Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer

Breast Cancer Research

Volumn 4, Issue 6, 2002, Pages

  Campbell, Ian G ^a   Baxter, Simon W ^a   Eccles, Diana M ^b   Choong, David Y H ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b PRINCESS ANNE HOSPITAL   (United Kingdom)

Author keywords

Breast cancer; MTHFR; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALANINE; VALINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXIDOREDUCTASE;

ADULT; AGED; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MTHFR GENE; RISK ASSESSMENT; DNA METHYLATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED;

ADULT; AGED; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, GENETIC;

EID: 84925549046     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr457     Document Type: Article

References (20)

1. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen RA: Candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet. 1995, 10: 111-113.
2. Chen J, Giovannucci EL, Hunter DJ: MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. J Nutr. 1999, 129: 560-564.
3. Potter JD: Colorectal cancer: molecules and populations. J Natl Cancer Inst. 1999, 91: 916-932. 10.1093/jnci/91.11.916.
4. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN: Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA. 1997, 94: 3290-3295. 10.1073/pnas.94.7.3290.
5. Slattery ML, Potter JD, Samowitz W, Schaffer D, Leppert M: Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 1999, 8: 513-518.
6. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G: Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA. 1999, 96: 12810-12815. 10.1073/pnas.96.22.12810.
7. Esteller M, Garcia A, Martinez-Palones JM, Xercavins J, Reventos J: Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility. Carcinogenesis. 1997, 18: 2307-2311. 10.1093/carcin/18.12.2307.
8. Piyathilake CJ, Macaluso M, Johanning GL, Whiteside M, Heimburger DC, Giuliano A: Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraep-ithelial neoplasia. Anticancer Res. 2000, 20: 1751-1757.
9. Kundu TK, Rao MR: CpG islands in chromatin organization and gene expression. J Biochem. 1999, 125: 217-222.
10. Lengauer C, Kinzler KW, Vogelstein B: DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci USA. 1997, 94: 2545-2550. 10.1073/pnas.94.6.2545.
11. Cheng P, Schmutte C, Cofer KF, Felix JC, Yu MC, Dubeau L: Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis. Br J Cancer. 1997, 75: 396-402.
12. Stern LL, Mason JB, Selhub J, Choi SW: Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev. 2000, 9: 849-853.
13. Rohan TE, Jain MG, Howe GR, Miller AB: Dietary folate consumption and breast cancer risk. J Natl Cancer Inst. 2000, 92: 266-269. 10.1093/jnci/92.3.266.
14. Zhang S, Hunter DJ, Hankinson SE, Giovannucci EL, Rosner BA, Colditz GA, Speizer FE, Willett WCA: Prospective study of folate intake and the risk of breast cancer. JAMA. 1999, 281: 1632-1637. 10.1001/jama.281.17.1632.
15. Goodman JE, Lavigne JA, Wu K, Helzlsouer KJ, Strickland PT, Selhub J, Yager JD: COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk. Carcinogenesis. 2001, 22: 1661-1665. 10.1093/carcin/22.10.1661.
16. Negri E, La Vecchia C, Franceschi S: Re: dietary folate consumption and breast cancer risk. J Natl Cancer Inst. 2000, 92: 1270-1271. 10.1093/jnci/92.15.1270-a.
17. Gershoni-Baruch R, Dagan E, Israeli D, Kasinetz L, Kadouri E, Friedman E: Association of the C677T polymorphism in the MTHFR gene with breast and/or ovarian cancer risk in Jewish women. Eur. Cancer. 2000, 36: 2313-2316. 10.1016/S0959-8049(00)00306-3.
18. Sharp L, Little J, Schofield AC, Pavlidou E, Cotton SC, Miedzybrodzka Z, Baird JO, Haites NE, Heys SD, Grubb DA: Folate and breast cancer: the role of polymorphisms in methylenete-trahydrofolate reductase (MTHFR). Cancer Lett. 2002, 181: 65-71. 10.1016/S0304-3835(02)00030-7.
19. Eccles DM, Englefield P, Soulby MA, Campbell IG: BRCA1 mutations in southern England. Br J Cancer. 1998, 77: 2199-2203.
20. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R: Methylenete-trahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res. 1997, 57: 1098-1102.