-
1
-
-
84881115846
-
The structural network of inflammation and cancer: Merits and challenges
-
E. Guven Maiorov, and O. Keskin R. Nussinov The structural network of inflammation and cancer: merits and challenges Semin. Cancer Biol. 23 2013 243 251
-
(2013)
Semin. Cancer Biol.
, vol.23
, pp. 243-251
-
-
Guven Maiorov, E.1
Keskin, O.2
Nussinov, R.3
-
2
-
-
84859401430
-
Cancer and inflammation: An old intuition with rapidly evolving new concepts
-
G. Trinchieri Cancer and inflammation: an old intuition with rapidly evolving new concepts Annu. Rev. Immunol. 30 2012 677 706
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 677-706
-
-
Trinchieri, G.1
-
3
-
-
77956742502
-
Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics
-
T. Matsumura, and M. Oyama J. Inoue Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics Biochem. Biophys. Res. Commun. 400 2010 265 270
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.400
, pp. 265-270
-
-
Matsumura, T.1
Oyama, M.2
Inoue, J.3
-
4
-
-
77956929099
-
Important aspects of Toll-like receptors, ligands and their signaling pathways
-
Z.L. Chang Important aspects of Toll-like receptors, ligands and their signaling pathways Inflamm. Res. 59 2010 791 808
-
(2010)
Inflamm. Res.
, vol.59
, pp. 791-808
-
-
Chang, Z.L.1
-
5
-
-
84855992592
-
B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
-
M. Ni, and A.W. MacFarlane 4th J.A. Hamerman B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K Proc. Natl. Acad. Sci. USA 109 2012 267 272
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 267-272
-
-
Ni, M.1
MacFarlane, A.W.2
Hamerman, J.A.3
-
6
-
-
84856008042
-
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
-
T.D. Troutman, and W. Hu C. Pasare Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt Proc. Natl. Acad. Sci. USA 109 2012 273 278
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 273-278
-
-
Troutman, T.D.1
Hu, W.2
Pasare, C.3
-
7
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
F.Y. Liew, and D. Xu L.A. O'Neill Negative regulation of toll-like receptor-mediated immune responses Nat. Rev. Immunol. 5 2005 446 458
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
O'Neill, L.A.3
-
8
-
-
62649124147
-
Negative regulation of Toll-like receptor signaling pathway
-
J. Wang, Y. Hu, W.W. Deng, and B. Sun Negative regulation of Toll-like receptor signaling pathway Microbes Infect. 11 2009 321 327
-
(2009)
Microbes Infect.
, vol.11
, pp. 321-327
-
-
Wang, J.1
Hu, Y.2
Deng, W.W.3
Sun, B.4
-
9
-
-
84903884741
-
The Yin and Yang of Toll-like receptors in cancer
-
J.P. Pradere, D.H. Dapito, and R.F. Schwabe The Yin and Yang of Toll-like receptors in cancer Oncogene 33 2014 3485 3495
-
(2014)
Oncogene
, vol.33
, pp. 3485-3495
-
-
Pradere, J.P.1
Dapito, D.H.2
Schwabe, R.F.3
-
10
-
-
84939824619
-
The architecture of the TIR domain signalosome in the Toll-like Receptor-4 signaling pathway
-
Guven Maiorov, E., O. Keskin,..., R. Nussinov. 2015. The architecture of the TIR domain signalosome in the Toll-like Receptor-4 signaling pathway. Sci. Rep. 10.1038/srep13128.
-
(2015)
Sci. Rep.
-
-
Guven Maiorov, E.1
Keskin, O.2
Nussinov, R.3
-
11
-
-
84897045141
-
Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy
-
E. Guven-Maiorov, and S.E. Acuner-Ozbabacan R. Nussinov Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy Cancers (Basel) 6 2014 663 683
-
(2014)
Cancers (Basel)
, vol.6
, pp. 663-683
-
-
Guven-Maiorov, E.1
Acuner-Ozbabacan, S.E.2
Nussinov, R.3
-
12
-
-
84907569494
-
The structural network of Interleukin-10 and its implications in inflammation and cancer
-
E.S. Acuner-Ozbabacan, and B.H. Engin R. Nussinov The structural network of Interleukin-10 and its implications in inflammation and cancer BMC Genomics 15 Suppl 4 2014 S2
-
(2014)
BMC Genomics
, vol.15
, Issue.4
, pp. S2
-
-
Acuner-Ozbabacan, E.S.1
Engin, B.H.2
Nussinov, R.3
-
13
-
-
23144463510
-
PRISM: Protein interactions by structural matching
-
U. Ogmen, and O. Keskin A. Gursoy PRISM: protein interactions by structural matching Nucleic Acids Res. 33 2005 W331 W336
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. W331-W336
-
-
Ogmen, U.1
Keskin, O.2
Gursoy, A.3
-
14
-
-
80052411919
-
Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM
-
N. Tuncbag, and A. Gursoy O. Keskin Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM Nat. Protoc. 6 2011 1341 1354
-
(2011)
Nat. Protoc.
, vol.6
, pp. 1341-1354
-
-
Tuncbag, N.1
Gursoy, A.2
Keskin, O.3
-
15
-
-
84904801952
-
PRISM: A web server and repository for prediction of protein-protein interactions and modeling their 3D complexes
-
A. Baspinar, and E. Cukuroglu A. Gursoy PRISM: a web server and repository for prediction of protein-protein interactions and modeling their 3D complexes Nucleic Acids Res. 42 2014 W285 W289
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. W285-W289
-
-
Baspinar, A.1
Cukuroglu, E.2
Gursoy, A.3
-
16
-
-
77951232176
-
FiberDock: Flexible induced-fit backbone refinement in molecular docking
-
E. Mashiach, R. Nussinov, and H.J. Wolfson FiberDock: flexible induced-fit backbone refinement in molecular docking Proteins 78 2010 1503 1519
-
(2010)
Proteins
, vol.78
, pp. 1503-1519
-
-
Mashiach, E.1
Nussinov, R.2
Wolfson, H.J.3
-
17
-
-
84856657449
-
Human proteome-scale structural modeling of E2-E3 interactions exploiting interface motifs
-
G. Kar, and O. Keskin A. Gursoy Human proteome-scale structural modeling of E2-E3 interactions exploiting interface motifs J. Proteome Res. 11 2012 1196 1207
-
(2012)
J. Proteome Res.
, vol.11
, pp. 1196-1207
-
-
Kar, G.1
Keskin, O.2
Gursoy, A.3
-
18
-
-
84862588440
-
Enriching the human apoptosis pathway by predicting the structures of protein-protein complexes
-
S.E. Acuner Ozbabacan, and O. Keskin A. Gursoy Enriching the human apoptosis pathway by predicting the structures of protein-protein complexes J. Struct. Biol. 179 2012 338 346
-
(2012)
J. Struct. Biol.
, vol.179
, pp. 338-346
-
-
Acuner Ozbabacan, S.E.1
Keskin, O.2
Gursoy, A.3
-
19
-
-
84857790849
-
Fast and accurate modeling of protein-protein interactions by combining template-interface-based docking with flexible refinement
-
N. Tuncbag, and O. Keskin A. Gursoy Fast and accurate modeling of protein-protein interactions by combining template-interface-based docking with flexible refinement Proteins 80 2012 1239 1249
-
(2012)
Proteins
, vol.80
, pp. 1239-1249
-
-
Tuncbag, N.1
Keskin, O.2
Gursoy, A.3
-
20
-
-
77954065271
-
I-TASSER: A unified platform for automated protein structure and function prediction
-
A. Roy, A. Kucukural, and Y. Zhang I-TASSER: a unified platform for automated protein structure and function prediction Nat. Protoc. 5 2010 725 738
-
(2010)
Nat. Protoc.
, vol.5
, pp. 725-738
-
-
Roy, A.1
Kucukural, A.2
Zhang, Y.3
-
21
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
E. Cerami, and J. Gao N. Schultz The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data Cancer Discov. 2 2012 401 404
-
(2012)
Cancer Discov.
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Schultz, N.3
-
22
-
-
84861036418
-
HotRegion: A database of predicted hot spot clusters
-
E. Cukuroglu, A. Gursoy, and O. Keskin HotRegion: a database of predicted hot spot clusters Nucleic Acids Res. 40 2012 D829 D833
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D829-D833
-
-
Cukuroglu, E.1
Gursoy, A.2
Keskin, O.3
-
23
-
-
34548232365
-
Inference of macromolecular assemblies from crystalline state
-
E. Krissinel, and K. Henrick Inference of macromolecular assemblies from crystalline state J. Mol. Biol. 372 2007 774 797
-
(2007)
J. Mol. Biol.
, vol.372
, pp. 774-797
-
-
Krissinel, E.1
Henrick, K.2
-
24
-
-
84861732291
-
Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily
-
R. Ferrao, and J. Li H. Wu Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily Sci. Signal. 5 2012 re3
-
(2012)
Sci. Signal.
, vol.5
, pp. re3
-
-
Ferrao, R.1
Li, J.2
Wu, H.3
-
25
-
-
84924080511
-
Dynamic multiprotein assemblies shape the spatial structure of cell signaling
-
R. Nussinov, and H. Jang Dynamic multiprotein assemblies shape the spatial structure of cell signaling Prog. Biophys. Mol. Biol. 116 2014 158 164
-
(2014)
Prog. Biophys. Mol. Biol.
, vol.116
, pp. 158-164
-
-
Nussinov, R.1
Jang, H.2
-
26
-
-
84876296757
-
A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery
-
R. Nussinov, B. Ma, and C.J. Tsai A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery Biochim. Biophys. Acta 1834 2013 820 829
-
(2013)
Biochim. Biophys. Acta
, vol.1834
, pp. 820-829
-
-
Nussinov, R.1
Ma, B.2
Tsai, C.J.3
-
27
-
-
84919933634
-
Principles of allosteric interactions in cell signaling
-
R. Nussinov, C.J. Tsai, and J. Liu Principles of allosteric interactions in cell signaling J. Am. Chem. Soc. 136 2014 17692 17701
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 17692-17701
-
-
Nussinov, R.1
Tsai, C.J.2
Liu, J.3
-
28
-
-
0042733592
-
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
-
D. Wald, and J. Qin X. Li SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling Nat. Immunol. 4 2003 920 927
-
(2003)
Nat. Immunol.
, vol.4
, pp. 920-927
-
-
Wald, D.1
Qin, J.2
Li, X.3
-
29
-
-
2942721674
-
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
-
E.K. Brint, and D. Xu F.Y. Liew ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance Nat. Immunol. 5 2004 373 379
-
(2004)
Nat. Immunol.
, vol.5
, pp. 373-379
-
-
Brint, E.K.1
Xu, D.2
Liew, F.Y.3
-
30
-
-
33745868678
-
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
-
S.H. Rhee, and H. Kim C. Pothoulakis Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells J. Biol. Chem. 281 2006 18560 18568
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 18560-18568
-
-
Rhee, S.H.1
Kim, H.2
Pothoulakis, C.3
-
31
-
-
84867277240
-
Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K
-
T.D. Troutman, J.F. Bazan, and C. Pasare Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K Cell Cycle 11 2012 3559 3567
-
(2012)
Cell Cycle
, vol.11
, pp. 3559-3567
-
-
Troutman, T.D.1
Bazan, J.F.2
Pasare, C.3
-
32
-
-
84876898443
-
Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal)
-
C. Bovijn, and A.S. Desmet F. Peelman Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal) J. Biol. Chem. 288 2013 12054 12066
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 12054-12066
-
-
Bovijn, C.1
Desmet, A.S.2
Peelman, F.3
-
33
-
-
22544445221
-
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4
-
E. Aksoy, and W. Vanden Berghe F. Willems Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4 Eur. J. Immunol. 35 2005 2200 2209
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2200-2209
-
-
Aksoy, E.1
Vanden Berghe, W.2
Willems, F.3
-
34
-
-
84889642191
-
Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling
-
Y. Enokizono, and H. Kumeta F. Inagaki Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling Proc. Natl. Acad. Sci. USA 110 2013 19908 19913
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 19908-19913
-
-
Enokizono, Y.1
Kumeta, H.2
Inagaki, F.3
-
35
-
-
77953714711
-
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
-
S.C. Lin, Y.C. Lo, and H. Wu Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling Nature 465 2010 885 890
-
(2010)
Nature
, vol.465
, pp. 885-890
-
-
Lin, S.C.1
Lo, Y.C.2
Wu, H.3
-
36
-
-
69949161905
-
An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4
-
P.G. Motshwene, and M.C. Moncrieffe N.J. Gay An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4 J. Biol. Chem. 284 2009 25404 25411
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 25404-25411
-
-
Motshwene, P.G.1
Moncrieffe, M.C.2
Gay, N.J.3
-
37
-
-
84928215189
-
On human disease-causing amino acid variants: Statistical study of sequence and structural patterns
-
M. Petukh, T.G. Kucukkal, and E. Alexov On human disease-causing amino acid variants: statistical study of sequence and structural patterns Hum. Mutat. 36 2015 524 534
-
(2015)
Hum. Mutat.
, vol.36
, pp. 524-534
-
-
Petukh, M.1
Kucukkal, T.G.2
Alexov, E.3
-
39
-
-
84874217124
-
TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity
-
F. Riva, and E. Bonavita C. Garlanda TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity Front. Immunol. 3 2012 322
-
(2012)
Front. Immunol.
, vol.3
, pp. 322
-
-
Riva, F.1
Bonavita, E.2
Garlanda, C.3
-
40
-
-
76749092614
-
Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: A computational approach
-
J. Gong, and T. Wei S.C. Rössle Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: a computational approach J. Struct. Biol. 169 2010 323 330
-
(2010)
J. Struct. Biol.
, vol.169
, pp. 323-330
-
-
Gong, J.1
Wei, T.2
Rössle, S.C.3
-
41
-
-
21644477461
-
SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms
-
J. Qin, and Y. Qian X. Li SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms J. Biol. Chem. 280 2005 25233 25241
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25233-25241
-
-
Qin, J.1
Qian, Y.2
Li, X.3
-
42
-
-
77949846853
-
Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis
-
M. Lech, and V. Skuginna H.J. Anders Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis J. Pathol. 220 2010 596 607
-
(2010)
J. Pathol.
, vol.220
, pp. 596-607
-
-
Lech, M.1
Skuginna, V.2
Anders, H.J.3
-
43
-
-
68949181883
-
TIR8/SIGIRR: An IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization
-
C. Garlanda, H.J. Anders, and A. Mantovani TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization Trends Immunol. 30 2009 439 446
-
(2009)
Trends Immunol.
, vol.30
, pp. 439-446
-
-
Garlanda, C.1
Anders, H.J.2
Mantovani, A.3
-
44
-
-
77955350086
-
SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis
-
S.K. Drexler, and P. Kong B.M. Foxwell SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis Arthritis Rheum. 62 2010 2249 2261
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 2249-2261
-
-
Drexler, S.K.1
Kong, P.2
Foxwell, B.M.3
-
45
-
-
0032524335
-
MyD88, an adapter protein involved in interleukin-1 signaling
-
K. Burns, and F. Martinon J. Tschopp MyD88, an adapter protein involved in interleukin-1 signaling J. Biol. Chem. 273 1998 12203 12209
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12203-12209
-
-
Burns, K.1
Martinon, F.2
Tschopp, J.3
-
46
-
-
84866072549
-
Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling
-
O. Fekonja, M. Benčina, and R. Jerala Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling J. Biol. Chem. 287 2012 30993 31002
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 30993-31002
-
-
Fekonja, O.1
Benčina, M.2
Jerala, R.3
-
47
-
-
0037178785
-
IRAK-M is a negative regulator of Toll-like receptor signaling
-
K. Kobayashi, and L.D. Hernandez R.A. Flavell IRAK-M is a negative regulator of Toll-like receptor signaling Cell 110 2002 191 202
-
(2002)
Cell
, vol.110
, pp. 191-202
-
-
Kobayashi, K.1
Hernandez, L.D.2
Flavell, R.A.3
-
48
-
-
51349083101
-
Roles of ubiquitination in pattern-recognition receptors and type i interferon receptor signaling
-
A. Bibeau-Poirier, and M.J. Servant Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling Cytokine 43 2008 359 367
-
(2008)
Cytokine
, vol.43
, pp. 359-367
-
-
Bibeau-Poirier, A.1
Servant, M.J.2
-
49
-
-
84906266951
-
Physicochemical mechanisms of protein regulation by phosphorylation
-
H. Nishi, A. Shaytan, and A.R. Panchenko Physicochemical mechanisms of protein regulation by phosphorylation Front. Genet. 5 2014 270
-
(2014)
Front. Genet.
, vol.5
, pp. 270
-
-
Nishi, H.1
Shaytan, A.2
Panchenko, A.R.3
-
50
-
-
84920849281
-
Crosstalk between signaling pathways provided by single and multiple protein phosphorylation sites
-
H. Nishi, E. Demir, and A.R. Panchenko Crosstalk between signaling pathways provided by single and multiple protein phosphorylation sites J. Mol. Biol. 427 2015 511 520
-
(2015)
J. Mol. Biol.
, vol.427
, pp. 511-520
-
-
Nishi, H.1
Demir, E.2
Panchenko, A.R.3
-
51
-
-
79959630000
-
Expanding TRAF function: TRAF3 as a tri-faced immune regulator
-
H. Häcker, P.H. Tseng, and M. Karin Expanding TRAF function: TRAF3 as a tri-faced immune regulator Nat. Rev. Immunol. 11 2011 457 468
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 457-468
-
-
Häcker, H.1
Tseng, P.H.2
Karin, M.3
-
52
-
-
33749369277
-
Ubiquitin: Tool and target for intracellular NF-kappaB inhibitors
-
A. Wullaert, and K. Heyninck R. Beyaert Ubiquitin: tool and target for intracellular NF-kappaB inhibitors Trends Immunol. 27 2006 533 540
-
(2006)
Trends Immunol.
, vol.27
, pp. 533-540
-
-
Wullaert, A.1
Heyninck, K.2
Beyaert, R.3
-
53
-
-
67649229630
-
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type i interferon
-
C. Wang, and T. Chen X. Cao The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon Nat. Immunol. 10 2009 744 752
-
(2009)
Nat. Immunol.
, vol.10
, pp. 744-752
-
-
Wang, C.1
Chen, T.2
Cao, X.3
-
54
-
-
84878187442
-
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme
-
T.T. Lu, and M. Onizawa A. Ma Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme Immunity 38 2013 896 905
-
(2013)
Immunity
, vol.38
, pp. 896-905
-
-
Lu, T.T.1
Onizawa, M.2
Ma, A.3
-
55
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
-
I.E. Wertz, and K.M. O'Rourke V.M. Dixit De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling Nature 430 2004 694 699
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
O'Rourke, K.M.2
Dixit, V.M.3
-
57
-
-
38549146936
-
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20
-
S.C. Lin, and J.Y. Chung H. Wu Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20 J. Mol. Biol. 376 2008 526 540
-
(2008)
J. Mol. Biol.
, vol.376
, pp. 526-540
-
-
Lin, S.C.1
Chung, J.Y.2
Wu, H.3
-
58
-
-
77649225756
-
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
-
N. Shembade, A. Ma, and E.W. Harhaj Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes Science 327 2010 1135 1139
-
(2010)
Science
, vol.327
, pp. 1135-1139
-
-
Shembade, N.1
Ma, A.2
Harhaj, E.W.3
-
59
-
-
84899604555
-
Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6
-
S.M. Jung, and J.H. Lee S.H. Park Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6 Nat. Commun. 4 2013 2562
-
(2013)
Nat. Commun.
, vol.4
, pp. 2562
-
-
Jung, S.M.1
Lee, J.H.2
Park, S.H.3
-
60
-
-
84867898782
-
A20: Linking a complex regulator of ubiquitylation to immunity and human disease
-
A. Ma, and B.A. Malynn A20: linking a complex regulator of ubiquitylation to immunity and human disease Nat. Rev. Immunol. 12 2012 774 785
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 774-785
-
-
Ma, A.1
Malynn, B.A.2
-
61
-
-
77449150629
-
CYLD: A tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes
-
S.C. Sun CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes Cell Death Differ. 17 2010 25 34
-
(2010)
Cell Death Differ.
, vol.17
, pp. 25-34
-
-
Sun, S.C.1
-
62
-
-
28844460239
-
The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 and TRAF7
-
H. Yoshida, and H. Jono J.D. Li The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7 J. Biol. Chem. 280 2005 41111 41121
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 41111-41121
-
-
Yoshida, H.1
Jono, H.2
Li, J.D.3
-
63
-
-
4444220680
-
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
-
M.L. Seibenhener, and J.R. Babu M.W. Wooten Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation Mol. Cell. Biol. 24 2004 8055 8068
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8055-8068
-
-
Seibenhener, M.L.1
Babu, J.R.2
Wooten, M.W.3
-
64
-
-
42049100859
-
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
-
M.W. Wooten, and T. Geetha J. Moscat Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins J. Biol. Chem. 283 2008 6783 6789
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 6783-6789
-
-
Wooten, M.W.1
Geetha, T.2
Moscat, J.3
-
65
-
-
4444349272
-
The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma
-
K. Saito, and T. Kigawa S. Yokoyama The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma Structure 12 2004 1719 1728
-
(2004)
Structure
, vol.12
, pp. 1719-1728
-
-
Saito, K.1
Kigawa, T.2
Yokoyama, S.3
-
66
-
-
78650915536
-
Structural studies of NF-κB signaling
-
C. Zheng, Q. Yin, and H. Wu Structural studies of NF-κB signaling Cell Res. 21 2011 183 195
-
(2011)
Cell Res.
, vol.21
, pp. 183-195
-
-
Zheng, C.1
Yin, Q.2
Wu, H.3
-
67
-
-
0035896518
-
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor
-
M.W. Wooten, and M.L. Seibenhener J. Moscat The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor J. Biol. Chem. 276 2001 7709 7712
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7709-7712
-
-
Wooten, M.W.1
Seibenhener, M.L.2
Moscat, J.3
-
68
-
-
84941083034
-
ComPPI: A cellular compartment-specific database for protein-protein interaction network analysis
-
D.V. Veres, and D.M. Gyurkó P. Csermely ComPPI: a cellular compartment-specific database for protein-protein interaction network analysis Nucleic Acids Res. 43 2015 D485 D493
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. D485-D493
-
-
Veres, D.V.1
Gyurkó, D.M.2
Csermely, P.3
-
69
-
-
39549106692
-
The structure of the CYLD USP domain explains its specificity for Lys-63-linked polyubiquitin and reveals a B box module
-
D. Komander, and C.J. Lord D. Barford The structure of the CYLD USP domain explains its specificity for Lys-63-linked polyubiquitin and reveals a B box module Mol. Cell 29 2008 451 464
-
(2008)
Mol. Cell
, vol.29
, pp. 451-464
-
-
Komander, D.1
Lord, C.J.2
Barford, D.3
-
70
-
-
36448943427
-
DUBA: A deubiquitinase that regulates type i interferon production
-
N. Kayagaki, and Q. Phung V.M. Dixit DUBA: a deubiquitinase that regulates type I interferon production Science 318 2007 1628 1632
-
(2007)
Science
, vol.318
, pp. 1628-1632
-
-
Kayagaki, N.1
Phung, Q.2
Dixit, V.M.3
-
71
-
-
0034641743
-
Molecular basis for CD40 signaling mediated by TRAF3
-
C.Z. Ni, and K. Welsh K.R. Ely Molecular basis for CD40 signaling mediated by TRAF3 Proc. Natl. Acad. Sci. USA 97 2000 10395 10399
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10395-10399
-
-
Ni, C.Z.1
Welsh, K.2
Ely, K.R.3
-
72
-
-
10344226678
-
Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: Implications for intracellular signaling regulation
-
C.Z. Ni, and G. Oganesyan K.R. Ely Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation J. Immunol. 173 2004 7394 7400
-
(2004)
J. Immunol.
, vol.173
, pp. 7394-7400
-
-
Ni, C.Z.1
Oganesyan, G.2
Ely, K.R.3
-
73
-
-
25844450231
-
LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3
-
S. Wu, and P. Xie K.R. Ely LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3 J. Biol. Chem. 280 2005 33620 33626
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33620-33626
-
-
Wu, S.1
Xie, P.2
Ely, K.R.3
-
74
-
-
84869406282
-
Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5
-
P. Zhang, and A. Reichardt Y. Liu Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5 Sci. Signal. 5 2012 ra81
-
(2012)
Sci. Signal.
, vol.5
, pp. ra81
-
-
Zhang, P.1
Reichardt, A.2
Liu, Y.3
-
75
-
-
84868152454
-
A signal transduction score flow algorithm for cyclic cellular pathway analysis, which combines transcriptome and ChIP-seq data
-
Z. Isik, and T. Ersahin R. Cetin-Atalay A signal transduction score flow algorithm for cyclic cellular pathway analysis, which combines transcriptome and ChIP-seq data Mol. Biosyst. 8 2012 3224 3231
-
(2012)
Mol. Biosyst.
, vol.8
, pp. 3224-3231
-
-
Isik, Z.1
Ersahin, T.2
Cetin-Atalay, R.3
|