Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A

Biogerontology

Volumn 10, Issue 4, 2009, Pages 443-456

  Petersen Shay, Kate ^a   Hagen, Tory M ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Aging; Alpha lipoic acid; Oxidative stress; Phosphatase; PI3 kinase; PKB Akt

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; SERINE; THIOCTIC ACID; THREONINE;

AGE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL AGING; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; GLUCOSE UTILIZATION; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT;

AGE FACTORS; AGING; ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; HEPATOCYTES; INSULIN; MALE; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, INBRED F344; SERINE; SIGNAL TRANSDUCTION; THIOCTIC ACID;

EID: 67649646949     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-008-9187-x     Document Type: Article

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