
15. Kim KJ, Lee OH, Lee HH and Lee BY: A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley rats. Toxicology 267: 154-158, 2010.
16. Iop A, Manfredi AM and Bonura S: Fatigue in cancer patients receiving chemotherapy: an analysis of published studies. Ann Oncol 15: 712-720, 2004.
17. Riou D, Colliec-Jouault S, Pinczon du Sel D, et al: Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Anticancer Res 16: 1213-1218, 1996.
18. Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T and Ito H: Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae. Anticancer Res 13: 2045-2052, 1993.
19. Maruyama H, Tamauchi H, Hashimoto M and Nakano T: Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida. In Vivo 17: 245-249, 2003.
20. Koyanagi S, Tanigawa N, Nakagawa H, Soeda S and Shimeno H: Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochem Pharmacol 65: 173-179, 2003.
21. Hyun JH, Kim SC, Kang JI, et al: Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. Biol Pharm Bull 32: 1760-1764, 2009.