Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

Nature Communications

Volumn 6, Issue , 2015, Pages

  Lee, Jeong Hyun ^a   Leaman, Daniel P ^a   Kim, Arthur S ^a   Torrents De La Penã, Alba ^b   Sliepen, Kwinten ^b   Yasmeen, Anila ^c   Derking, Ronald ^b   Ramos, Alejandra ^a   De Taeye, Steven W ^b   Ozorowski, Gabriel ^a   Klein, Florian ^d   Burton, Dennis R ^a,e   Nussenzweig, Michel C ^d   Poignard, Pascal ^a   Moore, John P ^c   Klasse, Per Johan ^c   Sanders, Rogier W ^b,c   Zwick, Michael B ^a   Wilson, Ian A ^a   Ward, Andrew B ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; EPITOPE; GLYCAN; GLYCOPROTEIN; GLYCOPROTEIN GP 41; NEUTRALIZING ANTIBODY; VIRUS GLYCOPROTEIN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G;

ANTIBODY; ANTIGEN; BIOCHEMISTRY; BIOPHYSICS; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; PROTEIN; REACTION KINETICS;

ANTIGEN BINDING; ARTICLE; BINDING KINETICS; CRYSTALLIZATION; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PROTEIN EXPRESSION; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; VIRUS SPIKE; COMPUTER SIMULATION; CRYOELECTRON MICROSCOPY; EPITOPE MAPPING; HEK293 CELL LINE; IMMUNOLOGY; MOLECULAR MODEL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIBODIES, NEUTRALIZING; COMPUTER SIMULATION; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; EPITOPE MAPPING; EPITOPES; HEK293 CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 84942811379     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9167     Document Type: Article

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