Rheology as a tool for evaluation of melt processability of innovative dosage forms

International Journal of Pharmaceutics

Volumn 494, Issue 2, 2015, Pages 623-642

  Aho, Johanna ^a   Boetker, Johan P ^a   Baldursdottir, Stefania ^a   Rantanen, Jukka ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

3D printing; Hot melt extrusion; Polymers; Process design; Rheology; Rheometry

Indexed keywords

ACETYLSALICYLIC ACID; CARBAMAZEPINE; CARVEDILOL; DICLOFENAC; EFAVIRENZ; EXCIPIENT; GRISEOFULVIN; IBUPROFEN; INDOMETACIN; ITRACONAZOLE; LAMIVUDINE; PARACETAMOL; PHENAZONE; POLYMER; TRAMADOL; ZIDOVUDINE;

CAPILLARY; CHEMICAL INTERACTION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DOSAGE FORM; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG SOLUBILITY; FLOW KINETICS; FLOW MEASUREMENT; GLASS TRANSITION TEMPERATURE; HOT MELT EXTRUSION; KINEMATICS; MISCIBILITY; MOLECULAR WEIGHT; MOLECULE; OSCILLATION; PARAMETERS; PELLET EXTRUSION; PERSONALIZED MEDICINE; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS MODEL; REVIEW; SHEAR FLOW; SHEAR RATE; SHEAR STRENGTH; SHEAR STRESS; SMALL ANGLE OSCILLATORY SHEAR; STEADY STATE; TEMPERATURE DEPENDENCE; THREE DIMENSIONAL PRINTING; TIME; VISCOELASTICITY; VISCOSITY; CHEMISTRY; DEVICES; DRUG DELIVERY SYSTEM; HEAT; HUMAN; PHARMACEUTICS;

DRUG DELIVERY SYSTEMS; EXCIPIENTS; HOT TEMPERATURE; HUMANS; POLYMERS; PRINTING, THREE-DIMENSIONAL; RHEOLOGY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84941985904     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.02.009     Document Type: Review

References (128)

1. J. Aho Rheological Characterization of Polymer Melts in Shear and Extension: Measurement Reliability and Data for Practical Processing. Ph.D. Thesis 2011 Tampere University of Technology, Department of Materials Science Tampere, Finland
2. J. Aho, and S. Syrjala Evaluation of different methods for determining the entrance pressure drop in capillary rheometry Appl. Rheol. 18 2008 632581 632585
3. J. Aho, and S. Syrjala On the measurement and modeling of viscosity of polymers at low temperatures Polym. Test. 27 2008 35 40
4. J. Aho, V.H. Rolon-Garrido, S. Syrjala, and M.H. Wagner Measurement technique and data analysis of extensional viscosity for polymer melts by Sentmanat extensional rheometer (SER) Rheol. Acta 49 2010 359 370
5. J. Aho, M. Edinger, J.P. Boetker, S. Baldursdottir, and J. Rantanen Solubility of small-molecule drugs into polymer excipients in hot melt extruded dosage forms A. Sorvari, The Nordic Rheology Conference 2014 Reykjavik Iceland 55 59
6. C. Aitken-Nichol, F. Zhang, and J. McGinity Hot melt extrusion of acrylic films Pharm. Res. 13 1996 804 808
7. N.J. Alvarez, J.M.R. Marin, Q. Huang, M.L. Michelsen, and O. Hassager Creep measurements confirm steady flow after stress maximum in extension of branched polymer melts Phys. Rev. Lett. 2013 110
8. G.P. Andrews, D.S. Jones, O. Abu Diak, C.P. McCoy, A.B. Watts, and J.W. McGinity The manufacture and characterisation of hot-melt extruded enteric tablets Eur. J. Pharm. Biopharm. 69 2008 264 273
9. S.L. Anna, and G.H. McKinley Elasto-capillary thinning and breakup of model elastic liquids J. Rheol. 45 2001 115 138
10. A. Bach, H.K. Rasmussen, and O. Hassager Extensional viscosity for polymer melts measured in the filament stretching rheometer J. Rheol. 47 2003 429 441
11. E.B. Bagley End corrections in the capillary flow of polyethylene J. Appl. Phys. 28 1957 624 627
12. B. Bahramian, G.H. Motlagh, S.S. Majidi, B. Kaffashi, S.A. Nojoumi, and I. Haririan Evaluation of melt rheology of lactose-filled polyethylene glycol composites by means of capillary rheometery Pharm. Dev. Technol. 18 2013 98 105
13. D.G. Baird The role of extensional rheology in polymer processing Korea-Aust. Rheol. J. 11 1999 305 311
14. H. Bechgaard, and G.H. Nielsen Controlled-release multiple-units and single-unit doses - literature-review Drug Dev. Ind. Pharm. 4 1978 53 67
15. B. Berman 3-D printing: the new industrial revolution Bus. Horiz. 55 2012 155 162
16. S. Bialleck, and H. Rein Preparation of starch-based pellets by hot-melt extrusion Eur. J. Pharm. Biopharm. 79 2011 440 448
17. D.M. Binding An approximate analysis for contraction and converging flows J. Non-Newton. Fluid Mech. 27 1988 173 189
18. J. Breitenbach Melt extrusion: from process to drug delivery technology Eur. J. Pharm. Biopharm. 54 2002 107 117
19. C. Capone, L. Di Landro, F. Inzoli, M. Penco, and L. Sartore Thermal and mechanical degradation during polymer extrusion processing Polym. Eng. Sci. 47 2007 1813 1819
20. D. Cardozo A brief history of the filling simulation of injection moulding Proc. Inst. Mech. Eng. C J. Mech. Eng. Sci. 223 2009 711 721
21. H. Chmiel, and P. Schummer New method for evaluation of tube rheometer data Chem. Ing. Tech. 43 1971 1257 1259
22. R.J. Chokshi, H.K. Sandhu, R.M. Iyer, N.H. Shah, A.W. Malick, and H. Zia Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion processs as a means to manufacture solid dispersion/solution J. Pharm. Sci. 94 2005 2463 2474
23. N. Chomcharn, and M. Xanthos Properties of aspirin modified enteric polymer prepared by hot-melt mixing Int. J. Pharm. 450 2013 259 267
24. F. Cilurzo, I.E. Cupone, P. Minghetti, F. Selmin, and L. Montanari Fast dissolving films made of maltodextrins Eur. J. Pharm. Biopharm. 70 2008 895 900
25. S.D. Clas, C.R. Dalton, and B.C. Hancock Differential scanning calorimetry: applications in drug development Pharm. Sci. Technol. Today 2 1999 311 320
26. F.N. Cogswell Converging flow of polymer melts in extrusion dies Polym. Eng. Sci. 12 1972 64 73
27. F.N. Cogswell Stretching flow instabilities at exits of extrusion dies J. Non-Newton. Fluid Mech. 2 1977 37 47
28. W.P. Cox, and E.H. Merz Correlation of dynamic and steady flow viscosities J. Polym. Sci. 28 1958 619 622
29. D.Q.M. Craig, and F.A. Johnson Pharmaceutical applications of dynamic-mechanical thermal-analysis Thermochim. Acta 248 1995 97 115
30. M.M. Crowley, F. Zhang, M.A. Repka, S. Thumma, S.B. Upadhye, S.K. Battu, J.W. McGinity, and C. Martin Pharmaceutical applications of hot-melt extrusion: part I Drug Dev. Ind. Pharm. 33 2007 909 926
31. A.L. Darling, and W. Sun 3D microtomographic characterization of precision extruded poly-epsilon-caprolactone scaffolds J. Biomed. Mater. Res. B 70B 2004 311 317
32. C. De Brabander, G. Van den Mooter, C. Vervaet, and J.P. Remon Characterization of ibuprofen as a nontraditional plasticizer of ethyl cellulose J. Pharm. Sci. 91 2002 1678 1685
33. J.M. Dealy, and R.G. Larson Linear Viscoelasticity - Behavior of Molten Polymers, Structure and rheology of molten polymers - From Structure to Flow Behavior and Back Again 2006 Carl Hanser Verlag Munich 131 191
34. J.M. Dealy, and R.G. Larson Nonlinear Viscoelasticity, Structure and Rheology of Molten Polymers - From Structure to Flow Behavior and Back Again 2006 Carl Hanser Verlag Munich 329 413
35. J.M. Dealy, and R.G. Larson Structure and Rheology of Molten Polymers - From Structure to Flow Behavior and Back Again 2006 Carl Hanser Verlag Munich
36. J.M. Dealy, and K.F. Wissbrun Extensional Flow Properties and Their Measurement, Melt Rheology and Its Role in Plastics Processing-theory and Applications 1999 Kluwer Academic Publishers Dordrecht 231 267
37. J.M. Dealy, and K.F. Wissbrun Flow in Capillaries, Slits and Dies, Melt Rheology and Its Role in Plastics Processing-theory and Applications 1999 Kluwer Academic Publishers Dordrecht 298 344
38. J.M. Dealy, and K.F. Wissbrun Linear Viscoelasticity, Melt Rheology and Its Role in Plastics Processing-Theory and Applications 1999 Kluwer Academic Publishers Dordrecht 42 101
39. J.M. Dealy, and K.F. Wissbrun Melt Rheology and Its Role in Plastics Processing-theory and Applications 1999 Kluwer Academic Publishers Dordrecht
40. J.M. Dealy, and K.F. Wissbrun Role of Rheology in Extrusion, Melt Rheology and Its Role in Plastics Processing-Theory and Applications 1999 Kluwer Academic Publishers Dordrecht 441 489
41. J.P. Dealy Time-temperature superposition - a users guide Rheol. Bull. 78 2009 16 31
42. A. Eitzlmayr, J. Khinast, G. Horl, G. Koscher, G. Reynolds, Z.Y. Huang, J. Booth, and P. Shering Experimental characterization and modeling of twin-screw extruder elements for pharmaceutical hot melt extrusion AIChE J. 59 2013 4440 4450
43. N. El Kissi, and J.M. Piau Adhesion of linear low density polyethylene for flow regimes with sharkskin J. Rheol. 38 1994 1447 1463
44. N. Elkissi, and J.M. Piau The different capillary-flow regimes of entangled polydimethylsiloxane polymers - macroscopic slip at the wall hysteresis and cork flow J. Non-Newton. Fluid Mech. 37 1990 55 94
45. J.D. Ferry Dependence of Viscoelastic Behavior on Temperature and Pressure, Viscoelastic Properties of Polymers third ed. 1980 Wiley New York 264 320
46. S. Filipe, B. Knogler, K. Buchmann, and M. Obadal Shear and extensional flows as drivers for the crystallisation of isotactic polypropylene J. Therm. Anal. Calorim. 98 2009 667 674
47. A. Forster, J. Hempenstall, I. Tucker, and T. Rades Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis Int. J. Pharm. 226 2001 147 161
48. Franck, A., 2007. The ARES-EVF: Option for Measuring Extensional Viscosity of Polymer Melts, http://www.tainstruments.com/pdf/literature/APN002-V2-ARES-EVF-to-measure-elongation-viscosity.pdf.
49. H. Giesekus, and G. Langer Determination of real flow curves of non-Newtonian liquids and plastic materials using method of representative viscosity Rheol. Acta 16 1977 1 22
50. C.G. Gogos, and B. Maxell Velocity profiles of the exit region of molten polyethylene extrudates Polym. Eng. Sci. 6 1966 353 358
51. A. Goyanes, A.B.M. Buanz, A.W. Basit, and S. Gaisford Fused-filament 3D printing (3DP) for fabrication of tablets Int. J. Pharm. 476 2014 88 92
52. B.C. Gross, J.L. Erkal, S.Y. Lockwood, C.P. Chen, and D.M. Spence Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences Anal. Chem. 86 2014 3240 3253
53. J.C. Gutierrez-Rocca, and J.W. McGinity Influence of aging on the physical-mechanical properties of acrylic resin films cast from aqueous dispersions and organic solutions Drug Dev. Ind. Pharm. 19 1993 315 332
54. A. Haddout, and G. Villoutreix Polymer melt rheology at high shear rates Int. Polym. Process. 15 2000 291 296
55. Q. Hamid, J. Snyder, C. Wang, M. Timmer, J. Hammer, S. Guceri, and W. Sun Fabrication of three-dimensional scaffolds using precision extrusion deposition with an assisted cooling device Biofabrication 3 2011
56. U. Hanenberg, O. Schinzinger, H. Maier, and S. Junkering Usage of pharmaceutical extrudates in the manufacturing of drug products Pharm. Ind. 75 2013 319 326
57. H. Hinsken, S. Moss, J.R. Pauquet, and H. Zweifel Degradation of polyolefins during melt processing Polym. Degrad. Stabil. 34 1991 279 293
58. J.M. Kaschta Measuring the elongational properties of polymer melts-a simple task? The XVth International Congress on Rheology 2008 1105 1107
59. S.A. Khaled, J.C. Burley, M.R. Alexander, and C.J. Roberts Desktop 3D printing of controlled release pharmaceutical bilayer tablets Int. J. Pharm. 461 2014 105 111
60. J.Y. Kim, E.K. Park, S.Y. Kim, J.W. Shin, and D.W. Cho Fabrication of a SFF-based three-dimensional scaffold using a precision deposition system in tissue engineering J. Micromech. Microeng. 18 2008
61. K. Kolter, M. Karl, and A. Gryczke Hot-Melt Extrusion with BASF Pharma Polymers - Extrusion Compendium second ed. 2012 BASF SE Pharma Ingredients & Services Ludwigshafen, Germany
62. R. Koopmans, J. den Doelder, and J. Molenaar Understanding Melt Fracture, Polymer Melt Fracture 2011 Taylor and Francis Group LLC Boca Raton, FL 201 231
63. R.G. Larson Instabilities in viscoelastic flows Rheol. Acta 31 1992 213 263
64. H.M. Laun Polymer melt rheology with a slit die Rheol. Acta 22 1983 171 185
65. H.M. Laun Pressure dependent viscosity and dissipative heating in capillary rheometry of polymer melts Rheol. Acta 42 2003 295 308
66. D. Leister, T. Geilen, and T. Geissler Twin-screw extruders for pharmaceutical hot-melt extrusion: technology, techniques and practices D. Douroumis, Hot Melt Extrusion-Pharmaceutical Applications 2012 John Wiley & Sons Ltd. West Sussex 23 42
67. J.G. Lyons, D.M. Devine, J.E. Kennedy, L.M. Geever, P. O'Sullivan, and C.L. Higginbotham The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion Eur. J. Pharm. Biopharm. 64 2006 75 81
68. J.G. Lyons, M. Hallinan, J.E. Kennedy, D.M. Devine, L.M. Geever, P. Blackie, and C.L. Higginbotham Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion process Int. J. Pharm. 329 2007 62 71
69. J.G. Lyons, P. Blackie, and C.L. Higginbotham The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug delivery Int. J. Pharm. 351 2008 201 208
70. J. Läuger, and P. Heyer Rheo small angle light scattering (rheo-SALS) and rheo-microscopy as tools for investigations of structure-property relations in complex fluids J. Aho, Nordic Rheology Conference Stockholm, Sweden 2006 193 196
71. C.W. Macosko Rheology: Principles, Measurements and Applications 1994 Wiley-VHC, Inc. New York
72. C.W. Macosko Shear Rheometry: Drag Flows, Rheology: Principles, Measurements and Applications 1994 Wiley-VHC, Inc. New York 181 235
73. C.W. Macosko Shear Rheometry: Pressure-driven Flows, Rheology: Principles, Measurements and Applications 1994 Wiley-VHC, Inc. New York 237 283
74. P. Marsac, T. Li, and L. Taylor Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters Pharm. Res. 26 2009 139 151
75. C. Martin Twin screw extrusion for pharmaceutical processes M.A. Repka, N. Langley, J. DiNunzio, Melt Extrusion - Materials, Technology and Drug Product Design 2013 Springer New york 47 79
76. S.M. Maru, M. de Matas, A. Kelly, and A. Paradkar Characterization of thermal and rheological properties of zidovidine: lamivudine and plasticizer blends with ethyl cellulose to assess their suitability for hot melt extrusion Eur. J. Pharm. Sci. 44 2011 471 478
77. S. Mascia, P.L. Heider, H. Zhang, R. Lakerveld, B. Benyahia, P.I. Barton, R.D. Braatz, C.L. Cooney, J.M.B. Evans, T.F. Jamison, K.F. Jensen, A.S. Myerson, and B.L. Trout End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation Angew. Chem. Int. Ed. 52 2013 12359 12363
78. J. Meissner Dehnunhgsverhalten von polyetylen-schmelzen Rheol. Acta 10 1971 230 240
79. T.G. Mezger The Rheology Handbook: For Users of Rotational and Oscillatory Rheometers 2006 Vincentz Network Hannover, Germany
80. P. Micic, S.N. Bhattacharya, and G. Field Transient elongational viscosity of LLDPE/LDPE blends and its relevance to bubble stability in the film blowing process Polym. Eng. Sci. 38 1998 1685 1693
81. P.K. Mididoddi, S. Prodduturi, and M.A. Repka Influence of tartaric acid on the bioadhesion and mechanical properties of hot-melt extruded hydroxypropyl cellulose films for the human nail Drug Dev. Ind. Pharm. 32 2006 1059 1066
82. E. Mitsoulis, S.G. Hatzikiriakos, K. Christodoulou, and D. Vlassopoulos Sensitivity analysis of the Bagley correction to shear and extensional rheology Rheol. Acta 37 1998 438 448
83. M. Mooney Explicit formulas for slip and fluidity J. Rheol. 2 1931 210 222
84. J.O. Morales, and J.T. McConville Manufacture and characterization of mucoadhesive buccal films Eur. J. Pharm. Biopharm. 77 2011 187 199
85. F.A. Morrison Experimental Data, Understanding Rheology 2001 Oxford University Press New York 169 224
86. F.A. Morrison Rheometry, Understanding Rheology 2001 Oxford University Press New York 382 437
87. F.A. Morrison Understanding Rheology 2001 Oxford University Press New York
88. H. Munstedt, and Z. Stary Steady states in extensional flow of strain hardening polymer melts and the uncertainties of their determination J. Rheol. 57 2013 1065 1077
89. S.V. Murphy, and A. Atala 3D bioprinting of tissues and organs Nat. Biotechnol. 32 2014 773 785
90. B. Nelson Capillary Rheometry Hubert Lobo, Jose V. Bonilla, Handbook in Plastics Analysis 2003 Marcel Dekker Inc. New York
91. T. Osswald, and J.P. Hernández-Ortiz Polymer Processing-Modeling and Simulation 2009 Carl Hanser Verlag Munich
92. M. Padmanabhan, and M. Bhattacharya In-line measurement of rheological properties of polymer melts Rheol. Acta 33 1994 71 87
93. M. Padmanabhan, L.J. Kasehagen, and C. Macosko Transient extensional viscosity from a rotational shear rheometer using fiber-windup technique J. Rheol. 40 1996 473 481
94. H. Palza, S. Filipe, I.F.C. Naue, and M. Wilhelm Correlation between polyethylene topology and melt flow instabilities by determining in-situ pressure fluctuations and applying advanced data analysis Polymer 51 2010 522 534
95. A. Paradkar, A. Kelly, P. Coates, and P. York Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry J. Pharm. Biomed. Anal. 49 2009 304 310
96. B. Perissutti, J.M. Newton, F. Podczeck, and F. Rubessa Preparation of extruded carbamazepine and PEG 4000 as a potential rapid release dosage form Eur. J. Pharm. Biopharm. 53 2002 125 132
97. I. Pillin, N. Montrelay, A. Bourmaud, and Y. Grohens Effect of thermo-mechanical cycles on the physico-chemical properties of poly(lactic acid) Polym. Degrad. Stabil. 93 2008 321 328
98. F. Qian, J. Huang, Q. Zhu, R. Haddadin, J. Gawel, R. Garmise, and M. Hussain Is a distinctive single Tg a reliable indicator for the homogeneity of amorphous solid dispersion? Int. J. Pharm. 395 2010 232 235
99. M.A. Repka, and J.W. McGinity Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion J. Control. Release 70 2001 341 351
100. M.A. Repka, S. Shah, J.N. Lu, S. Maddineni, J. Morott, K. Patwardhan, and N.N. Mohammed Melt extrusion: process to product Expert Opin. Drug Deliv. 9 2012 105 125
101. E. Sachs, E. Wylonis, S. Allen, M. Cima, and H.L. Guo Production of injection molding tooling with conformal cooling channels using the three dimensional printing process Polym. Eng. Sci. 40 2000 1232 1247
102. N. Sandler, I. Salmela, A. Fallarero, A. Rosling, M. Khajeheian, R. Kolakovic, N. Genina, J. Nyman, and P. Vuorela Towards fabrication of 3D printed medical devices to prevent biofilm formation Int. J. Pharm. 459 2014 62 64
103. A.L. Sarode, H. Sandhu, N. Shah, W. Malick, and H. Zia Hot melt extrusion (HME) for amorphous solid dispersions: predictive tools for processing and impact of drug-polymer interactions on supersaturation Eur. J. Pharm. Sci. 48 2013 371 384
104. S.K. Sathigari, V.K. Radhakrishnan, V.A. Davis, D.L. Parsons, and R.J. Babu Amorphous-state characterization of efavirenz-polymer hot-melt extrusion systems for dissolution enhancement J. Pharm. Sci. 101 2012 3456 3464
105. P. Schummer, and R.H. Worthoff Elementary method for evaluation of a flow curve Chem. Eng. Sci. 33 1978 759 763
106. M.L. Sentmanat Miniature universal testing platform: from extensional melt rheology to solid-state deformation behavior Rheol. Acta 43 2004 657 669
107. S. Shah, S. Maddineni, J. Lu, and M.A. Repka Melt extrusion with poorly soluble drugs Int. J. Pharm. 453 2013 233 252
108. L. Shor, S. Guceri, R. Chang, J. Gordon, Q. Kang, L. Hartsock, Y.H. An, and W. Sun Precision extruding deposition (PED) fabrication of polycaprolactone (PCL) scaffolds for bone tissue engineering Biofabrication 2009 1
109. T. Sridhar, V. Tirtaatmadja, D.A. Nguyen, and R.K. Gupta Measurement of extensional viscosity of polymer-solutions J. Non-Newton. Fluid Mech. 40 1991 271 280
110. H. Suwardie, P. Wang, D.B. Todd, V. Panchal, M. Yang, and C.G. Gogos Rheological study of the mixture of acetaminophen and polyethylene oxide for hot-melt extrusion application Eur. J. Pharm. Biopharm. 78 2011 506 512
111. P.K. Svrcinova, and A. Filip On the measurement of elongational viscosity of polyethylene materials Acta Tech. 54 2009 49 57
112. T.F. Tadros Rheology of Dispersions - Principles and Applications 2010 Wiley-VCH Verlag GmbH & Co., KGaA Germany
113. H. Takahashi, T. Matsuoka, and T. Kurauchi Rheology of polymer melts in high shear rate J. Appl. Polym. Sci. 30 1985 4669 4684
114. J.P. Tordella Fracture in the extrusion of amorphous polymers through capillaries J. Appl. Phys. 27 1956 454 458
115. C.J. Tsenoglou, E. Voyiatzis, and A.D. Gotsis Simple constitutive modelling of nonlinear viscoelasticity under general extension J. Non-Newton. Fluid Mech. 138 2006 33 43
116. K.E. Uhrich, S.M. Cannizzaro, R.S. Langer, and K.M. Shakesheff Polymeric systems for controlled drug release Chem. Rev. 99 1999 3181 3198
117. C.M. Vaz, P.F.N.M. van Doeveren, G.R. Dias, R.L. Reis, and A.M. Cunha Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding Macromol. Biosci. 4 2004 795 801
118. J. Vlachopoulos, and D. Strutt The Role of Rheology in Polymer Extrusion 2003 New Technologies for Extrusion Milan, Italy
119. M.H. Wagner, A. Bernnat, and V. Schulze The rheology of the rheotens test J. Rheol. 42 1998 917 928
120. M.H. Wagner, and V.H. Rolón-Garrido Constant force elongational flow of polymer melts: experiment and modelling J. Rheol. 56 2012 1279 1298
121. K. Wening, and J. Breitkreutz Novel delivery device for monolithical solid oral dosage forms for personalized medicine Int. J. Pharm. 395 2010 174 181
122. K. Wening, and J. Breitkreutz Oral drug delivery in personalized medicine: unmet needs and novel approaches Int. J. Pharm. 404 2011 1 9
123. S.A. White, A.D. Gotsis, and D.G. Baird Review of the entry flow problem: experimental and numerical J. Non-Newton. Fluid Mech. 24 1987 121 160
124. M.L. Williams, R.F. Landel, and J.D. Ferry Temperature dependence of relaxation mechanisms in amorphous polymers and other glass-forming liquids Physical Review 98 1955 3701 3707
125. J.X. Wu, M. Yang, F. Berg, J. Pajander, T. Rades, and J. Rantanen Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability Eur. J. Pharm. Sci. 44 2011 610 620
126. M. Yang, P. Wang, H. Suwardie, and C. Gogos Determination of acetaminophen's solubility in poly(ethylene oxide) by rheological: thermal and microscopic methods Int. J. Pharm. 403 2011 83 89
127. D.E. Zecevic, and K.G. Wagner Rational development of solid dispersions via hot-melt extrusion using screening, material characterization, and numeric simulation tools J. Pharm. Sci. 102 2013 2297 2310
128. L. Zema, G. Loreti, A. Melocchi, A. Maroni, and A. Gazzaniga Injection molding and its application to drug delivery J. Control. Release 159 2012 324 331