Heterogeneity in simvastatin-induced cytotoxicity in AML is caused by differences in Ras-isoprenylation

Leukemia

Volumn 26, Issue 4, 2012, Pages 845-848

  Van Der Weide, K ^a   Korthuis, P M ^a   Kuipers, F ^a   De Vries, E G E ^a   Vellenga, E ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CHOLESTEROL; GGTI 298; MEVALONIC ACID; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; RAS PROTEIN; RHO FACTOR; SIMVASTATIN; SQUALENE SYNTHASE INHIBITOR; TIPIFARNIB;

ACUTE GRANULOCYTIC LEUKEMIA; AUTOCRINE EFFECT; CELL DEATH; CELL GROWTH; CELL HETEROGENEITY; CELL SURVIVAL; CHEMOLUMINESCENCE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE MUTATION; HOMEOSTASIS; HUMAN; IN VITRO STUDY; LETTER; LEUKEMIA CELL LINE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PRENYLATION; SIGNAL TRANSDUCTION;

BUTADIENES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKEMIA, MYELOID, ACUTE; NITRILES; PRENYLATION; RAS PROTEINS; SIMVASTATIN;

EID: 84859633257     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.259     Document Type: Letter

References (13)

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