Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: A case-control study in Taiwan

Carcinogenesis

Volumn 27, Issue 11, 2006, Pages 2295-2300

  Chou, Yu Ching ^a   Wu, Mei Hsuan ^a   Yu, Jyh Cherng ^b   Lee, Meei Shyuan ^a   Yang, Tsan ^c   Shih, Hsiu Lan ^a   Wu, Tsai Yi ^a   Sun, Chien An ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c MEIHO UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HORMONE; ORAL CONTRACEPTIVE AGENT; PYRIMIDINE NUCLEOTIDE;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; FOLATE METABOLISM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HISTOLOGY; HOMOZYGOTE; HOSPITAL; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MENOPAUSAL SYNDROME; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; STATISTICAL ANALYSIS; TAIWAN; VITAMIN BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; RADIOIMMUNOASSAY; RISK; TAIWAN;

EID: 33750475972     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgl108     Document Type: Article

References (43)

1. Zang,S., Hunter,D.J., Hankinson,S.E., Giovannucci,E.L., Rosner,B.A., Colditz,G.A., Speizer,F.E. and Willett,W.C. (1999) A prospective study of folate intake and risk of breast cancer. JAMA, 281, 1632-1637.
2. Rohan,T.E., Jain,M.G., Howe,G.R. and Miller,A.B. (2000) Dietary folate consumption and breast cancer risk. J. Natl Cancer Inst., 92, 266-269.
3. Sellers,T.A., Kushi,L.H., Cerhan,J.R., Vierkant,R.A., Gapstur,S.M., Vachon,C.M., Olson,J.E., Therneau,T.M. and Folsom,A.R. (2001) Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology, 12, 420-428.
4. Shrubsole,M.J., Jin,F., Dai,Q., Shu,X.O., Potter,J.D., Hebert,J.R., Gao,Y.T. and Zheng, W. (2001) Dietary folate intake and breast cancer risk: Results from the Shranghai Breast Cancer Study. Cancer Res., 61, 7136-7141.
5. Feigelson,H.S., Jonas,C.R., Robertson,A.S., McCullough,M.L., Thun,M.J. and Calle,E.E. (2003) Alcohol, folate, methionine, and risk of incident breast cancer in the American Cancer Society Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol. Biomarkers Prev., 12, 161-164.
6. Mason,J.B. and Levesque,T. (1996) Folate: Effects on carcinogenesis and potential for cancer chemoprevention. Oncology, 10, 1727-1736.
7. Friso,S., Choi,S.W., Girelli,D., Mason,J.B., Dolinikowski,G.G., Bagley,P.T., Olivieri,O., Jacques,P.F., Rosenberg,I.H., Corrocher,R. and Selhub,B.J. (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc. Natl Acad. Sci. USA, 99, 5606-5611.
8. Blount,B.C., Mack,M.M., Wehr,C.M., MacGregor,J.T., Hiatt,R.A., Wang,G., Wickramasinghe,S.N., Everson,R.B. and Ames,B.N. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neural damage. Proc. Natl Acad. Sci. USA, 94, 3290-3295.
9. Bailey,L.B. and Gregory,J.F. (1999) Polymorphisms of methylenetetra hydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement. J. Nutr., 129, 919-922.
10. Goyette,P., Pai,A., Milos,R., Frosst,P., Tran,P., Chen,Z., Chan,M. and Rozen,R. (1998) Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm. Genome, 9, 652-656.
11. Kim,Y.I. (2000) Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: A paradigm of gene-nutrient interactions in carcinogenesis. Nutr. Rev., 58, 205-209.
12. Frosst,P., Blom,H.J., Milos,P., Goyette,P., Sheppard,C.A., Matthews,R.G., Boers,G.J., den Heijer,M., Kluijtmans,L.A. and van den Heuvel,L,P. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet., 10, 111-113.
13. Weisberg,I., Iran,P., Christensen,B., Sibani,S. and Rozen,R. (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol. Genet. Metab., 64, 169-172.
14. Ma,J., Stampfer,M.J., Giovannucci,E., Artigas,C., Hunter,D.J., Fuchs,C., Willett,W., Selhub,J., Hennkens,C.H. and Rozen,R. (1997) Methylenetetra hydrofolate reductase polymorphism, dietary interactions and risk of colorectal cancer. Cancer Res., 57, 1098-1102.
15. Chen,J., Giovannucci,E.L. and Hunter,D.J. (1999) MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: An example of gene-environment interactions in colorectal tumorigenesis. J. Nutr., 129, 560-564.
16. Slattery,M.L., Potter,J.D., Samowitz,W., Schaffeer,D. and Leppert,M. (1999) Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol. Biomarkers Prev., 8, 513-518.
17. Skibola,C.F., Smith,M.T., Kane,E., Roman,E., Rallinson,S., Cartwright,R.A. and Morgan,G. (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc. Natl Acad. Sci. USA, 96, 12810-12815.
18. 450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometral cancer susceptibility. Carcinogenesis, 18, 2307-2311.
19. Piyathilake,C.J., Macaluso,M., Johanning,G.L., Whiteside,M., Heimburger,D.C. and Giulians,A. (2000) Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. Anticancer Res., 20, 1751-1757.
20. Song,C., Xing,D., Tan,W., Wei,Q. and Lin,D. (2001) Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Res., 61, 3272-3275.
21. Shen,H.B., Xu,Y.C., Zheng,Y.X., Qian,Y., Yu,R.B., Qian,Y., Wang,X.R., Spitz,M.R. and Wei,Q. (2001) Polymorphisms of 5,10-methylenetetra hydrofolate reductase and risk of gastric cancer in a Chinese population: A case-control study. Int. J. Cancer, 95, 332-336.
22. Lin,J., Spitz,M.R., Wang,Y., Schabath,M.B., Gorlov,I.P., Hernandez,L.M., Pillow,P.C., Grossman,H.B. and Wu,X. (2004) Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: A case-control study. Carcinogenesis, 25, 1639-1647.
23. Neumann,A.S., Lyons,H.J., Shen,H., Liu,Z., Shi,Q., Sturgis,E.M., Shete,S., Spitz,M.R., El-Naggar,A., Hong,W.K. and Wei,Q. (2005) Methylenetetra hydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: A case-control analysis. Int. J. Cancer, 115, 131-136.
24. Campbell,I.G., Baxter,S.W., Eccles,D.M. and Choong,D.Y. (2002) Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Res., 4, R14.
25. Ergul,E., Sazci,A., Utkan,Z. and Canturk,N.E. (2003) Polymorphisms in the MTHFR gene are associated with breast cancer. Tumor Biol., 24, 286-290.
26. Semenza,J.C., Delfino,R.J., Ziogas,A. and Anton-Culver,H. (2003) Breast cancer risk and methylenetetrahydrofolate reductase polymorphisms. Breast Cancer Res. Treat., 77, 217-223.
27. Gershoni-Baruch,R., Dagan,E., Israeli,D., Kasinetz,L., Kadouri,E. and Friedman,E. (2000) Association of the C677T polymorphism in the MTHFR gene with breast and or ovarian cancer risk in Jewish women. Ear. J. Cancer, 36, 2313-2316.
28. Shrubsole,M.J., Gao,Y.T., Cai,Q., Shu,X.O., Dai,Q., Hebert,J.R., Jin,F. and Zheng,W. (2004) MTHFR polymorphisms, dietary folate intake, and breast cancer risk: Results from the Shanghai Breast Cancer Study. Cancer Epidemiol. Biomarkers Prev., 13, 190-196.
29. Chen,J., Gammon,M.D., Chan,W., Palomeque,C., Wetmur,J.G., Kabat,G.C., Teitelbaum,S.L., Britton,J.A., Terry,M.B., Neugut,A.I. and Santella,R.M. (2005) One-carbon metabolism, MTHFR polymorphism and risk of breast cancer. Cancer Res., 65, 1606-1614.
30. Langsenlehner,U., Krippl,P., Renner,W., Yazdani-Biuki,B., Wolf,CT., Wascher,T.C., Paulweber,B., Weitzer,W. and Samonigg,H. (2003) The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk. Breast Cancer Res. Treat., 81, 169-172.
31. Le Marchand,L., Haiman,C.A., Wilkens,L.R., Kolonel,L.N. and Henderson,B.E. (2004) MTHFR polymorphisms, diet, HRT, and breast cancer risk: The multiethnic cohort study. Cancer Epidemiol. Biomarkers Prev., 13, 2071-2077.
32. Lee,S.A., Kang,D., Nishio,H., Lee,M.J., Kim,D.H., Han,W., Yoo,K.Y., Ahn,S.H., Choe,K.J., Hirvonen,A. and Noh,D.Y. (2004) Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women. Exp. Mol. Med., 36, 116-121.
33. Justenhoven,C., Hamann,U., Pierl,C.B., Rabstein,S., Pesch,B., Harth,V., Baisch,C., Vollmert,C., Illig,T., Bruning,T., Ko,Y. and Brauch,H. (2005) One-carbon metabolism and breast cancer risk: No association of MTHFR, MTR, and TYMS polymorphisms in the GENICA Study from Germany. Cancer Epidemiol. Biomarkers Prev., 14, 3015-3018.
34. Sharp,L., Little,J., Schofield,A.C., Pavlidou,E., Cotton,S.C., Miedzybrodzka,Z., Baird,J.O.C., Haites,N.E. and Grubb,D.A. (2002) Folate and breast cancer: The role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Cancer Lett., 181, 65-71.
35. Laird,P.W. and Jaenisch,R. (1994) DNA methylation and cancer. Hum. Mot. Genet., 3, 1487-1495.
36. Nass,S.J., Herman,J.G. and Gabrielson,E. (2000) Aberrant methylation of the estrogen receptor and E-cadherm 5′ CpG islands increase with malignant progression in human breast cancer. Cancer Res., 60, 4346-4349.
37. Yager,J.D. and Liehr,J.G. (1996) Molecular mechanism of estrogen carcinogensis. Ann. Rev. Pharmacol. Toxicol., 36, 203-232.
38. Chen,J., Ma,J., Stampfer,M.J., Palomeque,C., Selhub,J. and Hunter,D.J. (2000) Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contribution to risk of colorectal cancer. Pharmacogenetics, 12, 339-342.
39. Zhao,J.H. (2004) ILD, Genecounting and HAP: Computer programs for linkage disequilibrium analysis. Bioinformatics, 20, 1325-1326.
40. Kim,Y.I. (2004) Folate and DNA methylation: A mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol. Biomarkers Prev., 13, 511-519.
41. Narayanan,S., McConnell,J., Sharp.,L., Piyathilake,C.J., Power,H., Basten,G. and Duthie,S.J. (2004) Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. Cancer Epidemiol. Biomarkers Prev., 13, 1436-1443.
42. Fu,Y.P., Yu,J.C., Cheng,T.C., Lou,M.A., Hsu,G.C., Wu,C.Y., Chen,S.T., Wu,H.S., Wu,P.E. and Shen,C.T. (2003) Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: A multigenic study on cancer susceptibility. Cancer Res., 63, 2440-2446.
43. Han,J., Hankinson,S.E., Ranu,H., De Vivo,I. and Hunter,D.J. (2004) Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study. Carcinogenesis, 25, 189-195.