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Volumn 14, Issue 7, 2013, Pages 13763-13781

Biosynthetic pathway and health benefits of fucoxanthin, an algae-specific xanthophyll in brown seaweeds

Author keywords

Biosynthetic pathway; Brown seaweed; Carotenogenic gene; Carotenoid; Ectocarpus siliculosus; Fucoxanthin; Genome; Health benefit

Indexed keywords

ANTHERAXANTIN; BETA CAROTENE; CAROTENOID; DIADINOXANTHIN; DIATOXANTHINE; FUCOXANTHIN; FUCOXANTHINOL; NEOXANTHIN; UNCLASSIFIED DRUG; VIOLAXANTHIN; XANTHOPHYLL; ZEAXANTHIN;

EID: 84879990532     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140713763     Document Type: Review
Times cited : (180)

References (81)
  • 2
    • 79959698375 scopus 로고    scopus 로고
    • Carotenoids in algae: Distributions, biosynthesis and functions
    • Takaichi, S. Carotenoids in algae: Distributions, biosynthesis and functions. Mar. Drugs 2011, 9, 1101-1108.
    • (2011) Mar. Drugs , vol.9 , pp. 1101-1108
    • Takaichi, S.1
  • 3
    • 0029328503 scopus 로고
    • Plant carotenoids: Pigments for photoprotection, visual attraction, and human health
    • Bartley, G.; Scolinik, P.A. Plant carotenoids: Pigments for photoprotection, visual attraction, and human health. Plant Cell 1995, 7, 1027-1038.
    • (1995) Plant Cell , vol.7 , pp. 1027-1038
    • Bartley, G.1    Scolinik, P.A.2
  • 4
    • 0033014127 scopus 로고    scopus 로고
    • Carrotenoid sequestration in plants: The role of carotenoid-associated proteins
    • Vishnevetsky, M.; Ovadis, M.; Vainstein, A. Carrotenoid sequestration in plants: The role of carotenoid-associated proteins. Trends Plant Sci. 1999, 4, 232-235.
    • (1999) Trends Plant Sci , vol.4 , pp. 232-235
    • Vishnevetsky, M.1    Ovadis, M.2    Vainstein, A.3
  • 5
    • 0034932991 scopus 로고    scopus 로고
    • The pathway of biosynthesis of abscisic acid in vascular plants: A review of the present state of knowledge of ABA biosynthesis
    • Milborrow, B.V. The pathway of biosynthesis of abscisic acid in vascular plants: A review of the present state of knowledge of ABA biosynthesis. J. Exp. Bot. 2001, 52, 1145-1164.
    • (2001) J. Exp. Bot , vol.52 , pp. 1145-1164
    • Milborrow, B.V.1
  • 6
    • 0036007393 scopus 로고    scopus 로고
    • Complex regulation of ABA biosynthesis in plants
    • Seo, M.; Koshiba, T. Complex regulation of ABA biosynthesis in plants. Trends Plant Sci. 2002, 7, 41-48.
    • (2002) Trends Plant Sci , vol.7 , pp. 41-48
    • Seo, M.1    Koshiba, T.2
  • 7
    • 84856606078 scopus 로고    scopus 로고
    • AP2/ERF family transcription factors in plant abiotic stress responses
    • Mizoi, J.; Shinozaki, K.; Yamaguchi-Shinozaki, K. AP2/ERF family transcription factors in plant abiotic stress responses. Biochim. Biophys. Acta 2012, 1819, 86-96.
    • (2012) Biochim. Biophys. Acta , vol.1819 , pp. 86-96
    • Mizoi, J.1    Shinozaki, K.2    Yamaguchi-Shinozaki, K.3
  • 10
    • 84869192883 scopus 로고    scopus 로고
    • Recent advances in strigolactone research: Chemical and biological aspectes
    • Seto, Y.; Kameoka, H., Yamaguchi, S.; Kyozuka, J. Recent advances in strigolactone research: chemical and biological aspectes. Planr Cell Physiol. 2012, 53, 1843-1853.
    • (2012) Planr Cell Physiol , vol.53 , pp. 1843-1853
    • Seto, Y.1    Kameoka, H.2    Yamaguchi, S.3    Kyozuka, J.4
  • 11
    • 79954514126 scopus 로고    scopus 로고
    • Absorption and metabolism of dietary carotenoids
    • Nagao, A. Absorption and metabolism of dietary carotenoids. Biofactors 2011, 37, 83-87.
    • (2011) Biofactors , vol.37 , pp. 83-87
    • Nagao, A.1
  • 12
    • 79953726716 scopus 로고    scopus 로고
    • The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds
    • Miyashita, K.; Nishikawa, S.; Beppu, F.; Tsukui, T.; Abe, M.; Hosokawa, M. The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds. J. Sci. Food Agric. 2011, 91, 1166-1174.
    • (2011) J. Sci. Food Agric , vol.91 , pp. 1166-1174
    • Miyashita, K.1    Nishikawa, S.2    Beppu, F.3    Tsukui, T.4    Abe, M.5    Hosokawa, M.6
  • 13
    • 80054921621 scopus 로고    scopus 로고
    • Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health
    • Peng, J.; Yuan, J.P.; Wu, C.F.; Wang, J.H. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health. Mar. Drugs 2011, 9, 1806-1828.
    • (2011) Mar. Drugs , vol.9 , pp. 1806-1828
    • Peng, J.1    Yuan, J.P.2    Wu, C.F.3    Wang, J.H.4
  • 14
    • 78650251771 scopus 로고    scopus 로고
    • Carotenoid biosynthesis in diatoms
    • Bertrand, M. Carotenoid biosynthesis in diatoms. Photosynth. Res. 2010, 106, 89-102.
    • (2010) Photosynth. Res , vol.106 , pp. 89-102
    • Bertrand, M.1
  • 15
    • 51649110735 scopus 로고    scopus 로고
    • Evolutionary origins and functions of the carotenoid biosynthesis pathway in marine diatoms
    • e2896
    • Coesel, S.; Oborník, M.; Varela, J.; Falciatore, A.; Bowler, C. Evolutionary origins and functions of the carotenoid biosynthesis pathway in marine diatoms. PLoS One 2008, 3, e2896.
    • (2008) PLoS One , vol.3
    • Coesel, S.1    Oborník, M.2    Varela, J.3    Falciatore, A.4    Bowler, C.5
  • 16
    • 84866651198 scopus 로고    scopus 로고
    • Biosynthesis of fucoxanthin and diadinoxanthin and function of initial pathway genes in Phaeodactylum tricornutum
    • Dambek, M.; Eilers, U.; Breitenbach, J.; Steiger, S.; Büchel, C.; Sandmann, G. Biosynthesis of fucoxanthin and diadinoxanthin and function of initial pathway genes in Phaeodactylum tricornutum. J. Exp. Bot. 2012, 63, 5607-5612.
    • (2012) J. Exp. Bot , vol.63 , pp. 5607-5612
    • Dambek, M.1    Eilers, U.2    Breitenbach, J.3    Steiger, S.4    Büchel, C.5    Sandmann, G.6
  • 18
    • 33947659354 scopus 로고    scopus 로고
    • Carotenod biosynthesis in the primitive red alga Cyanidioschyzon merolae
    • 5330545
    • Cunningham, F.X., Jr.; Lee, H.; Gantt, E. Carotenod biosynthesis in the primitive red alga Cyanidioschyzon merolae. Eukaryot. Cell 2007, 6, 5330545.
    • (2007) Eukaryot. Cell , vol.6
    • Cunningham Jr., F.X.1    Lee, H.2    Gantt, E.3
  • 20
    • 0035037090 scopus 로고    scopus 로고
    • Thermal stress response of a sterile mutant of Ulva pertusa (Chlorophyta)
    • Kakinuma, M.; Shibahara, N.; Ikeda, H.; Maegawa, M.; Amano, H. Thermal stress response of a sterile mutant of Ulva pertusa (Chlorophyta). Fish. Sci. 2001, 68, 287-294.
    • (2001) Fish. Sci , vol.68 , pp. 287-294
    • Kakinuma, M.1    Shibahara, N.2    Ikeda, H.3    Maegawa, M.4    Amano, H.5
  • 21
    • 78650231192 scopus 로고    scopus 로고
    • Regulation and function of xanthophyll cycle-dependent photoprotection in algae
    • Goss, R.; Jakob, T. Regulation and function of xanthophyll cycle-dependent photoprotection in algae. Photosynth. Res. 2010, 106, 103-122.
    • (2010) Photosynth. Res , vol.106 , pp. 103-122
    • Goss, R.1    Jakob, T.2
  • 22
    • 0033587763 scopus 로고    scopus 로고
    • Algae displaying the diadinoxanthin cycle also possess the violaxanthin cycle
    • Lohr, M.; Wilhelm, C. Algae displaying the diadinoxanthin cycle also possess the violaxanthin cycle. Proc. Natl. Acad. Sci. USA 1999, 96, 8784-8789.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8784-8789
    • Lohr, M.1    Wilhelm, C.2
  • 26
    • 34249780818 scopus 로고    scopus 로고
    • The Arabidopsis ABA-deficient mutant aba4 demonstrates that the major route for stress-induced ABA accumulation is via neoxanthin isomers
    • North, H.M.; de Almeida, A.; Boutin, J.-P.; Frey, A.; To, A.; Botran, L.; Sotta, B.; Marion-Poll, A. The Arabidopsis ABA-deficient mutant aba4 demonstrates that the major route for stress-induced ABA accumulation is via neoxanthin isomers. Plant J. 2007, 50, 810-824.
    • (2007) Plant J , vol.50 , pp. 810-824
    • North, H.M.1    de Almeida, A.2    Boutin, J.-P.3    Frey, A.4    To, A.5    Botran, L.6    Sotta, B.7    Marion-Poll, A.8
  • 27
    • 79960220136 scopus 로고    scopus 로고
    • Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis
    • Zhong, Y.J.; Huang, J.C.; Liu, J.; Li, Y.; Jiang, Y.; Xu, Z.F.; Sandmann, G.; Chen, F. Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis. J. Exp. Bot. 2011, 62, 3659-3669.
    • (2011) J. Exp. Bot , vol.62 , pp. 3659-3669
    • Zhong, Y.J.1    Huang, J.C.2    Liu, J.3    Li, Y.4    Jiang, Y.5    Xu, Z.F.6    Sandmann, G.7    Chen, F.8
  • 28
    • 84864331986 scopus 로고    scopus 로고
    • Cloning and selection of carotenoid ketolase genes for the engineering of high-yield astaxanthin in plants
    • Huang, J.; Zhong, Y.; Sandmann, G.; Liu, J.; Chen, F. Cloning and selection of carotenoid ketolase genes for the engineering of high-yield astaxanthin in plants. Planta 2012, 236, 691-699.
    • (2012) Planta , vol.236 , pp. 691-699
    • Huang, J.1    Zhong, Y.2    Sandmann, G.3    Liu, J.4    Chen, F.5
  • 29
    • 27244453757 scopus 로고    scopus 로고
    • Genome-based examination of chlorophyll and carotenoid biosynthesis in Chlamydomonas reinhardtii
    • Lohr, M.; Im, C.S.; Grossman, A.R. Genome-based examination of chlorophyll and carotenoid biosynthesis in Chlamydomonas reinhardtii. Plant Physiol. 2005, 138, 490-515.
    • (2005) Plant Physiol , vol.138 , pp. 490-515
    • Lohr, M.1    Im, C.S.2    Grossman, A.R.3
  • 30
    • 84865006438 scopus 로고    scopus 로고
    • Intragenic enhancers and suppressors of phytoene desaturase mutations in Chlamydomonas reinhardtii
    • e42196
    • Tran, P.T.; Sharifi, M.N.; Poddar, S.; Dent, R.M.; Niyogi, K.K. Intragenic enhancers and suppressors of phytoene desaturase mutations in Chlamydomonas reinhardtii. PLoS One 2012, 7, e42196.
    • (2012) PLoS One , vol.7
    • Tran, P.T.1    Sharifi, M.N.2    Poddar, S.3    Dent, R.M.4    Niyogi, K.K.5
  • 32
    • 84858311354 scopus 로고    scopus 로고
    • Photoprotection by dietary carotenoids: Concept, mechanism, evidence and future development
    • Stahl, W.; Sies, H. Photoprotection by dietary carotenoids: Concept, mechanism, evidence and future development. Mol. Nutr. Food Res. 2012, 56, 287-295.
    • (2012) Mol. Nutr. Food Res , vol.56 , pp. 287-295
    • Stahl, W.1    Sies, H.2
  • 33
    • 0033094880 scopus 로고    scopus 로고
    • Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed
    • Yan, X.; Chuda, Y.; Suzuki, M.; Nagata, T. Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed. Biosci. Biotechnol. Biochem. 1999, 63, 605-607.
    • (1999) Biosci. Biotechnol. Biochem , vol.63 , pp. 605-607
    • Yan, X.1    Chuda, Y.2    Suzuki, M.3    Nagata, T.4
  • 34
    • 35548992780 scopus 로고    scopus 로고
    • Radical scavenging and singlet oxygen quenchingactivity of marine carotenoid fucoxanthin and its metabokites
    • Sachindra, N.M.; Sato, E.; Maeda, H.; Hosokawa, M.; Niwano, Y.; Kohno, M.; Miyashita, K. Radical scavenging and singlet oxygen quenchingactivity of marine carotenoid fucoxanthin and its metabokites. J. Agric. Food Chem. 2007, 55, 8516-8522.
    • (2007) J. Agric. Food Chem , vol.55 , pp. 8516-8522
    • Sachindra, N.M.1    Sato, E.2    Maeda, H.3    Hosokawa, M.4    Niwano, Y.5    Kohno, M.6    Miyashita, K.7
  • 35
    • 0031394857 scopus 로고    scopus 로고
    • Proton-donative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl (DPPH)
    • Nomura, T.; Kikuchi, M.; Kubodera, A.; Kawakami, Y. Proton-donative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl (DPPH). Biochem. Mol. Biol. Int. 1997, 42, 361-370.
    • (1997) Biochem. Mol. Biol. Int , vol.42 , pp. 361-370
    • Nomura, T.1    Kikuchi, M.2    Kubodera, A.3    Kawakami, Y.4
  • 36
    • 0034611675 scopus 로고    scopus 로고
    • Obesity in the new millennium
    • Friedman, J.M. Obesity in the new millennium. Nature 2000, 404, 632-634.
    • (2000) Nature , vol.404 , pp. 632-634
    • Friedman, J.M.1
  • 37
    • 33646572904 scopus 로고    scopus 로고
    • The metabolic syndrome and adipocytokines
    • Matsuzawa, Y. The metabolic syndrome and adipocytokines. FEBS Lett. 2006, 580, 2917-2922.
    • (2006) FEBS Lett , vol.580 , pp. 2917-2922
    • Matsuzawa, Y.1
  • 39
    • 19444376373 scopus 로고    scopus 로고
    • Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues
    • Maeda, H.; Hosokawa, M.; Sashima, T.; Funayama, K.; Miyashita, K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem. Biophys. Res. Commun. 2005, 332, 392-397.
    • (2005) Biochem. Biophys. Res. Commun , vol.332 , pp. 392-397
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Funayama, K.4    Miyashita, K.5
  • 40
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B.; Nedergaard, J. Brown adipose tissue: Function and physiological significance. Physiol. Rev. 2004, 84, 277-359.
    • (2004) Physiol. Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 41
    • 0031895220 scopus 로고    scopus 로고
    • Stimulation of uncoupling protein synthesis in white adipose tissue of mice treated with the beta 3-adrenergic agonist CGP-12177
    • Pico, C.; Bonet, M.L.; Palou, A. Stimulation of uncoupling protein synthesis in white adipose tissue of mice treated with the beta 3-adrenergic agonist CGP-12177. Cell Mol. Life Sci. 1998, 54, 191-195.
    • (1998) Cell Mol. Life Sci , vol.54 , pp. 191-195
    • Pico, C.1    Bonet, M.L.2    Palou, A.3
  • 43
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic, N.; Walden, T.B.; Shabalina, I.G.; Timmons, J.A.; Cannon, B.; Nedergaard, J. Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 2010, 285, 7153-7164.
    • (2010) J. Biol. Chem , vol.285 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 45
    • 34948878515 scopus 로고    scopus 로고
    • Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice
    • Maeda, H.; Hosokawa, M.; Sashima, T.; Miyashita, K. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. J. Agric. Food Chem. 2007, 55, 7701-7706.
    • (2007) J. Agric. Food Chem , vol.55 , pp. 7701-7706
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Miyashita, K.4
  • 46
    • 77954385541 scopus 로고    scopus 로고
    • Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice
    • Woo, M.N.; Jeon, S.M.; Kim, H.J.; Lee, M.K.; Shin, S.K.; Shin, Y.C.; Park, Y.B.; Choi, M.S. Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice. Chem. Biol. Interact. 2010, 186, 316-322.
    • (2010) Chem. Biol. Interact , vol.186 , pp. 316-322
    • Woo, M.N.1    Jeon, S.M.2    Kim, H.J.3    Lee, M.K.4    Shin, S.K.5    Shin, Y.C.6    Park, Y.B.7    Choi, M.S.8
  • 47
    • 84858075859 scopus 로고    scopus 로고
    • Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-Ay mice
    • Nishikawa, S.; Hosokawa, M.; Miyashita, K. Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-Ay mice. Phytomedicine 2012, 19, 389-394.
    • (2012) Phytomedicine , vol.19 , pp. 389-394
    • Nishikawa, S.1    Hosokawa, M.2    Miyashita, K.3
  • 48
    • 73349138274 scopus 로고    scopus 로고
    • The effect of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
    • Abidov, M.; Ramazanov, Z.; Seifulla, R.; Grachev, S. The effect of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes. Metab. 2010, 12, 72-81.
    • (2010) Diabetes Obes. Metab , vol.12 , pp. 72-81
    • Abidov, M.1    Ramazanov, Z.2    Seifulla, R.3    Grachev, S.4
  • 49
    • 0034011263 scopus 로고    scopus 로고
    • Chemoprevention of cancer
    • Sporn, M.B.; Suh, N. Chemoprevention of cancer. Carcinogenesis 2000, 21, 525-530.
    • (2000) Carcinogenesis , vol.21 , pp. 525-530
    • Sporn, M.B.1    Suh, N.2
  • 50
    • 0028863013 scopus 로고
    • Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene
    • Levy, J.; Bosin, E.; Feldman, B.; Giat, Y.; Miinster, A.; Danilenko, M.; Sharoni, Y. Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene. Nutr. Cancer 1995, 24, 257-266.
    • (1995) Nutr. Cancer , vol.24 , pp. 257-266
    • Levy, J.1    Bosin, E.2    Feldman, B.3    Giat, Y.4    Miinster, A.5    Danilenko, M.6    Sharoni, Y.7
  • 51
    • 0038690425 scopus 로고    scopus 로고
    • Carotenoid update
    • Rock, C.L. Carotenoid update. J. Am. Diet Assoc. 2003, 103, 423-425.
    • (2003) J. Am. Diet Assoc , vol.103 , pp. 423-425
    • Rock, C.L.1
  • 52
    • 0010607277 scopus 로고
    • The effect of vitamin E and β carotene on the incidence of lung cancer and other cancers in male smokers. The α-Tocopherol, β Carotene Cancer Prevention Study Group
    • Heinonen, O.P.; Albanes, D. The effect of vitamin E and β carotene on the incidence of lung cancer and other cancers in male smokers. The α-Tocopherol, β Carotene Cancer Prevention Study Group. N. Engl. J. Med. 1994, 330, 1029-1035.
    • (1994) N. Engl. J. Med , vol.330 , pp. 1029-1035
    • Heinonen, O.P.1    Albanes, D.2
  • 55
    • 40949104695 scopus 로고    scopus 로고
    • Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D
    • Das, S.K.; Hashimoto, T.; Kanazawa, K. Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D. Biochim. Biophys. Acta 2008, 1780, 743-749.
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 743-749
    • Das, S.K.1    Hashimoto, T.2    Kanazawa, K.3
  • 56
    • 7744240624 scopus 로고    scopus 로고
    • Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells
    • Hosokawa, M.; Kudo, M.; Maeda, H.; Kohno, H.; Tanaka, T.; Miyashita, K. Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim. Biophys. Acta 2004, 1675, 113-119.
    • (2004) Biochim. Biophys. Acta , vol.1675 , pp. 113-119
    • Hosokawa, M.1    Kudo, M.2    Maeda, H.3    Kohno, H.4    Tanaka, T.5    Miyashita, K.6
  • 57
    • 0842304213 scopus 로고    scopus 로고
    • Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: Formation and cytotoxicity of fucoxanthin metabolites
    • Asai, A.; Sugawara, T.; Ono, H.; Nagao, A. Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: Formation and cytotoxicity of fucoxanthin metabolites. Drug Metab. Dispos. 2004, 32, 205-211.
    • (2004) Drug Metab. Dispos , vol.32 , pp. 205-211
    • Asai, A.1    Sugawara, T.2    Ono, H.3    Nagao, A.4
  • 58
    • 31344463235 scopus 로고    scopus 로고
    • Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells
    • Konishi, I.; Hosokawa, M.; Sashima, T.; Kobayashi, H.; Miyashita, K. Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells. Comp. Biochem. Physiol. C 2006, 142, 53-59.
    • (2006) Comp. Biochem. Physiol. C , vol.142 , pp. 53-59
    • Konishi, I.1    Hosokawa, M.2    Sashima, T.3    Kobayashi, H.4    Miyashita, K.5
  • 60
    • 84867273775 scopus 로고    scopus 로고
    • In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice
    • Wang, J.; Chen, S.; Xu, S.; Yu, X.; Ma, D.; Hu, X.; Cao, X. In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice. Mar. Drugs 2012, 10, 2055-2068.
    • (2012) Mar. Drugs , vol.10 , pp. 2055-2068
    • Wang, J.1    Chen, S.2    Xu, S.3    Yu, X.4    Ma, D.5    Hu, X.6    Cao, X.7
  • 61
    • 70350134708 scopus 로고    scopus 로고
    • Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication
    • Liu, C.L.; Huang, Y.S.; Hosokawa, M.; Miyashita, K.; Hu, M.L. Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication. Chem. Biol. Interact. 2009, 182, 165-172.
    • (2009) Chem. Biol. Interact , vol.182 , pp. 165-172
    • Liu, C.L.1    Huang, Y.S.2    Hosokawa, M.3    Miyashita, K.4    Hu, M.L.5
  • 62
    • 80054942205 scopus 로고    scopus 로고
    • Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity
    • Liu, C.L.; Chiu, Y.T.; Hu, M.L. Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity. J. Agric. Food Chem. 2011, 59, 11344-11351.
    • (2011) J. Agric. Food Chem , vol.59 , pp. 11344-11351
    • Liu, C.L.1    Chiu, Y.T.2    Hu, M.L.3
  • 64
    • 70349904741 scopus 로고    scopus 로고
    • Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice
    • Beppu, F.; Niwano, Y.; Tsukui, T.; Hosokawa, M.; Miyashita, K. Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice. J. Toxicol. Sci. 2009, 34, 501-510.
    • (2009) J. Toxicol. Sci , vol.34 , pp. 501-510
    • Beppu, F.1    Niwano, Y.2    Tsukui, T.3    Hosokawa, M.4    Miyashita, K.5
  • 65
    • 84865836821 scopus 로고    scopus 로고
    • Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice
    • Beppu, F.; Hosokawa, M.; Niwano, Y.; Miyashita, K. Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice. Lipids Health Dis. 2012, 11, 112.
    • (2012) Lipids Health Dis , vol.11 , pp. 112
    • Beppu, F.1    Hosokawa, M.2    Niwano, Y.3    Miyashita, K.4
  • 67
    • 0025602410 scopus 로고
    • Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells
    • Okuzumi, J.; Nishino, H.; Murakoshi, M.; Iwashima, A.; Tanaka, Y.; Yamane, T.; Fujita, Y.; Takahashi, T. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells. Cancer Lett. 1990, 55, 75-81.
    • (1990) Cancer Lett , vol.55 , pp. 75-81
    • Okuzumi, J.1    Nishino, H.2    Murakoshi, M.3    Iwashima, A.4    Tanaka, Y.5    Yamane, T.6    Fujita, Y.7    Takahashi, T.8
  • 69
    • 77956181267 scopus 로고    scopus 로고
    • Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway
    • Kim, K.N.; Heo, S.J.; Kang, S.M.; Ahn, G.; Jeon, Y.J. Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway. Toxicol. in Vitro 2010, 24, 1648-1654.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 1648-1654
    • Kim, K.N.1    Heo, S.J.2    Kang, S.M.3    Ahn, G.4    Jeon, Y.J.5
  • 70
    • 79952697175 scopus 로고    scopus 로고
    • Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells
    • Ganesan, P.; Noda, K.; Manabe, Y.; Ohkubo, T.; Tanaka, Y.; Maoka, T.; Sugawara, T.; Hirata, T. Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells. Biochim. Biophys. Acta 2011, 1810, 497-503.
    • (2011) Biochim. Biophys. Acta , vol.1810 , pp. 497-503
    • Ganesan, P.1    Noda, K.2    Manabe, Y.3    Ohkubo, T.4    Tanaka, Y.5    Maoka, T.6    Sugawara, T.7    Hirata, T.8
  • 71
    • 14644445985 scopus 로고    scopus 로고
    • Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells
    • Kotake-Nara, E.; Asai, A.; Nagao, A. Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells. Cancer Lett. 2005, 220, 75-84.
    • (2005) Cancer Lett , vol.220 , pp. 75-84
    • Kotake-Nara, E.1    Asai, A.2    Nagao, A.3
  • 72
    • 34047207526 scopus 로고    scopus 로고
    • Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells
    • Satomi, Y.; Nishino, H. Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells. In Vivo 2007, 21, 305-309.
    • (2007) In Vivo , vol.21 , pp. 305-309
    • Satomi, Y.1    Nishino, H.2
  • 73
    • 84858782415 scopus 로고    scopus 로고
    • Fucoxanthin induces GADD45A expression and G1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells
    • Satomi, Y. Fucoxanthin induces GADD45A expression and G1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells. Anticancer Res. 2012, 32, 807-813.
    • (2012) Anticancer Res , vol.32 , pp. 807-813
    • Satomi, Y.1
  • 74
    • 79952487250 scopus 로고    scopus 로고
    • Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway
    • Yu, R.X.; Hu, X.M.; Xu, S.Q.; Jiang, Z.J.; Yang, W. Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway. Eur. J. Pharmacol. 2011, 657, 10-19.
    • (2011) Eur. J. Pharmacol , vol.657 , pp. 10-19
    • Yu, R.X.1    Hu, X.M.2    Xu, S.Q.3    Jiang, Z.J.4    Yang, W.5
  • 75
    • 58149350379 scopus 로고    scopus 로고
    • Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line
    • Zhang, Z.Y.; Zhang, P.J.; Hamada, M.; Takahashi, S.; Xing, G.Q.; Liu, J.Q.; Sugiura, N. Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line. Oncol. Rep. 2008, 20, 1099-1103.
    • (2008) Oncol. Rep , vol.20 , pp. 1099-1103
    • Zhang, Z.Y.1    Zhang, P.J.2    Hamada, M.3    Takahashi, S.4    Xing, G.Q.5    Liu, J.Q.6    Sugiura, N.7
  • 76
    • 84865222831 scopus 로고    scopus 로고
    • Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters
    • Eid, S.Y.; Ei-Readi, M.Z.; Wink, M. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine 2012, 19, 977-987.
    • (2012) Phytomedicine , vol.19 , pp. 977-987
    • Eid, S.Y.1    Ei-Readi, M.Z.2    Wink, M.3
  • 78
    • 78649629110 scopus 로고    scopus 로고
    • Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas
    • Yamamoto, K.; Ishikawa, C.; Katano, H.; Yasumoto, T.; Mori, N. Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas. Cancer Lett. 2011, 300, 225-234.
    • (2011) Cancer Lett , vol.300 , pp. 225-234
    • Yamamoto, K.1    Ishikawa, C.2    Katano, H.3    Yasumoto, T.4    Mori, N.5
  • 79
    • 0032543363 scopus 로고    scopus 로고
    • Cancer prevention by carotenoids
    • Nishino, H. Cancer prevention by carotenoids. Mutat. Res. 1998, 402, 159-163.
    • (1998) Mutat. Res , vol.402 , pp. 159-163
    • Nishino, H.1
  • 80
    • 0027480268 scopus 로고
    • Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis
    • Okuzumi, J.; Takahashi, T.; Yamane, T.; Kitao, Y.; Inagake, M.; Ohya, K.; Tanaka, Y. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis. Cancer Lett. 1993, 68, 159-168.
    • (1993) Cancer Lett , vol.68 , pp. 159-168
    • Okuzumi, J.1    Takahashi, T.2    Yamane, T.3    Kitao, Y.4    Inagake, M.5    Ohya, K.6    Tanaka, Y.7
  • 81
    • 77955262356 scopus 로고    scopus 로고
    • Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules
    • Shimoda, H.; Tanaka, J.; Shan, S.J.; Maoka, T. Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules. J. Pharm. Pharmacol. 2010, 62, 1137-1145.
    • (2010) J. Pharm. Pharmacol , vol.62 , pp. 1137-1145
    • Shimoda, H.1    Tanaka, J.2    Shan, S.J.3    Maoka, T.4


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