-
1
-
-
34848814178
-
Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription
-
Almeida M., Han L., Martin-Millan M., O'Brien C.A., Manolagas S.C. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J. Biol. Chem. 2007, 282:27298-27305.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 27298-27305
-
-
Almeida, M.1
Han, L.2
Martin-Millan, M.3
O'Brien, C.A.4
Manolagas, S.C.5
-
2
-
-
66149172131
-
Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study
-
Anselmi C.V., Malovini A., Roncarati R., Novelli V., Villa F., Condorelli G., Bellazzi R., Puca A.A. Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Res. 2009, 12:95-104.
-
(2009)
Rejuvenation Res.
, vol.12
, pp. 95-104
-
-
Anselmi, C.V.1
Malovini, A.2
Roncarati, R.3
Novelli, V.4
Villa, F.5
Condorelli, G.6
Bellazzi, R.7
Puca, A.A.8
-
3
-
-
10644282295
-
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
-
Apfeld J., O'Connor G., McDonagh T., DiStefano P.S., Curtis R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 2004, 18:3004-3009.
-
(2004)
Genes Dev.
, vol.18
, pp. 3004-3009
-
-
Apfeld, J.1
O'Connor, G.2
McDonagh, T.3
DiStefano, P.S.4
Curtis, R.5
-
4
-
-
84866248375
-
Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity
-
Bahia P.K., Pugh V., Hoyland K., Hensley V., Rattray M., Williams R.J. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J. Neurochem. 2012, 123:182-191.
-
(2012)
J. Neurochem.
, vol.123
, pp. 182-191
-
-
Bahia, P.K.1
Pugh, V.2
Hoyland, K.3
Hensley, V.4
Rattray, M.5
Williams, R.J.6
-
5
-
-
37349025432
-
FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
-
Bakker W.J., Harris I.S., Mak T.W. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol. Cell 2007, 28:941-953.
-
(2007)
Mol. Cell
, vol.28
, pp. 941-953
-
-
Bakker, W.J.1
Harris, I.S.2
Mak, T.W.3
-
6
-
-
84858638822
-
Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans
-
Boccitto M., Lamitina T., Kalb R.G. Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans. PLoS One 2012, 7:e33494.
-
(2012)
PLoS One
, vol.7
, pp. e33494
-
-
Boccitto, M.1
Lamitina, T.2
Kalb, R.G.3
-
7
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
Brenner, S.1
-
8
-
-
78549243034
-
IkappaB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia
-
Chapuis N., Park S., Leotoing L., Tamburini J., Verdier F., Bardet V., Green A.S., Willems L., Agou F., Ifrah N., Dreyfus F., Bismuth G., Baud V., Lacombe C., Mayeux P., Bouscary D. IkappaB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia. Blood 2010, 116:4240-4250.
-
(2010)
Blood
, vol.116
, pp. 4240-4250
-
-
Chapuis, N.1
Park, S.2
Leotoing, L.3
Tamburini, J.4
Verdier, F.5
Bardet, V.6
Green, A.S.7
Willems, L.8
Agou, F.9
Ifrah, N.10
Dreyfus, F.11
Bismuth, G.12
Baud, V.13
Lacombe, C.14
Mayeux, P.15
Bouscary, D.16
-
9
-
-
70349644002
-
Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism
-
Chiacchiera F., Simone C. Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism. Autophagy 2009, 5:1030-1033.
-
(2009)
Autophagy
, vol.5
, pp. 1030-1033
-
-
Chiacchiera, F.1
Simone, C.2
-
10
-
-
69049096002
-
P38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription
-
Chiacchiera F., Matrone A., Ferrari E., Ingravallo G., Lo Sasso G., Murzilli S., Petruzzelli M., Salvatore L., Moschetta A., Simone C. p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. Cell Death Differ. 2009, 16:1203-1214.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1203-1214
-
-
Chiacchiera, F.1
Matrone, A.2
Ferrari, E.3
Ingravallo, G.4
Lo Sasso, G.5
Murzilli, S.6
Petruzzelli, M.7
Salvatore, L.8
Moschetta, A.9
Simone, C.10
-
11
-
-
80755184820
-
A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development
-
Christensen R., de la Torre-Ubieta L., Bonni A., Colon-Ramos D.A. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development 2011, 138:5257-5267.
-
(2011)
Development
, vol.138
, pp. 5257-5267
-
-
Christensen, R.1
de la Torre-Ubieta, L.2
Bonni, A.3
Colon-Ramos, D.A.4
-
12
-
-
0033968166
-
Small heat-shock proteins and their potential role in human disease
-
Clark J.I., Muchowski P.J. Small heat-shock proteins and their potential role in human disease. Curr. Opin. Struct. Biol. 2000, 10:52-59.
-
(2000)
Curr. Opin. Struct. Biol.
, vol.10
, pp. 52-59
-
-
Clark, J.I.1
Muchowski, P.J.2
-
13
-
-
49849093007
-
Unravelling the tumor-suppressive functions of FOXO proteins
-
Dansen T.B., Burgering B.M. Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol. 2008, 18:421-429.
-
(2008)
Trends Cell Biol.
, vol.18
, pp. 421-429
-
-
Dansen, T.B.1
Burgering, B.M.2
-
14
-
-
48249083398
-
Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling
-
Davila D., Torres-Aleman I. Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling. Mol. Biol. Cell 2008, 19:2014-2025.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2014-2025
-
-
Davila, D.1
Torres-Aleman, I.2
-
15
-
-
84866097174
-
Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate
-
Davila D., Connolly N.M., Bonner H., Weisova P., Dussmann H., Concannon C.G., Huber H.J., Prehn J.H. Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate. Cell Death Differ. 2012, 19:1677-1688.
-
(2012)
Cell Death Differ.
, vol.19
, pp. 1677-1688
-
-
Davila, D.1
Connolly, N.M.2
Bonner, H.3
Weisova, P.4
Dussmann, H.5
Concannon, C.G.6
Huber, H.J.7
Prehn, J.H.8
-
16
-
-
84906283646
-
Estrogen receptor beta upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer
-
Dey P., Strom A., Gustafsson J.A. Estrogen receptor beta upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene 2014, 33:4213-4225.
-
(2014)
Oncogene
, vol.33
, pp. 4213-4225
-
-
Dey, P.1
Strom, A.2
Gustafsson, J.A.3
-
17
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers P.F., Medema R.H., Lammers J.W., Koenderman L., Coffer P.J. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 2000, 10:1201-1204.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
18
-
-
34547628891
-
Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress
-
Erol A. Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress. BioEssays 2007, 29:811-818.
-
(2007)
BioEssays
, vol.29
, pp. 811-818
-
-
Erol, A.1
-
19
-
-
18844382368
-
Functional interaction between beta-catenin and FOXO in oxidative stress signaling
-
Essers M.A., de Vries-Smits L.M., Barker N., Polderman P.E., Burgering B.M., Korswagen H.C. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science (New York, N.Y.) 2005, 308:1181-1184.
-
(2005)
Science (New York, N.Y.)
, vol.308
, pp. 1181-1184
-
-
Essers, M.A.1
de Vries-Smits, L.M.2
Barker, N.3
Polderman, P.E.4
Burgering, B.M.5
Korswagen, H.C.6
-
20
-
-
62449083712
-
Association of FOXO3A variation with human longevity confirmed in German centenarians
-
Flachsbart F., Caliebe A., Kleindorp R., Blanche H., von Eller-Eberstein H., Nikolaus S., Schreiber S., Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2700-2705.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2700-2705
-
-
Flachsbart, F.1
Caliebe, A.2
Kleindorp, R.3
Blanche, H.4
von Eller-Eberstein, H.5
Nikolaus, S.6
Schreiber, S.7
Nebel, A.8
-
21
-
-
0023831256
-
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
-
Friedman D.B., Johnson T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 1988, 118:75-86.
-
(1988)
Genetics
, vol.118
, pp. 75-86
-
-
Friedman, D.B.1
Johnson, T.E.2
-
22
-
-
84899808625
-
Chaperone function and mechanism of small heat-shock proteins
-
Fu X. Chaperone function and mechanism of small heat-shock proteins. Acta Biochim. Biophys. Sin. 2014, 46:347-356.
-
(2014)
Acta Biochim. Biophys. Sin.
, vol.46
, pp. 347-356
-
-
Fu, X.1
-
23
-
-
34848850156
-
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
-
Greer E.L., Dowlatshahi D., Banko M.R., Villen J., Hoang K., Blanchard D., Gygi S.P., Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol. 2007, 17:1646-1656.
-
(2007)
Curr. Biol.
, vol.17
, pp. 1646-1656
-
-
Greer, E.L.1
Dowlatshahi, D.2
Banko, M.R.3
Villen, J.4
Hoang, K.5
Blanchard, D.6
Gygi, S.P.7
Brunet, A.8
-
24
-
-
0035846604
-
Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
Henderson S.T., Johnson T.E. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 2001, 11:1975-1980.
-
(2001)
Curr. Biol.
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
25
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu A.L., Murphy C.T., Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (New York, N.Y.) 2003, 300:1142-1145.
-
(2003)
Science (New York, N.Y.)
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
26
-
-
11144357466
-
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
-
Hu M.C., Lee D.F., Xia W., Golfman L.S., Ou-Yang F., Yang J.Y., Zou Y., Bao S., Hanada N., Saso H., Kobayashi R., Hung M.C. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004, 117:225-237.
-
(2004)
Cell
, vol.117
, pp. 225-237
-
-
Hu, M.C.1
Lee, D.F.2
Xia, W.3
Golfman, L.S.4
Ou-Yang, F.5
Yang, J.Y.6
Zou, Y.7
Bao, S.8
Hanada, N.9
Saso, H.10
Kobayashi, R.11
Hung, M.C.12
-
27
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
28
-
-
84881231465
-
FOXOs attenuate bone formation by suppressing Wnt signaling
-
Iyer S., Ambrogini E., Bartell S.M., Han L., Roberson P.K., de Cabo R., Jilka R.L., Weinstein R.S., O'Brien C.A., Manolagas S.C., Almeida M. FOXOs attenuate bone formation by suppressing Wnt signaling. J. Clin. Invest. 2013, 123:3409-3419.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3409-3419
-
-
Iyer, S.1
Ambrogini, E.2
Bartell, S.M.3
Han, L.4
Roberson, P.K.5
de Cabo, R.6
Jilka, R.L.7
Weinstein, R.S.8
O'Brien, C.A.9
Manolagas, S.C.10
Almeida, M.11
-
29
-
-
84855544817
-
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
-
Jiang M., Wang J., Fu J., Du L., Jeong H., West T., Xiang L., Peng Q., Hou Z., Cai H., Seredenina T., Arbez N., Zhu S., Sommers K., Qian J., Zhang J., Mori S., Yang X.W., Tamashiro K.L., Aja S., Moran T.H., Luthi-Carter R., Martin B., Maudsley S., Mattson M.P., Cichewicz R.H., Ross C.A., Holtzman D.M., Krainc D., Duan W. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat. Med. 2011, 18:153-158.
-
(2011)
Nat. Med.
, vol.18
, pp. 153-158
-
-
Jiang, M.1
Wang, J.2
Fu, J.3
Du, L.4
Jeong, H.5
West, T.6
Xiang, L.7
Peng, Q.8
Hou, Z.9
Cai, H.10
Seredenina, T.11
Arbez, N.12
Zhu, S.13
Sommers, K.14
Qian, J.15
Zhang, J.16
Mori, S.17
Yang, X.W.18
Tamashiro, K.L.19
Aja, S.20
Moran, T.H.21
Luthi-Carter, R.22
Martin, B.23
Maudsley, S.24
Mattson, M.P.25
Cichewicz, R.H.26
Ross, C.A.27
Holtzman, D.M.28
Krainc, D.29
Duan, W.30
more..
-
30
-
-
0025004091
-
Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
-
Johnson T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science (New York, N.Y.) 1990, 249:908-912.
-
(1990)
Science (New York, N.Y.)
, vol.249
, pp. 908-912
-
-
Johnson, T.E.1
-
31
-
-
84872527628
-
MTOR is a key modulator of ageing and age-related disease
-
Johnson S.C., Rabinovitch P.S., Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013, 493:338-345.
-
(2013)
Nature
, vol.493
, pp. 338-345
-
-
Johnson, S.C.1
Rabinovitch, P.S.2
Kaeberlein, M.3
-
32
-
-
79251470797
-
The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
-
Kenyon C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2011, 366:9-16.
-
(2011)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.366
, pp. 9-16
-
-
Kenyon, C.1
-
33
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993, 366:461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
34
-
-
55449095000
-
Molecular origin of polyglutamine aggregation in neurodegenerative diseases
-
Khare S.D., Ding F., Gwanmesia K.N., Dokholyan N.V. Molecular origin of polyglutamine aggregation in neurodegenerative diseases. PLoS Comput. Biol. 2005, 1:230-235.
-
(2005)
PLoS Comput. Biol.
, vol.1
, pp. 230-235
-
-
Khare, S.D.1
Ding, F.2
Gwanmesia, K.N.3
Dokholyan, N.V.4
-
35
-
-
77952373274
-
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1
-
Khatri S., Yepiskoposyan H., Gallo C.A., Tandon P., Plas D.R. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J. Biol. Chem. 2010, 285:15960-15965.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 15960-15965
-
-
Khatri, S.1
Yepiskoposyan, H.2
Gallo, C.A.3
Tandon, P.4
Plas, D.R.5
-
36
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (New York, N.Y.) 1997, 277:942-946.
-
(1997)
Science (New York, N.Y.)
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
37
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
Kitamura T., Nakae J., Kitamura Y., Kido Y., Biggs W.H., Wright C.V., White M.F., Arden K.C., Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 2002, 110:1839-1847.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs, W.H.5
Wright, C.V.6
White, M.F.7
Arden, K.C.8
Accili, D.9
-
38
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops G.J., Dansen T.B., Polderman P.E., Saarloos I., Wirtz K.W., Coffer P.J., Huang T.T., Bos J.L., Medema R.H., Burgering B.M. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002, 419:316-321.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
39
-
-
33646934067
-
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
-
Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villen J., Becker E.B., DiBacco S., de la Iglesia N., Gygi S., Blackwell T.K., Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 2006, 125:987-1001.
-
(2006)
Cell
, vol.125
, pp. 987-1001
-
-
Lehtinen, M.K.1
Yuan, Z.2
Boag, P.R.3
Yang, Y.4
Villen, J.5
Becker, E.B.6
DiBacco, S.7
de la Iglesia, N.8
Gygi, S.9
Blackwell, T.K.10
Bonni, A.11
-
40
-
-
0030657540
-
Daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K., Dorman J.B., Rodan A., Kenyon C. daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (New York, N.Y.) 1997, 278:1319-1322.
-
(1997)
Science (New York, N.Y.)
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
41
-
-
35648929883
-
Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
-
Manolagas S.C., Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol. Endocrinol. 2007, 21:2605-2614.
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 2605-2614
-
-
Manolagas, S.C.1
Almeida, M.2
-
42
-
-
77958494422
-
Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress
-
Manolopoulos K.N., Klotz L.O., Korsten P., Bornstein S.R., Barthel A. Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress. Mol. Psychiatry 2010, 15:1046-1052.
-
(2010)
Mol. Psychiatry
, vol.15
, pp. 1046-1052
-
-
Manolopoulos, K.N.1
Klotz, L.O.2
Korsten, P.3
Bornstein, S.R.4
Barthel, A.5
-
43
-
-
67649366086
-
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases
-
Mojsilovic-Petrovic J., Nedelsky N., Boccitto M., Mano I., Georgiades S.N., Zhou W., Liu Y., Neve R.L., Taylor J.P., Driscoll M., Clardy J., Merry D., Kalb R.G. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J. Neurosci. Off. J. Soc. Neurosci. 2009, 29:8236-8247.
-
(2009)
J. Neurosci. Off. J. Soc. Neurosci.
, vol.29
, pp. 8236-8247
-
-
Mojsilovic-Petrovic, J.1
Nedelsky, N.2
Boccitto, M.3
Mano, I.4
Georgiades, S.N.5
Zhou, W.6
Liu, Y.7
Neve, R.L.8
Taylor, J.P.9
Driscoll, M.10
Clardy, J.11
Merry, D.12
Kalb, R.G.13
-
44
-
-
44849094781
-
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
-
Morimoto R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev. 2008, 22:1427-1438.
-
(2008)
Genes Dev.
, vol.22
, pp. 1427-1438
-
-
Morimoto, R.I.1
-
45
-
-
0036678146
-
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
Morley J.F., Brignull H.R., Weyers J.J., Morimoto R.I. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:10417-10422.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
46
-
-
0030014296
-
A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
-
Murakami S., Johnson T.E. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 1996, 143:1207-1218.
-
(1996)
Genetics
, vol.143
, pp. 1207-1218
-
-
Murakami, S.1
Johnson, T.E.2
-
47
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., Ahringer J., Li H., Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003, 424:277-283.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
48
-
-
0036787607
-
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
Nakae J., Biggs W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 2002, 32:245-253.
-
(2002)
Nat. Genet.
, vol.32
, pp. 245-253
-
-
Nakae, J.1
Biggs, W.H.2
Kitamura, T.3
Cavenee, W.K.4
Wright, C.V.5
Arden, K.C.6
Accili, D.7
-
49
-
-
84865964715
-
Role and therapeutic potential of the pro-longevity factor FOXO and its regulators in neurodegenerative disease
-
Neri C. Role and therapeutic potential of the pro-longevity factor FOXO and its regulators in neurodegenerative disease. Front. Pharmacol. 2012, 3:15.
-
(2012)
Front. Pharmacol.
, vol.3
, pp. 15
-
-
Neri, C.1
-
50
-
-
2342652188
-
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
-
Nollen E.A., Garcia S.M., van Haaften G., Kim S., Chavez A., Morimoto R.I., Plasterk R.H. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:6403-6408.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 6403-6408
-
-
Nollen, E.A.1
Garcia, S.M.2
van Haaften, G.3
Kim, S.4
Chavez, A.5
Morimoto, R.I.6
Plasterk, R.H.7
-
51
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A., Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 1997, 389:994-999.
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
52
-
-
84888109029
-
Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy
-
Oh K.H., Kim H. Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:19024-19029.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 19024-19029
-
-
Oh, K.H.1
Kim, H.2
-
53
-
-
15444371989
-
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
-
Oh S.W., Mukhopadhyay A., Svrzikapa N., Jiang F., Davis R.J., Tissenbaum H.A. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:4494-4499.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
Jiang, F.4
Davis, R.J.5
Tissenbaum, H.A.6
-
54
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik J.H., Kollipara R., Chu G., Ji H., Xiao Y., Ding Z., Miao L., Tothova Z., Horner J.W., Carrasco D.R., Jiang S., Gilliland D.G., Chin L., Wong W.H., Castrillon D.H., DePinho R.A. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007, 128:309-323.
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
Miao, L.7
Tothova, Z.8
Horner, J.W.9
Carrasco, D.R.10
Jiang, S.11
Gilliland, D.G.12
Chin, L.13
Wong, W.H.14
Castrillon, D.H.15
DePinho, R.A.16
-
55
-
-
33747588775
-
Mutations that increase the life span of C. elegans inhibit tumor growth
-
Pinkston J.M., Garigan D., Hansen M., Kenyon C. Mutations that increase the life span of C. elegans inhibit tumor growth. Science (New York, N.Y.) 2006, 313:971-975.
-
(2006)
Science (New York, N.Y.)
, vol.313
, pp. 971-975
-
-
Pinkston, J.M.1
Garigan, D.2
Hansen, M.3
Kenyon, C.4
-
56
-
-
35648973774
-
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
-
Pinkston-Gosse J., Kenyon C. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat. Genet. 2007, 39:1403-1409.
-
(2007)
Nat. Genet.
, vol.39
, pp. 1403-1409
-
-
Pinkston-Gosse, J.1
Kenyon, C.2
-
57
-
-
84934442193
-
Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization
-
Simon M.C. Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization. Adv. Exp. Med. Biol. 2006, 588:165-170.
-
(2006)
Adv. Exp. Med. Biol.
, vol.588
, pp. 165-170
-
-
Simon, M.C.1
-
58
-
-
78249280592
-
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
-
Soerensen M., Dato S., Christensen K., McGue M., Stevnsner T., Bohr V.A., Christiansen L. Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 2010, 9:1010-1017.
-
(2010)
Aging Cell
, vol.9
, pp. 1010-1017
-
-
Soerensen, M.1
Dato, S.2
Christensen, K.3
McGue, M.4
Stevnsner, T.5
Bohr, V.A.6
Christiansen, L.7
-
59
-
-
0037134491
-
The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor
-
Tang T.T., Dowbenko D., Jackson A., Toney L., Lewin D.A., Dent A.L., Lasky L.A. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J. Biol. Chem. 2002, 277:14255-14265.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 14255-14265
-
-
Tang, T.T.1
Dowbenko, D.2
Jackson, A.3
Toney, L.4
Lewin, D.A.5
Dent, A.L.6
Lasky, L.A.7
-
60
-
-
84881175076
-
PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity
-
Tepper R.G., Ashraf J., Kaletsky R., Kleemann G., Murphy C.T., Bussemaker H.J. PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell 2013, 154:676-690.
-
(2013)
Cell
, vol.154
, pp. 676-690
-
-
Tepper, R.G.1
Ashraf, J.2
Kaletsky, R.3
Kleemann, G.4
Murphy, C.T.5
Bussemaker, H.J.6
-
61
-
-
33751382748
-
P38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
-
Troemel E.R., Chu S.W., Reinke V., Lee S.S., Ausubel F.M., Kim D.H. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2006, 2:e183.
-
(2006)
PLoS Genet.
, vol.2
, pp. e183
-
-
Troemel, E.R.1
Chu, S.W.2
Reinke, V.3
Lee, S.S.4
Ausubel, F.M.5
Kim, D.H.6
-
62
-
-
84925081605
-
DAF-16 target identification in C. elegans: past, present and future
-
Tullett J.M.A. DAF-16 target identification in C. elegans: past, present and future. Biogerontol. 2015, 16:221-234.
-
(2015)
Biogerontol.
, vol.16
, pp. 221-234
-
-
Tullett, J.M.A.1
-
63
-
-
80052970809
-
FoxO transcription factors; regulation by AKT and 14-3-3 proteins
-
Tzivion G., Dobson M., Ramakrishnan G. FoxO transcription factors; regulation by AKT and 14-3-3 proteins. Biochim. Biophys. Acta 2011, 1813:1938-1945.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 1938-1945
-
-
Tzivion, G.1
Dobson, M.2
Ramakrishnan, G.3
-
64
-
-
41849086320
-
FOXO-binding partners: it takes two to tango
-
van der Vos K.E., Coffer P.J. FOXO-binding partners: it takes two to tango. Oncogene 2008, 27:2289-2299.
-
(2008)
Oncogene
, vol.27
, pp. 2289-2299
-
-
van der Vos, K.E.1
Coffer, P.J.2
-
65
-
-
52949122885
-
FOXO3A genotype is strongly associated with human longevity
-
Willcox B.J., Donlon T.A., He Q., Chen R., Grove J.S., Yano K., Masaki K.H., Willcox D.C., Rodriguez B., Curb J.D. FOXO3A genotype is strongly associated with human longevity. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:13987-13992.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 13987-13992
-
-
Willcox, B.J.1
Donlon, T.A.2
He, Q.3
Chen, R.4
Grove, J.S.5
Yano, K.6
Masaki, K.H.7
Willcox, D.C.8
Rodriguez, B.9
Curb, J.D.10
-
66
-
-
33644750381
-
SMK-1, an essential regulator of DAF-16-mediated longevity
-
Wolff S., Ma H., Burch D., Maciel G.A., Hunter T., Dillin A. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 2006, 124:1039-1053.
-
(2006)
Cell
, vol.124
, pp. 1039-1053
-
-
Wolff, S.1
Ma, H.2
Burch, D.3
Maciel, G.A.4
Hunter, T.5
Dillin, A.6
-
67
-
-
68149108384
-
PUMA, a potent killer with or without p53
-
Yu J., Zhang L. PUMA, a potent killer with or without p53. Oncogene 2008, 27(Suppl. 1):S71-S83.
-
(2008)
Oncogene
, vol.27
, pp. S71-S83
-
-
Yu, J.1
Zhang, L.2
|