Airway mesenchymal cell death by mevalonate cascade inhibition: Integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1843, Issue 7, 2014, Pages 1259-1271

  Ghavami, Saeid ^a   Sharma, Pawan ^a   Yeganeh, Behzad ^a   Ojo, Oluwaseun O ^a   Jha, Aruni ^a   Mutawe, Mark M ^a   Kashani, Hessam H ^a   Los, Marek J ^b   Klonisch, Thomas ^a   Unruh, Helmut ^a   Halayko, Andrew J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Cell death; Endoplasmic reticulum stress; Fibroblast; Statin

Indexed keywords

ACTIVATED TRANSCRIPTION FACTOR 4; ACTIVATED TRANSCRIPTION FACTOR 6; AUTOPHAGY PROTEIN 3; AUTOPHAGY PROTEIN 7; CASPASE 4; CASPASE 7; CASPASE 9; CHOLESTEROL; HIGH MOBILITY GROUP B1 PROTEIN; MEVALONIC ACID; PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN IRE1; SIMVASTATIN; UNCLASSIFIED DRUG; ATG3 PROTEIN, HUMAN; ATG7 PROTEIN, HUMAN; BAK1 PROTEIN, MOUSE; BAX PROTEIN, MOUSE; CASP4 PROTEIN, HUMAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INITIATOR CASPASE; SMALL INTERFERING RNA; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG FIBROBLAST; MESENCHYME CELL; PRIORITY JOURNAL; PROTEIN SECRETION; SMOOTH MUSCLE FIBER; TRANSMISSION ELECTRON MICROSCOPY; UNFOLDED PROTEIN RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRONCHUS; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; AUTOPHAGY; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BRONCHI; CASPASES, INITIATOR; CELL SURVIVAL; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; MICE; MYOCYTES, SMOOTH MUSCLE; PRIMARY CELL CULTURE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIMVASTATIN; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-CONJUGATING ENZYMES; UNFOLDED PROTEIN RESPONSE;

EID: 84898614083     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2014.03.006     Document Type: Article

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