Hot melt extrusion (HME) for amorphous solid dispersions: Predictive tools for processing and impact of drug-polymer interactions on supersaturation

European Journal of Pharmaceutical Sciences

Volumn 48, Issue 3, 2013, Pages 371-384

  Sarode, Ashish L ^a   Sandhu, Harpreet ^b   Shah, Navnit ^b   Malick, Waseem ^b   Zia, Hossein ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

Amorphous; Hot melt extrusion; Interaction; Rheology; Solid dispersion; Supersaturation

Indexed keywords

EUDRAGIT; GRISEOFULVIN; HYDROXYPROPYLMETHYLCELLULOSE; INDOMETACIN; ITRACONAZOLE; POVIDONE; ACRYLIC ACID RESIN; ANTIFUNGAL AGENT; EUDRAGIT E PO; EUDRAGIT L100-55; EXCIPIENT; METHYLCELLULOSE; NONSTEROID ANTIINFLAMMATORY AGENT; POLYMETHACRYLIC ACID DERIVATIVE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; FLOW KINETICS; GLASS TRANSITION TEMPERATURE; HOT MELT EXTRUSION; INFRARED SPECTROSCOPY; MELTING POINT; PRIORITY JOURNAL; PROCESS TECHNOLOGY; SOLUBILITY; X RAY DIFFRACTION; ANALOGS AND DERIVATIVES; CHEMISTRY; COMPARATIVE STUDY; DRUG FORMULATION; HEAT; OSMOLARITY; PHASE TRANSITION; POWDER DIFFRACTION; PROCEDURES; TRANSITION TEMPERATURE; VISCOSITY;

ACRYLIC RESINS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIFUNGAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; EXCIPIENTS; GRISEOFULVIN; HOT TEMPERATURE; INDOMETHACIN; ITRACONAZOLE; METHYLCELLULOSE; OSMOLAR CONCENTRATION; PHASE TRANSITION; POLYMETHACRYLIC ACIDS; POWDER DIFFRACTION; RHEOLOGY; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRANSITION TEMPERATURE; VISCOSITY;

EID: 84872130842     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.12.012     Document Type: Article

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