The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans

American Journal of Human Genetics

Volumn 70, Issue 3, 2002, Pages 758-762

  Rosenberg, Nurit ^a   Murata, Mitsuru ^b   Ikeda, Yasuo ^b   Opare Sem, Ohene ^c   Zivelin, Ariella ^a   Geffen, Eli ^d   Seligsohn, Uri ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b KEIO UNIVERSITY   (Japan)

^c KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LYMPHOCYTIC LEUKEMIA; AFRICA; ALLELE; ARTERY THROMBOSIS; ARTICLE; COLON CANCER; EXON; FETUS WASTAGE; FOLIC ACID DEFICIENCY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; HYPERHOMOCYSTEINEMIA; INTRON; JAPAN; MULTIINFARCT DEMENTIA; NEURAL TUBE DEFECT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VEIN THROMBOSIS;

PIERINAE;

EID: 0036178211     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/338932     Document Type: Article

References (26)

1. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
2. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review
3. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis
4. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
5. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
6. Low folate levels and thermolabile methylenetetrahydrofolate reductase as primary determinant of mild hyperhomocystinemia in normal and thromboembolic subjects
7. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
8. Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification
9. Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent: The Nimes obstetricians and haematologists study 5 (NOHA5)
10. V677 mutation of methylenetetrahydro-folate reductase and cardiovascular disease in Canadian Inuit
11. Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: An examination of C677T and A1298C mutations
12. The prevalence and linkage disequilibrium of three methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms varies in different ethnic groups
13. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
14. Genetic selection and folate intake during pregnancy
15. Genetic risk factor for unexplained recurrent early pregnancy loss
16. Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-methylenetetrahydrofolate reductase
17. Inherited disorders of folate and cobalamin transport and metabolism
18. Cobalamine and folate deficiency: Acquired and hereditary disorders in children
19. Thrombophilia as a multigenic disorder
20. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults
21. Association between platelet glycoprotein Ibα genotype and ischemic cerebrovascular disease
22. Is the common C677T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis
23. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
24. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia
25. Hyperhomocysteinemia: A risk factor in women with unexplained recurrent loss
26. Pathogenicity of thermolabile methylenetetrahydro-folate reductase for vascular dementia