SIGIRR/TIR-8 is an inhibitor of toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis

Arthritis and Rheumatism

Volumn 62, Issue 8, 2010, Pages 2249-2261

  Drexler, Stefan K ^a,d   Kong, Philip ^a   Inglis, Julia ^a   Williams, Richard O ^a   Garlanda, Cecilia ^b,c   Mantovani, Alberto ^b,c   Yazdi, Amir S ^d   Brennan, Fionula ^a   Feldmann, Marc ^a   Foxwell, Brian M J ^e  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN ANTIBODY; INTERLEUKIN 1 RECEPTOR; SINGLE IMMUNOGLOBULIN INTERLEUKIN 1 RECEPTOR RELATED; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE SEVERITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOREGULATION; IN VIVO STUDY; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BLOTTING, WESTERN; DENDRITIC CELLS; GENE TRANSFER TECHNIQUES; HUMANS; INFLAMMATION; MACROPHAGES; MICE; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 77955350086     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27517     Document Type: Article

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