The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: A nested case-control study in Taiwan

Anticancer Research

Volumn 24, Issue 6, 2004, Pages 3863-3868

  Lin, Wei Yu ^a   Chou, Yu Ching ^a   Wu, Mei Hsuan ^a   Huang, Han Bin ^a   Jeng, Yi Lin ^a   Wu, Cho Chieh ^a   Yu, Cheng Pung ^b   Yu, Jyh Cherng ^b   You, San Lin ^c   Chu, Tang Yuan ^b   Chen, Chien Jen ^c   Sun, Chien An ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Breast cancer; Estrogen exposure; MTHFR; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ESTROGEN; ORAL CONTRACEPTIVE AGENT; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TAIWAN; THIRD TRIMESTER PREGNANCY; BREAST TUMOR; CASE CONTROL STUDY; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; MALE; MENARCHE; MIDDLE AGED; PHYSIOLOGY;

ADULT; BREAST NEOPLASMS; CASE-CONTROL STUDIES; ESTROGENS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MENARCHE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; TAIWAN;

EID: 14944380160     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kim YI: Folate and carcinogenesis: Evidence, mechanisms, and implications. J Nutr Biochem 10: 66-88, 1999.
2. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB and Ames BN: Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94: 3290-3295, 1997.
3. Bailey LB and Gregory JF: Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutr 129: 919-922, 1999.
4. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, Denheijer M, Kluijtmans LAJ, Vandenheuvel LP and Rozen R: A candidate genetic risk factor for vascular-disease - a common mutation in methylenetetrahydrofolate reductase. Nature Genet 10: 111-113, 1995.
5. Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC and Hunter DJ: A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 56: 4862-4864, 1996.
6. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA and Morgan G: Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 96: 12810-12815, 1999.
7. Jeng YL, Wu MH, Huang HB, Lin WY, You SL, Chu TY, Chen CJ and Sun CA: The methylenetetrahydrofolate reductase 677C -> T polymorphism and lung cancer risk in a Chinese population. Anticancer Res 23: 5149-5152, 2003.
8. Shen HB, Xu YC, Zheng YX, Qian Y, Yu RB, Qin Y, Wang XR, Spitz MR and Wei QY: Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of gastric cancer in a Chinese population: A case-control study. Int J Cancer 95: 332-336, 2001.
9. Esteller M, Garcia A, Martinez-Palones JM, Xercavins J and Reventos J: Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility. Carcinogenesis 18: 2307-2311, 1997.
10. Henderson BE and Feigelson HS: Hormonal carcinogenesis. Carcinogenesis 21: 427-433, 1996.
11. Yager JD and Liehr JG: Molecular mechanisms of estrogen carcinogenesis. Annu Rev Pharmacol Toxicol 36: 203-232, 1996.
12. Chen CJ, Lu SN, You SL, Wu MH, Wang LY, Lee LT, Huang GT, Yang PM and Lee HS: Community-based hepatocellular carcinoma screening in seven townships in Taiwan. J Formos Med Assoc 94 (Suppl. 2): S94-S102, 1995.
13. Yu MW, Yang YC, Yang SY, Cheng SW, Liaw YF, Lin SM and Chen CJ: Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men. J Natl Cancer Inst 93: 1644-1651, 2001.
14. Rothman KJ: Modern Epidemiology. Boston, MA: Little, Brown and Company, pp.322-326, 1986.
15. Hosmer DW and Lemeshow S: Confidence interval estimation of interaction. Epidemiology 3: 452-456, 1992.
16. Apter D, Reinila M and Vihko R: Some endocrine characteristics of early menarche, a risk factor for breast-cancer, are preserved into adulthood. Int J Cancer 44: 783-787, 1989.
17. Russo J, Tay LK and Russo IH: Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 2: 5-73, 1982.
18. Colditz GA and Frazier AL: Models of breast cancer show that risk is set by events of early-life: prevention efforts must shift focus. Cancer Epidemiol Biomarkers Prev 4: 567-571, 1995.
19. Bernstein L, Yuan JM, Ross RK, Pike MC, Hanisch R, Lobo R, Stanczyk F, Gao YT and Henderson BE: Serum hormone levels in pre-menopausal Chinese women in Shanghai and white women in Los Angeles: results from two breast cancer case-control studies. Cancer Causes Control 1: 51-58, 1990.
20. Shrubsole MJ, Gao YT, Cai QY, Shu XO, Dai Q, Hebert JR, Jin F and Zheng W: MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai breast cancer study. Cancer Epidemiol Biomarkers Prev 13: 190-196, 2004.
21. Sharp L, Little J, Schofield AC, Pavlidou E, Cotton SC, Miedzybrodzka Z, Baird JOC, Haites NE, Heys SD and Grubb DA: Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Cancer Lett 181: 65-71, 2002.
22. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH and Rozen R: Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57: 1098-1102, 1997.