Hydrophobic statins induce autophagy and cell death in human rhabdomyosarcoma cells by depleting geranylgeranyl diphosphate

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 95-103

  Araki, Makoto ^a,b   Maeda, Masatomo ^b   Motojima, Kiyoto ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Autophagy; Geranylgeranyl diphosphate; mTORC1; Rhabdomyolysis; Statin

Indexed keywords

CERIVASTATIN; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN; PROTEIN P62; RAS PROTEIN; RHEB PROTEIN; SIMVASTATIN;

ANTIBODY SPECIFICITY; ARTICLE; AUTOPHAGY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SARCOMA CELL;

AUTOPHAGY; CELL LINE, TUMOR; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICROTUBULE-ASSOCIATED PROTEINS; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; POLYISOPRENYL PHOSPHATES; RHABDOMYOSARCOMA;

EID: 84855547801     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.10.044     Document Type: Article

References (28)

1. Araki, M., Motojima, K., 2008. Hydrophobic statins induce autophagy in cultured human rhabdomyosarcoma cells. Biochem. Biophys. Res. Commun. 367, 462-467.
2. Arora, R., Liebo, M., Maldonado, F., 2006. Statin-induced myopathy: the two faces of Janus. J. Cardiovasc. Pharmacol. Ther. 11, 105-112. (Pubitemid 44449099)
3. Ashibe, B., Motojima, K., 2009. Fatty aldehyde dehydrogenase is up-regulated by polyunsaturated fatty acid via peroxisome proliferator-activated receptor alpha and suppresses polyunsaturated fatty acid-induced endoplasmic reticulum stress. FEBS J. 276, 6956-6970.
4. Boberg, M., Angerbauer, R., Kanhai, W., Karl, W., Kern, A., Radtke, M., Steinke, W., 1998. Biotransformation of cerivastatin in mice, rats, and dogs in vivo. Drug Metab. Dispos. 26, 640-652. (Pubitemid 28345847)
5. Davidson, M., Clark, J., Glass, L., Kanumalla, A., 2006. Statin safety: an appraisal from the adverse event reporting system. Am. J. Cardiol. 97, 32C-43C.
6. Endo, A., Tsujita, Y., Kuroda, M., Tanzawa, K., 1977. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Eur. J. Biochem. 77, 31-36. (Pubitemid 8122952)
7. He, C., Klionsky, D., 2009. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43, 67-93.
8. Holdgate, G.A., Ward, W.H.J., McTaggart, F., 2003. Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin. Biochem. Soc. Trans. 31, 528-531. (Pubitemid 36750725)
9. Horiguchi, Y., Araki, M., Motojima, K., 2008. Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11. Arch. Biochem. Biophys. 479, 121-130.
10. Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S., Natsume, T., Takehana, K., Yamada, N., Guan, J., Oshiro, N., Mizushima, N., 2009. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991.
11. Huang, J., Manning, B., 2008. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem. J. 412, 179-190. (Pubitemid 351758225)
12. Ichimura, Y., Kumanomidou, T., Sou, Y., Mizushima, T., Ezaki, J., Ueno, T., Kominami, E., Yamane, T., Tanaka, K., Komatsu, M., 2008. Structural basis for sorting mechanism of p62 in selective autophagy. J. Biol. Chem. 283, 22847-22857.
13. Inoki, K., Li, Y., Xu, T., Guan, K., 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834. (Pubitemid 36944560)
14. Ishigami, M., Honda, T., Takasaki, W., Ikeda, T., Komai, T., Ito, K., Sugiyama, Y., 2001. A comparison of the effects of 3-hydroxy-3-methylglutaryl- coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro. Drug Metab. Dispos. 29, 282-288. (Pubitemid 32179528)
15. Jung, C., Jun, C., Ro, S., Kim, Y., Otto, N., Cao, J., Kundu, M., Kim, D., 2009. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 20, 1992-2003.
16. König, J., Seithel, A., Gradhand, U., Fromm, M., 2006. Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch. Pharmacol. 372, 432-443.
17. Mizushima, N., 2007. Autophagy: process and function. Genes Dev. 21, 2861-2873. (Pubitemid 350133435)
18. Mizushima, N., Levine, B., Cuervo, A., Klionsky, D., 2008. Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075. (Pubitemid 351317450)
19. Neuvonen, P., Niemi, M., Backman, J., 2006. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin. Pharmacol. Ther. 80, 565-581. (Pubitemid 44908269)
20. Omar, M., Wilson, J., 2002. FDA adverse event reports on statin-associated rhabdomyolysis. Ann. Pharmacother. 36, 288-295. (Pubitemid 34126824)
21. Ostrowski, S.M., Wilkinson, B.L., Golde, T.E., Landreth, G., 2007. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. J. Biol. Chem. 282, 26832-26844. (Pubitemid 47501902)
22. Parikh, A., Childress, C., Deitrick, K., Lin, Q., Rukstalis, D., Yang, W., 2010. Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells. Prostate 70, 971-981.
23. Prueksaritanont, T., Ma, B., Fang, X., Subramanian, R., Yu, J., Lin, J., 2001. Beta-oxidation of simvastatin in mouse liver preparations. Drug Metab. Dispos. 29, 1251-1255. (Pubitemid 32896572)
24. Sane, K., Mynderse, M., Lalonde, D., Dean, I., Wojtkowiak, J., Fouad, F., Borch, R., Reiners, J.J., Gibbs, R., Mattingly, R., 2010. A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells. J. Pharmacol. Exp. Ther. 333, 23-33.
25. Schaefer, W., Lawrence, J., Loughlin, A., Stoffregen, D., Mixson, L., Dean, D., Raab, C., Yu, N., Lankas, G., Frederick, C., 2004. Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats. Toxicol. Appl. Pharmacol. 194, 10-23. (Pubitemid 38064437)
26. Seachrist, J., Loi, C., Evans, M., Criswell, K., Rothwell, C., 2005. Roles of exercise and pharmacokinetics in cerivastatin-induced skeletal muscle toxicity. Toxicol. Sci. 88, 551-561. (Pubitemid 41672163)
27. Takahashi, K., Nakagawa, M., Young, S., Yamanaka, S., 2005. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. J. Biol. Chem. 280, 32768-32774. (Pubitemid 41368323)
28. Wong, W.W.-L., Dimitroulakos, J., Minden, M.D., Penn, L.Z., 2002. HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16, 508-519. (Pubitemid 34460459)