Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells

European Journal of Pharmacology

Volumn 765, Issue , 2015, Pages 415-428

  Vilimanovich, Urosh ^a   Bosnjak, Mihajlo ^a   Bogdanovic, Andrija ^a   Markovic, Ivanka ^a   Isakovic, Aleksandra ^a   Kravic Stevovic, Tamara ^a   Mircic, Aleksandar ^a   Trajkovic, Vladimir ^a   Bumbasirevic, Vladimir ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Apoptosis; Autophagy; Cholesterol; Leukemia; Statins

Indexed keywords

2 [[4 (1H IMIDAZOL 5 YLMETHYLAMINO) 2 NAPHTHALEN 1 YLBENZOYL]AMINO] 4 METHYLPENTANOIC ACID:2,2,2 TRIFLUOROACETIC ACID; 4 BROMOPHENYL[2 FLUORO 4 [6 [METHYL(PROP 2 ENYL)AMINO]HEXOXY]PHENYL]METHANONE; ATORVASTATIN; BAFILOMYCIN A1; CHOLESTEROL; ISOMERASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MEVINOLIN; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE B; S6 KINASE; SIMVASTATIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CHOLESTEROL SYNTHESIS; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; DRUG POTENTIATION; DRUG RESISTANCE; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG SENSITIZATION; FARNESYLATION; GENE SILENCING; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL; LEUKEMIA CELL LINE; LEUKOCYTE; LIPID RAFT; PRIORITY JOURNAL; RNA INTERFERENCE; BIOSYNTHESIS; CELL MEMBRANE; DOSE RESPONSE; DRUG EFFECTS; HL 60 CELL LINE; K562 CELL LINE; LEUKEMIA; METABOLISM; PATHOLOGY; PHYSIOLOGY;

AUTOPHAGY; CHOLESTEROL; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; K562 CELLS; LEUKEMIA; MEMBRANE MICRODOMAINS;

EID: 84941906087     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.09.004     Document Type: Article

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