TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves

Cardiovascular Research

Volumn 99, Issue 1, 2013, Pages 175-184

  Hagler, Michael A ^a   Hadley, Thomas M ^a   Zhang, Heyu ^a   Mehra, Kashish ^a   Roos, Carolyn M ^a   Schaff, Hartzell V ^a   Suri, Rakesh M ^a   Miller, Jordan D ^a  

^a MAYO CLINIC   (United States)

Author keywords

Antioxidants; Cardiovascular surgery; Mitral valve; Regurgitation; Valves

Indexed keywords

ANTIOXIDANT; CONNECTIVE TISSUE GROWTH FACTOR; COPPER ZINC SUPEROXIDE DISMUTASE; GELATINASE A; HYDROETHIDINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANONICAL ANALYSIS; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION; HEART MYXOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MITRAL VALVE; MITRAL VALVE DISEASE; MOUSE; MYXOMATOUS MITRAL VALVE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTIOXIDANTS; CARDIOVASCULAR SURGERY; MITRAL VALVE; REGURGITATION; VALVES;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION REGULATION; HEART VALVE DISEASES; HUMANS; MATRIX METALLOPROTEINASE 2; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITRAL VALVE; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN-PROTEIN LIGASES;

EID: 84879398211     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt083     Document Type: Article

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