No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study

European Journal of Clinical Nutrition

Volumn 64, Issue 1, 2010, Pages 108-110

  Bentley, A R ^a   Raiszadeh, F ^a   Stover, P J ^a   Hunter, D J ^b,c   Hankinson, S E ^b,c   Cassano, P A ^a  

^a Department of Obstetrics Gynecology   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Breast cancer; CSHMT; Folate; MTHFR

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; CYTIDINE; ESTROGEN RECEPTOR; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; HOMOCYSTEINE; PROGESTERONE RECEPTOR; PYRIDOXINE; THYMIDINE;

ARTICLE; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; TUMOR VOLUME; VITAMIN BLOOD LEVEL;

BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLYCINE HYDROXYMETHYLTRANSFERASE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NURSES; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 75049085990     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2009.104     Document Type: Article

References (9)

1. Chen J, Gammon MD, Chan W, Palomeque C,Wetmur JG, Kabat GC et al. (2005). One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 65, 1606-1614.
2. Han J, Hankinson SE, Ranu H, De Vivo I, Hunter DJ (2004). Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study. Carcinogenesis 25, 189-195.
3. Herbig K, Chiang EP, Lee LR, Hills J, Shane B, Stover PJ (2002). Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem 277, 38381-38389.
4. Lewis SJ, Ebrahim S, Davey Smith G (2005). Meta-analysis of MTHFR 677C-4T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ 331, 1053.
5. Lim U, Peng K, Shane B, Stover PJ, Litonjua AA,Weiss ST et al. (2005). Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr 135, 1989-1994.
6. Lissowska J, Gaudet MM, Brinton LA, Chanock SJ, Peplonska B, Welch R et al. (2007). Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses. Int J Cancer 120, 2696-2703.
7. Shrubsole MJ, Gao YT, Cai Q, Shu XO, Dai Q, Hébert JR et al. (2004). MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 13, 190-196.
8. Skibola CF, Smith MT, Hubbard A, Shane B, Roberts AC, Law GR et al. (2002). Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood 99, 3786-3791.
9. Zhang SM,Willett WC, Selhub J, Hunter DJ, Giovannucci EL, Holmes MD et al. (2003). Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst 95, 373-380.