Twin-screw Extruders for Pharmaceutical Hot-melt Extrusion: Technology, Techniques and Practices

Hot-Melt Extrusion: Pharmaceutical Applications

Volumn , Issue , 2012, Pages 23-42

  Leister, Dirk ^a   Geilen, Tom ^a   Geissler, Thobias ^a  

^a THERMO FISHER SCIENTIFIC   (Germany)

Author keywords

Critical, non critical parameters and design, control space; Equipment limitations and knowledge space; Extrudate shape and downstreaming; Extruder types and working principle; Feeding of solids; HME Process using QbD; Residence time distribution; Screw speed and feed rate on melt temperature; TSE for pharmaceutical hot melt extrusion; TSE parameters, filling level, screw speed, feed rate

Indexed keywords

EID: 84886114937     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470711415.ch2     Document Type: Chapter

References (4)

1. Kolter, K., Karl, M., Nalawade, S. and Rottmann N. (2010) Hot-Melt Extrusion with BASF Pharma Polymers. Extrusion Compendium. BASF SE, Ludwigshafen.
2. Kohlgruber, K. (2008) Co-rotating Twin-Screw Extruders: Fundamentals, Technology, and Applications. Carl Hanser Verlag, Munich.
3. Geilen, T. (2011) Doppelschencken extrusion. Presentation at APV Seminar No. 6382, HME Masterclass, Karlsruhe.
4. Swanborough, A. (2008) Benefits of continuous granulation for pharmaceutical research, development and manufacture. Application Note LR-63, Thermo Fisher Scientific, Karlsruhe.