Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women

African Health Sciences

Volumn 12, Issue 2, 2012, Pages 204-209

  Diakite, B ^a   Tazzite, A ^a   Hamzi, K ^a   Jouhadi, H ^b   Nadifi, S ^a  

^a HASSAN II UNIVERSITY   (Morocco)

^b IBN ROCHD UNIVERSITY HOSPITAL   (Morocco)

Author keywords

Breast neoplasm; Morocco; MTHFR polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); PROGESTERONE RECEPTOR;

ARTICLE; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENZYME POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSE; MOROCCO; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PREMENOPAUSE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SAMPLE SIZE; STATISTICAL SIGNIFICANCE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MENOPAUSE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MOROCCO; ODDS RATIO; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, PROGESTERONE; RISK FACTORS; SPECTROPHOTOMETRY;

EID: 84864353046     PISSN: 16806905     EISSN: None     Source Type: Journal    
DOI: 10.4314/ahs.v12i2.20     Document Type: Article

References (19)

1. Benider A, Bennani Othmani M, Harif M, Karkouri M, Quessar A, Sahraoui S, Sqalli S. Registre des cancers de la région du Grand Casablanca, Année 2004. Association Lalla Salma 2007.
2. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000; 343:78-85.
3. Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997; 94:3290-3295.
4. Kim YI. Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev 1999; 57:314-321.
5. Stern LL, Mason JB, Selhub J, Choi SW. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 2000; 9(8):849-853.
6. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767.
7. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3(6): 415-428.
8. Jan C. Semenza, Ralph J. Delfino, et al. Breast cancer risk and methylenetetrahydrofolate reductase polymorphism. Breast Cancer Res Treat 2003; 77: 217-223.
9. Carvalho-Silva DR, Santos FR, Rocha J, Pena SD. The phylogeography of Brazilian Ychromosome lineages. Am J Hum Genet 2001; 68: 281-286
10. Frosst P, Blom HJ, Milos R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10:111-113.
11. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 1998; 95(22):13217-13220
12. Schneider JA, Rees DC, Liu YT, Clegg JB. Worldwide distribution of a common methylenetetrahydrofolate reductase mutation. Am J Hum Genet 1998; 62 (5):1258-1260.
13. Langsenlehner U, Krippl P, Renner W, et al. The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk. Breast Cancer Res Treat 2003; 81: 169-172
14. Batschauer AP, Cruz NG, Oliveira VC, et al. HEF, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women. Mol Cell Biochem 2011.
15. Qi X, Ma X, Yang X, et al. Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a metaanalysis from 41 studies with 16,480 cases and 22,388 controls. Breast Cancer Res Treat 2010; 123:499-506
16. Macis D, Maisonneuve P, Johansson H, et al. Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis. Breast Cancer Res Treat 2007; 106:263-271
17. Lin WY, Chou YC, Wu MH, Huang HB, Jeng YL, Wu CC, Yu CP, Yu JC, You SL, Chu TY, Chen CJ, Sun CA. The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan. Anticancer Res 2004; 24(6):3863-3868.
18. Maruti SS, Ulrich CM, Jupe ER, White E. MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study. Breast Cancer Res 2009; 11(6):R91.
19. Zhang J, Qiu LX, Wang ZH, et al. MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls. Breast Cancer Res Treat 2010; 123:549-555.