Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: An update meta-analysis based on 51 research studies

Diagnostic Pathology

Volumn 7, Issue 1, 2012, Pages

  Yu, Liwa ^a   Chen, Jianqiu ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Ala222Val; Breast cancer; Meta analysis; MTFHR; Polymorphism

Indexed keywords

METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

BREAST TUMOR; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; ENZYMOLOGY; ETHNOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; META ANALYSIS; PHENOTYPE; RACE; REVIEW; RISK; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL;

BREAST NEOPLASMS; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CONTINENTAL POPULATION GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINEAR MODELS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ODDS RATIO; PHENOTYPE; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS;

MLCS; MLOWN;

EID: 84870566569     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-7-171     Document Type: Article

References (63)

1. Hankinson SE, Colditz GA, Willett WC. Towards an integrated mod breast cancer etiology. The lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res 2004, 6:213-218. 10.1186/bcr921, 549181, 15318928.
2. Umitrescu RG, Cotarla I. Understanding breast cancer risk-where do we stand in 2005. J Cell Mol Med 2005, 9:208-221. 10.1111/j.1582-4934.2005.tb00350.x, 15784178.
3. Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E, Seligsohn U. The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in Whites, Japanese, and Africans. Am J Hum Genet 2002, 70:758-762. 10.1086/338932, 384952, 11781870.
4. Vander Put NM. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects. Am J Hum Genet 1998, 62:1044-1051. 10.1086/301825, 1377082, 9545395.
5. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, Den Heijer M, Kluijtmans LA, Van den Heuvel LP. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995, 10:111-113. 10.1038/ng0595-111, 7647779.
6. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959, 22:719-748.
7. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177-188. 10.1016/0197-2456(86)90046-2, 3802833.
8. Sharp L, Little J, Schofield AC, Pavlidou E, Cotton SC, Miedzybrodzka Z, Baird JO, Haites NE, Heys SD, Grubb DA. Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Cancer Lett 2002, 181:65-71. 10.1016/S0304-3835(02)00030-7, 12430180.
9. Campbell IG, Baxter SW, Eccles DM, Choong DY. Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Res 2002, 4(6):R14. 10.1186/bcr457, 137931, 12473175.
10. Semenza JC, Delfino RJ, Ziogas A, Anton-Culver H. Breast cancer risk and methylenetetrahydrofolate reductase polymorphism. Breast Cancer Res Treat 2003, 77:217-223. 10.1023/A:1021843019755, 12602921.
11. Langsenlehner U, Krippl P, Renner W, Yazdani-Biuki B, Wolf G, Wascher TC, Paulweber B, Weitzer W, Samonigg H. The common 677C>T gene polymorphism of methylenetetrahy- drofolate reductase gene is not associated with breast cancer risk. Breast Cancer Res Treat 2003, 81:169-172. 10.1023/A:1025752420309, 14572159.
12. Chen J, Gammon MD, Chan W, Palomeque C, Wetmur JG, Kabat GC, Teitelbaum SL, Britton JA, Terry MB, Neugut AI, Santella RM. One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 2005, 65:1606-1614. 10.1158/0008-5472.CAN-04-2630, 15735051.
13. Shrubsole MJ, Gao YT, Cai Q, Shu XO, Dai Q, Hebert JR, Jin F, Zheng W. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 2004, 13:190-196. 10.1158/1055-9965.EPI-03-0273, 14973091.
14. Forsti A, Angelini S, Festa F, Sanyal S, Zhang Z, Grzybowska E, Pamula J, Pekala W, Zientek H, Hemminki K, Kumar R. Single nucleotide polymorphisms in breast cancer. Oncol Rep 2004, 11:917-922.
15. Lee SA, Kang D, Nishio H, Lee MJ, Kim DH, Han W, Yoo KY, Ahn SH, Choe KJ, Hirvonen A, Noh DY. Methylenete-trahydrofolate reductase polymorphism, diet, and breast cancer in Korean women. Exp Mol Med 2004, 36:116-121.
16. Grieu F, Powell B, Beilby J, Iacopetta B. Methylenete-Trahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype. Anticancer Res 2004, 24:3215-3219.
17. Lin WY, Chou YC, Wu MH, Huang HB, Jeng YL, Wu CC, Yu CP, Yu JC, You SL, Chu TY, Chen CJ, Sun CA. The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan. Anticancer Res 2004, 24:3863-3868.
18. Qi J, Miao XP, Tan W, Yu CY, Liang G, Lu WF, Lin DX. Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer. Chin J Oncol 2004, 26:287-289.
19. Justenhoven C, Hamann U, Pierl CB, Rabstein S, Pesch B, Harth V, Baisch C, Vollmert C, Illig T, Bruning T, Ko Y, Brauch H. One-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA study from Germany. Cancer Epidemiol Biomark Prev 2005, 14:3015-3018.
20. Kalemi TG, Lambropoulos AF, Gueorguiev M, Chrisafi S, Papazisis KT, Kotsis A. The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece. Cancer Lett 2005, 222:57-65. 10.1016/j.canlet.2004.11.025, 15837541.
21. Deligezer U, Akisik EE, Dalay N. Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population. In Vivo 2005, 19:889-893.
22. Ergul E, Sazci A, Utkan Z, Canturk NZ. Polymorphisms in the MTHFR gene are associated with breast cancer. Tumour Biol 2003, 24:286-290. 10.1159/000076460, 15004488.
23. Chou YC, Wu MH, Yu JC, Lee MS, Yang T, Shih HL, Wu TY, Sun CA. Genetic polymorphisms of the methylenete-trahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. Carcinogenesis 2006, 27:2295-2300. 10.1093/carcin/bgl108, 16777985.
24. Kalyankumar C, Jamil K. Methylene tetrahydofolate reductase (MTHFR) C677T and A1298C polymorphisms and breast cancer in South Indian population. Int J Cancer Res 2006, 2:143-151.
25. Xu X, Gammon MD, Zhang H, Wetmur JG, Rao M, Teitelbaum SL, Britton JA, Neugut AI, Santella RM, Chen J. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis 2007, 28:1504-1509. 10.1093/carcin/bgm061, 17372271.
26. Hekim N, Ergen A, Yaylim I, Yilmaz H, Zeybek U, Ozturk O, Isbir T. No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer. Cell Biochem Funct 2007, 25:115-117. 10.1002/cbf.1274, 16134079.
27. Macis D, Maisonneuve P, Johansson H, Bonanni B, Botteri E, Iodice S, Santillo B, Penco S, Gucciardo G, D'Aiuto G, Rosselli Del Turco M, Amadori M, Costa A, Decensi A. Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis. Breast Cancer Res Treat 2007, 106:263-271. 10.1007/s10549-006-9491-6, 17260091.
28. Yu CP, Wu MH, Chou YC, Yang T, You SL, Chen CJ, Sun CA. Breast cancer risk associated with multigenotypic poly-Morphisms in folate-metabolizing genes: a nested case-control study in Taiwan. Anticancer Res 2007, 27:1727-1732.
29. Reljic A, Simundic AM, Topic E, Nikolac N, Justinic D, Stefanovic M. The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study. Clin Biochem 2007, 40:981-985. 10.1016/j.clinbiochem.2007.05.005, 17573062.
30. Inoue M, Robien K, Wang R, Van Den Berg DJ, Koh WP, Yu MC. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis 2008, 29:1967-1972. 10.1093/carcin/bgn177, 2574755,2574755, 18669903.
31. Kotsopoulos J, Zhang WW, Zhang S, McCready D, Trudeau M, Zhang P, Sun P, Narod SA. Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer. Breast Cancer Res Treat 2008, 112:585-593. 10.1007/s10549-008-9895-6, 18204969.
32. Suzuki T, Matsuo K, Hirose K, Hiraki A, Kawase T, Watanabe M, Yamashita T, Iwata H, Tajima K. One-carbon metab-olism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 2008, 2:356-362.
33. Cheng CW, Yu JC, Huang CS, Shieh JC, Fu YP, Wang HW, Wu PE, Shen CY. Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res Treat 2008, 111:145-155. 10.1007/s10549-007-9754-x, 17896178.
34. Langsenlehner T, Renner W, Yazdani-Biuki B, Langsenlehner U. Methylenetetrahydrofolatereductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis. Breast Cancer Res Treat 2008, 107:459-460. 10.1007/s10549-007-9564-1, 17453338.
35. Ericson U, Sonestedt E, Ivarsson MI, Gullberg B, Carlson J, Olsson H, Wirfalt E. Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmö Diet and Cancer cohort. Cancer Epidemiol Biomarkers Prev 2009, 18:1101-1110. 10.1158/1055-9965.EPI-08-0401, 19336565.
36. Gao CM, Tang JH, Cao HX, Ding JH, Wu JZ, Wang J, Liu YT, Li SP, Su P, Matsuo K, Takezaki T, Tajima K. MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. J Hum Genet 2009, 54:414-418. 10.1038/jhg.2009.57, 19557016.
37. Ma E, Iwasaki M, Kobayashi M, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Tsugane S. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutr Cancer 2009, 61:447-456. 10.1080/01635580802610123, 19838916.
38. Platek ME, Shields PG, Marian C, McCann SE, Bonner MR, Nie J, Ambrosone CB, Millen AE, Ochs-Balcom HM, Quick SK, et al. Alcohol consumption and genetic variation in Methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate homocysteine methyltransferase in relation to breast cancer risk. Cancer Epidemiol Biomark Prev 2009, 18:2453-2459.
39. Henri{dotless}quez-Hernandez LA, Murias-Rosales A, Hernandez Gon-zalez A, Cabrera De Leon A, Di{dotless}az-Chico BN, Mori De Santiago M, Fernandez Perez L. Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study. Oncol Rep 2009, 22:1425-1433.
40. Cam R, Eroglu A, Egin Y, Akar N. Dihydrofolate reduc-Tase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancer. Breast Cancer Res Treat 2009, 115:431-432. 10.1007/s10549-008-0054-x, 18498051.
41. Maruti SS, Ulrich CM, Jupe ER, White E. MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study. Breast Cancer Res 2009, 11:R91. 10.1186/bcr2462, 2815555, 20030812.
42. Ma E, Iwasaki M, Junko I, Hamada GS, Nishimoto IN, Carvalho SM, Motola J, Laginha FM, Tsugane S. Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women. BMC Cancer 2009, 9:122. 10.1186/1471-2407-9-122, 2684745, 19389261.
43. Li WD, Chen SQ. Association of methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk. J Prac Med 2009, 25:2031-2033.
44. Yuan H, Xu XY, Wang ZL. The relation between polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of breast cancer. J MuDanJiang Med Univ 2009, 30:2-4.
45. Jin ZZ, Lu Q, Ge DH, Zong M, Zhu QH. Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer. Mol Med Rep 2009, 2:283-289.
46. Bentley AR, Raiszadeh F, Stover PJ, Hunter DJ, Hankinson SE, Cassano PA. No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study. Eur J Clin Nutr 2010, 64:108-110. 10.1038/ejcn.2009.104, 3033771, 19707223.
47. Alshatwi AA. Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms. Food Chem Toxicol 2010, 48:881-1885.
48. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Khuhaprema T, Yoshida T. Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res Treat 2010, 123:885-893. 10.1007/s10549-010-0804-4, 20180013.
49. Weiner AS, Boyarskih UA, Voronina EN, Selezneva IA, Sinkina TV, Lazarev AF, Petrova VD, Filipenko ML. Polymorphic Variants of Folate Metabolizing Genes (C677T and A1298C MTHFR and C1420T SHMT1 and G1958A MTHFD) are Not Associated with the Risk of Breast Cancer in the West Siberian Region of Russia. Mol Biol 2010, 44(5):720-727.
50. Vidudala V.T.S. Prasad Harpreet Wilkhoo Association of the Functional Polymorphism C677T in the Methylenetetrahydrofolate Reductase Gene with Colorectal, Thyroid, Breast, Ovarian, and Cervical Cancers. Onkologie 2011, 34:422-426. 10.1159/000331131, 21934341, Vidudala V.T.S. Prasad Harpreet Wilkhoo.
51. Batschauer AP, Cruz NG, Oliveira VC, Coelho FF, Santos IR, Alves MT, Fernandes AP, Carvalho MG, Gomes KB. HFE, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women. Mol Cell Biochem 2011, 357:247-253. 10.1007/s11010-011-0895-1, 21625954.
52. Mohammad NS, Rupasree Y, Addepalli P, Gottumukkala SR, Digumarti RR, Kutala VK. Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. Mol Cell Biochem 2011, 349:159-167. 10.1007/s11010-010-0670-8, 21113649.
53. Mohammad NS, Addepalli P, Digumarti RR, Gottumukkala SR, Kutala VK. Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer. Mol Biol Rep 2011, 38:4893-4901. 10.1007/s11033-010-0631-z, 21161404.
54. Ja SMina Ziva C, Vida STG, KSeniJa GSK, Kovic S. Lack of association between methylenetetrahydrofolate reductase genetic polymorphisms and postmenopausal breast cancer risk. Molecular Medicine Reports 2011, 4:175-179.
55. Muhammad A, Malik FA, Mahmood Akhtar K. Mutational Analysis of the MTHFR Gene in Breast Cancer Patients of Pakistani Population. Asian Pacific J Cancer Pre 2012, 13:1599-1603.
56. de Cassia Carvalho Barbosa R, Debora Costa M, Thiago Fernando Vasconcelos F, Diogo Campos S, Victor Hugo Medeiros A, Silvia Helena Barem R. Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent. Mol Biol Rep 2012, 39:4899-4907. 10.1007/s11033-011-1285-1, 22134752.
57. Lajin B, Sakur AA, Ghabreau L, Alachkar A. Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women. Tumor Biol 2012, 33:1133-1139.
58. Jakubowska A, Rozkrut D, Antoniou A, et al. Association of PHB 1630 C4T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. British Journal of Cancer 2012, 106:2016-2024. 10.1038/bjc.2012.160, 22669161.
59. Skoog T, Van't Hooft FM, Kallin B, Jovinge S, Boquist S, Nilsson J, Eriksson P, Hamsten A. A common functional polymorphism (C-->A substitution at position -863) in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha. Hum Mol Genet 1999, 8:1443-1449. 10.1093/hmg/8.8.1443, 10400991.
60. Momparler RL, Bovenzi V. DNA methylation and cancer. J Cell Physiol 2000, 183:145-154. 10.1002/(SICI)1097-4652(200005)183:2<145::AID-JCP1>3.0.CO;2-V, 10737890.
61. Shen H, Wang L, Spitz MR, Hong WK, Mao L, Wei Q. A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res 2002, 62:4992-4995.
62. Fujisawa T, Ikegami H, Kawaguchi Y. Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy. Diabetologia 1998, 41(1):47-53. 10.1007/s001250050865, 9498629.
63. Liwei L, Chunyu L, Ruifa H. Association between manganese superoxide dismutase gene polymorphism and risk of prostate cancer: a meta-analysis. Urology 2009, 74(4):884-888. 10.1016/j.urology.2008.11.016, 19647296.