Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate

Cell Death and Differentiation

Volumn 19, Issue 10, 2012, Pages 1677-1688

  Davila, D ^a   Connolly, N M C ^a   Bonner, H ^a   Weisova P ^a,b   Dussmann, H ^a   Concannon, C G ^a   Huber, H J ^a   Prehn, J H M ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

BH3 only protein BIM; computational modeling; energy depletion; Excitotoxicity; FOXO3; network motifs

Indexed keywords

BIM PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITOTOXICITY; GENE ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL NUCLEUS; CELLS, CULTURED; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; MEMBRANE PROTEINS; MICE; NEURONS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR AP-1;

EID: 84866097174     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.49     Document Type: Article

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