Precision extruding deposition (PED) fabrication of polycaprolactone (PCL) scaffolds for bone tissue engineering

Biofabrication

Volumn 1, Issue 1, 2009, Pages

  Shor, Lauren ^a   Güçeri, Selçuk ^a   Chang, Robert ^a   Gordon, Jennifer ^b   Kang, Qian ^b   Hartsock, Langdon ^b   An, Yuehuei ^b   Sun, Wei ^a  

^a Drexel University   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BONE GROWTH; BONE REGENERATION; BONE TISSUE ENGINEERING; COMPLEX SHAPES; FREEFORM FABRICATION; IN-VITRO; IN-VIVO; INTERCONNECTIVITY; INTERNAL ARCHITECTURE; METABOLIC ACTIVITY; MICRO ARCHITECTURES; MICRO COMPUTED TOMOGRAPHY (MICRO-CT); MULTIPLE AREAS; NUDE MICE; OSSEOINTEGRATION; OSTEOGENESIS; POLYCAPROLACTONE SCAFFOLDS; PRECISION EXTRUDING DEPOSITIONS; PROCESS TOOLS; SCAFFOLD MORPHOLOGY; SCIENTISTS AND ENGINEERS; SEM; STRUCTURAL ORIENTATIONS; THREE-DIMENSIONAL POROUS SCAFFOLDS; TIME INTERVAL;

BIOMECHANICS; BONE; CALCIUM; CELL PROLIFERATION; COMPLEXATION; COMPUTERIZED TOMOGRAPHY; FABRICATION; MECHANICAL PROPERTIES; MECHANICAL TESTING; OSTEOBLASTS; PHOSPHATASES; POLYCAPROLACTONE; PORE SIZE; PRECISION ENGINEERING; SCANNING ELECTRON MICROSCOPY; THREE DIMENSIONAL; TISSUE ENGINEERING;

SCAFFOLDS;

BOVINAE; MUS MUSCULUS;

CALCIUM; POLYCAPROLACTONE; POLYESTER; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BIOMIMETICS; BONE DEVELOPMENT; CATTLE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CHEMISTRY; COMPRESSIVE STRENGTH; CYTOLOGY; METABOLISM; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NUDE MOUSE; OSTEOBLAST; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING;

ANIMALS; BIOMIMETICS; CALCIUM; CATTLE; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELLS, CULTURED; COMPRESSIVE STRENGTH; MICE; MICE, NUDE; MICROSCOPY, ELECTRON, SCANNING; OSTEOBLASTS; OSTEOGENESIS; POLYESTERS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; X-RAY MICROTOMOGRAPHY;

EID: 77956761652     PISSN: 17585082     EISSN: 17585090     Source Type: Journal    
DOI: 10.1088/1758-5082/1/1/015003     Document Type: Article

References (22)

1. Bellini A 2002 Fused deposition of ceramics: a comprehensive experimental, analytical and computational study of material behavior, fabrication process and equipment design, Department of Mechanical Engineering and Mechanics Thesis Drexel University, Philadelphia, PA http://dspace.library. drexel.edu/handle/1860/22
2. Cancedda R, Cedola A, Giuliani A, Komlev V, Lagomarsino S, Mastrogiacomo M, Peyrin F and Rustichelli F 2007 Bulk and interface investigations of scaffolds and tissue-engineered bones by X-ray microtomography and X-ray microdiffraction Biomaterials 28 2505-15
3. Chim H, Hutmacher D W, Chou A M, Oliveira A L, Reis R L, Lim T C and Schantz J T 2006 Comparative analysis of scaffold material modifications for load-bearing applications in bone tissue engineering Int. J. Oral Maxillofac. Surg. 35 928-34
4. Ho S T and Hutmacher D W 2006 A comparison of micro CT with other techniques used in the characterization of scaffolds Biomaterials 27 1362-76
5. Hollister S 2005 Porous scaffold design for tissue engineering Nature Mater. 4 518-24
6. Hollister S J, Maddox R D and Taboas J M 2002 Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints Biomaterials 23 4095-103
7. Hutmacher D W 2000 Scaffolds in tissue engineering bone and cartilage Biomaterials 21 2529-43
8. Hutmacher D W 2001 Scaffold design and fabrication technologies for engineering tissues-state of the art and future perspectives J. Biomater. Sci., Polym. Ed. 12 107-24
9. Koch K U, Biesinger B, Arnholz C and Jansson V 1998 Creating of bio-compatible, high stress resistant and resorbable implants using multiphase jet solidification technology Time-Compression Technology 1998 Conf.:3rd Ann. Conf. and Exhibition (Nottingham, UK, Oct 1998) (Cheshire, UK: Rapid News Pub.) pp 209-14
10. Lin A S P, Barrows T H, Cartmell S H and Guldberg R E 2003 Micro-architectural and mechanical characterization of oriented porous polymer scaffolds Biomaterials 24 481-9
11. Müller R and Rüegsegger P 1997 Micro-tomographic imaging for the nondestructive evaluation of trabecular bone architecture Bone Research in Biomechanics ed G Lowet (Amsterdam: IOS Press) pp 1-80
12. Oest M E, Dupont K M, Kong H J, Mooney D J and Guldberg R E 2007 Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects J. Orthop. Res. 25 941-50
13. Rohner D, Hutmacher D W, Cheng T K, Oberholzer M and Hammer B 2003 Efficacy of bone-marrow-coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig J. Biomed. Mater. Res. A 66 574-80
14. Sun W, Darling A, Starly B and Nam J 2004a Computer aided tissue engineering: overview, scope and challenges J. Biotechnol. Appl. Biochem. 39 29-47
15. Sun W and Lal P 2002 Recent development on computer aided tissue engineering: a review Comput. Methods Programs Biomed. 67 85-103
16. Sun W, Starly B, Darling A and Gomez C 2004b Computer aided tissue engineering: application in biomimetic modeling and design of tissue scaffold J. Biotechnol. Appl. Biochem. 39 49-58
17. Vozzi G, Previti A, Rossi D and Ahluwalia A 2002 Microsyringe-based deposition of two-dimensional and three-dimensional polymer scaffolds with a well-defined geometry for application to tissue engineering Tissue Eng. 8 1089-98
18. Whang K, Healy K E, Elenz D R, Nam E K, Tsai D C and Thomas C H 1999 Engineering bone regeneration with bioabsorable scaffolds with novel microarchitecture Tissue Eng. 5 35-51
19. Williams J M, Adewunmi A, Schek R M, Flanagan C L, Krebsbach P H, Feinberg S E, Hollister S J and Das S 2005 Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering Biomaterials 26 4817-27 (Pubitemid 40347312)
20. Wu B M, Borland S W, Giordano R A, Cima L G, Sachs E M and Cima M J 1996 Solid free-form fabrication of drug delivery devices J. Control Release 40 77-87
21. Xiong Z, Yan Y, Zhang R and Sun L 2001 Fabrication of porous poly(L-lactic acid) scaffolds for bone tissue engineering via precise extrusion Scr. Mater. 46 771-76
22. Zein I W, Hutmacher D W, Tan K C and Toch S H 2002 Fused deposition modeling of novel scaffold architecture for tissue engineering application Biomaterials 23 1169-85