Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo

Chemico-Biological Interactions

Volumn 185, Issue 3, 2010, Pages 215-226

  Kang, Kyoung Ah ^a   Zhang, Rui ^a   Chae, Sungwook ^b   Lee, Su Jae ^c   Kim, Jihoon ^d   Kim, Jeongtae ^d   Jeong, Jinwoo ^d   Lee, Juyeon ^d   Shin, Taekyun ^d   Lee, Nam Ho ^d   Hyun, Jin Won ^a  

^a Jeju National University School of Medicine   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^c Hanyang University   (South Korea)

^d Jeju National University   (South Korea)

Author keywords

Apoptosis; Cell damage; Oxidative stress; Phloroglucinol; Reactive oxygen species; Reduced glutathione

Indexed keywords

CASPASE 3; CASPASE 9; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHLOROGLUCINOL; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; CASPASE; RADIOPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; GAMMA RADIATION; HAMSTER; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; WHOLE BODY RADIATION; ANIMAL; BAGG ALBINO MOUSE; CELL DEATH; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CRICETULUS; DNA DAMAGE; DRUG EFFECT; METABOLISM; MITOCHONDRION; MOUSE;

ECKLONIA CAVA; MUS;

ANIMALS; APOPTOSIS; CASPASES; CELL DEATH; CELL LINE; CELL SURVIVAL; CRICETINAE; CRICETULUS; CYTOPROTECTION; DNA DAMAGE; FEMALE; GAMMA RAYS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICE; MICE, INBRED BALB C; MITOCHONDRIA; MOLECULAR STRUCTURE; OXIDATIVE STRESS; PHLOROGLUCINOL; RADIATION-PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR AP-1; WHOLE-BODY IRRADIATION;

EID: 77952314064     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.02.031     Document Type: Article

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