The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug delivery

International Journal of Pharmaceutics

Volumn 351, Issue 1-2, 2008, Pages 201-208

  Lyons, John G ^a   Blackie, Paul ^a   Higginbotham, Clement L ^a  

^a Athletic Rehabilitation Therapy Ireland   (Ireland)

Author keywords

Drug delivery; Extrusion; Matrix; PCL; PEO; Temperature

Indexed keywords

CARVEDILOL; MACROGOL; POLYCAPROLACTONE;

ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; FLOW MEASUREMENT; PRIORITY JOURNAL; TEMPERATURE; VISCOSITY;

ADMINISTRATION, ORAL; CALORIMETRY, DIFFERENTIAL SCANNING; CARBAZOLES; DELAYED-ACTION PREPARATIONS; POLYESTERS; PROPANOLAMINES; RHEOLOGY; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 38749090965     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.09.041     Document Type: Article

References (22)

1. In: Alderborn G., and Aulton M. (Eds). Pharmaceutics; The Science of Dosage Form Design (2002), Elsevier Science 397-441
2. Aliabadi H., Mahmud A., Sharifabadi A., and Lavasanifar A. Micelles of methoxy poly(ethylene oxide)-b-poly(q caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine. A. J. Control. Release 104 (2005) 301
3. Allen C., Han J., Yu Y., Maysinger D., and Eisenberg A. Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone. J. Control. Release 63 (2000) 275
4. In: Chasin M., and Langer R. (Eds). Biodegradable Polymers as Drug Delivery Systems vol. 45 (1990), Marcel Dekker, New York 1-8
5. Geever L., Devine D., Nugent M., Kennedy J., Lyons J., and Higginbotham C. The synthesis, characterisation, phase behaviour and swelling of temperature sensitive physically crosslinked poly(1-vinyl-2 pyrrolidinone)/poly(N-isopropylacrylamide) hydrogels. Eur. Polym. J. 42 (2006) 69-80
6. Geng Y., and Discher D. Visualization of degradable worm micelle breakdown in relation to drug release. Polymer 47 (2006) 2519
7. Holy E., and Fialkov J. Use of a biomimetic strategy to engineer bone. J. Biomed. Mater. Res. Part A 15 (2003) 447-453
8. Homminga D., Goderis B., Hoffman S., Reynaers H., and Groeninck G. Influence of shear flow on the preparation of polymer layered silicate nanocomposites. Polymer 23 (2005) 46
9. Kuo S., Lin C., and Chang F. Phase behavior and hydrogen bonding in ternary polymer blends of phenolic resin/poly(ethylene oxide)/poly(ε-caprolactone). Macromolecules 35 (2002) 278
10. Lin W., Flanagan D., and Linhardt R. A novel fabrication of poly(e-caprolactone) microspheres from blends of poly(e-caprolactone) and poly(ethylene glycol)s. Polymer 40 (1999) 1731
11. Lyons J., Devine D., Kennedy J., Geever L., O Sullivan P., and Higginbotham C. The use of Agar as a novel filler for monolithic matrices produced using hot melt extrusion. Eur. J. Pharm. Biopharm. 64 (2006) 75-81
12. Lyons J., Hallinan M., Kennedy J., Devine D., Geever L., Blackie P., and Higginbotham C. Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion process. Int. J. Pharm. 329 (2007) 62-71
13. Lyons J., Holehonnur H., Kennedy J., Devine D., Geever L., Blackie P., and Higginbotham C. The incorporation of an organically modified layered silicate in monolithic matrices produced using hot melt extrusion. Mater. Chem. Phys. 103 (2007) 419-426
14. Ma P., and Zhang R. Microtubular architecture of biodegradable polymer scaffolds. Biomed. Mater. Res. 15 (2001) 469-477
15. Ozeki T., Yuasa H., and Kanaya Y. Application of the solid dispersion method to the controlled release of medicine. Difference in the controlled release of flurbiprofen from solid dispersions with PEO and HPMC. Int. J. Pharm. 155 (1997) 209
16. Park S., Kim K., and Kim K. Effect of poly(ethylene oxide) on the release behaviors of poly(e-caprolactone) microcapsules containing erythromycin. Colloids Surf. B: Biointerf. 43 (2005) 238-244
17. Paul D. Polymer Blends (1978), Academic press p. 1
18. Qiu Z., Ikehara T., and Nishi T. Miscibility and crystallization of poly(ethylene oxide) and poly(e-caprolactone) blends. Polymer 44 (2003) 3101
19. Rauwendaal C. Polymer Extrusion (1986), Hanser publishers, Germany
20. Verreck G., Chun I., Li Y., Kataria R., Zhang Q., Rosenblatt J., Decorte A., Heymans K., Adriaensen J., Bruining M., Remoortere M., Borghys H., Meert T., Peeters J., and Brewster M. Preparation and physiochemical characterization of biodegradable nerve guides containing the nerve growth agent abeluzole. Biomaterials 26 (2005) 1307
21. Verreck G., Decorte A., Li H., Tomasko D., Arien A., Peeters J., Rombaut P., Van den Mooter G., and Brewster M. The effect of pressurized carbon dioxide as a plasticizer and foaming agent on the hot melt extrusion process and extrudate properties of pharmaceutical polymers. J. Supercrit. Fluids 38 (2006) 383-391
22. Washburn N., Simon C., Tona A., Elgendy H., Karim A., and Amis E. Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology. J. Biomed. Mater. Res. 60 (2002) 20-29