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Volumn 6, Issue , 2015, Pages 72-84

Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibility

Author keywords

Breast cancer; Folic acid; Meta analysis; MTHFR; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 84942588128     PISSN: None     EISSN: 22145400     Source Type: Journal    
DOI: 10.1016/j.mgene.2015.08.008     Document Type: Review
Times cited : (37)

References (128)
  • 1
    • 84871922220 scopus 로고    scopus 로고
    • Mutational analysis of the MTHFR gene in breast cancer patients of Pakistani population
    • Akram M., Malik F.A., Kayani M.A. Mutational analysis of the MTHFR gene in breast cancer patients of Pakistani population. Asian Pac. J. Cancer Prev. 2012, 13:1599-1603.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 1599-1603
    • Akram, M.1    Malik, F.A.2    Kayani, M.A.3
  • 2
    • 77953535512 scopus 로고    scopus 로고
    • Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms
    • Alshatwi A.A. Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms. Food Chem. Toxicol. 2010, 48:1881-1885.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 1881-1885
    • Alshatwi, A.A.1
  • 3
    • 84863110040 scopus 로고    scopus 로고
    • Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent
    • Barbosa Rde C., Menezes D.C., Freire T.F., Sales D.C., Alencar V.H. Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent. Mol. Biol. Rep. 2012, 39:4899-4907.
    • (2012) Mol. Biol. Rep. , vol.39 , pp. 4899-4907
    • Barbosa Rde, C.1    Menezes, D.C.2    Freire, T.F.3    Sales, D.C.4    Alencar, V.H.5
  • 5
    • 33750524394 scopus 로고    scopus 로고
    • Development and validation of MIX: comprehensive free software for meta-analysis of causal research data
    • Bax L., Yu L.M., Ikeda N., Tsuruta H., Moons K.G. Development and validation of MIX: comprehensive free software for meta-analysis of causal research data. BMC Med. Res. Methodol. 2006, 6:50.
    • (2006) BMC Med. Res. Methodol. , vol.6 , pp. 50
    • Bax, L.1    Yu, L.M.2    Ikeda, N.3    Tsuruta, H.4    Moons, K.G.5
  • 6
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg C.B., Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994, 50:1088-1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 7
    • 75049085990 scopus 로고    scopus 로고
    • No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study
    • Bentley A.R., Raiszadeh F., Stover P.J., Hunter D.J., Hankinson S.E. No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study. Eur. J. Clin. Nutr. 2010, 64:108-110.
    • (2010) Eur. J. Clin. Nutr. , vol.64 , pp. 108-110
    • Bentley, A.R.1    Raiszadeh, F.2    Stover, P.J.3    Hunter, D.J.4    Hankinson, S.E.5
  • 8
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage
    • Blount B.C., Mack M.M., Wehr C.M., MacGregor J.T., Hiatt R.A., Wang G., et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:3290-3295.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 3290-3295
    • Blount, B.C.1    Mack, M.M.2    Wehr, C.M.3    MacGregor, J.T.4    Hiatt, R.A.5    Wang, G.6
  • 9
    • 56349130046 scopus 로고    scopus 로고
    • Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer
    • Boccia S., Boffetta P., Brennan P., Ricciardi G., Gianfagna F., Matsuo K., et al. Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. Cancer Lett. 2009, 273:55-61.
    • (2009) Cancer Lett. , vol.273 , pp. 55-61
    • Boccia, S.1    Boffetta, P.2    Brennan, P.3    Ricciardi, G.4    Gianfagna, F.5    Matsuo, K.6
  • 10
    • 40049103754 scopus 로고    scopus 로고
    • Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review
    • Boccia S., Hung R., Ricciardi G., Gianfagn F., Ebert M.P.A., Fang J.Y., et al. Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am. J. Epidemiol. 2008, 167(5):505-516.
    • (2008) Am. J. Epidemiol. , vol.167 , Issue.5 , pp. 505-516
    • Boccia, S.1    Hung, R.2    Ricciardi, G.3    Gianfagn, F.4    Ebert, M.P.A.5    Fang, J.Y.6
  • 11
    • 67349108801 scopus 로고    scopus 로고
    • Dihydrofolate reductase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancer
    • Cam R., Eroglu A., Egin Y., Akar N. Dihydrofolate reductase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancer. Breast Cancer Res. Treat. 2009, 115:431-432.
    • (2009) Breast Cancer Res. Treat. , vol.115 , pp. 431-432
    • Cam, R.1    Eroglu, A.2    Egin, Y.3    Akar, N.4
  • 12
    • 84925549046 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
    • Campbell I.G., Baxter S.W., Eccles D.M., Choong D.Y. Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Res. 2002, 4:R14.
    • (2002) Breast Cancer Res. , vol.4 , pp. R14
    • Campbell, I.G.1    Baxter, S.W.2    Eccles, D.M.3    Choong, D.Y.4
  • 13
    • 79960726116 scopus 로고    scopus 로고
    • Age at menarche and menopause is not associated with two common genetic variants in the methylenetetrahydrofolate reductase (MTHFR) gene
    • Cerne J.Z., Pohar-Perme M., Cerkovnik P., Gersak K., Novakovic S. Age at menarche and menopause is not associated with two common genetic variants in the methylenetetrahydrofolate reductase (MTHFR) gene. Eur. J. Contracept. Reprod. Health Care 2011, 16(4):241-247.
    • (2011) Eur. J. Contracept. Reprod. Health Care , vol.16 , Issue.4 , pp. 241-247
    • Cerne, J.Z.1    Pohar-Perme, M.2    Cerkovnik, P.3    Gersak, K.4    Novakovic, S.5
  • 14
  • 15
    • 47549118870 scopus 로고    scopus 로고
    • Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan
    • Cheng C.W., Yu J.C., Huang C.S., Shieh J.C., Fu Y.P., Wang H.W., et al. Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res. Treat. 2008, 111:145-155.
    • (2008) Breast Cancer Res. Treat. , vol.111 , pp. 145-155
    • Cheng, C.W.1    Yu, J.C.2    Huang, C.S.3    Shieh, J.C.4    Fu, Y.P.5    Wang, H.W.6
  • 16
    • 33750475972 scopus 로고    scopus 로고
    • Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels, and breast cancer susceptibility: a case-control study in Taiwan
    • Chou Y.C., Wu M.H., Yu J.C., Lee M.S., Yang T., Shih H.L., et al. Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels, and breast cancer susceptibility: a case-control study in Taiwan. Carcinogenesis 2006, 27:2295-2300.
    • (2006) Carcinogenesis , vol.27 , pp. 2295-2300
    • Chou, Y.C.1    Wu, M.H.2    Yu, J.C.3    Lee, M.S.4    Yang, T.5    Shih, H.L.6
  • 17
    • 0030843969 scopus 로고    scopus 로고
    • Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer
    • Collaborative Group on Hormonal Factors in Breast Cancer
    • Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer. Lancet 1997, 350:1047-1059. Collaborative Group on Hormonal Factors in Breast Cancer.
    • (1997) Lancet , vol.350 , pp. 1047-1059
  • 18
    • 23044484714 scopus 로고    scopus 로고
    • Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population
    • Deligezer U., Akisik E.E., Dalay N. Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population. In Vivo 2005, 19:889-893.
    • (2005) In Vivo , vol.19 , pp. 889-893
    • Deligezer, U.1    Akisik, E.E.2    Dalay, N.3
  • 20
    • 84864353046 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women
    • Diakite B., Tazzite A., Hamzi K., Jouhadi H., Nadifi S. Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women. Afr. Health Sci. 2012, 12(2):204-209.
    • (2012) Afr. Health Sci. , vol.12 , Issue.2 , pp. 204-209
    • Diakite, B.1    Tazzite, A.2    Hamzi, K.3    Jouhadi, H.4    Nadifi, S.5
  • 21
    • 84873635486 scopus 로고    scopus 로고
    • MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis
    • Ding X.P., Feng L., Ma L. MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis. Asian Pac. J. Cancer Prev. 2012, 13:3937-3942.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 3937-3942
    • Ding, X.P.1    Feng, L.2    Ma, L.3
  • 22
    • 0032713838 scopus 로고    scopus 로고
    • Folic acid deficiency and cancer: mechanisms of DNA instability
    • Duthie S.J. Folic acid deficiency and cancer: mechanisms of DNA instability. Br. Med. Bull. 1999, 55:578-592.
    • (1999) Br. Med. Bull. , vol.55 , pp. 578-592
    • Duthie, S.J.1
  • 23
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M., Davey S., Schneider G., Minder M.C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey, S.2    Schneider, G.3    Minder, M.C.4
  • 24
    • 1542357618 scopus 로고    scopus 로고
    • Polymorphisms in the MTHFR gene are associated with breast cancer
    • Ergul E., Sazci A., Utkan Z., Canturk N.Z. Polymorphisms in the MTHFR gene are associated with breast cancer. Tumor Biol. 2003, 24:286-290.
    • (2003) Tumor Biol. , vol.24 , pp. 286-290
    • Ergul, E.1    Sazci, A.2    Utkan, Z.3    Canturk, N.Z.4
  • 25
    • 66649088009 scopus 로고    scopus 로고
    • Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmö Diet and Cancer cohort
    • Ericson U., Sonestedt E., Ivarsson M.I., Gullberg B., Carlson J., Olsson H., et al. Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmö Diet and Cancer cohort. Cancer Epidemiol. Biomark. Prev. 2009, 18:1101-1110.
    • (2009) Cancer Epidemiol. Biomark. Prev. , vol.18 , pp. 1101-1110
    • Ericson, U.1    Sonestedt, E.2    Ivarsson, M.I.3    Gullberg, B.4    Carlson, J.5    Olsson, H.6
  • 28
    • 34547768323 scopus 로고    scopus 로고
    • The role of one-carbon metabolism in schizophrenia and depression
    • Frankenburg F.R. The role of one-carbon metabolism in schizophrenia and depression. Harv. Rev. Psychiatry 2007, 15(4):146-160.
    • (2007) Harv. Rev. Psychiatry , vol.15 , Issue.4 , pp. 146-160
    • Frankenburg, F.R.1
  • 29
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Bloom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 1995, 10:111-113.
    • (1995) Nat. Genet. , vol.10 , pp. 111-113
    • Frosst, P.1    Bloom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 30
    • 68449103543 scopus 로고    scopus 로고
    • MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women
    • Gao C.M., Tang J.H., Cao H.X., Ding J.H., Wu J.Z., Wang J., et al. MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. J. Hum. Genet. 2009, 5:414-418.
    • (2009) J. Hum. Genet. , vol.5 , pp. 414-418
    • Gao, C.M.1    Tang, J.H.2    Cao, H.X.3    Ding, J.H.4    Wu, J.Z.5    Wang, J.6
  • 31
    • 33845887461 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review
    • Gilbody S., Lewis S., Lightfoot T. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am. J. Epidemiol. 2007, 165(1):1-13.
    • (2007) Am. J. Epidemiol. , vol.165 , Issue.1 , pp. 1-13
    • Gilbody, S.1    Lewis, S.2    Lightfoot, T.3
  • 32
    • 0034789631 scopus 로고    scopus 로고
    • COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk
    • Goodman J.E., Lavigne J.A., Wu K., Helzlsouer K.J., Strickland P.T., Selhub J., et al. COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk. Carcinogenesis 2001, 22(10):1661-1665.
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1661-1665
    • Goodman, J.E.1    Lavigne, J.A.2    Wu, K.3    Helzlsouer, K.J.4    Strickland, P.T.5    Selhub, J.6
  • 33
    • 6344254633 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype
    • Grieu F., Powell B., Beilby J., Iacopetta B. Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype. Anticancer Res. 2004, 24:3215-3219.
    • (2004) Anticancer Res. , vol.24 , pp. 3215-3219
    • Grieu, F.1    Powell, B.2    Beilby, J.3    Iacopetta, B.4
  • 34
    • 84856138064 scopus 로고    scopus 로고
    • Genetic variant in miR-196a2 increased digestive system cancer risks: a meat-analysis of 15 case-control studies
    • Guo J., Jin M., Zhang M., Chen L.A. Genetic variant in miR-196a2 increased digestive system cancer risks: a meat-analysis of 15 case-control studies. PLoS ONE 2012, 7(1):e30585.
    • (2012) PLoS ONE , vol.7 , Issue.1 , pp. e30585
    • Guo, J.1    Jin, M.2    Zhang, M.3    Chen, L.A.4
  • 35
    • 84908510175 scopus 로고    scopus 로고
    • Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer
    • He J.M., Pu Y.D., Wu Y.J., Qin R., Zhang Q.J., Sun Y.S., et al. Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer. Genet. Mol. Res. 2014, 13(4):8925-8931.
    • (2014) Genet. Mol. Res. , vol.13 , Issue.4 , pp. 8925-8931
    • He, J.M.1    Pu, Y.D.2    Wu, Y.J.3    Qin, R.4    Zhang, Q.J.5    Sun, Y.S.6
  • 36
    • 33846376566 scopus 로고    scopus 로고
    • No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer
    • Hekim N., Ergen A., Yaylim I., Yilmaz H., Zeybek U., Oztürk O., et al. No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer. Cell Biochem. Funct. 2007, 25:115-117.
    • (2007) Cell Biochem. Funct. , vol.25 , pp. 115-117
    • Hekim, N.1    Ergen, A.2    Yaylim, I.3    Yilmaz, H.4    Zeybek, U.5    Oztürk, O.6
  • 38
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 2002, 21:1539-1558.
    • (2002) Stat. Med. , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 39
    • 80051695692 scopus 로고    scopus 로고
    • Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomized trials
    • Holmes M.V., Newcombe P., Hubacek J.A., Sofat R., Ricketts S.L., Cooper J., et al. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomized trials. Lancet 2011, 378:584-594.
    • (2011) Lancet , vol.378 , pp. 584-594
    • Holmes, M.V.1    Newcombe, P.2    Hubacek, J.A.3    Sofat, R.4    Ricketts, S.L.5    Cooper, J.6
  • 41
    • 84887410082 scopus 로고    scopus 로고
    • Serum folate, vitamin B12 concentration and MTHFR, MS gene polymorphism associated with risk of breast cancer research
    • Hua Z., Wang Y., Ni J., Ge F., Zou T. Serum folate, vitamin B12 concentration and MTHFR, MS gene polymorphism associated with risk of breast cancer research. Mod. Oncol. 2011, 19:L428-L431.
    • (2011) Mod. Oncol. , vol.19 , pp. L428-L431
    • Hua, Z.1    Wang, Y.2    Ni, J.3    Ge, F.4    Zou, T.5
  • 42
    • 84908703221 scopus 로고    scopus 로고
    • Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer
    • Huang C.Y., Chang W.S., Shui H.A., Hsieh Y.H., Loh C.H., Wang H.C., et al. Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer. Anticancer Res. 2014, 34:4109-4115.
    • (2014) Anticancer Res. , vol.34 , pp. 4109-4115
    • Huang, C.Y.1    Chang, W.S.2    Shui, H.A.3    Hsieh, Y.H.4    Loh, C.H.5    Wang, H.C.6
  • 44
    • 0029163088 scopus 로고
    • Breast cancer: cause and prevention
    • Hulka B.S., Stark A.T. Breast cancer: cause and prevention. Lancet 1995, 346:883-887.
    • (1995) Lancet , vol.346 , pp. 883-887
    • Hulka, B.S.1    Stark, A.T.2
  • 45
    • 53449102887 scopus 로고    scopus 로고
    • Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese health study
    • Inoue M., Robien K., Wang R., Van Den Berg D.J., Koh W.P., Yu M.C. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese health study. Carcinogenesis 2008, 29:1967-1972.
    • (2008) Carcinogenesis , vol.29 , pp. 1967-1972
    • Inoue, M.1    Robien, K.2    Wang, R.3    Van Den Berg, D.J.4    Koh, W.P.5    Yu, M.C.6
  • 46
    • 84862017252 scopus 로고    scopus 로고
    • Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
    • Jakubowska A., Rozkrut D., Antoniou A., Hamann U., Scott R.J., McGuffog L., et al. Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. Br. J. Cancer 2012, 106:2016-2024.
    • (2012) Br. J. Cancer , vol.106 , pp. 2016-2024
    • Jakubowska, A.1    Rozkrut, D.2    Antoniou, A.3    Hamann, U.4    Scott, R.J.5    McGuffog, L.6
  • 47
    • 84925282746 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B 12 intakes
    • Jiang-Hua Q., De-Chuang J., Zhen-Duo L., Shu-de C., Zhenzhen L. Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B 12 intakes. Tumor Biol. 2014, 35(12):11895-11901.
    • (2014) Tumor Biol. , vol.35 , Issue.12 , pp. 11895-11901
    • Jiang-Hua, Q.1    De-Chuang, J.2    Zhen-Duo, L.3    Shu-de, C.4    Zhenzhen, L.5
  • 48
    • 69249083228 scopus 로고    scopus 로고
    • Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer
    • Jin Z.Z., Lu Q., Ge D.H., Zong M., Zhu Q.H. Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer. Mol. Med. Rep. 2009, 2:283-289.
    • (2009) Mol. Med. Rep. , vol.2 , pp. 283-289
    • Jin, Z.Z.1    Lu, Q.2    Ge, D.H.3    Zong, M.4    Zhu, Q.H.5
  • 49
    • 30344438559 scopus 로고    scopus 로고
    • One-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA study from Germany
    • Justenhoven C., Hamann U., Pierl C.B., Rabstein S., Pesch B. One-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA study from Germany. Cancer Epidemiol. Biomark. Prev. 2005, 14:3015-3018.
    • (2005) Cancer Epidemiol. Biomark. Prev. , vol.14 , pp. 3015-3018
    • Justenhoven, C.1    Hamann, U.2    Pierl, C.B.3    Rabstein, S.4    Pesch, B.5
  • 50
    • 84921382013 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case-control study in the Greek-Cypriot female population
    • Kakkoura M.G., Demetriou C.A., Loizidou M.A., Loucaides G., Neophytou I., Marcou Y., Hadjisavvas A., et al. Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case-control study in the Greek-Cypriot female population. Genes Nutr. 2015, 10(2):453.
    • (2015) Genes Nutr. , vol.10 , Issue.2 , pp. 453
    • Kakkoura, M.G.1    Demetriou, C.A.2    Loizidou, M.A.3    Loucaides, G.4    Neophytou, I.5    Marcou, Y.6    Hadjisavvas, A.7
  • 51
    • 17444387812 scopus 로고    scopus 로고
    • The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece
    • Kalemi T.G., Lambropoulos A.F., Gueorguiev M., Chrisafi S., Papazisis K.T. The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece. Cancer Lett. 2005, 222:57-65.
    • (2005) Cancer Lett. , vol.222 , pp. 57-65
    • Kalemi, T.G.1    Lambropoulos, A.F.2    Gueorguiev, M.3    Chrisafi, S.4    Papazisis, K.T.5
  • 52
    • 33646433711 scopus 로고    scopus 로고
    • Methylene tetrahydofolate reductase (MTHFR) C677T and A1298C polymorphisms and breast cancer in South Indian population
    • Kalyankumar C., Jamil K. Methylene tetrahydofolate reductase (MTHFR) C677T and A1298C polymorphisms and breast cancer in South Indian population. Int. J. Cancer Res. 2006, 2:143-151.
    • (2006) Int. J. Cancer Res. , vol.2 , pp. 143-151
    • Kalyankumar, C.1    Jamil, K.2
  • 53
    • 84898845548 scopus 로고    scopus 로고
    • Yunnan methylenetetrahydrofolate reductase gene polymorphism associated with breast cancer susceptibility
    • Kan X., Zou T., Wu X., Wang X. Yunnan methylenetetrahydrofolate reductase gene polymorphism associated with breast cancer susceptibility. Cancer Res. 2007, 34:716-718.
    • (2007) Cancer Res. , vol.34 , pp. 716-718
    • Kan, X.1    Zou, T.2    Wu, X.3    Wang, X.4
  • 54
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase
    • Kang S.S., Zhou J., Wong P., Kowalisyn J., Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am. J. Hum. Genet. 1988, 43:414.
    • (1988) Am. J. Hum. Genet. , vol.43 , pp. 414
    • Kang, S.S.1    Zhou, J.2    Wong, P.3    Kowalisyn, J.4    Strokosch, G.5
  • 55
    • 0027218972 scopus 로고
    • Breast cancer epidemiology: summary and future directions
    • Kelsey J.L. Breast cancer epidemiology: summary and future directions. Epidemiol. Rev. 1993, 15:256-263.
    • (1993) Epidemiol. Rev. , vol.15 , pp. 256-263
    • Kelsey, J.L.1
  • 56
    • 0033007272 scopus 로고    scopus 로고
    • Folate and carcinogenesis: evidence, mechanisms, and implications
    • Kim Y.I. Folate and carcinogenesis: evidence, mechanisms, and implications. J. Nutr. Biochem. 1999, 10:66-88.
    • (1999) J. Nutr. Biochem. , vol.10 , pp. 66-88
    • Kim, Y.I.1
  • 57
    • 84905968059 scopus 로고    scopus 로고
    • Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer
    • Kotsopoulos J., Zhang W.W., Zhang S., McCready D., Trudeau M., Zhang P., et al. Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer. Breast Cancer Res. Treat. 2008, 8:9895-9896.
    • (2008) Breast Cancer Res. Treat. , vol.8 , pp. 9895-9896
    • Kotsopoulos, J.1    Zhang, W.W.2    Zhang, S.3    McCready, D.4    Trudeau, M.5    Zhang, P.6
  • 58
    • 77950356480 scopus 로고    scopus 로고
    • Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability
    • Laanpere M., Altmäe S., Stavreus-Evers A., Nilsson T.K., Yngve A., Salumets A. Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability. Nutr. Rev. 2010, 68(2):99-113.
    • (2010) Nutr. Rev. , vol.68 , Issue.2 , pp. 99-113
    • Laanpere, M.1    Altmäe, S.2    Stavreus-Evers, A.3    Nilsson, T.K.4    Yngve, A.5    Salumets, A.6
  • 59
    • 85027917327 scopus 로고    scopus 로고
    • Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women
    • Lajin B., Sakur A.A., Ghabreau L., Alachkar A. Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women. Tumor Biol. 2012, 33:1133-1139.
    • (2012) Tumor Biol. , vol.33 , pp. 1133-1139
    • Lajin, B.1    Sakur, A.A.2    Ghabreau, L.3    Alachkar, A.4
  • 60
    • 0141863309 scopus 로고    scopus 로고
    • The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk
    • Langsenlehner U., Krippl P., Renner W., Yazdani-Biuki B., Wolf G., Wascher T.C., et al. The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk. Breast Cancer Res. Treat. 2003, 81:169-172.
    • (2003) Breast Cancer Res. Treat. , vol.81 , pp. 169-172
    • Langsenlehner, U.1    Krippl, P.2    Renner, W.3    Yazdani-Biuki, B.4    Wolf, G.5    Wascher, T.C.6
  • 61
    • 38649141191 scopus 로고    scopus 로고
    • Methylenetetrahydrofolatereductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis
    • Langsenlehner T., Renner W., Yazdani-Biuki B., Langsenlehner U. Methylenetetrahydrofolatereductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis. Breast Cancer Res. Treat. 2008, 107:459-460.
    • (2008) Breast Cancer Res. Treat. , vol.107 , pp. 459-460
    • Langsenlehner, T.1    Renner, W.2    Yazdani-Biuki, B.3    Langsenlehner, U.4
  • 63
    • 2442678016 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women
    • Lee S.A., Kang D., Nishio H., Lee M.J., Kim D.H., Han W., et al. Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women. Exp. Mol. Med. 2004, 36:116-121.
    • (2004) Exp. Mol. Med. , vol.36 , pp. 116-121
    • Lee, S.A.1    Kang, D.2    Nishio, H.3    Lee, M.J.4    Kim, D.H.5    Han, W.6
  • 64
    • 77956184678 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk
    • Li W.D., Chen S.Q. Association of methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk. J. Prac. Med. 2009, 25:2031-2033.
    • (2009) J. Prac. Med. , vol.25 , pp. 2031-2033
    • Li, W.D.1    Chen, S.Q.2
  • 65
    • 84903287088 scopus 로고    scopus 로고
    • Association of 677 C>T (rs1801133) and 1298A>C (rs1801131) polymorphisms in the MTHFR gene and breast cancer susceptibility: a meta-analysis based on 57 individual studies
    • Li K., Li W., Dong X. Association of 677 C>T (rs1801133) and 1298A>C (rs1801131) polymorphisms in the MTHFR gene and breast cancer susceptibility: a meta-analysis based on 57 individual studies. PLoS ONE 2014, 9:e71290.
    • (2014) PLoS ONE , vol.9 , pp. e71290
    • Li, K.1    Li, W.2    Dong, X.3
  • 66
    • 84898849558 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies
    • Liang H., Yan Y., Li T., Li R., Li M., Li S., et al. Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies. Tumor Biol. 2014, 35:1695-1701.
    • (2014) Tumor Biol. , vol.35 , pp. 1695-1701
    • Liang, H.1    Yan, Y.2    Li, T.3    Li, R.4    Li, M.5    Li, S.6
  • 67
    • 84969628945 scopus 로고    scopus 로고
    • Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk
    • (Epub ahead of print:
    • Lin W., Cen Y.L., Lin Y., Su F.X., Wu B.H., Tang L.Y., et al. Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk. Neoplasma 2015, (Epub ahead of print: DOI:10.4149/neo_2015_059).
    • (2015) Neoplasma
    • Lin, W.1    Cen, Y.L.2    Lin, Y.3    Su, F.X.4    Wu, B.H.5    Tang, L.Y.6
  • 68
    • 14944380160 scopus 로고    scopus 로고
    • The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan
    • Lin W.Y., Chou Y.C., Wu M.H., Huang H.B., Jeng Y.L., Wu C.C., et al. The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan. Anticancer Res. 2004, 24:3863-3868.
    • (2004) Anticancer Res. , vol.24 , pp. 3863-3868
    • Lin, W.Y.1    Chou, Y.C.2    Wu, M.H.3    Huang, H.B.4    Jeng, Y.L.5    Wu, C.C.6
  • 69
    • 34247478510 scopus 로고    scopus 로고
    • Genetic polymorphisms in the one carbon metabolism pathway and breast cancer risk: a population-based case-control study and metaanalyses
    • Lissowska J., Gaudet M.M., Brinton L.A., Chanock S.J., Peplonska B. Genetic polymorphisms in the one carbon metabolism pathway and breast cancer risk: a population-based case-control study and metaanalyses. Int. J. Cancer 2007, 120:2696-2703.
    • (2007) Int. J. Cancer , vol.120 , pp. 2696-2703
    • Lissowska, J.1    Gaudet, M.M.2    Brinton, L.A.3    Chanock, S.J.4    Peplonska, B.5
  • 70
    • 84887574834 scopus 로고    scopus 로고
    • Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk
    • Liu Y., Zhou L.S., Xu X.M., Deng L.Q., Xiao Q.K. Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk. Asian Pac. J. Cancer Prev. 2013, 14:5189-5192.
    • (2013) Asian Pac. J. Cancer Prev. , vol.14 , pp. 5189-5192
    • Liu, Y.1    Zhou, L.S.2    Xu, X.M.3    Deng, L.Q.4    Xiao, Q.K.5
  • 71
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller K.E., Pearce C.L., Pike M., Lander E.S., Hirschhorn J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 2003, 33(2):177-182.
    • (2003) Nat. Genet. , vol.33 , Issue.2 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 72
    • 84940435580 scopus 로고    scopus 로고
    • Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population
    • (Epub ahead of print:
    • López-Cortés A., Echeverría C., Oña-Cisneros F., Sánchez M.E., Herrera C., Cabrera-Andrade A., et al. Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population. Tumor Biol. 2015, (Epub ahead of print: DOI 10.1007/s13277-015-3335-0).
    • (2015) Tumor Biol.
    • López-Cortés, A.1    Echeverría, C.2    Oña-Cisneros, F.3    Sánchez, M.E.4    Herrera, C.5    Cabrera-Andrade, A.6
  • 73
    • 84929950702 scopus 로고    scopus 로고
    • Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population
    • (Epub ahead of print:
    • Lu Q., Jiang K., Li Q., Ji Y.J., Chen W.L., Xue X.H. Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population. Tumor Biol. 2015, (Epub ahead of print: DOI 10.1007/s13277-014-3016-4).
    • (2015) Tumor Biol.
    • Lu, Q.1    Jiang, K.2    Li, Q.3    Ji, Y.J.4    Chen, W.L.5    Xue, X.H.6
  • 74
    • 66149168707 scopus 로고    scopus 로고
    • Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women
    • Ma E., Iwasaki M., Junko I., Hamada G.S., Nishimoto I.N. Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women. BMC Cancer 2009, 9:122.
    • (2009) BMC Cancer , vol.9 , pp. 122
    • Ma, E.1    Iwasaki, M.2    Junko, I.3    Hamada, G.S.4    Nishimoto, I.N.5
  • 75
    • 70449638266 scopus 로고    scopus 로고
    • Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case control study in Japan
    • Ma E., Iwasaki M., Kobayashi M., Kasuga Y., Yokoyama S., Onuma H., et al. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case control study in Japan. Nutr. Cancer 2009, 61:447-456.
    • (2009) Nutr. Cancer , vol.61 , pp. 447-456
    • Ma, E.1    Iwasaki, M.2    Kobayashi, M.3    Kasuga, Y.4    Yokoyama, S.5    Onuma, H.6
  • 76
    • 34250900256 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis
    • Macis D., Maisonneuve P., Johansson H., Bonanni B., Botteri E., Iodice S., et al. Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis. Breast Cancer Res. Treat. 2007, 106:263-271.
    • (2007) Breast Cancer Res. Treat. , vol.106 , pp. 263-271
    • Macis, D.1    Maisonneuve, P.2    Johansson, H.3    Bonanni, B.4    Botteri, E.5    Iodice, S.6
  • 77
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N., Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 1959, 22:719-748.
    • (1959) J. Natl. Cancer Inst. , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 78
    • 77954592857 scopus 로고    scopus 로고
    • MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study
    • Maruti S.S., Ulrich C.M., Jupe E.R., White E. MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study. Breast Cancer Res. 2009, 11:R9.
    • (2009) Breast Cancer Res. , vol.11 , pp. R9
    • Maruti, S.S.1    Ulrich, C.M.2    Jupe, E.R.3    White, E.4
  • 79
    • 84867236301 scopus 로고    scopus 로고
    • The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis
    • Mei Q., Zhou D., Gao J., Shen S., Wu J., Guo L., et al. The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis. BMC Cancer 2012, 12:467-476.
    • (2012) BMC Cancer , vol.12 , pp. 467-476
    • Mei, Q.1    Zhou, D.2    Gao, J.3    Shen, S.4    Wu, J.5    Guo, L.6
  • 80
    • 84871273990 scopus 로고    scopus 로고
    • Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in Kashmiri women
    • Mir M.M., Dar J.A., Dar N.A., Dar M.S., Salam I., Lone M.M., et al. Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in Kashmiri women. In. J. Health Sciences. 2008, 2:3-14.
    • (2008) In. J. Health Sciences. , vol.2 , pp. 3-14
    • Mir, M.M.1    Dar, J.A.2    Dar, N.A.3    Dar, M.S.4    Salam, I.5    Lone, M.M.6
  • 81
    • 81155131086 scopus 로고    scopus 로고
    • Cross-talk between one-carbon metabolism and xenobiotic metabolism: implications on oxidative DNA damage and susceptibility to breast cancer
    • Naushad S.M., Reddy C.A., Rupasree Y., Pavani A., Digumarti R.R., Gottumukkala S.R., et al. Cross-talk between one-carbon metabolism and xenobiotic metabolism: implications on oxidative DNA damage and susceptibility to breast cancer. Cell Biochem. Biophys. 2011, 61:715-723.
    • (2011) Cell Biochem. Biophys. , vol.61 , pp. 715-723
    • Naushad, S.M.1    Reddy, C.A.2    Rupasree, Y.3    Pavani, A.4    Digumarti, R.R.5    Gottumukkala, S.R.6
  • 83
    • 70349317366 scopus 로고    scopus 로고
    • Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk
    • Platek M.E., Shields P.G., Marian C., McCann S.E., Bonner M.R., Nie J., et al. Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 2009, 18(2459):2453-2459.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , Issue.2459 , pp. 2453-2459
    • Platek, M.E.1    Shields, P.G.2    Marian, C.3    McCann, S.E.4    Bonner, M.R.5    Nie, J.6
  • 84
    • 80053243541 scopus 로고    scopus 로고
    • Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers
    • Prasad V.V., Wilkhoo H. Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers. Onkologie 2011, 34:422-426.
    • (2011) Onkologie , vol.34 , pp. 422-426
    • Prasad, V.V.1    Wilkhoo, H.2
  • 86
    • 77956190896 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls
    • Qi X., Ma X., Yang X., Fan L., Zhang Y. Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls. Breast Cancer Res. Treat. 2011, 123:499-506.
    • (2011) Breast Cancer Res. Treat. , vol.123 , pp. 499-506
    • Qi, X.1    Ma, X.2    Yang, X.3    Fan, L.4    Zhang, Y.5
  • 87
    • 16644366240 scopus 로고    scopus 로고
    • Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer
    • Qi J., Miao X.P., Tan W., Yu C.Y., Liang G., Lü W.F., et al. Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer. Zhonghua Zhong Liu Za Zhi 2004, 26:287-289.
    • (2004) Zhonghua Zhong Liu Za Zhi , vol.26 , pp. 287-289
    • Qi, J.1    Miao, X.P.2    Tan, W.3    Yu, C.Y.4    Liang, G.5    Lü, W.F.6
  • 88
    • 84856407386 scopus 로고    scopus 로고
    • Evaluation of methylenetetrahydrofolate reductase gene variant (C677T) as risk factor for bipolar disorder
    • (Noisy-le-grand). 57, Suppl:OL1558-OL1566
    • Rai V. Evaluation of methylenetetrahydrofolate reductase gene variant (C677T) as risk factor for bipolar disorder. Cell. Mol. Biol. 2011, (Noisy-le-grand). 57, Suppl:OL1558-OL1566.
    • (2011) Cell. Mol. Biol.
    • Rai, V.1
  • 89
    • 84905971237 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations
    • Rai V. The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations. Asian Pac. J. Cancer Prev. 2014, 15:5853-5860.
    • (2014) Asian Pac. J. Cancer Prev. , vol.15 , pp. 5853-5860
    • Rai, V.1
  • 90
    • 84907484144 scopus 로고    scopus 로고
    • Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies
    • Rai V., Yadav U., Kumar P., Yadav S.K., Mishra O.P. Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies. PLoS ONE 2014, 9:e108552.
    • (2014) PLoS ONE , vol.9 , pp. e108552
    • Rai, V.1    Yadav, U.2    Kumar, P.3    Yadav, S.K.4    Mishra, O.P.5
  • 91
    • 34548127241 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study
    • Reljic A., Simundic A.M., Topic E., Nikolac N., Justinic D. The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study. Clin. Biochem. 2007, 40:981-985.
    • (2007) Clin. Biochem. , vol.40 , pp. 981-985
    • Reljic, A.1    Simundic, A.M.2    Topic, E.3    Nikolac, N.4    Justinic, D.5
  • 92
    • 0037377977 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview
    • Robien K., Ulrich C.M. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am. J. Epidemiol. 2003, 157(7):571-582.
    • (2003) Am. J. Epidemiol. , vol.157 , Issue.7 , pp. 571-582
    • Robien, K.1    Ulrich, C.M.2
  • 94
    • 0036178211 scopus 로고    scopus 로고
    • The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans
    • Rosenberg N., Murata M., Ikeda Y., Opare-Sem O., Zivelin A., Geffen E., et al. The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans. Am. J. Hum. Genet. 2002, 70:758-762.
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 758-762
    • Rosenberg, N.1    Murata, M.2    Ikeda, Y.3    Opare-Sem, O.4    Zivelin, A.5    Geffen, E.6
  • 95
    • 79952114981 scopus 로고    scopus 로고
    • Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women
    • Sangrajrang S., Sato Y., Sakamoto H., Ohnami S., Khuhaprema T., Yoshida T. Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res. Treat. 2010, 123:885-893.
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 885-893
    • Sangrajrang, S.1    Sato, Y.2    Sakamoto, H.3    Ohnami, S.4    Khuhaprema, T.5    Yoshida, T.6
  • 97
    • 49749101642 scopus 로고    scopus 로고
    • Serum BDNF, depression and anti-depressant medications: meta-analyses and implications
    • Sen S., Duman R., Sanacora G. Serum BDNF, depression and anti-depressant medications: meta-analyses and implications. Biol. Psychiatry 2008, 64(6):527-532.
    • (2008) Biol. Psychiatry , vol.64 , Issue.6 , pp. 527-532
    • Sen, S.1    Duman, R.2    Sanacora, G.3
  • 98
    • 1442300286 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    • Sharp L., Little J. Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am. J. Epidemiol. 2004, 159(5):423-443.
    • (2004) Am. J. Epidemiol. , vol.159 , Issue.5 , pp. 423-443
    • Sharp, L.1    Little, J.2
  • 99
    • 18344375462 scopus 로고    scopus 로고
    • Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)
    • Sharp L., Little J., Schofield A.C., Pavlidou E., Cotton S.C., Meidzybrodzka Z., et al. Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Cancer Lett. 2002, 181:65-71.
    • (2002) Cancer Lett. , vol.181 , pp. 65-71
    • Sharp, L.1    Little, J.2    Schofield, A.C.3    Pavlidou, E.4    Cotton, S.C.5    Meidzybrodzka, Z.6
  • 100
    • 1242269326 scopus 로고    scopus 로고
    • MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study
    • Shrubsole M.J., Gao Y.T., Cai Q., Shu X.O., Dai Q., Hébert J.R., et al. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol. Biomark. Prev. 2004, 13:190-196.
    • (2004) Cancer Epidemiol. Biomark. Prev. , vol.13 , pp. 190-196
    • Shrubsole, M.J.1    Gao, Y.T.2    Cai, Q.3    Shu, X.O.4    Dai, Q.5    Hébert, J.R.6
  • 101
    • 84925797448 scopus 로고    scopus 로고
    • MTHFR 677C>T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controls
    • Singh P., Carlus J., Sekhar D., Francis A., Gupta N., Konwar R., et al. MTHFR 677C>T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controls. PLoS ONE 2015, 10(3):e0120654.
    • (2015) PLoS ONE , vol.10 , Issue.3 , pp. e0120654
    • Singh, P.1    Carlus, J.2    Sekhar, D.3    Francis, A.4    Gupta, N.5    Konwar, R.6
  • 102
    • 63449123250 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification
    • Sohn K.J., Jang H., Campan M., Weisenberger D.J., Dickhout J., Wang Y.C., et al. The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int. J. Cancer 2009, 124:1999-2005.
    • (2009) Int. J. Cancer , vol.124 , pp. 1999-2005
    • Sohn, K.J.1    Jang, H.2    Campan, M.3    Weisenberger, D.J.4    Dickhout, J.5    Wang, Y.C.6
  • 103
    • 0033846460 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
    • Stern L.L., Mason J.B., Selhub J., Choi S.W. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol. Biomark. Prev. 2000, 9:849-853.
    • (2000) Cancer Epidemiol. Biomark. Prev. , vol.9 , pp. 849-853
    • Stern, L.L.1    Mason, J.B.2    Selhub, J.3    Choi, S.W.4
  • 106
    • 40549098422 scopus 로고    scopus 로고
    • One-carbon metabolism-related gene polymorphisms and risk of breast cancer
    • Suzuki T., Matsuo K., Hirose K., Hiraki A., Kawase T., Watanabe M., et al. One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 2008, 2:356-362.
    • (2008) Carcinogenesis , vol.2 , pp. 356-362
    • Suzuki, T.1    Matsuo, K.2    Hirose, K.3    Hiraki, A.4    Kawase, T.5    Watanabe, M.6
  • 107
    • 84874007637 scopus 로고    scopus 로고
    • MTHFR gene polymorphisms are not involved in pancreatic cancer risk: a meta-analysis
    • Tu Y.L., Wang S.B., Tan X.L. MTHFR gene polymorphisms are not involved in pancreatic cancer risk: a meta-analysis. Asian Pac. J. Cancer Prev. 2012, 13:4627-4630.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 4627-4630
    • Tu, Y.L.1    Wang, S.B.2    Tan, X.L.3
  • 109
    • 79952108799 scopus 로고    scopus 로고
    • Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia
    • Vainer A.S., Boiarskikh U.A., Voronina E.N., Selezneva I.A., Sinkina T.V. Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia. Mol. Biol. (Mosk) 2010, 44:816-823.
    • (2010) Mol. Biol. (Mosk) , vol.44 , pp. 816-823
    • Vainer, A.S.1    Boiarskikh, U.A.2    Voronina, E.N.3    Selezneva, I.A.4    Sinkina, T.V.5
  • 111
    • 84904979264 scopus 로고    scopus 로고
    • Association of dietary intake of folate and MTHFR genotype with breast cancer risk
    • Wang Z.G., Cui W., Yang L.F., Zhu Y.Q., Wei W.H. Association of dietary intake of folate and MTHFR genotype with breast cancer risk. Genet. Mol. Res. 2014, 13:5446-5451.
    • (2014) Genet. Mol. Res. , vol.13 , pp. 5446-5451
    • Wang, Z.G.1    Cui, W.2    Yang, L.F.3    Zhu, Y.Q.4    Wei, W.H.5
  • 112
    • 84905974834 scopus 로고    scopus 로고
    • Association between dietary intake of folate, vitamin B6, B12 & MTHFR, MTR genotype and breast cancer risk
    • Weiwei Z., Liping C., Dequan L. Association between dietary intake of folate, vitamin B6, B12 & MTHFR, MTR genotype and breast cancer risk. Pak. J. Med. Sci. 2014, 30:106-110.
    • (2014) Pak. J. Med. Sci. , vol.30 , pp. 106-110
    • Weiwei, Z.1    Liping, C.2    Dequan, L.3
  • 113
    • 84877150034 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: a meta-analysis of case-control studies
    • Wen Y.Y., Yang S.J., Zhang J.X., Chen X.Y. Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: a meta-analysis of case-control studies. Asian Pac. J. Cancer Prev. 2013, 14:21-25.
    • (2013) Asian Pac. J. Cancer Prev. , vol.14 , pp. 21-25
    • Wen, Y.Y.1    Yang, S.J.2    Zhang, J.X.3    Chen, X.Y.4
  • 114
    • 0041326346 scopus 로고    scopus 로고
    • Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas worldwide
    • Wilcken B., Bamforth F., Li Z., Zhu H., Ritvanen A., Renlund M., et al. Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas worldwide. J. Med. Genet. 2003, 40(8):619-625.
    • (2003) J. Med. Genet. , vol.40 , Issue.8 , pp. 619-625
    • Wilcken, B.1    Bamforth, F.2    Li, Z.3    Zhu, H.4    Ritvanen, A.5    Renlund, M.6
  • 115
    • 84872685096 scopus 로고    scopus 로고
    • Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population
    • Wu X.Y., Ni J., Xu W.J., Zhou T., Wang X. Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population. Asian Pac. J. Cancer Prev. 2012, 13:2199-2206.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 2199-2206
    • Wu, X.Y.1    Ni, J.2    Xu, W.J.3    Zhou, T.4    Wang, X.5
  • 116
    • 84898899682 scopus 로고    scopus 로고
    • Northeast methylenetetrahydrofolate reductase gene c677t single nucleotide polymorphisms and susceptibility to breast cancer research
    • Wu Y., Yuan X., Zheng H., et al. Northeast methylenetetrahydrofolate reductase gene c677t single nucleotide polymorphisms and susceptibility to breast cancer research. Mod. Oncol. 2010, 18:2375-2378.
    • (2010) Mod. Oncol. , vol.18 , pp. 2375-2378
    • Wu, Y.1    Yuan, X.2    Zheng, H.3
  • 117
    • 34547778505 scopus 로고    scopus 로고
    • Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study
    • Xu X., Gammon M.D., Zhang H., Wetmur J.G., Rao M. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis 2007, 28:1504-1509.
    • (2007) Carcinogenesis , vol.28 , pp. 1504-1509
    • Xu, X.1    Gammon, M.D.2    Zhang, H.3    Wetmur, J.G.4    Rao, M.5
  • 118
    • 84942607351 scopus 로고    scopus 로고
    • Global prevalence of MTHFR C677T gene polymorphism: a meta-analysis of population based studies
    • Yadav U., Kumar P., Rai V. Global prevalence of MTHFR C677T gene polymorphism: a meta-analysis of population based studies. Indian J. Clin. Biochem. 2014, 29(1):123-124.
    • (2014) Indian J. Clin. Biochem. , vol.29 , Issue.1 , pp. 123-124
    • Yadav, U.1    Kumar, P.2    Rai, V.3
  • 119
    • 84930422911 scopus 로고    scopus 로고
    • Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis
    • Yadav U., Kumar P., Yadav S.K., Mishra O.P., Rai V. Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis. Metab. Brain Dis. 2015, 30:7-14.
    • (2015) Metab. Brain Dis. , vol.30 , pp. 7-14
    • Yadav, U.1    Kumar, P.2    Yadav, S.K.3    Mishra, O.P.4    Rai, V.5
  • 121
    • 84870566569 scopus 로고    scopus 로고
    • Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: an update meta-analysis based on 51 research studies
    • Yu L., Chen J. Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: an update meta-analysis based on 51 research studies. Diagn. Pathol. 2012, 7:171.
    • (2012) Diagn. Pathol. , vol.7 , pp. 171
    • Yu, L.1    Chen, J.2
  • 122
    • 34249276752 scopus 로고    scopus 로고
    • Breast cancer risk associated with multigenotypic polymorphisms in folate metabolizing genes: a nested case-control study in Taiwan
    • Yu C.P., Wu M.H., Chou Y.C., Yang T., You S.L., Chen C.J., et al. Breast cancer risk associated with multigenotypic polymorphisms in folate metabolizing genes: a nested case-control study in Taiwan. Anticancer Res. 2007, 27:1727-1732.
    • (2007) Anticancer Res. , vol.27 , pp. 1727-1732
    • Yu, C.P.1    Wu, M.H.2    Chou, Y.C.3    Yang, T.4    You, S.L.5    Chen, C.J.6
  • 123
    • 77956182248 scopus 로고    scopus 로고
    • The relation between polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of breast cancer
    • Yuan H., Xu X.Y., Wang Z.L. The relation between polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of breast cancer. J. MuDan Jiang Med. Univ. 2009, 30:2-4.
    • (2009) J. MuDan Jiang Med. Univ. , vol.30 , pp. 2-4
    • Yuan, H.1    Xu, X.Y.2    Wang, Z.L.3
  • 125
    • 84875963812 scopus 로고    scopus 로고
    • Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature
    • Zhang T., Lou J., Zhong R., Wu J., Zou L., Sun Y., et al. Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature. PLoS ONE 2013, 8:e59570.
    • (2013) PLoS ONE , vol.8 , pp. e59570
    • Zhang, T.1    Lou, J.2    Zhong, R.3    Wu, J.4    Zou, L.5    Sun, Y.6
  • 126
    • 77956191116 scopus 로고    scopus 로고
    • MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls
    • Zhang J., Qiu L.X., Wang Z.H., Wu X.H., Liu X.J. MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls. Breast Cancer Res. Treat. 2010, 123:549-555.
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 549-555
    • Zhang, J.1    Qiu, L.X.2    Wang, Z.H.3    Wu, X.H.4    Liu, X.J.5
  • 127
    • 84874016409 scopus 로고    scopus 로고
    • The MTHFR C677T polymorphism and prostate cancer risk: new findings from a meta-analysis of 7306 cases and 8062 controls
    • Zhang W.B., Zhang J.H., Pan Z.Q., Yang Q.S., Liu B. The MTHFR C677T polymorphism and prostate cancer risk: new findings from a meta-analysis of 7306 cases and 8062 controls. Asian Pac. J. Cancer Prev. 2012, 13:2597-2604.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 2597-2604
    • Zhang, W.B.1    Zhang, J.H.2    Pan, Z.Q.3    Yang, Q.S.4    Liu, B.5
  • 128
    • 33645472458 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis
    • Zintzaras E. Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis. Clin. Genet. 2006, 69:327-336.
    • (2006) Clin. Genet. , vol.69 , pp. 327-336
    • Zintzaras, E.1


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