메뉴 건너뛰기




Volumn 72, Issue , 2015, Pages 1-7

Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related disease

Author keywords

Age related disease; Aging; C. elegans; Daf 16 FOXO; Human; Translational

Indexed keywords

DYSTROPHIN; ESTROGEN RECEPTOR BETA; HEAT SHOCK TRANSCRIPTION FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; POLYGLUTAMINE; PROTEIN KINASE B; PROTEIN P53; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TUBERIN; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; IGF1 PROTEIN, HUMAN;

EID: 84941898124     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2015.09.006     Document Type: Review
Times cited : (67)

References (67)
  • 1
    • 34848814178 scopus 로고    scopus 로고
    • Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription
    • Almeida M., Han L., Martin-Millan M., O'Brien C.A., Manolagas S.C. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J. Biol. Chem. 2007, 282:27298-27305.
    • (2007) J. Biol. Chem. , vol.282 , pp. 27298-27305
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    O'Brien, C.A.4    Manolagas, S.C.5
  • 3
    • 10644282295 scopus 로고    scopus 로고
    • The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
    • Apfeld J., O'Connor G., McDonagh T., DiStefano P.S., Curtis R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 2004, 18:3004-3009.
    • (2004) Genes Dev. , vol.18 , pp. 3004-3009
    • Apfeld, J.1    O'Connor, G.2    McDonagh, T.3    DiStefano, P.S.4    Curtis, R.5
  • 4
    • 84866248375 scopus 로고    scopus 로고
    • Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity
    • Bahia P.K., Pugh V., Hoyland K., Hensley V., Rattray M., Williams R.J. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J. Neurochem. 2012, 123:182-191.
    • (2012) J. Neurochem. , vol.123 , pp. 182-191
    • Bahia, P.K.1    Pugh, V.2    Hoyland, K.3    Hensley, V.4    Rattray, M.5    Williams, R.J.6
  • 5
    • 37349025432 scopus 로고    scopus 로고
    • FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
    • Bakker W.J., Harris I.S., Mak T.W. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol. Cell 2007, 28:941-953.
    • (2007) Mol. Cell , vol.28 , pp. 941-953
    • Bakker, W.J.1    Harris, I.S.2    Mak, T.W.3
  • 6
    • 84858638822 scopus 로고    scopus 로고
    • Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans
    • Boccitto M., Lamitina T., Kalb R.G. Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans. PLoS One 2012, 7:e33494.
    • (2012) PLoS One , vol.7 , pp. e33494
    • Boccitto, M.1    Lamitina, T.2    Kalb, R.G.3
  • 7
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 9
    • 70349644002 scopus 로고    scopus 로고
    • Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism
    • Chiacchiera F., Simone C. Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism. Autophagy 2009, 5:1030-1033.
    • (2009) Autophagy , vol.5 , pp. 1030-1033
    • Chiacchiera, F.1    Simone, C.2
  • 11
    • 80755184820 scopus 로고    scopus 로고
    • A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development
    • Christensen R., de la Torre-Ubieta L., Bonni A., Colon-Ramos D.A. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development 2011, 138:5257-5267.
    • (2011) Development , vol.138 , pp. 5257-5267
    • Christensen, R.1    de la Torre-Ubieta, L.2    Bonni, A.3    Colon-Ramos, D.A.4
  • 12
    • 0033968166 scopus 로고    scopus 로고
    • Small heat-shock proteins and their potential role in human disease
    • Clark J.I., Muchowski P.J. Small heat-shock proteins and their potential role in human disease. Curr. Opin. Struct. Biol. 2000, 10:52-59.
    • (2000) Curr. Opin. Struct. Biol. , vol.10 , pp. 52-59
    • Clark, J.I.1    Muchowski, P.J.2
  • 13
    • 49849093007 scopus 로고    scopus 로고
    • Unravelling the tumor-suppressive functions of FOXO proteins
    • Dansen T.B., Burgering B.M. Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol. 2008, 18:421-429.
    • (2008) Trends Cell Biol. , vol.18 , pp. 421-429
    • Dansen, T.B.1    Burgering, B.M.2
  • 14
    • 48249083398 scopus 로고    scopus 로고
    • Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling
    • Davila D., Torres-Aleman I. Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling. Mol. Biol. Cell 2008, 19:2014-2025.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2014-2025
    • Davila, D.1    Torres-Aleman, I.2
  • 16
    • 84906283646 scopus 로고    scopus 로고
    • Estrogen receptor beta upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer
    • Dey P., Strom A., Gustafsson J.A. Estrogen receptor beta upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene 2014, 33:4213-4225.
    • (2014) Oncogene , vol.33 , pp. 4213-4225
    • Dey, P.1    Strom, A.2    Gustafsson, J.A.3
  • 17
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers P.F., Medema R.H., Lammers J.W., Koenderman L., Coffer P.J. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 2000, 10:1201-1204.
    • (2000) Curr. Biol. , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medema, R.H.2    Lammers, J.W.3    Koenderman, L.4    Coffer, P.J.5
  • 18
    • 34547628891 scopus 로고    scopus 로고
    • Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress
    • Erol A. Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress. BioEssays 2007, 29:811-818.
    • (2007) BioEssays , vol.29 , pp. 811-818
    • Erol, A.1
  • 21
    • 0023831256 scopus 로고
    • A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
    • Friedman D.B., Johnson T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 1988, 118:75-86.
    • (1988) Genetics , vol.118 , pp. 75-86
    • Friedman, D.B.1    Johnson, T.E.2
  • 22
    • 84899808625 scopus 로고    scopus 로고
    • Chaperone function and mechanism of small heat-shock proteins
    • Fu X. Chaperone function and mechanism of small heat-shock proteins. Acta Biochim. Biophys. Sin. 2014, 46:347-356.
    • (2014) Acta Biochim. Biophys. Sin. , vol.46 , pp. 347-356
    • Fu, X.1
  • 24
    • 0035846604 scopus 로고    scopus 로고
    • Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • Henderson S.T., Johnson T.E. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 2001, 11:1975-1980.
    • (2001) Curr. Biol. , vol.11 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 25
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu A.L., Murphy C.T., Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (New York, N.Y.) 2003, 300:1142-1145.
    • (2003) Science (New York, N.Y.) , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 27
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 30
    • 0025004091 scopus 로고
    • Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
    • Johnson T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science (New York, N.Y.) 1990, 249:908-912.
    • (1990) Science (New York, N.Y.) , vol.249 , pp. 908-912
    • Johnson, T.E.1
  • 31
    • 84872527628 scopus 로고    scopus 로고
    • MTOR is a key modulator of ageing and age-related disease
    • Johnson S.C., Rabinovitch P.S., Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013, 493:338-345.
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 32
    • 79251470797 scopus 로고    scopus 로고
    • The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
    • Kenyon C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2011, 366:9-16.
    • (2011) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.366 , pp. 9-16
    • Kenyon, C.1
  • 33
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993, 366:461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 34
    • 55449095000 scopus 로고    scopus 로고
    • Molecular origin of polyglutamine aggregation in neurodegenerative diseases
    • Khare S.D., Ding F., Gwanmesia K.N., Dokholyan N.V. Molecular origin of polyglutamine aggregation in neurodegenerative diseases. PLoS Comput. Biol. 2005, 1:230-235.
    • (2005) PLoS Comput. Biol. , vol.1 , pp. 230-235
    • Khare, S.D.1    Ding, F.2    Gwanmesia, K.N.3    Dokholyan, N.V.4
  • 35
    • 77952373274 scopus 로고    scopus 로고
    • FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1
    • Khatri S., Yepiskoposyan H., Gallo C.A., Tandon P., Plas D.R. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J. Biol. Chem. 2010, 285:15960-15965.
    • (2010) J. Biol. Chem. , vol.285 , pp. 15960-15965
    • Khatri, S.1    Yepiskoposyan, H.2    Gallo, C.A.3    Tandon, P.4    Plas, D.R.5
  • 36
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (New York, N.Y.) 1997, 277:942-946.
    • (1997) Science (New York, N.Y.) , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 40
    • 0030657540 scopus 로고    scopus 로고
    • Daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • Lin K., Dorman J.B., Rodan A., Kenyon C. daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (New York, N.Y.) 1997, 278:1319-1322.
    • (1997) Science (New York, N.Y.) , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 41
    • 35648929883 scopus 로고    scopus 로고
    • Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
    • Manolagas S.C., Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol. Endocrinol. 2007, 21:2605-2614.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 2605-2614
    • Manolagas, S.C.1    Almeida, M.2
  • 42
    • 77958494422 scopus 로고    scopus 로고
    • Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress
    • Manolopoulos K.N., Klotz L.O., Korsten P., Bornstein S.R., Barthel A. Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress. Mol. Psychiatry 2010, 15:1046-1052.
    • (2010) Mol. Psychiatry , vol.15 , pp. 1046-1052
    • Manolopoulos, K.N.1    Klotz, L.O.2    Korsten, P.3    Bornstein, S.R.4    Barthel, A.5
  • 44
    • 44849094781 scopus 로고    scopus 로고
    • Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    • Morimoto R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev. 2008, 22:1427-1438.
    • (2008) Genes Dev. , vol.22 , pp. 1427-1438
    • Morimoto, R.I.1
  • 45
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley J.F., Brignull H.R., Weyers J.J., Morimoto R.I. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:10417-10422.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 10417-10422
    • Morley, J.F.1    Brignull, H.R.2    Weyers, J.J.3    Morimoto, R.I.4
  • 46
    • 0030014296 scopus 로고    scopus 로고
    • A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
    • Murakami S., Johnson T.E. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 1996, 143:1207-1218.
    • (1996) Genetics , vol.143 , pp. 1207-1218
    • Murakami, S.1    Johnson, T.E.2
  • 48
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • Nakae J., Biggs W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 2002, 32:245-253.
    • (2002) Nat. Genet. , vol.32 , pp. 245-253
    • Nakae, J.1    Biggs, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6    Accili, D.7
  • 49
    • 84865964715 scopus 로고    scopus 로고
    • Role and therapeutic potential of the pro-longevity factor FOXO and its regulators in neurodegenerative disease
    • Neri C. Role and therapeutic potential of the pro-longevity factor FOXO and its regulators in neurodegenerative disease. Front. Pharmacol. 2012, 3:15.
    • (2012) Front. Pharmacol. , vol.3 , pp. 15
    • Neri, C.1
  • 51
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A., Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 1997, 389:994-999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 52
    • 84888109029 scopus 로고    scopus 로고
    • Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy
    • Oh K.H., Kim H. Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:19024-19029.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 19024-19029
    • Oh, K.H.1    Kim, H.2
  • 53
    • 15444371989 scopus 로고    scopus 로고
    • JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    • Oh S.W., Mukhopadhyay A., Svrzikapa N., Jiang F., Davis R.J., Tissenbaum H.A. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:4494-4499.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 4494-4499
    • Oh, S.W.1    Mukhopadhyay, A.2    Svrzikapa, N.3    Jiang, F.4    Davis, R.J.5    Tissenbaum, H.A.6
  • 55
    • 33747588775 scopus 로고    scopus 로고
    • Mutations that increase the life span of C. elegans inhibit tumor growth
    • Pinkston J.M., Garigan D., Hansen M., Kenyon C. Mutations that increase the life span of C. elegans inhibit tumor growth. Science (New York, N.Y.) 2006, 313:971-975.
    • (2006) Science (New York, N.Y.) , vol.313 , pp. 971-975
    • Pinkston, J.M.1    Garigan, D.2    Hansen, M.3    Kenyon, C.4
  • 56
    • 35648973774 scopus 로고    scopus 로고
    • DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
    • Pinkston-Gosse J., Kenyon C. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat. Genet. 2007, 39:1403-1409.
    • (2007) Nat. Genet. , vol.39 , pp. 1403-1409
    • Pinkston-Gosse, J.1    Kenyon, C.2
  • 57
    • 84934442193 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization
    • Simon M.C. Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization. Adv. Exp. Med. Biol. 2006, 588:165-170.
    • (2006) Adv. Exp. Med. Biol. , vol.588 , pp. 165-170
    • Simon, M.C.1
  • 58
    • 78249280592 scopus 로고    scopus 로고
    • Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
    • Soerensen M., Dato S., Christensen K., McGue M., Stevnsner T., Bohr V.A., Christiansen L. Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 2010, 9:1010-1017.
    • (2010) Aging Cell , vol.9 , pp. 1010-1017
    • Soerensen, M.1    Dato, S.2    Christensen, K.3    McGue, M.4    Stevnsner, T.5    Bohr, V.A.6    Christiansen, L.7
  • 59
    • 0037134491 scopus 로고    scopus 로고
    • The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor
    • Tang T.T., Dowbenko D., Jackson A., Toney L., Lewin D.A., Dent A.L., Lasky L.A. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J. Biol. Chem. 2002, 277:14255-14265.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14255-14265
    • Tang, T.T.1    Dowbenko, D.2    Jackson, A.3    Toney, L.4    Lewin, D.A.5    Dent, A.L.6    Lasky, L.A.7
  • 60
    • 84881175076 scopus 로고    scopus 로고
    • PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity
    • Tepper R.G., Ashraf J., Kaletsky R., Kleemann G., Murphy C.T., Bussemaker H.J. PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell 2013, 154:676-690.
    • (2013) Cell , vol.154 , pp. 676-690
    • Tepper, R.G.1    Ashraf, J.2    Kaletsky, R.3    Kleemann, G.4    Murphy, C.T.5    Bussemaker, H.J.6
  • 61
    • 33751382748 scopus 로고    scopus 로고
    • P38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    • Troemel E.R., Chu S.W., Reinke V., Lee S.S., Ausubel F.M., Kim D.H. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2006, 2:e183.
    • (2006) PLoS Genet. , vol.2 , pp. e183
    • Troemel, E.R.1    Chu, S.W.2    Reinke, V.3    Lee, S.S.4    Ausubel, F.M.5    Kim, D.H.6
  • 62
    • 84925081605 scopus 로고    scopus 로고
    • DAF-16 target identification in C. elegans: past, present and future
    • Tullett J.M.A. DAF-16 target identification in C. elegans: past, present and future. Biogerontol. 2015, 16:221-234.
    • (2015) Biogerontol. , vol.16 , pp. 221-234
    • Tullett, J.M.A.1
  • 63
    • 80052970809 scopus 로고    scopus 로고
    • FoxO transcription factors; regulation by AKT and 14-3-3 proteins
    • Tzivion G., Dobson M., Ramakrishnan G. FoxO transcription factors; regulation by AKT and 14-3-3 proteins. Biochim. Biophys. Acta 2011, 1813:1938-1945.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1938-1945
    • Tzivion, G.1    Dobson, M.2    Ramakrishnan, G.3
  • 64
    • 41849086320 scopus 로고    scopus 로고
    • FOXO-binding partners: it takes two to tango
    • van der Vos K.E., Coffer P.J. FOXO-binding partners: it takes two to tango. Oncogene 2008, 27:2289-2299.
    • (2008) Oncogene , vol.27 , pp. 2289-2299
    • van der Vos, K.E.1    Coffer, P.J.2
  • 66
    • 33644750381 scopus 로고    scopus 로고
    • SMK-1, an essential regulator of DAF-16-mediated longevity
    • Wolff S., Ma H., Burch D., Maciel G.A., Hunter T., Dillin A. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 2006, 124:1039-1053.
    • (2006) Cell , vol.124 , pp. 1039-1053
    • Wolff, S.1    Ma, H.2    Burch, D.3    Maciel, G.A.4    Hunter, T.5    Dillin, A.6
  • 67
    • 68149108384 scopus 로고    scopus 로고
    • PUMA, a potent killer with or without p53
    • Yu J., Zhang L. PUMA, a potent killer with or without p53. Oncogene 2008, 27(Suppl. 1):S71-S83.
    • (2008) Oncogene , vol.27 , pp. S71-S83
    • Yu, J.1    Zhang, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.