메뉴 건너뛰기




Volumn 34, Issue 8-9, 2011, Pages 422-426

Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers

Author keywords

Cervical cancer; Colorectal cancer; MTHFR; Ovarian cancer; Polymorphism; Thyroid cancer

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); GENOMIC DNA;

EID: 80053243541     PISSN: 0378584X     EISSN: 14230240     Source Type: Journal    
DOI: 10.1159/000331131     Document Type: Article
Times cited : (68)

References (57)
  • 1
    • 0002942853 scopus 로고
    • Biochemical role of folate in cellular metabolism
    • in Bailey LB (ed) New York, NY, Marcel Dekker Inc.
    • Wagner C: Biochemical role of folate in cellular metabolism; in Bailey LB (ed): Folate in Health and Disease. New York, NY, Marcel Dekker Inc., 1995, pp. 23-42.
    • (1995) Folate in Health and Disease , pp. 23-42
    • Wagner, C.1
  • 2
    • 0036328028 scopus 로고    scopus 로고
    • Folate status: Effects on pathways of colorectal carcinogenesis
    • Choi SW, Mason JB: Folate status: Effects on pathways of colorectal carcinogenesis. J Nutr 2002;132:2413S-2418S.
    • (2002) J Nutr , vol.132
    • Choi, S.W.1    Mason, J.B.2
  • 4
    • 58149138834 scopus 로고    scopus 로고
    • Too much folate - a risk factor for cancer and cardiovascular disease?
    • Sauer J, Mason JB, Choi S-W: Too much folate - a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care 2009;12:30-36.
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 30-36
    • Sauer, J.1    Mason, J.B.2    Choi, S.-W.3
  • 6
    • 0036178211 scopus 로고    scopus 로고
    • The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans
    • DOI 10.1086/338932
    • Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E, Seligsohn U: The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in Whites, Japanese, and Africans. Am J Hum Genet 2002;70:758-762. (Pubitemid 34177929)
    • (2002) American Journal of Human Genetics , vol.70 , Issue.3 , pp. 758-762
    • Rosenberg, N.1    Murata, M.2    Ikeda, Y.3    Opare-Sem, O.4    Zivelin, A.5    Geffen, E.6    Seligsohn, U.7
  • 7
    • 4444224055 scopus 로고    scopus 로고
    • Prevalence of methylene tetrahydrofolate reductase polymorphism in South Indian population
    • Rama Devi AR, Govindaiah V, Ramakrishna G, Naushad SM: Prevalence of methylene tetrahydrofolate reductase polymorphism in South Indian population. Curr Sci 2004;86:440-443. (Pubitemid 39160285)
    • (2004) Current Science , vol.86 , Issue.3 , pp. 440-443
    • Radha Rama Devi, A.1    Govindaiah, V.2    Ramakrishna, G.3    Naushad, S.M.4
  • 8
    • 0043166547 scopus 로고    scopus 로고
    • Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy
    • DOI 10.1093/ndt/gfg211
    • Moczulski D, Fojcik H, Zukowska-Szczechowska E, Szydlowska I, Grzeszczak W: Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy. Nephrol Dial Transplant 2003;18: 1535-1540. (Pubitemid 36939625)
    • (2003) Nephrology Dialysis Transplantation , vol.18 , Issue.8 , pp. 1535-1540
    • Moczulski, D.1    Fojcik, H.2    Zukowska-Szczechowska, E.3    Szydlowska, I.4    Grzeszczak, W.5
  • 9
    • 33749490522 scopus 로고    scopus 로고
    • Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: A meta-analysis
    • DOI 10.1053/j.gastro.2006.08.010, PII S0016508506017276
    • Larsson SC, Giovannucci E, Wolk A: Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: A meta-analysis. Gastroenterology 2006;131:1271-1283. (Pubitemid 44515102)
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1271-1283
    • Larsson, S.C.1    Giovannucci, E.2    Wolk, A.3
  • 11
    • 33750475972 scopus 로고    scopus 로고
    • Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: A case-control study in Taiwan
    • DOI 10.1093/carcin/bgl108
    • Chou Y-C, Wu M-H, Yu J-C, Lee M-S, Yang T, Shih H-L, Wu T-Y, Sun C-A: Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels, and breast cancer susceptibility: A case-control study in Taiwan. Carcinogenesis 2006;27:2295-2300. (Pubitemid 44644819)
    • (2006) Carcinogenesis , vol.27 , Issue.11 , pp. 2295-2300
    • Chou, Y.-C.1    Wu, M.-H.2    Yu, J.-C.3    Lee, M.-S.4    Yang, T.5    Shih, H.-L.6    Wu, T.-Y.7    Sun, C.-A.8
  • 12
    • 54349107004 scopus 로고    scopus 로고
    • Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population
    • Shekari M, Sobti RC, Tamandani DMK, Suri V: Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population. Arch Gynecol Obstet 2008;278:517-524.
    • (2008) Arch Gynecol Obstet , vol.278 , pp. 517-524
    • Shekari, M.1    Sobti, R.C.2    Tamandani, D.M.K.3    Suri, V.4
  • 13
    • 33745889354 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: A meta-analysis
    • DOI 10.1007/s10038-006-0405-6
    • Zintzaras E: Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: A meta-analysis. J Hum Genet 2006;51:618-624. (Pubitemid 44048695)
    • (2006) Journal of Human Genetics , vol.51 , Issue.7 , pp. 618-624
    • Zintzaras, E.1
  • 16
    • 33646436441 scopus 로고    scopus 로고
    • A case-control study of methylenetetrahydrofolate reductase polymorphisms in cervical carcinogenesis
    • Rao GG, Kurien A, Gossett D, Griffith WF, Coleman RL, Muller CY: A case-control study of methylenetetrahydrofolate reductase polymorphisms in cervical carcinogenesis. Gynecol Oncol 2006;101:250-254.
    • (2006) Gynecol Oncol , vol.101 , pp. 250-254
    • Rao, G.G.1    Kurien, A.2    Gossett, D.3    Griffith, W.F.4    Coleman, R.L.5    Muller, C.Y.6
  • 17
    • 66149168707 scopus 로고    scopus 로고
    • Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: A case-control study in Brazilian women
    • Ma E, Iwasaki M, Junko I, Hamada GS, Nishimoto IN, Carvalho SMT, Motola J Jr, Laginha FM, Tsugan S: Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: A case-control study in Brazilian women. BMC Cancer 2009;9:122.
    • (2009) BMC Cancer , vol.9 , pp. 122
    • Ma, E.1    Iwasaki, M.2    Junko, I.3    Hamada, G.S.4    Nishimoto, I.N.5    Carvalho, S.M.T.6    Motola Jr., J.7    Laginha, F.M.8    Tsugan, S.9
  • 19
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller S, Dykes D, Polesky H: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.1    Dykes, D.2    Polesky, H.3
  • 21
    • 79951558236 scopus 로고    scopus 로고
    • An increased risk of differentiated thyroid carcinoma in Iran with the 677C>T homozygous polymorphism in the MTHFR gene
    • Fard-Esfahani P, Fard-Esfahani A, Saidi P, Fayaz S, Mohabati R, Majdi M: An increased risk of differentiated thyroid carcinoma in Iran with the 677C>T homozygous polymorphism in the MTHFR gene. Cancer Epidemiol 2011;35:56-58.
    • Cancer Epidemiol , vol.2011 , Issue.35 , pp. 56-58
    • Fard-Esfahani, P.1    Fard-Esfahani, A.2    Saidi, P.3    Fayaz, S.4    Mohabati, R.5    Majdi, M.6
  • 22
    • 11144236628 scopus 로고    scopus 로고
    • Colorectal cancer and the methylenetetrahydrofolate reductase 677C → T and methionine synthase 2756A → G polymorphisms: A study of 2,168 case-control pairs from the JANUS cohort
    • Ulvik A, Vollset SE, Hansen S, Gislefoss R, Jellum E, Ueland PM: Colorectal cancer and the methylenetetrahydrofolate reductase 677C?T and methionine synthase 2756A?G polymorphisms: A study of 2,168 case-control pairs from the JANUS cohort. Cancer Epidemiol Biomarkers Prev 2004; 13:2175-2180. (Pubitemid 40054314)
    • (2004) Cancer Epidemiology Biomarkers and Prevention , vol.13 , Issue.12 , pp. 2175-2180
    • Ulvik, A.1    Vollset, S.E.2    Hansen, S.3    Gislefoss, R.4    Jellum, E.5    Ueland, P.M.6
  • 24
    • 0036895068 scopus 로고    scopus 로고
    • Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands
    • DOI 10.1136/gut.51.6.797
    • Rijnsoever MV, Grieu F, Elsaleh H, Joseph D, Iacopetta B: Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut 2002;51:797-802. (Pubitemid 35408598)
    • (2002) Gut , vol.51 , Issue.6 , pp. 797-802
    • Van Rijnsoever, M.1    Grieu, F.2    Elsaleh, H.3    Joseph, D.4    Iacopetta, B.5
  • 26
    • 76749104337 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals
    • El Awady MK, Karim AM, Hanna LS, El Husseiny LA, El Sahar M, Menem HA, Meguid NA: Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals. Cancer Biomark 2009;5:233-240.
    • (2009) Cancer Biomark , vol.5 , pp. 233-240
    • El Awady, M.K.1    Karim, A.M.2    Hanna, L.S.3    El Husseiny, L.A.4    El Sahar, M.5    Menem, H.A.6    Meguid, N.A.7
  • 31
    • 27144526086 scopus 로고    scopus 로고
    • Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma
    • Kono S, Chen K: Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma. Cancer Sci 2005;96:535-342.
    • (2005) Cancer Sci , vol.96 , pp. 535-342
    • Kono, S.1    Chen, K.2
  • 32
    • 31544481440 scopus 로고    scopus 로고
    • Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: A case-control study in an Indian population
    • DOI 10.1002/ijc.21438
    • Wang J, Gajalakshmi V, Jiang J, Kuriki K, Susuki S, Nagaya T, Nakamura S, Akasaka S, Ishikawa H, Tokudome S: Associations between 5, 10- methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: A case-control study in an Indian population. Int J Cancer 2006;118:991-997. (Pubitemid 43157676)
    • (2006) International Journal of Cancer , vol.118 , Issue.4 , pp. 991-997
    • Wang, J.1    Gajalakshmi, V.2    Jiang, J.3    Kuriki, K.4    Suzuki, S.5    Nagaya, T.6    Nakamura, S.7    Akasaka, S.8    Ishikawa, H.9    Tokudome, S.10
  • 37
    • 77954592857 scopus 로고    scopus 로고
    • MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: A nested case-control study
    • Maruti SS, Ulrich CM, Jupe ER, White E: MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: A nested case-control study. Breast Cancer Res 2009;11:R91.
    • (2009) Breast Cancer Res , vol.11
    • Maruti, S.S.1    Ulrich, C.M.2    Jupe, E.R.3    White, E.4
  • 38
    • 84925549046 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
    • Campbell IG, Baxter SW, Eccles DM, Choong DYH: Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Res 2002;4:R14.
    • (2002) Breast Cancer Res , vol.4
    • Campbell, I.G.1    Baxter, S.W.2    Eccles, D.M.3    Choong, D.Y.H.4
  • 39
    • 0033868044 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia
    • Piyathilake CJ, Macaluso M, Johanning GL, Whiteside M, Heimburger DC, Giuliano A: Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. Anticancer Res 2000; 20:1751-1757. (Pubitemid 30628198)
    • (2000) Anticancer Research , vol.20 , Issue.3 A , pp. 1751-1757
    • Piyathilake, C.J.1    Macaluso, M.2    Johanning, G.L.3    Whiteside, M.4    Heimburger, D.C.5    Giuliano, A.6
  • 40
  • 41
    • 0031961002 scopus 로고    scopus 로고
    • Worldwide distribution of a common methylenetetrahydrofolate reductase mutation [4]
    • DOI 10.1086/301836
    • Schneider JA, Rees DC, Liu YT, Clegg JB: Worldwide distribution of a common methylenetetrahydrofolate reductase mutation. Am J Hum Genet 1998;62:1258-1260. (Pubitemid 28199029)
    • (1998) American Journal of Human Genetics , vol.62 , Issue.5 , pp. 1258-1260
    • Schneider, J.A.1    Rees, D.C.2    Liu, Y.-T.3    Clegg, J.B.4
  • 42
    • 4444305073 scopus 로고    scopus 로고
    • Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians
    • DOI 10.1016/j.yexmp.2004.04.006, PII S0014480004000383
    • Angeline T, Jeyaraj N, Granito S, Tsongalis GJ: Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians. Exp Mol Pathol 2004;77:85-88. (Pubitemid 39209289)
    • (2004) Experimental and Molecular Pathology , vol.77 , Issue.2 , pp. 85-88
    • Angeline, T.1    Jeyaraj, N.2    Granito, S.3    Tsongalis, G.J.4
  • 43
    • 16244371735 scopus 로고    scopus 로고
    • Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population
    • DOI 10.1111/j.1365-2605.2004.00513.x
    • Singh K, Singh SK, Sah R, Singh I, Raman R: Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population. Int J Androl 2005;28:115-119. (Pubitemid 40461182)
    • (2005) International Journal of Andrology , vol.28 , Issue.2 , pp. 115-119
    • Singh, K.1    Singh, S.K.2    Sah, R.3    Singh, I.4    Raman, R.5
  • 45
    • 70249132588 scopus 로고    scopus 로고
    • MTHFR Gene variants C677T, A1298C and association with Down syndrome: A case-control study from South India
    • Cyril C, Rai P, Chandra N, Gopinath PM, Satyamoorthy K: MTHFR Gene variants C677T, A1298C and association with Down syndrome: A case-control study from South India. Indian J Hum Genet 2009;15:60-64.
    • (2009) Indian J Hum Genet , vol.15 , pp. 60-64
    • Cyril, C.1    Rai, P.2    Chandra, N.3    Gopinath, P.M.4    Satyamoorthy, K.5
  • 46
    • 67651046677 scopus 로고    scopus 로고
    • Genetic polymorphism of 5, 10-methylenetetrahydrofolate reductase C677T in Kashmiri population
    • Bhat TA, Mir MR, Qasim I, Misra SS, Kirmani MA: Genetic polymorphism of 5, 10-methylenetetrahydrofolate reductase C677T in Kashmiri population. Biotechnology 2008;7:822-825.
    • (2008) Biotechnology , vol.7 , pp. 822-825
    • Bhat, T.A.1    Mir, M.R.2    Qasim, I.3    Misra, S.S.4    Kirmani, M.A.5
  • 50
    • 0346966836 scopus 로고    scopus 로고
    • Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
    • DOI 10.1182/blood-2003-06-1794
    • Krajinovic M, Lamoha S, Labuda DE, Milie LB, Theoret Y, Moghrabi A, Sinnett D: Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004;103:252-257. (Pubitemid 38029946)
    • (2004) Blood , vol.103 , Issue.1 , pp. 252-257
    • Krajinovic, M.1    Lamothe, S.2    Labuda, D.3    Lemieux-Blanchard, E.4    Theoret, Y.5    Moqhrabi, A.6    Sinnett, D.7
  • 51
    • 39749111325 scopus 로고    scopus 로고
    • MTHFR C677T mutation in central retinal vein occlusion: A case-control study in Chinese population
    • DOI 10.1016/j.thromres.2007.05.026, PII S0049384807002605
    • Gao W, Wang Y, Zhang P, Wang H: MTHFR C677T mutation in central retinal vein occlusion; a case-control study in Chinese population. Thromb Res 2008;121:699-703. (Pubitemid 351305289)
    • (2008) Thrombosis Research , vol.121 , Issue.5 , pp. 699-703
    • Gao, W.1    Wang, Y.-S.2    Zhang, P.3    Wang, H.-Y.4
  • 53
    • 0033768636 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677 C?T mutation and coronary heart disease risk in UK Indian Asians
    • Chambers JC, Ireland H, Thompson E, Reilly P, et al.: Methylenetetrahydrofolate reductase 677 C?T mutation and coronary heart disease risk in UK Indian Asians. Arterioscler Thromb Vasc Biol 2000;20:2448-2452.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2448-2452
    • Chambers, J.C.1    Ireland, H.2    Thompson, E.3    Reilly, P.4
  • 54
    • 0042974212 scopus 로고    scopus 로고
    • Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction
    • Ranjith N, Pegoraro RJ, Rom L: Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction. Cardiovasc J S Afr 2003;14:127-132. (Pubitemid 37010267)
    • (2003) Cardiovascular Journal of South Africa , vol.14 , Issue.3 , pp. 127-132
    • Ranjith, N.1    Pegoraro, R.J.2    Rom, L.3
  • 55
    • 1042292043 scopus 로고    scopus 로고
    • Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cell to 5-fluorouracil and methotrexate
    • Sohn K-J, Croxford R, Yates Z, Lucock M, Kim Y-I: Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J Natl Cancer Inst 2004;96:134-144. (Pubitemid 38195904)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.2 , pp. 134-144
    • Sohn, K.-J.1    Croxford, R.2    Yates, Z.3    Lucock, M.4    Kim, Y.-I.5
  • 56
    • 67349244038 scopus 로고    scopus 로고
    • Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer
    • Gusella M, Frigo AC, Bolzonella C, Marinelli R, et al.: Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer. Br J Cancer 2009;100:1549-1557.
    • (2009) Br J Cancer , vol.100 , pp. 1549-1557
    • Gusella, M.1    Frigo, A.C.2    Bolzonella, C.3    Marinelli, R.4
  • 57
    • 77956634420 scopus 로고    scopus 로고
    • MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer
    • Wettergren Y, Odin E, Carlsson G, Gustavsson B: MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer. Mol Med 2010;16:425-432.
    • (2010) Mol Med , vol.16 , pp. 425-432
    • Wettergren, Y.1    Odin, E.2    Carlsson, G.3    Gustavsson, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.