Transdermal cumin essential oil nanoemulsions with potent antioxidant and hepatoprotective activities: In-vitro and in-vivo evaluation

Journal of Molecular Liquids

Volumn 212, Issue , 2015, Pages 6-15

  Mostafa, Dina Mahmoud ^a   Kassem, Ahmed Alaa ^a   Asfour, Marwa Hasanein ^a   Al Okbi, Sahar Youssef ^a   Mohamed, Doha Abdou ^a   Hamed, Thanaa El Sayed ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antioxidant; Cumin essential oil; Hepatoprotective; Nanoemulsions; Transdermal delivery

Indexed keywords

AMPHIBIOUS VEHICLES; ANTIOXIDANTS; ENCAPSULATION; FREE RADICALS; PHENOLS;

ANTIOXIDANT EFFICIENCIES; ENCAPSULATION EFFICIENCY; FREE RADICAL SCAVENGING ACTIVITY; HEPATOPROTECTIVE; HEPATOPROTECTIVE ACTIVITIES; NANO-EMULSIONS; PHYSICOCHEMICAL PROPERTY; TRANSDERMAL DELIVERY;

ESSENTIAL OILS;

EID: 84940689147     PISSN: 01677322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molliq.2015.08.047     Document Type: Article

References (94)

1. F.Y. Al Juhaimi, and K. Ghafoor Extraction optimization and in vitro antioxidant properties of phenolic compounds from cumin (Cuminum cyminum L.) seed Int. Food Res. J. 20 2013 1669 1675
2. M. Motamedifar, N. Ghafari, and P.T. Shirazi The effect of cumin seed extracts against herpes simplex virus type 1 in Vero cell culture Iran. J. Med. Sci. 35 2010 304 309
3. R. Li, and Z.T. Jiang Chemical composition of the essential oil of Cuminum cyminum L. from China Flavour Fragr. J. 19 2004 311 313
4. I. Bettaieb Rebey, I. Jabri-Karoui, I. Hamrouni-Sellami, S. Bourgou, F. Limam, and B. Marzouk Effect of drought on the biochemical composition and antioxidant activities of cumin (Cuminum cyminum L.) seeds Ind. Crop. Prod. 36 2012 238 245
5. P. Ninfali, G. Mea, S. Giorgini, M. Rocchi, and M. Bacchiocca Antioxidant capacity of vegetables, spices and dressings relevant to nutrition Br. J. Nutr. 93 2005 257 266
6. S.M. Barlow Toxicological Aspects of Antioxidants Used as Food Additives 1990 Elsevier Science Publishing London and New York
7. B. Halliwell Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344 1994 721 724
8. E. Middleton Jr., C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol. Rev. 52 2000 673 751
9. A. Dua, S.K. Gupta, A. Mittal, and R. Mahajan A study of antioxidant properties and antioxidant compounds of cumin (Cuminum cyminum) Int. J. Pharm. Biol. Arch. 3 2012 1110 1116
10. A. Jain, P. Jain, J. Kurmi, D. Jain, R. Jain, S. Chandel, A. Sahu, N. Mody, S. Upadhaya, and A. Jain Novel strategies for effective transdermal drug delivery: a review Crit. Rev. Ther. Drug Carrier Syst. 31 2014 219 272
11. C.M. Schoellhammer, D. Blankschtein, and R. Langer Skin permeabilization for transdermal drug delivery: recent advances and future prospects Expert Opin. Drug Deliv. 11 2014 393 407
12. K. Rehman, and M.H. Zulfakar Recent advances in gel technologies for topical and transdermal drug delivery Drug Dev. Ind. Pharm. 40 2014 433 440
13. O. Perumal, S.N. Murthy, and Y.N. Kalia Turning theory into practice: the development of modern transdermal drug delivery systems and future trends Skin Pharmacol. Physiol. 26 2013 331 342
14. A. Schroeter, T. Engelbrecht, R.H. Neubert, and A.S. Goebel New nanosized technologies for dermal and transdermal drug delivery. A review J. Biomed. Nanotechnol. 6 2010 511 528
15. M.R. Prausnitz, and R. Langer Transdermal drug delivery Nat. Biotechnol. 26 2008 1261 1268
16. M.B. Brown, G.P. Martin, S.A. Jones, and F.K. Akomeah Dermal and transdermal drug delivery systems: current and future prospects Drug Deliv. 13 2006 175 187
17. H.A. Benson Transdermal drug delivery: penetration enhancement techniques Curr. Drug Deliv. 2 2005 23 33
18. A.G. Sandig, A.C. Campmany, F.F. Campos, M.J. Villena, and B.C. Naveros Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation Colloids Surf B: Biointerfaces. 103 2013 558 565
19. C. Solans, P. Izquierdo, J. Nolla, N. Azemar, and M.J. Garcia-Celma Nano-emulsions Curr. Opin. Colloid Interface Sci. 10 2005 102 110
20. Q. Huang, H. Yu, and Q. Ru Bioavailability and delivery of nutraceuticals using nanotechnology J. Food Sci. 75 2010 R50 R57
21. A. Soottitantawata, F. Bigeardb, H. Yoshiia, T. Furutaa, M. Ohkawarac, and P. Linkod Influence of emulsion and powder size on the stability of encapsulated d-limonene by spray drying Innov. Food Sci. Emerg. Technol. 6 2005 107 114
22. A. Karadag, X. Yang, B. Ozcelik, and Q. Huang Optimization of preparation conditions for quercetin nanoemulsions using response surface methodology J. Agric. Food Chem. 61 2013 2130 2139
23. S. Rebolleda, M.T. Sanz, J.M. Benito, S. Beltran, I. Escudero, and M.L. Gonzalez San-Jose Formulation and characterisation of wheat bran oil-in-water nanoemulsions Food Chem. 167 2015 16 23
24. D.M. Mostafa, S.H. Abd El-Alim, M.H. Asfour, S.Y. Al-Okbi, D.A. Mohamed, and G. Awad Transdermal nanoemulsions of Foeniculum vulgare Mill. Essential oil: preparation, characterization and evaluation of antidiabetic potential J. Drug Deliv. Sci. Technol. 29 2015 99 106
25. S.A. Fouad, E.B. Basalious, M.A. El-Nabarawi, and S.A. Tayel Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation Int. J. Pharm. 453 2013 569 578
26. S. Akhter, G.K. Jain, F.J. Ahmad, R.K. Khar, N. Jain, Z.I. Khan, and S. Talegaonkar Investigation of nanoemulsion system for transdermal delivery of domperidone: ex-vivo and in vivo studies Curr. Nanosci. 4 2008 381 390
27. V.L. Singleton, and J.A. Rossi Jr. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents Am. J. Enol. Vitic. 16 1965 144 158
28. W.C. Lu, B.H. Chiang, D.W. Huang, and P.H. Li Skin permeation of d-limonene-based nanoemulsions as a transdermal carrier prepared by ultrasonic emulsification Ultrason. Sonochem. 21 2014 826 832
29. V. Bali, M. Ali, and J. Ali Nanocarrier for the enhanced bioavailability of a cardiovascular agent: in vitro, pharmacodynamic, pharmacokinetic and stability assessment Int. J. Pharm. 403 2011 46 56
30. G.N. Teke, P.K. Lunga, H.K. Wabo, J.R. Kuiate, G. Vilarem, G. Giacinti, H. Kikuchi, and Y. Oshima Antimicrobial and antioxidant properties of methanol extract, fractions and compounds from the stem bark of Entada abyssinica Stend ex A. Satabie BMC Complement. Altern. Med. 11 2011 57
31. A.H. El-Ghorab, M.H. Mahgoub, and M. Bekheta Effect of some bioregulators on the chemical composition of essential oil and its antioxidant activity of Egyptian carnation (Dianthus caryophyllus L.) J. Essent. Oil Bear. Plants 9 2006 214 222
32. M. Ekor, A.O. Odewabi, O.E. Kale, T.O. Bamidele, O.A. Adesanoye, and E.O. Farombi Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study J. Basic Clin. Physiol. Pharmacol. 24 2013 73 79
33. M.B. Ahmed, and M.R. Khater Evaluation of the protective potential of Ambrosia maritima extract on acetaminophen-induced liver damage J. Ethnopharmacol. 75 2001 169 174
34. D.L. Laskin, and A.M. Pilaro Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver Toxicol. Appl. Pharmacol. 86 1986 204 215
35. D. Koracevic, G. Koracevic, V. Djordjevic, S. Andrejevic, and V. Cosic Method for the measurement of antioxidant activity in human fluids J. Clin. Pathol. 54 2001 356 361
36. K. Satoh Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method Clin. Chim. Acta 90 1978 37 43
37. S. Reitman, and S. Frankel Colorimetric methods for aspartate and alanine aminotransferase Am. J. Clin. Pathol. 28 1957 55 60
38. R.M. Hathout, and M. Nasr Transdermal delivery of betahistine hydrochloride using microemulsions: physical characterization, biophysical assessment, confocal imaging and permeation studies Colloids Surf B: Biointerfaces. 110 2013 254 260
39. C.S. Asbill, A.F. El-Kattan, and B. Michniak Enhancement of transdermal drug delivery: chemical and physical approaches Crit. Rev. Ther. Drug Carrier Syst. 17 2000 621 658
40. A.C. Williams, and B.W. Barry Penetration enhancers Adv. Drug Deliv. Rev. 56 2004 603 618
41. I.B. Rebey, I. Jabri-Karoui, I. Hamrouni-Sellami, S. Bourgou, F. Limam, and B. Marzouk Effect of drought on the biochemical composition and antioxidant activities of cumin (Cuminum cyminum L.) seeds Ind. Crop. Prod. 36 2012 238 245
42. T. Allahghadri, I. Rasooli, P. Owlia, M.J. Nadooshan, T. Ghazanfari, M. Taghizadeh, and S.D. Astaneh Antimicrobial property, antioxidant capacity, and cytotoxicity of essential oil from cumin produced in Iran J. Food Sci. 75 2010 H54 H61
43. J. Wang, B. Sun, Y. Cao, Y. Tian, and X. Li Optimisation of ultrasound-assisted extraction of phenolic compounds from wheat bran Food Chem. 106 2008 804 810
44. J. Zhang, and B. Michniak-Kohn Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine Int. J. Pharm. 421 2011 34 44
45. H. Chen, X. Chang, T. Weng, X. Zhao, Z. Gao, Y. Yang, H. Xu, and X. Yang A study of microemulsion systems for transdermal delivery of triptolide J. Control. Release 98 2004 427 436
46. H. Liu, Y. Wang, Y. Lang, H. Yao, Y. Dong, and S. Li Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo J. Pharm. Sci. 98 2009 1167 1176
47. Y.S. Rhee, J.G. Choi, E.S. Park, and S.C. Chi Transdermal delivery of ketoprofen using microemulsions Int. J. Pharm. 228 2001 161 170
48. B. Ongpipattanakul, R.R. Burnette, R.O. Potts, and M.L. Francoeur Evidence that oleic acid exists in a separate phase within stratum corneum lipids Pharm. Res. 8 1991 350 354
49. A. Naik, L.A.R.M. Pechtold, R.O. Potts, and R.H. Guy Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans J. Control. Release 37 1995 299 306
50. A.S. Guinedi, N.D. Mortada, S. Mansour, and R.M. Hathout Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide Int. J. Pharm. 306 2005 71 82
51. M.J. Lawrence, and G.D. Rees Microemulsion-based media as novel drug delivery systems Adv. Drug Deliv. Rev. 45 2000 89 121
52. M. Malmstein Microemulsion in Pharmaceuticals 1999 Marcel Dekker New York
53. N.A. Megrab, A.C. Williams, and B.W. Barry Oestradiol permeation across human skin, silastic and snake skin membranes: the effects of ethanol/water co-solvent systems Int. J. Pharm. 116 1995 101 112
54. R.M. Hathout, and A.H. Elshafeey Development and characterization of colloidal soft nano-carriers for transdermal delivery and bioavailability enhancement of an angiotensin II receptor blocker Eur. J. Pharm. Biopharm. 82 2012 230 240
55. N. Parmar, N. Singla, S. Amin, and K. Kohli Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system Colloids Surf B: Biointerfaces. 86 2011 327 338
56. R.M. Hathout, T.J. Woodman, S. Mansour, N.D. Mortada, A.S. Geneidi, and R.H. Guy Microemulsion formulations for the transdermal delivery of testosterone Eur. J. Pharm. Sci. 40 2010 188 196
57. R.C. Baker, A.T. Florence, R.H. Ottewill, and T.F. Tadros Investigations into the formation and characterization of microemulsions. II. Light scattering conductivity and viscosity studies of microemulsions J. Colloid Interface Sci. 100 1984 332 349
58. J. Hadgraft Skin, the final frontier Int. J. Pharm. 224 2001 1 18
59. J.M. Gutiérrez, C. González, A. Maestro, I. Solè, C.M. Pey, and J. Nolla Nano-emulsions: new applications and optimization of their preparation Curr. Opin. Colloid Interface Sci. 13 2008
60. D. Morales, C. Solans, J.M. Gutierrez, M.J. Garcia-Celma, and U. Olsson Oil/water droplet formation by temperature change in the water/c(16)e(6)/mineral oil system Langmuir 22 2006 3014 3020
61. V.B. Patravale, A.A. Date, and R.M. Kulkarni Nanosuspensions: a promising drug delivery strategy J. Pharm. Pharmacol. 56 2004 827 840
62. P.R. Mishra, L. Al Shaal, R.H. Muller, and C.M. Keck Production and characterization of hesperetin nanosuspensions for dermal delivery Int. J. Pharm. 371 2009 182 189
63. M. Fanun Formulation and characterization of microemulsions based on mixed nonionic surfactants and peppermint oil J. Colloid Interface Sci. 343 2010 496 503
64. K.H. Cho, J.H. Hong, and K.T. Lee Monoacylglycerol (MAG)-oleic acid has stronger antioxidant, anti-atherosclerotic, and protein glycation inhibitory activities than MAG-palmitic acid J. Med. Food 13 2010 99 107
65. K.F. Khattak, and T.J. Simpson Effect of gamma irradiation on the antimicrobial and free radical scavenging activities of Glycyrrhiza glabra root Radiat. Phys. Chem. 179 2010 507 512
66. J.L. Wallace Acetaminophen hepatotoxicity: NO to the rescue Br. J. Pharmacol. 143 2004 1 2
67. D. Krishnan, N. Prasanna, E. Sabina, and M. Rasool Hepatoprotective and antioxidant potential of ferulic acid against acetaminophen-induced liver damage in mice Comp. Clin. Pathol. 22 2013 1177 1181
68. Z. Song, C.J. McClain, and T. Chen S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice Pharmacology 71 2004 199 208
69. A. Ghosh, and P.C. Sil Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappaB pathway: role of a novel plant protein Chem. Biol. Interact. 177 2009 96 106
70. D.V. Parmar, G. Ahmed, M.A. Khandkar, and S.S. Katyare Mitochondrial ATPase: a target for paracetamol-induced hepatotoxicity Eur. J. Pharmacol. 293 1995 225 229
71. B.H. Lauterburg, and M.E. Velez Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity Gut 29 1988 1153 1157
72. H. Jaeschke, T.R. Knight, and M.L. Bajt The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity Toxicol. Lett. 144 2003 279 288
73. B.S. Thampi, G. Manoj, S. Leelamma, and V.P. Menon Dietary fiber and lipid peroxidation: effect of dietary fiber on levels of lipids and lipid peroxides in high fat diet Indian J. Exp. Biol. 29 1991 563 567
74. M. Comporti Lipid peroxidation and cellular damage in toxic liver injury Lab. Investig. 53 1985 599 623
75. M.B. Chenoweth, and C.L. Hake The smaller halogenated aliphatic hydrocarbons Annu. Rev. Pharmacol. 2 1962 363 398
76. R. Sallie, J.M. Tredger, and R. Williams Drugs and the liver. Part 1: testing liver function Biopharm. Drug Dispos. 12 1991 251 259
77. Y.B. Solanki, and S.M. Jain Hepatoprotective effects of Clitoria ternatea and Vigna mungo against acetaminophen and carbon tetrachloride-induced hepatotoxicity in rats J. Pharmacol. Toxicol. 6 2011 30 48
78. K.S. Murugesh, V.C. Yeligar, B.C. Maiti, and T.K. Maity Hepato protective and antioxidant role of Berberis tinctoria Lesch leaves on paracetamol induced hepatic damage in rats Iran. J. Pharmacol. Ther. 4 2005 64 69
79. K.H. Janbaz, S.A. Saeed, and A.H. Gilani Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents Fitoterapia 73 2002 557 563
80. S.Y. Al-Okbi, D.A. Mohamed, T.E. Hamed, and A.E. Edris Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome J. Med. Food 17 2014 764 771
81. S.Y. Al-Okbi, H.H.M. Fadel, and D.A. Mohamed Phytochemical constituents, antioxidant and anticancer activity of Mentha citrata and Mentha longifolia Res. J. Pharm. Biol. Chem. Sci. 6 2015 739 751
82. R. Schreck, and P.A. Baeuerle A role for oxygen radicals as second messengers Trends Cell Biol. 1 1991 39 42
83. D. Maron Flavonoids for reduction of atherosclerotic risk Curr. Atheroscler. Rep. 6 2004 73 78
84. T. Finkel, and N.J. Holbrook Oxidants, oxidative stress and the biology of ageing Nature 408 2000 239 247
85. F.Q. Schafer, E.E. Kelly, and G.R. Buettner Oxidative Stress and Antioxidant Intervention 2003 World Scientific New Jersey
86. F. Shahidi Antioxidants in food and food antioxidants Nahrung 44 2000 158 163
87. K.L. Khanduja, and A. Bhardwaj Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids Indian J. Biochem. Biophys. 40 2003 416 422
88. C.A. Rice-Evans, N.J. Miller, and G. Paganga Structure-antioxidant activity relationships of flavonoids and phenolic acids Free Radic. Biol. Med. 20 1996 933 956
89. W. Bors, and C. Michel Chemistry of the antioxidant effect of polyphenols Ann. N. Y. Acad. Sci. 957 2002 57 69
90. K. Zhou, J.-J. Yin, and L. Yu ESR determination of the reactions between selected phenolic acids and free radicals or transition metals Food Chem. 95 2006 446 457
91. I. Bettaieb, S. Bourgou, W.A. Wannes, I. Hamrouni, F. Limam, and B. Marzouk Essential oils, phenolics, and antioxidant activities of different parts of cumin (Cuminum cyminum L.) J. Agric. Food Chem. 58 2010 10410 10418
92. B. Balasinska, and A. Troszynska Total antioxidative activity of evening primrose (Oenothera paradoxa) cake extract measured in vitro by liposome model and murine L1210 cells J. Agric. Food Chem. 46 1998 3558 3563
93. N. Balasundram, K. Sundram, and S. Samman Phenolic compounds in plants and agri-industrial by-products: antioxidant activity, occurrence, and potential uses Food Chem. 99 2006 191 203
94. R. Lucarini, W.A. Bernardes, M.G. Tozatti, A.A. da Silva Filho, M.L.A.E. Silva, C. Momo, A.E.M. Crotti, C.H.G. Martins, and W.R. Cunha Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage Emir. J. Food Agric. 26 2014 878 884