The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure

Urologic Oncology: Seminars and Original Investigations

Volumn 32, Issue 4, 2014, Pages 449-457

  Lima, Luís ^a,b,c,d   Oliveira, Daniela ^a   Tavares, Ana ^a   Amaro, Teresina ^e   Cruz, Ricardo ^a   Oliveira, Maria J ^b,f,g   Ferreira, José A ^a,h   Santos, Lúcio ^a,i  

^a PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c POLYTECHNIC INSTITUTE OF PORTO   (Portugal)

^d Research Department   (Portugal)

^e HOSPITAL PEDRO HISPANO   (Portugal)

^f INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^g University of Porto   (Portugal)

^h UNIVERSITY OF AVEIRO   (Portugal)

ⁱ UNIVERSIDADE FERNANDO PESSOA   (Portugal)

Author keywords

BCG immunotherapy; Bladder cancer; CD163; CD68; Tumor associated macrophages

Indexed keywords

BCG VACCINE; CD163 ANTIGEN; CD68 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; CD68 ANTIGEN, HUMAN; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; HIF1A PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

ADULT; AGED; ARTICLE; BCG VACCINATION; BLADDER CANCER; CANCER IMMUNOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CELL COUNT; DRUG TREATMENT FAILURE; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; M2 POLARIZED MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; RECURRENCE RISK; STROMA; TREATMENT OUTCOME; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY; VERY ELDERLY; ADVERSE EFFECTS; ANOXIA; CANCER GRADING; CANCER STAGING; CASE CONTROL STUDY; DRUG EFFECTS; ENZYME IMMUNOASSAY; FOLLOW UP; IMMUNOLOGY; IMMUNOTHERAPY; MACROPHAGE; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PROSPECTIVE STUDY; STROMA CELL; SURVIVAL RATE; TREATMENT FAILURE; TUMOR MICROENVIRONMENT; TUMOR RECURRENCE; URINARY BLADDER NEOPLASMS;

ADULT; AGED; AGED, 80 AND OVER; ANOXIA; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BCG VACCINE; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOENZYME TECHNIQUES; IMMUNOTHERAPY; MACROPHAGES; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROSPECTIVE STUDIES; RECEPTORS, CELL SURFACE; STROMAL CELLS; SURVIVAL RATE; TREATMENT FAILURE; TUMOR MICROENVIRONMENT; URINARY BLADDER NEOPLASMS;

EID: 84899473274     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2013.10.012     Document Type: Article

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