Differential effects of the antioxidant α-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells

Molecular Immunology

Volumn 38, Issue 10, 2002, Pages 733-745

  Pack, Robert A ^a   Hardy, Kristine ^a   Madigan, Michele C ^b   Hunt, Nicholas H ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b SYDNEY EYE HOSPITAL   (Australia)

Author keywords

Apoptosis; Cell proliferation; Interleukin 2; Leukaemia; Lipoic acid; Lymphocyte; Redox regulation

Indexed keywords

ANTIOXIDANT; INTERLEUKIN 2; IONOMYCIN; MESSENGER RNA; MITOGENIC AGENT; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; THIOCTIC ACID;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA SYNTHESIS; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; STEADY STATE; T LYMPHOCYTE;

ANTIOXIDANTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IONOMYCIN; IONOPHORES; JURKAT CELLS; LEUKEMIA, T-CELL; LYMPHOCYTE ACTIVATION; MITOGENS; OXIDATION-REDUCTION; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; THIOCTIC ACID;

EID: 0036178013     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(01)00110-9     Document Type: Article

References (58)

1. The interplay between lymphoid-specific and ubiquitous transcription factors controls the expression of interleukin-2 gene in T lymphocytes
2. Factors influencing the oxidation of cysteamine and other thiols: Implications for hyperthermic sensitization and radiation protection
3. α-Lipoic acid in liver metabolism and disease
4. Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation
5. Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin
6. Single-step method of RNA isolation by acid-guanidium thiocyanate-phenol-chloroform extraction
7. Induction of apoptosis by sodium butyrate in the human Y-79 retinoblastoma cell line
8. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry
9. Inhibition of murine T cell responses by anti-oxidants: The targets of lipo-oxygenase pathway inhibitors
10. Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1-infected patients
11. Stimulation of glucose uptake by the natural coenzyme α-lipoic acid/thioctic acid: Participation of elements of the insulin signaling pathway
12. The generation of oxygen radicals: A positive signal for lymphocyte activation
13. Transcription factors as targets for oxidative signaling during lymphocyte activation
14. Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis
15. α-Lipoic acid increases intracellular glutathione in a human T lymphocyte Jurkat cell line
16. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
17. α-Lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium, and release into the culture medium
18. Redox regulation of gene expression in mitogen-activated T lymphocytes
19. Role of copper in the oxygen radical-mediated toxicity of the thiol-containing radioprotector dithiothreitol in mammalian cells
20. Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells
21. Role of Fenton chemistry in thiol-induced toxicity and apoptosis
22. Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells: Convergence of costimulatory signals and differences from transformed T cells
23. Interference with oxidative processes inhibits proliferation of human peripheral blood lymphocytes and murine B lymphocytes
24. Thiol-mediated redox regulation of lymphocyte proliferation: Possible involvement of adult T cell leukaemia-derived factor and glutathione in transferrin receptor expression
25. Inhibition of drug-naive and resistant leukaemia cell proliferation by low molecular weight thiols
26. Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content
27. Apoptosis: Its significance in cancer and cancer therapy
28. Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T cell leukaemia patients
29. Lectins and superantigens: Membrane interactions of these compounds with T lymphocytes affect immune responses
30. Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants α-lipoic acid and N-acetylcysteine
31. Selective in vitro growth of T lymphocytes from normal human bone marrows
32. Hydroxyl radical scavengers inhibit lymphocyte mitogenesis
33. α-Lipoic acid as a biological antioxidant
34. α-Lipoic acid: A metabolic antioxidant and potential redox modulator of transcription
35. Oxygen and the control of gene expression
36. Endogenous oxygen radicals modulate protein tyrosine phosphorylation and JNK-1 activation in lectin-stimulated thymocytes
37. Stimulation of cardiac glucose transport by thioctic acid and insulin
38. Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis
39. Oxidative phenomena are implicated in human T cell stimulation
40. Antioxidant and redox regulation of gene transcription
41. Regulation of cellular thiols in human lymphocytes by α-lipoic acid: A flow cytometric analysis
42. Fas-mediated apoptosis of human Jurkat T cells: Intracellular events and potentiation by redox-active α-lipoic acid
43. The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
44. Interleukin-2
45. Glutathione deficiency and human immunodeficiency virus infection
46. Intracellular glutathione levels in T cell subsets decrease in HIV-infected individuals
47. Redox regulation of signal transduction: Tyrosine phosphorylation and calcium influx
48. Redox regulation of transcriptional activators
49. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens
50. α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells
51. Redox regulation of NF-κB DNA-binding activity by dihydrolipoate
52. Factors influencing the oxidation of the radioprotector WR-1065
53. Specificity of radioprotective and cytotoxic effects of cysteamine in hela cells: Generation of peroxide as the mechanism of paradoxical toxicity
54. The IL-2/IL-2 receptor system: A current overview
55. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester
56. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by α-lipoic acid in 3T3-L1 adipocytes