-
1
-
-
58149127992
-
Recent advances in the treatment of malignant pleural mesothelioma
-
S.S. Ramalingam, and C.P. Belani Recent advances in the treatment of malignant pleural mesothelioma J Thorac Oncol 3 2008 1056
-
(2008)
J Thorac Oncol
, vol.3
, pp. 1056
-
-
Ramalingam, S.S.1
Belani, C.P.2
-
4
-
-
54849131100
-
Statins and cancer: A systematic review and meta-analysis
-
J. Kuoppala, A. Lamminpaa, and E. Pukkala Statins and cancer: A systematic review and meta-analysis Eur J Cancer 44 2008 2122
-
(2008)
Eur J Cancer
, vol.44
, pp. 2122
-
-
Kuoppala, J.1
Lamminpaa, A.2
Pukkala, E.3
-
5
-
-
12544258857
-
Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux
-
C. Riganti, E. Miraglia, and D. Viarisio Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux Cancer Res 65 2005 516
-
(2005)
Cancer Res
, vol.65
, pp. 516
-
-
Riganti, C.1
Miraglia, E.2
Viarisio, D.3
-
6
-
-
33646515790
-
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma
-
C. Riganti, S. Orecchia, and G. Pescarmona Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma Int J Cancer 119 2006 17
-
(2006)
Int J Cancer
, vol.119
, pp. 17
-
-
Riganti, C.1
Orecchia, S.2
Pescarmona, G.3
-
8
-
-
77951182123
-
Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: Potential therapeutic relevance
-
A. Martirosyan, J.W. Clendening, and C.A. Goard Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: Potential therapeutic relevance BMC Cancer 10 2010 103
-
(2010)
BMC Cancer
, vol.10
, pp. 103
-
-
Martirosyan, A.1
Clendening, J.W.2
Goard, C.A.3
-
9
-
-
73549085851
-
In vivo evidence of duality effects for lovastatin in a nude mouse cancer model
-
C.Y. Wang, H.A. Shui, and T.C. Chang In vivo evidence of duality effects for lovastatin in a nude mouse cancer model Int J Cancer 126 2010 578
-
(2010)
Int J Cancer
, vol.126
, pp. 578
-
-
Wang, C.Y.1
Shui, H.A.2
Chang, T.C.3
-
10
-
-
56949083359
-
Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state
-
C. Laezza, L. Fiorentino, and S. Pisanti Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state J Mol Med 86 2008 1341
-
(2008)
J Mol Med
, vol.86
, pp. 1341
-
-
Laezza, C.1
Fiorentino, L.2
Pisanti, S.3
-
11
-
-
33846936157
-
Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from v cholerae
-
M.G. Gutierrez, H.A. Saka, and I. Chinen Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V cholerae Proc Natl Acad Sci U S A 104 2007 1829
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 1829
-
-
Gutierrez, M.G.1
Saka, H.A.2
Chinen, I.3
-
12
-
-
34547849623
-
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells
-
M.A. Merrell, S. Wakchoure, and P.P. Lehenkari Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells Eur J Pharmacol 570 2007 27
-
(2007)
Eur J Pharmacol
, vol.570
, pp. 27
-
-
Merrell, M.A.1
Wakchoure, S.2
Lehenkari, P.P.3
-
13
-
-
33646269011
-
Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases
-
J.E. Dunford, M.J. Rogers, and F.H. Ebetino Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases J Bone Miner Res 21 2006 684
-
(2006)
J Bone Miner Res
, vol.21
, pp. 684
-
-
Dunford, J.E.1
Rogers, M.J.2
Ebetino, F.H.3
-
14
-
-
26644442350
-
Mechanisms of statin-mediated inhibition of small G-protein function
-
A. Cordle, J. Koenigsknecht-Talboo, and B. Wilkinson Mechanisms of statin-mediated inhibition of small G-protein function J Biol Chem 280 2005 34202
-
(2005)
J Biol Chem
, vol.280
, pp. 34202
-
-
Cordle, A.1
Koenigsknecht-Talboo, J.2
Wilkinson, B.3
-
15
-
-
38449119971
-
Geranylgeranylation but not GTP loading determines rho migratory function in T cells
-
S. Waiczies, I. Bendix, and T. Prozorovski Geranylgeranylation but not GTP loading determines rho migratory function in T cells J Immunol 179 2007 6024
-
(2007)
J Immunol
, vol.179
, pp. 6024
-
-
Waiczies, S.1
Bendix, I.2
Prozorovski, T.3
-
16
-
-
0035846549
-
Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells
-
M. Higuchi, N. Masuyama, and Y. Fukui Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells Curr Biol 11 2001 1958
-
(2001)
Curr Biol
, vol.11
, pp. 1958
-
-
Higuchi, M.1
Masuyama, N.2
Fukui, Y.3
-
17
-
-
0037050260
-
Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB
-
C. Murga, M. Zohar, and H. Teramoto Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB Oncogene 21 2002 207
-
(2002)
Oncogene
, vol.21
, pp. 207
-
-
Murga, C.1
Zohar, M.2
Teramoto, H.3
-
18
-
-
41149095078
-
Nonadherent cells switch to a Rac-mediated, SHIP regulated, Akt activation mode for survival
-
B. Chaigne-Delalande, G. Anies, and I. Kramer Nonadherent cells switch to a Rac-mediated, SHIP regulated, Akt activation mode for survival Oncogene 27 2008 1876
-
(2008)
Oncogene
, vol.27
, pp. 1876
-
-
Chaigne-Delalande, B.1
Anies, G.2
Kramer, I.3
-
19
-
-
1942424799
-
Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells
-
H. Takeuchi, T. Kanzawa, and Y. Kondo Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells Br J Cancer 90 2004 1069
-
(2004)
Br J Cancer
, vol.90
, pp. 1069
-
-
Takeuchi, H.1
Kanzawa, T.2
Kondo, Y.3
-
20
-
-
34347238938
-
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of Akt and extracellular signal-regulated kinase signaling pathways
-
H. Aoki, Y. Takada, and S. Kondo Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of Akt and extracellular signal-regulated kinase signaling pathways Mol Pharmacol 72 2007 29
-
(2007)
Mol Pharmacol
, vol.72
, pp. 29
-
-
Aoki, H.1
Takada, Y.2
Kondo, S.3
-
21
-
-
57649227693
-
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
-
S. Sarkar, B. Ravikumar, and R.A. Floto Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies Cell Death Differ 16 2009 46
-
(2009)
Cell Death Differ
, vol.16
, pp. 46
-
-
Sarkar, S.1
Ravikumar, B.2
Floto, R.A.3
-
22
-
-
42249106042
-
C. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
-
A. Williams, S. Sarkar, and P. Cuddon C. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway Nat Chem Biol 4 2008 295
-
(2008)
Nat Chem Biol
, vol.4
, pp. 295
-
-
Williams, A.1
Sarkar, S.2
Cuddon, P.3
-
23
-
-
57649215701
-
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases
-
J.P. Seifert, Y. Zhou, and S.N. Hicks Dual activation of phospholipase C-epsilon by Rho and Ras GTPases J Biol Chem 283 2008 29690
-
(2008)
J Biol Chem
, vol.283
, pp. 29690
-
-
Seifert, J.P.1
Zhou, Y.2
Hicks, S.N.3
-
24
-
-
33144456377
-
Regulation of phospholipase C isozymes by ras superfamily GTPases
-
T.K. Harden, and J. Sondek Regulation of phospholipase C isozymes by ras superfamily GTPases Annu Rev Pharmacol Toxicol 46 2006 355
-
(2006)
Annu Rev Pharmacol Toxicol
, vol.46
, pp. 355
-
-
Harden, T.K.1
Sondek, J.2
-
25
-
-
66349113776
-
Phospholipase C isozymes as effectors of Ras superfamily GTPases
-
T.K. Harden, S.N. Hicks, and J. Sondek Phospholipase C isozymes as effectors of Ras superfamily GTPases J Lipid Res 50 Suppl 2009 S243
-
(2009)
J Lipid Res
, vol.50
, Issue.SUPPL.
, pp. 243
-
-
Harden, T.K.1
Hicks, S.N.2
Sondek, J.3
-
26
-
-
32144459473
-
Quantification of isozyme-specific activation of phospholipase C-β2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system
-
D.M. Bourdon, M.R. Wing, and E.B. Edwards Quantification of isozyme-specific activation of phospholipase C-β2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system Methods Enzymol 406 2006 489
-
(2006)
Methods Enzymol
, vol.406
, pp. 489
-
-
Bourdon, D.M.1
Wing, M.R.2
Edwards, E.B.3
-
27
-
-
1242340429
-
Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling
-
R. Fukuyama, T. Fujita, and Y. Azuma Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling Biochem Biophys Res Commun 315 2004 636
-
(2004)
Biochem Biophys Res Commun
, vol.315
, pp. 636
-
-
Fukuyama, R.1
Fujita, T.2
Azuma, Y.3
-
28
-
-
34347369084
-
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
-
P.A. Konstantinopoulos, M.V. Karamouzis, and A.G. Papavassiliou Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets Nat Rev Drug Discov 6 2007 541
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 541
-
-
Konstantinopoulos, P.A.1
Karamouzis, M.V.2
Papavassiliou, A.G.3
-
29
-
-
33745678744
-
Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis
-
D. Martarelli, A. Catalano, and A. Procopio Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis BMC Cancer 6 2006 130
-
(2006)
BMC Cancer
, vol.6
, pp. 130
-
-
Martarelli, D.1
Catalano, A.2
Procopio, A.3
-
30
-
-
37549056216
-
The roles of therapy-induced autophagy and necrosis in cancer treatment
-
R.K. Amaravadi, and C.B. Thompson The roles of therapy-induced autophagy and necrosis in cancer treatment Clin Cancer Res 13 2007 7271
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7271
-
-
Amaravadi, R.K.1
Thompson, C.B.2
-
32
-
-
34648823750
-
Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy
-
L. Moretti, E.S. Yang, and K.W. Kim Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy Drug Resist Updat 10 2007 135
-
(2007)
Drug Resist Updat
, vol.10
, pp. 135
-
-
Moretti, L.1
Yang, E.S.2
Kim, K.W.3
-
33
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
K. Degenhardt, R. Mathew, and B. Beaudoin Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Cancer Cell 10 2006 51
-
(2006)
Cancer Cell
, vol.10
, pp. 51
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
-
35
-
-
42649122953
-
Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells
-
I. Hashimoto, K. Koizumi, and M. Tatematsu Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells Eur J Cancer 44 2008 1022
-
(2008)
Eur J Cancer
, vol.44
, pp. 1022
-
-
Hashimoto, I.1
Koizumi, K.2
Tatematsu, M.3
-
36
-
-
2442706575
-
Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells
-
E.A. Collisson, C. Kleer, and M. Wu Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells Mol Cancer Ther 2 2003 941
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 941
-
-
Collisson, E.A.1
Kleer, C.2
Wu, M.3
-
37
-
-
57649217290
-
Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion
-
O. Fromigue, Z. Hamidouche, and P.J. Marie Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion J Biol Chem 283 2008 30549
-
(2008)
J Biol Chem
, vol.283
, pp. 30549
-
-
Fromigue, O.1
Hamidouche, Z.2
Marie, P.J.3
-
38
-
-
33751034408
-
Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho
-
T. Kusama, M. Mukai, and M. Tatsuta Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho Int J Oncol 29 2006 217
-
(2006)
Int J Oncol
, vol.29
, pp. 217
-
-
Kusama, T.1
Mukai, M.2
Tatsuta, M.3
-
39
-
-
77952933689
-
Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells
-
A. Parikh, C. Childress, and K. Deitrick Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells Prostate 70 2010 971
-
(2010)
Prostate
, vol.70
, pp. 971
-
-
Parikh, A.1
Childress, C.2
Deitrick, K.3
-
40
-
-
77949697998
-
A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells
-
K.M. Sane, M. Mynderse, and D.T. Lalonde A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells J Pharmacol Exp Ther 333 2010 23
-
(2010)
J Pharmacol Exp Ther
, vol.333
, pp. 23
-
-
Sane, K.M.1
Mynderse, M.2
Lalonde, D.T.3
-
41
-
-
0034715895
-
Rho GTPases: Signaling, migration, and invasion
-
A.A. Schmitz, E.E. Govek, and B. Bottner Rho GTPases: Signaling, migration, and invasion Exp Cell Res 261 2000 1
-
(2000)
Exp Cell Res
, vol.261
, pp. 1
-
-
Schmitz, A.A.1
Govek, E.E.2
Bottner, B.3
-
42
-
-
2442664118
-
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
-
Y. Gao, J.B. Dickerson, and F. Guo Rational design and characterization of a Rac GTPase-specific small molecule inhibitor Proc Natl Acad Sci USA 101 2004 7618
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 7618
-
-
Gao, Y.1
Dickerson, J.B.2
Guo, F.3
-
43
-
-
42049088710
-
Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2
-
Y.C. Lin, J.H. Lin, and C.W. Chou Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2 Cancer Res 68 2008 2375
-
(2008)
Cancer Res
, vol.68
, pp. 2375
-
-
Lin, Y.C.1
Lin, J.H.2
Chou, C.W.3
-
44
-
-
11144221007
-
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
-
Y. Shao, Z. Gao, and P.A. Marks Apoptotic and autophagic cell death induced by histone deacetylase inhibitors Proc Natl Acad Sci U S A 101 2004 18030
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 18030
-
-
Shao, Y.1
Gao, Z.2
Marks, P.A.3
-
45
-
-
41249099242
-
Inhibition of histone deacetylase1 induces autophagy
-
M. Oh, I.K. Choi, and H.J. Kwon Inhibition of histone deacetylase1 induces autophagy Biochem Biophys Res Commun 369 2008 1179
-
(2008)
Biochem Biophys Res Commun
, vol.369
, pp. 1179
-
-
Oh, M.1
Choi, I.K.2
Kwon, H.J.3
|