Oral drug delivery in personalized medicine: Unmet needs and novel approaches

International Journal of Pharmaceutics

Volumn 404, Issue 1-2, 2011, Pages 1-9

  Wening, Klaus ^a   Breitkreutz, Jörg ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Dosing errors; Drug delivery devices; Individual therapy; Medical devices; Personalized medicine

Indexed keywords

DEVICE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; PERSONALIZED MEDICINE; PRIORITY JOURNAL; REVIEW; TABLET;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; INDIVIDUALIZED MEDICINE; PHARMACEUTICAL PREPARATIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 78650677036     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.11.001     Document Type: Review

References (61)

1. Allen, J.D., Mungall, D., Cobb, M.E., Ostoich, V.E., Hillmann, R.S., Stroy, G.H., 1992. Integrated drug dosage form and metering system. EP 000000224335B1.
2. Bauriegel, L., 2007. Dosierspender für freifließendes, schüttfähiges Pulver und partikelförmiges Gut. DE 200 23 931 U1 (German).
3. Bramlage, 2007. Spender für tablettenartige Gegenstände. DE 102008007485A1 (German).
4. S. Bredenberg, D. Nyholm, S.M. Aquilonius, and C. Nystram An automatic dose dispenser for microtablets - a new concept for individual dosage of drugs in tablet form Int. J. Pharm. 261 2003 137 146
5. J. Breitkreutz, and J. Boos Pediatric and geriatric drug delivery Exp. Opin. Drug Deliv. 4 2007 37 45
6. J. Breitkreutz, T. Wessel, and J. Boos Dosage forms for peroral drug administration to children Paediatr. Perinat. Drug Ther. 3 1999 25 33
7. J. Breitkreutz, U. Holzgrabe, P. Kleinebudde, K. Michel, A. Ritter, and F. Stieneker Wann Tabletten geteilt werden dürfen Dtsch. Apoth. Ztg. 147 2007 2854 2855 (German)
8. Breitkreutz, J., Wazlawik, L., 2005. Microdose - Vorrichtung und Verfahren zur Dosierung einer frei waehlbaren Anzahl von stueckigen Festkoerpern. DE 102004001645 A1.
9. D. Brown, J.L. Ford, A.J. Nunn, and P.H. Rowe An assessment of dose-uniformity of samples delivered from paediatric oral droppers J. Clin. Pharm. Ther. 29 2004 521 529
10. P. Catzel The teaspoon dose S. Afr. Med. J. 51 1977 592 594
11. Chadwick, O.A., 1952. Pill dispenser. US 000002729366A.
12. T.J. Cook, S. Edwards, C. Gyemah, M. Shah, I. Shah, and T. Fox Variability in tablet fragment weights when splitting unscored cyclobenzaprine 10 mg tablets J. Am. Pharm. Assoc. 44 2004 583 586
13. Culpitt, P.J., 1978. Paper compositions incorporating medicaments. GB 2022999A.
14. Deadman, L.L.F., 1967. New impragnated or coated films. GB 000001061557A.
15. Debont, L., 1989. Distributeur pour pilules, granules, comprimés ou produits analogues. EP 000000337146A1 (France).
16. Dicke, S., 2008. Pharmazeutisch-technologische Untersuchungen zur Entwicklung von Theophyllin-Depotarzneiformen mit variabler Freisetzung. Dissertation, IPT Verlag, Muenster (German).
17. Dobkin, I.T., 1950. Can with built-in dispenser. US 000002664223A.
18. Food and Drug Administration (FDA) Tablet Splitting: A Risky Practice 2009 FDA Headquarter New Hampshire
19. Graff, J.C., 1985. Solid oral dosage dispenser with safety, tamper-proof and sanitation features. US 000004611727A.
20. Green, G.A., Berg, C., Valdez, N., Kaplan, A., 2009. Accuracy and ease of splitting scored Coumadin, Lanoxin and Toprol XL tablets. Poster Presentation, AAPS, Los Angeles.
21. K. Griessmann, J. Breitkreutz, M. Schubert-Zsilavecz, and M. Abdel-Tawab Dosing accuracy of measuring devices provided with antibiotic oral suspensions Paediatr. Perinat. Drug Ther. 8 2007 61 70
22. Y. Hattori, M. Hanya, A. Kondoh, Y. Tsunekawa, T. Ito, K. Tsuzuki, S. Ito, K. Inagaki, and M. Nishida Dosing of a child with a liquid form of cyclosporin using various measuring devices J. Appl. Ther. Res. 2 1999 299 304
23. Heimlich, P.F., 1984. Flowable material dispenser. US 000004579256A.
24. Hansen, I., 1993. Dispenser for pills or tablets. WO 001993011056A1.
25. M. Hermanns-Clausen, W. Weinmann, V. Auwärter, N. Ferreiros, R. Trittler, C. Müller, A. Pahl, A. Superti-Furga, and R. Hentschel Drug dosing error with drops-severe clinical course of codeine intoxication in twins Eur. J. Pediatr. 168 2009 819 824
26. Horstmann, M., Laux, W., 2004. Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance. US 006682756B1.
27. E. Kayitare, C. Vervaet, J.D. Ntawukulilyayo, B. Seminega, V. Bortel, and J.P. Remon Development of fixed dose combination tablets containing zidovudine and lamivudine for paediatric applications Int. J. Pharm. 370 2009 41 46
28. G.L. Kearns, S.M. Abdel-Rahman, S.W. Alander, D.L. Blowey, J.S. Leeder, and R.E. Kauffman Developmental pharmacology - drug disposition, action, and therapy in infants and children N. Engl. J. Med. 349 2003 1157 1167
29. Knoll, A.G., 1999. Dosierloeffel für Mikrotabletten. DE 29907996 U1 (German).
30. Laboratoires, Suppo-Steril, 1977. Bouchon pour le comptage et la distibution de granules. FR 000002396697A1 (France).
31. Le Blanc, G.J., 1960. Tablet dispenser. US 000003079043A.
32. J.T. McDevitt, A.H. Gurst, and Y. Chen Accuracy of tablet splitting Pharmacotherapy 18 1998 193 197
33. McConnel, J.A., Williamson, E.W., 1971. Pill dispensing device having plural cut-off trap chamber. US 000003730387A.
34. Neavin, W.T., 1973. Pill dispenser with movable trap chamber and agitator. US 000003885703A.
35. R. Quinzler, C. Gasse, A. Schneider, P. Kaufmann-Kolle, J. Szecsenyi, and W.E. Haefeli The frequency of inappropriate tablet splitting in primary care Eur. J. Clin. Pharmacol. 62 2006 1065 1073
36. Ronca, R., 2007. Pharmaceutical single dosage form. EP 1923056 A1.
37. J.M. Rosenberg, J.P. Nathan, and F. Plakogiannis Weight variability of pharmacist-dispensed split tablets J. Am. Pharm. Assoc. 42 2002 200 205
38. Russell, H.S., 1966. Methods and means for administering drugs. US 000003444858A.
39. Salamé, S.B., 1991. Distributeur doseur notamment pour des granules homépathiques pilules, comprimés ou autres produits analoques. EP 000000470919A1 (France).
40. Schmidt, W., 1986. Verfahren zur Herstellung einer Darreichungs- und Dosierungsform für Arzneimittel-Wirkstoffe, Reagenzien oder andere Wirkstoffe. EP 0219762A1 (German).
41. Schoenefeld, P., 1980. Dosierspender. DE 3048865 A1 (German).
42. O.A. Scholz, A. Wolff, A. Schumacher, L.I. Giannola, G. Campisi, T. Ciach, and T. Velten Drug delivery from the oral cavity: focus on a novel mechatronic delivery device Drug Discov. Today 13 2008 247 253
43. Schomakers, J., Grummel, A., 2002. Dosing stick containing rod-shaped tablets. WO 02/102296 A1.
44. Schuster, W., 1988. Dosierspender. DE 3632546 A1 (German).
45. A.C. Shah, and N.J. Britten Novel divisible tablet designs for sustained release formulations J. Control. Release 14 1990 179 185
46. P. Sobhani, J. Christopherson, P.J. Ambrose, and R.L. Corelli Accuracy of oral liquid measuring devices: comparison of dosing cup and oral dosing syringe Ann. Pharmacother. 42 2008 46 52
47. Solomon, L., Kaplan, A.S., 2010. Method of administering a partial dose of a segmented pharmaceutical tablet. US 0000007713547B2.
48. J.F. Standing, and C. Tuleu Paediatric formulations-getting to the heart of the problem Int. J. Pharm. 300 2005 56 66
49. Stanley, T.H., 1989. Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues. US 000005122127A.
50. S. Stegemann, F. Ecker, M. Maio, P. Kraahs, R. Wohlfart, J. Breitkreutz, A. Zimmer, D. Bar-Shalom, P. Hettrich, and B. Broegmann Geriatric drug therapy - neglecting the inevitable majority Ageing Res. Rev. 9 2010 384 398
51. J. Teng, C.K. Song, R.L. Williams, and J.E. Polli Lack of medication dose uniformity in commonly split tablets J. Am. Pharm. Assoc. 42 2002 195 199
52. Thomas, M.D., Ryder, F.E., 1976. Pill dispenser. US 000003991908A.
53. Uroshevich, M., Powers, T., Sperber, R.L., 1975. Child-resistant pill dispenser. US 000003889847A.
54. E. Van Santen, D.M. Barends, and H.W. Frijlink Breaking of scored tablets: a review Eur. J. Pharm. Biopharm. 53 2002 139 145
55. T. Velten, H. Schuck, T. Knoll, O. Scholz, A. Schumacher, T. Goettsche, A. Wolff, and B.Z. Beiski Intelligent intraoral drug delivery microsystem Proc. Inst. Mech. Eng.: J. Mech. Eng. Sci. 220 2006 1609 1617
56. Warren, R.P., 1940. Dispenser for tablets. US 000002227167A.
57. K. Wening, and J. Breitkreutz Novel delivery device for monolithical solid oral dosage forms for personalized medicine Int. J. Pharm. 395 2010 174 181
58. R.L. Weiss, M.N. Goldstein, A. Dharia, G. Zahtz, A.L. Abramson, and M. Patel Clear plastic cups: a childhood choking hazard Int. J. Pediatr. Otorhinolaryngol. 37 1996 243 251
59. T. Wessel, J. Breitkreutz, E. Ahlke, G. Hempel, and J. Boos Problems with mercaptopurine tablets in maintenance therapy Krankenhauspharmazie 22 2001 325 329 (German)
60. World Health Organisation (WHO), 2009. Report of the Informal Expert Meeting on Dosage Forms of Medicines for Children. WHO Headquarter, Geneva.
61. H.S. Yin, A.L. Mendelsohn, and M.S. Wolf Parents' medication administration errors Arch. Pediatr. Adolesc. Med. 164 2010 181 186