Investigations on the pharmacokinetics of α-lipoic acid in healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 12, 1998, Pages 625-628

  Teichert, J ^a   Kern, J ^b   Tritschler, H J ^b   Ulrich, H ^b   Preiss R ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b ASTA MEDICA AG   (Germany)

Author keywords

lipoic acid; Absolute bioavailability; Pharmacokinetics; Thioctic acid

Indexed keywords

THIOCTIC ACID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; ELECTROCHEMICAL DETECTION; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TABLET;

ADMINISTRATION, ORAL; ADULT; ANTIOXIDANTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; REFERENCE VALUES; THIOCTIC ACID;

EID: 0031743135     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Gleiter CH, Schug BS, Hermann R, Elze M, Blume HH, Gundert-Remy U 1996 Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur J Clin Pharmacol 50: 513-514
2. Locher M, Busker E, Borbe HO 1995 Metabolism of α-lipoic acid in human volunteers. Naunyn-Schmiedebergs Arch Pharmacol 351: R 52
3. 14C)rac-α-lipoic acid from in situ ligated segments of the gastrointestinal tract of the rat. Arzneim Forsch/Drug Res 45: 293-299
4. Hermann R, Niebch G, Borbe HO, Fieger-Büschges H, Ruus P, Nowak H, Riethmüller-Winzen H, Peukert M, Blume H 1996 Enantioselective pharmacokinetics and bioavailability of different racemic α-lipoic acid formulations in healthy volunteers. Eur J Pharm Sci 4: 167-174
5. Teichert J, Baumann F, Preiß R 1991 Determination of lipoic acid in human plasma. Naunyn-Schmiedebergs Arch Pharmacol 344 (Suppl): R 91
6. Teichert J, Preiß R 1992 HPLC-methods for determination of lipoic acid and its reduced form in human plasma. Int J Clin Pharmacol Ther Toxicol 30: 511-512
7. Teichert J, Preiß R 1995 Determination of lipoic acid in human plasma by high-performance liquid chromatography with electrochemical detection. J Chromatogr B 672: 277-281
8. Teichert J, Preiß R 1997 Studies on the metabolism of α-lipoic acid in humans. Naunyn-Schmiedebergs Arch Pharmacol 355 (Suppl 4): R 121
9. Ziegler D, Hanefeld M, Ruhnau KJ, Meißner HP, Lobisch M, Schütte K, Gries FA, The ALADIN Study Group 1995 Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid. Diabetologia 38: 1425-1433