메뉴 건너뛰기




Volumn 11, Issue 3, 2014, Pages 393-407

Skin permeabilization for transdermal drug delivery: Recent advances and future prospects

Author keywords

Cavitation; Drug delivery; Electroporation; Immunization; Iontophoresis; Microneedles; Microprojections; Penetration enhancers; Permeabilization; Sonophoresis; Transcutaneous immunization; Transdermal; Ultrasound; Vaccination

Indexed keywords

DRUG;

EID: 84894423581     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.875528     Document Type: Review
Times cited : (291)

References (101)
  • 1
    • 77950628997 scopus 로고    scopus 로고
    • Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays
    • Walter MNM, Wright KT, Fuller HR, et al. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res 2010;316(7):1271-81
    • (2010) Exp Cell Res , vol.316 , Issue.7 , pp. 1271-1281
    • Walter, M.N.M.1    Wright, K.T.2    Fuller, H.R.3
  • 2
    • 55749108348 scopus 로고    scopus 로고
    • Transdermal drug delivery
    • Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol 2008;26(11):1261-8
    • (2008) Nat Biotechnol , vol.26 , Issue.11 , pp. 1261-1268
    • Prausnitz, M.R.1    Langer, R.2
  • 3
    • 84876479660 scopus 로고    scopus 로고
    • Transdermal delivery of molecules is limited by full epidermis not just stratum corneum
    • Andrews SN, Jeong E, Prausnitz MR. Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum. Pharm Res 2012;30(4):1099-109
    • (2012) Pharm Res , vol.30 , Issue.4 , pp. 1099-109
    • Andrews, S.N.1    Jeong, E.2    Prausnitz, M.R.3
  • 5
    • 77956440192 scopus 로고    scopus 로고
    • Needle phobia: Etiology adverse consequences and patient management
    • Sokolowski CJ, Giovannitti JA Jr, Boynes SG. Needle phobia: Etiology, adverse consequences, and patient management. Dent Clin North Am 2010;54(4):731-44
    • (2010) Dent Clin North Am , vol.54 , Issue.4 , pp. 731-744
    • Sokolowski, C.J.1    Giovannitti Jr., J.A.2    Boynes, S.G.3
  • 6
    • 0037840399 scopus 로고    scopus 로고
    • Fear of injections in young adults: Prevalence and associations
    • Nir Y, Paz A, Sabo E, et al. Fear of injections in young adults: Prevalence and associations. Am J Trop Med Hyg 2003;68(3):341-4
    • (2003) Am J Trop Med Hyg , vol.68 , Issue.3 , pp. 341-344
    • Nir, Y.1    Paz, A.2    Sabo, E.3
  • 7
    • 58949083673 scopus 로고    scopus 로고
    • Transcutaneous immunisation assisted by low-frequency ultrasound
    • Dahlan A, Alpar HO, Stickings P, et al. Transcutaneous immunisation assisted by low-frequency ultrasound. Int J Pharm 2009;368(1):123-8
    • (2009) Int J Pharm , vol.368 , Issue.1 , pp. 123-128
    • Dahlan, A.1    Alpar, H.O.2    Stickings, P.3
  • 8
    • 34247171927 scopus 로고    scopus 로고
    • A geometrical model of dermal capillary clearance
    • Kretsos K, Kasting GB. A geometrical model of dermal capillary clearance. Math Biosci 2007;208(2):430-53
    • (2007) Math Biosci , vol.208 , Issue.2 , pp. 430-453
    • Kretsos, K.1    Kasting, G.B.2
  • 9
    • 18944375393 scopus 로고    scopus 로고
    • Low-frequency ultrasound as a transcutaneous immunization adjuvant
    • Tezel A, Paliwal S, Shen Z, et al. Low-frequency ultrasound as a transcutaneous immunization adjuvant. Vaccine 2005;23(29):3800-7
    • (2005) Vaccine , vol.23 , Issue.29 , pp. 3800-7
    • Tezel, A.1    Paliwal, S.2    Shen, Z.3
  • 11
    • 0345099468 scopus 로고    scopus 로고
    • Seventeen-point dermal ultrasound scoring system-A reliable measure of skin thickness in patients with systemic sclerosis
    • Moore TL. Seventeen-point dermal ultrasound scoring system-A reliable measure of skin thickness in patients with systemic sclerosis. Rheumatology 2003;42(12):1559-63
    • (2003) Rheumatology , vol.42 , Issue.12 , pp. 1559-1563
    • Moore, T.L.1
  • 12
    • 33947232153 scopus 로고    scopus 로고
    • In: Burns T Breathnach S Cox N Griffiths C editors Rook's textbook of dermatology. Blackwell Publishing, Inc., Hoboken, NJ
    • McGrath JA, Eady RAJ, Pope FM. Anatomy and organization of human skin. In: Burns T, Breathnach S, Cox N, Griffiths C, editors, Rook's textbook of dermatology. Blackwell Publishing, Inc., Hoboken, NJ; 2008. p. 45-128
    • (2008) Anatomy And Organization Of Human Skin , pp. 45-128
    • McGrath, J.A.1    Eady, R.A.J.2    Pope, F.M.3
  • 14
    • 78649772289 scopus 로고    scopus 로고
    • Advances in transcutaneous vaccine delivery do all ways lead to Rome?
    • Ding Z, van Riet E, Jiskoot W, et al. Advances in transcutaneous vaccine delivery: Do all ways lead to Rome?. J Control Release 2010;148(3):266-82
    • (2010) J Control Release , vol.148 , Issue.3 , pp. 266-282
    • Ding, Z.1    Van Riet, E.2    Jiskoot, W.3
  • 15
    • 39649116621 scopus 로고    scopus 로고
    • Using the method of homogenization to calculate the effective diffusivity of the stratum corneum with permeable corneocytes
    • Rim JE, Pinsky PM, van OsdolWW. Using the method of homogenization to calculate the effective diffusivity of the stratum corneum with permeable corneocytes. J Biomech 2008;41(4):788-96
    • (2008) J Biomech , vol.41 , Issue.4 , pp. 788-796
    • Rim, J.E.1    Pinsky, P.M.2    Van Osdol, W.W.3
  • 16
    • 79958223028 scopus 로고    scopus 로고
    • Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends
    • Polat BE, Hart D, Langer R, et al. Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends. J Control Release 2011;152(3):330-48
    • (2011) J Control Release , vol.152 , Issue.3 , pp. 330-348
    • Polat, B.E.1    Hart, D.2    Langer, R.3
  • 17
    • 63249110007 scopus 로고    scopus 로고
    • Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery
    • Deli MA. Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. Biochim Biophys Acta 2009;1788(4):892-910
    • (2009) Biochim Biophys Acta , vol.1788 , Issue.4 , pp. 892-910
    • Deli, M.A.1
  • 18
    • 77956082516 scopus 로고    scopus 로고
    • Characterization of acoustic cavitation bubbles in different sound fields
    • Brotchie A, Grieser F, Ashokkumar M. Characterization of acoustic cavitation bubbles in different sound fields. J Phys Chem B 2010;114(34):11010- 16
    • (2010) J Phys Chem B , vol.114 , Issue.34 , pp. 11010-16
    • Brotchie, A.1    Grieser, F.2    Ashokkumar, M.3
  • 19
    • 1542268930 scopus 로고    scopus 로고
    • Lipid vesicles and other colloids as drug carriers on the skin
    • Cevc G. Lipid vesicles and other colloids as drug carriers on the skin. Adv Drug Deliv Rev 2004;56(5):675-711
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.5 , pp. 675-711
    • Cevc, G.1
  • 20
    • 0042121374 scopus 로고    scopus 로고
    • Barrier function of the skin: La Raison detre of the epidermis
    • Madison KC. Barrier function of the skin: La Raison de tre of the epidermis. J Investig Dermatol 2003;121(2):231-41
    • (2003) J Investig Dermatol , vol.121 , Issue.2 , pp. 231-241
    • Madison, K.C.1
  • 21
    • 78649956855 scopus 로고    scopus 로고
    • Low-frequency sonophoresis: Application to the transdermal delivery of macromolecules and hydrophilic drugs
    • Polat BE, Blankschtein D, Langer R. Low-frequency sonophoresis: Application to the transdermal delivery of macromolecules and hydrophilic drugs. Expert Opin Drug Deliv 2010;7(12):1415-32
    • (2010) Expert Opin Drug Deliv , vol.7 , Issue.12 , pp. 1415-1432
    • Polat, B.E.1    Blankschtein, D.2    Langer, R.3
  • 22
    • 58049167275 scopus 로고    scopus 로고
    • Single-Transducer dual-frequency ultrasound generation to enhance acoustic cavitation
    • Liu H-L, Hsieh C-M. Single-Transducer dual-frequency ultrasound generation to enhance acoustic cavitation. Ultrason Sonochem 2009;16(3):431-8
    • (2009) Ultrason Sonochem , vol.16 , Issue.3 , pp. 431-438
    • Liu, H.-L.1    Hsieh, C.-M.2
  • 23
    • 33746290744 scopus 로고    scopus 로고
    • Epidermal thickness assessed by optical coherence tomography and routine histology: Preliminary results of method comparison
    • Gambichler T, Boms S, Stucker M, et al. Epidermal thickness assessed by optical coherence tomography and routine histology: Preliminary results of method comparison. J Eur Acad Dermatol Venerol 2006;20(7):791-5
    • (2006) J Eur Acad Dermatol Venerol , vol.20 , Issue.7 , pp. 791-795
    • Gambichler, T.1    Boms, S.2    Stucker, M.3
  • 24
    • 70349267509 scopus 로고    scopus 로고
    • Development of an ex vivo human skin model for intradermal vaccination: Tissue viability and Langerhans cell behaviour
    • Ng KW, Pearton M, Coulman S, et al. Development of an ex vivo human skin model for intradermal vaccination: Tissue viability and Langerhans cell behaviour. Vaccine 2009;27(43):5948-55
    • (2009) Vaccine , vol.27 , Issue.43 , pp. 5948-5955
    • Ng, K.W.1    Pearton, M.2    Coulman, S.3
  • 25
    • 77953247537 scopus 로고    scopus 로고
    • Spatial distribution of acoustic cavitation bubbles at different ultrasound frequencies
    • Ashokkumar M, Lee J, Iida Y, et al. Spatial distribution of acoustic cavitation bubbles at different ultrasound frequencies. ChemPhysChem 2010;11(8):1680-4
    • (2010) ChemPhysChem , vol.11 , Issue.8 , pp. 1680-1684
    • Ashokkumar, M.1    Lee, J.2    Iida, Y.3
  • 26
    • 76749135279 scopus 로고    scopus 로고
    • Low-frequency low-intensity ultrasounds do not influence the survival and immune functions of cultured keratinocytes and dendritic cells
    • Scarponi C, Nasorri F, Pavani F, et al. Low-frequency low-intensity ultrasounds do not influence the survival and immune functions of cultured keratinocytes and dendritic cells. J Biomed Biotechnol 2009;2009(1):1-13
    • (2009) J Biomed Biotechnol , vol.2009 , Issue.1 , pp. 1-13
    • Scarponi, C.1    Nasorri, F.2    Pavani, F.3
  • 27
    • 78649956855 scopus 로고    scopus 로고
    • Low-frequency sonophoresis: Application to the transdermal delivery of macromolecules and hydrophilic drugs
    • Polat BE, Blankschtein D, Langer R. Low-frequency sonophoresis: Application to the transdermal delivery of macromolecules and hydrophilic drugs. Expert Opin Drug Deliv 2010;7(12):1415-32
    • (2010) Expert Opin Drug Deliv , vol.7 , Issue.12 , pp. 1415-1432
    • Polat, B.E.1    Blankschtein, D.2    Langer, R.3
  • 28
    • 0036141739 scopus 로고    scopus 로고
    • Synergistic effect of low-frequency ultrasound and surfactants on skin permeability
    • Tezel A, Sens A, Tuchscherer J, et al. Synergistic effect of low-frequency ultrasound and surfactants on skin permeability. J Pharm Sci 2002;91(1):91-100
    • (2002) J Pharm Sci , vol.91 , Issue.1 , pp. 91-100
    • Tezel, A.1    Sens, A.2    Tuchscherer, J.3
  • 29
    • 36248953192 scopus 로고    scopus 로고
    • Dual-channel two-photon microscopy study of transdermal transport in skin treated with low-frequency ultrasound and a chemical enhancer
    • Kushner J, Kim D, So PTC, et al. Dual-channel two-photon microscopy study of transdermal transport in skin treated with low-frequency ultrasound and a chemical enhancer. J Investig Dermatol 2007;127:2832-46
    • (2007) J Investig Dermatol , vol.127 , pp. 2832-2846
    • Kushner, J.1    Kim, D.2    So, P.T.C.3
  • 30
    • 39749151228 scopus 로고    scopus 로고
    • Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with lowfrequency ultrasound and sodium lauryl sulfate
    • Kushner J, Blankschtein D, Langer R. Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with lowfrequency ultrasound and sodium lauryl sulfate. J Pharm Sci 2007;97(2):906-18
    • (2007) J Pharm Sci , vol.97 , Issue.2 , pp. 906-918
    • Kushner, J.1    Blankschtein, D.2    Langer, R.3
  • 31
    • 78650529814 scopus 로고    scopus 로고
    • Transport pathways and enhancement mechanisms within localized and non-localized transport regions in skin treated with lowfrequency sonophoresis and sodium lauryl sulfate
    • Polat BE, Figueroa PL, Blankschtein D, et al. Transport pathways and enhancement mechanisms within localized and non-localized transport regions in skin treated with lowfrequency sonophoresis and sodium lauryl sulfate. J Pharm Sci 2010;100(2):512-29
    • (2010) J Pharm Sci , vol.100 , Issue.2 , pp. 512-529
    • Polat, B.E.1    Figueroa, P.L.2    Blankschtein, D.3
  • 32
    • 44149105335 scopus 로고    scopus 로고
    • Low-frequency sonophoresis: Current status and future prospects
    • Ogura M, Paliwal S, Mitragotri S. Low-frequency sonophoresis: Current status and future prospects. Adv Drug Deliv Rev 2008;60(10):1218-23
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.10 , pp. 1218-1223
    • Ogura, M.1    Paliwal, S.2    Mitragotri, S.3
  • 33
    • 78549249985 scopus 로고    scopus 로고
    • Enhancing the transdermal delivery of rigid nanoparticles using the simultaneous application of ultrasound and sodium lauryl sulfate
    • Lopez RFV, Seto JE, Blankschtein D, et al. Enhancing the transdermal delivery of rigid nanoparticles using the simultaneous application of ultrasound and sodium lauryl sulfate. Biomaterials 2011;32(3):933-41
    • (2011) Biomaterials , vol.32 , Issue.3 , pp. 933-941
    • Lopez, R.F.V.1    Seto, J.E.2    Blankschtein, D.3
  • 34
    • 84866714104 scopus 로고    scopus 로고
    • Rapid skin permeabilization by the simultaneous application of dual-frequency, highintensity ultrasound
    • Schoellhammer CM, Polat BE, Mendenhall J, et al. Rapid skin permeabilization by the simultaneous application of dual-frequency, highintensity ultrasound. J Control Release 2012;163(2):154-60
    • (2012) J Control Release , vol.163 , Issue.2 , pp. 154-160
    • Schoellhammer, C.M.1    Polat, B.E.2    Mendenhall, J.3
  • 35
    • 84863718300 scopus 로고    scopus 로고
    • Optimization of un-Tethered low voltage 20-100 kHz flexural transducers for biomedical ultrasonics applications
    • Sunny Y, Bawiec CR, Nguyen AT, et al. Optimization of un-Tethered, low voltage, 20-100 kHz flexural transducers for biomedical ultrasonics applications. Ultrasonics 2012;52(7):943-8
    • (2012) Ultrasonics , vol.52 , Issue.7 , pp. 943-948
    • Sunny, Y.1    Bawiec, C.R.2    Nguyen, A.T.3
  • 36
    • 84870239259 scopus 로고    scopus 로고
    • Finite element static displacement optimization of 20-100kHz flexural transducers for fully portable ultrasound applicator
    • Bawiec CR, Sunny Y, Nguyen AT, et al. Finite element static displacement optimization of 20-100kHz flexural transducers for fully portable ultrasound applicator. Ultrasonics 2012;53(2):511-17
    • (2012) Ultrasonics , vol.53 , Issue.2 , pp. 511-517
    • Bawiec, C.R.1    Sunny, Y.2    Nguyen, A.T.3
  • 37
    • 77957280275 scopus 로고    scopus 로고
    • A microneedle roller for transdermal drug delivery
    • Park J-H, Choi S-O, Seo S, et al. A microneedle roller for transdermal drug delivery. Eur J Pharm Biopharm 2010;76(2):282-9
    • (2010) Eur J Pharm Biopharm , vol.76 , Issue.2 , pp. 282-289
    • Park, J.-H.1    Choi, S.-O.2    Seo, S.3
  • 38
    • 67649858840 scopus 로고    scopus 로고
    • Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles
    • Gupta J, Felner EI, Prausnitz MR. Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles. Diabetes Technol Ther 2009;11(6):329-37
    • (2009) Diabetes Technol Ther , vol.11 , Issue.6 , pp. 329-337
    • Gupta, J.1    Felner, E.I.2    Prausnitz, M.R.3
  • 39
    • 66049119152 scopus 로고    scopus 로고
    • Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge
    • Zhu Q, Zarnitsyn VG, Ye L, et al. Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge. Proc Natl Acad Sci 2009;106(19):7968-73
    • (2009) Proc Natl Acad Sci , vol.106 , Issue.19 , pp. 7968-7973
    • Zhu, Q.1    Zarnitsyn, V.G.2    Ye, L.3
  • 40
    • 79951577061 scopus 로고    scopus 로고
    • Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose
    • Lee K, Lee CY, Jung H. Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. Biomaterials 2011;32(11):3134-40
    • (2011) Biomaterials , vol.32 , Issue.11 , pp. 3134-3140
    • Lee, K.1    Lee, C.Y.2    Jung, H.3
  • 41
    • 84884906912 scopus 로고    scopus 로고
    • Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach
    • Moga KA, Bickford LR, Geil RD, et al. Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach. Adv Mater 2013;25(36):5060-6
    • (2013) Adv Mater , vol.25 , Issue.36 , pp. 5060-5066
    • Moga, K.A.1    Bickford, L.R.2    Geil, R.D.3
  • 42
    • 84885158039 scopus 로고    scopus 로고
    • Droplet-born air blowing: Novel dissolving microneedle fabrication
    • Kim JD, Kim M, Yang H, et al. Droplet-born air blowing: Novel dissolving microneedle fabrication. J Control Release 2013;170(3):430-6
    • (2013) J Control Release , vol.170 , Issue.3 , pp. 430-436
    • Kim, J.D.1    Kim, M.2    Yang, H.3
  • 43
    • 76749141012 scopus 로고    scopus 로고
    • In vivo visualization of microneedle conduits in human skin using laser scanning microscopy
    • Bal S, Kruithof AC, Liebl H, et al. In vivo visualization of microneedle conduits in human skin using laser scanning microscopy. Laser Phys Lett 2010;7(3):242-6
    • (2010) Laser Phys Lett , vol.7 , Issue.3 , pp. 242-246
    • Bal, S.1    Kruithof, A.C.2    Liebl, H.3
  • 44
    • 78651231668 scopus 로고    scopus 로고
    • Formation and closure of microchannels in skin following microporation
    • Kalluri H, Banga AK. Formation and closure of microchannels in skin following microporation. Pharm Res 2010;28(1):82-94
    • (2010) Pharm Res , vol.28 , Issue.1 , pp. 82-94
    • Kalluri, H.1    Banga, A.K.2
  • 45
    • 79955591093 scopus 로고    scopus 로고
    • Diclofenac enables prolonged delivery of naltrexone through microneedle-Treated skin
    • Banks SL, Paudel KS, Brogden NK, et al. Diclofenac enables prolonged delivery of naltrexone through microneedle-Treated skin. Pharm Res 2011;28(5):1211-19
    • (2011) Pharm Res , vol.28 , Issue.5 , pp. 1211-1219
    • Banks, S.L.1    Paudel, K.S.2    Brogden, N.K.3
  • 46
    • 84879796884 scopus 로고    scopus 로고
    • Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans
    • Brogden NK, Banks SL, Crofford LJ, et al. Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans. Pharm Res 2013;30(8):1947-55
    • (2013) Pharm Res , vol.30 , Issue.8 , pp. 1947-1955
    • Brogden, N.K.1    Banks, S.L.2    Crofford, L.J.3
  • 47
    • 34249875157 scopus 로고    scopus 로고
    • Coating formulations for microneedles
    • Gill HS, Prausnitz MR. Coating formulations for microneedles. Pharm Res 2007;24(7):1369-80
    • (2007) Pharm Res , vol.24 , Issue.7 , pp. 1369-1380
    • Gill, H.S.1    Prausnitz, M.R.2
  • 48
    • 75549084961 scopus 로고    scopus 로고
    • Nanotechnology and the transdermal route
    • Cevc G, Vierl U. Nanotechnology and the transdermal route. J Control Release 2010;141(3):277-99
    • (2010) J Control Release , vol.141 , Issue.3 , pp. 277-299
    • Cevc, G.1    Vierl, U.2
  • 49
    • 79955059525 scopus 로고    scopus 로고
    • Noninvasive and efficient transdermal delivery of CpGoligodeoxynucleotide for cancer immunotherapy
    • Kigasawa K, Kajimoto K, Nakamura T, et al. Noninvasive and efficient transdermal delivery of CpGoligodeoxynucleotide for cancer immunotherapy. J Control Release 2011;150(3):256-65
    • (2011) J Control Release , vol.150 , Issue.3 , pp. 256-265
    • Kigasawa, K.1    Kajimoto, K.2    Nakamura, T.3
  • 50
    • 56449094732 scopus 로고    scopus 로고
    • Electroosmotic flow and its contribution to iontophoretic delivery
    • Herr NR, Kile BM, Carelli RM, et al. Electroosmotic flow and its contribution to iontophoretic delivery. Anal Chem 2008;80(22):8635-41
    • (2008) Anal Chem , vol.80 , Issue.22 , pp. 8635-8641
    • Herr, N.R.1    Kile, B.M.2    Carelli, R.M.3
  • 51
    • 77954310173 scopus 로고    scopus 로고
    • Non-invasive iontophoretic delivery of enzymatically active ribonuclease A (13.6 kDa) across intact porcine and human skins
    • Dubey S, Kalia YN. Non-invasive iontophoretic delivery of enzymatically active ribonuclease A (13.6 kDa) across intact porcine and human skins. J Control Release 2010;145(3):203-9
    • (2010) J Control Release , vol.145 , Issue.3 , pp. 203-209
    • Dubey, S.1    Kalia, Y.N.2
  • 52
    • 77349126632 scopus 로고    scopus 로고
    • Transcutaneous electroporation mediated delivery of doxepin-HPCD complex: A sustained release approach for treatment of postherpetic neuralgia
    • Sammeta SM, Vaka SRK, Murthy SN. Transcutaneous electroporation mediated delivery of doxepin-HPCD complex: A sustained release approach for treatment of postherpetic neuralgia. J Control Release 2010;142(3):361-7
    • (2010) J Control Release , vol.142 , Issue.3 , pp. 361-367
    • Sammeta, S.M.1    Vaka, S.R.K.2    Murthy, S.N.3
  • 53
    • 84881555063 scopus 로고    scopus 로고
    • DNA vaccine coding for the rhesus prostate specific antigen delivered by intradermal electroporation in patients with relapsed prostate cancer
    • Eriksson F, Totterman T, Maltais A-K, et al. DNA vaccine coding for the rhesus prostate specific antigen delivered by intradermal electroporation in patients with relapsed prostate cancer. Vaccine 2013;31(37):3843-8
    • (2013) Vaccine , vol.31 , Issue.37 , pp. 3843-3848
    • Eriksson, F.1    Totterman, T.2    Maltais, A.-K.3
  • 54
    • 1542328820 scopus 로고    scopus 로고
    • Skin electroporation for transdermal and topical delivery
    • Denet A-R, Vanbever R, Preat V. Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev 2004;56(5):659-74
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.5 , pp. 659-674
    • Denet, A.-R.1    Vanbever, R.2    Preat, V.3
  • 55
    • 84888341466 scopus 로고    scopus 로고
    • Skin electroporation for transdermal drug delivery: The influence of the order of different square wave electric pulses
    • Zorec B, Becker S, Rebers?ek M, et al. Skin electroporation for transdermal drug delivery: The influence of the order of different square wave electric pulses. Int J Pharm 2013;457(1):214-23
    • (2013) Int J Pharm , vol.457 , Issue.1 , pp. 214-223
    • Zorec, B.1    Becker, S.2    Rebersek, M.3
  • 56
    • 0034601662 scopus 로고    scopus 로고
    • Non-linearity of molecular transport through human skin due to electric stimulus
    • Pliquett UF, Gusbeth CA, Weaver JC. Non-linearity of molecular transport through human skin due to electric stimulus. J Control Release 2000;68(3):373-86
    • (2000) J Control Release , vol.68 , Issue.3 , pp. 373-386
    • Pliquett, U.F.1    Gusbeth, C.A.2    Weaver, J.C.3
  • 57
    • 70449528423 scopus 로고    scopus 로고
    • Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat
    • Kigasawa K, Kajimoto K, Hama S, et al. Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat. Int J Pharm 2010;383(1):157-60
    • (2010) Int J Pharm , vol.383 , Issue.1 , pp. 157-160
    • Kigasawa, K.1    Kajimoto, K.2    Hama, S.3
  • 58
    • 84862820746 scopus 로고    scopus 로고
    • A circuit design of a low-cost, portable and programmable electroporation device for biomedical applications
    • Ching CT-S, Sun T-P, Huang W-T, et al. A circuit design of a low-cost, portable and programmable electroporation device for biomedical applications. Sensors Actuators B Chem 2012;166:292-300
    • (2012) Sensors Actuators B Chem , vol.166 , pp. 292-300
    • Ching, C.T.-S.1    Sun, T.-P.2    Huang, W.-T.3
  • 59
    • 73949083734 scopus 로고    scopus 로고
    • Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques
    • Livingston BD, Little SF, Luxembourg A, et al. Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques. Vaccine 2010;28(4):1056-61
    • (2010) Vaccine , vol.28 , Issue.4 , pp. 1056-1061
    • Livingston, B.D.1    Little, S.F.2    Luxembourg, A.3
  • 60
    • 84877138473 scopus 로고    scopus 로고
    • Controlled delivery of ropinirole hydrochloride through skin using modulated iontophoresis and microneedles
    • Singh ND, Banga AK. Controlled delivery of ropinirole hydrochloride through skin using modulated iontophoresis and microneedles. J Drug Target 2013;21(4):354-66
    • (2013) J Drug Target , vol.21 , Issue.4 , pp. 354-366
    • Singh, N.D.1    Banga, A.K.2
  • 61
    • 84883815286 scopus 로고    scopus 로고
    • Effect of lipophilicity on microneedlemediated iontophoretic transdermal delivery across human skin in vitro
    • Pawar KR, Smith F, Kolli CS, et al. Effect of lipophilicity on microneedlemediated iontophoretic transdermal delivery across human skin in vitro. J Pharm Sci 2013;102(10):3784-91
    • (2013) J Pharm Sci , vol.102 , Issue.10 , pp. 3784-3791
    • Pawar, K.R.1    Smith, F.2    Kolli, C.S.3
  • 62
    • 84864132156 scopus 로고    scopus 로고
    • Modulated iontophoretic delivery of small and large molecules through microchannels
    • Kumar V, Banga AK. Modulated iontophoretic delivery of small and large molecules through microchannels. Int J Pharm 2012;434(1):106-14
    • (2012) Int J Pharm , vol.434 , Issue.1 , pp. 106-114
    • Kumar, V.1    Banga, A.K.2
  • 63
    • 77955983468 scopus 로고    scopus 로고
    • Transdermal drug delivery by in-skin electroporation using a microneedle array
    • Yan K, Todo H, Sugibayashi K. Transdermal drug delivery by in-skin electroporation using a microneedle array. Int J Pharm 2010;397(1):77-83
    • (2010) Int J Pharm , vol.397 , Issue.1 , pp. 77-83
    • Yan, K.1    Todo, H.2    Sugibayashi, K.3
  • 64
    • 84859501688 scopus 로고    scopus 로고
    • Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery
    • Garland MJ, Salvador EC, Migalska K, et al. Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery. J Control Release 2012;159(1):52-9
    • (2012) J Control Release , vol.159 , Issue.1 , pp. 52-59
    • Garland, M.J.1    Salvador, E.C.2    Migalska, K.3
  • 65
    • 84883791295 scopus 로고    scopus 로고
    • Permeability enhancement for transdermal delivery of large molecule using low-frequency sonophoresis combined with microneedles
    • Han T, Das DB. Permeability enhancement for transdermal delivery of large molecule using low-frequency sonophoresis combined with microneedles. J Pharm Sci 2013;102(10):3614-22
    • (2013) J Pharm Sci , vol.102 , Issue.10 , pp. 3614-3622
    • Han, T.1    Das, D.B.2
  • 66
    • 77954394332 scopus 로고    scopus 로고
    • A physical method to enhance transdermal delivery of a tissue optical clearing agent: Combination of microneedling and sonophoresis
    • Yoon J, Park D, Son T, et al. A physical method to enhance transdermal delivery of a tissue optical clearing agent: Combination of microneedling and sonophoresis. Lasers Surg Med 2010;42(5):412-17
    • (2010) Lasers Surg Med , vol.42 , Issue.5 , pp. 412-417
    • Yoon, J.1    Park, D.2    Son, T.3
  • 67
    • 77149175967 scopus 로고    scopus 로고
    • Sonophoretic enhanced microneedles array (SEMA)-improving the efficiency of transdermal drug delivery
    • Chen B, Wei J, Iliescu C. Sonophoretic enhanced microneedles array (SEMA)-improving the efficiency of transdermal drug delivery. Sensors Actuators B Chem 2010;145(1):54-60
    • (2010) Sensors Actuators B Chem , vol.145 , Issue.1 , pp. 54-60
    • Chen, B.1    Wei, J.2    Iliescu, C.3
  • 68
    • 66749121267 scopus 로고    scopus 로고
    • Mechanisms of synergistic skin penetration by sonophoresis and iontophoresis
    • Hikima T, Ohsumi S, Shirouzu K, et al. Mechanisms of synergistic skin penetration by sonophoresis and iontophoresis. Biol Pharm Bull 2009;32:905-9
    • (2009) Biol Pharm Bull , vol.32 , pp. 905-909
    • Hikima, T.1    Ohsumi, S.2    Shirouzu, K.3
  • 69
    • 75149126727 scopus 로고    scopus 로고
    • Transdermal delivery of a approximately 13 kDa protein-An in vivocomparison of physical enhancement methods
    • Katikaneni S, Li G, Badkar A, et al. Transdermal delivery of a approximately 13 kDa protein-An in vivocomparison of physical enhancement methods. J Drug Target 2010;18(2):141-7
    • (2010) J Drug Target , vol.18 , Issue.2 , pp. 141-147
    • Katikaneni, S.1    Li, G.2    Badkar, A.3
  • 70
    • 0029125922 scopus 로고
    • Ultrasound-mediated transdermal protein delivery
    • Mitragotri S, Blankschtein D, Langer R. Ultrasound-mediated transdermal protein delivery. Science 1995;269(5225):850-3
    • (1995) Science , vol.269 , Issue.5225 , pp. 850-853
    • Mitragotri, S.1    Blankschtein, D.2    Langer, R.3
  • 71
    • 84862816721 scopus 로고    scopus 로고
    • Erythropoietin-coated ZP-microneedle transdermal system: Preclinical formulation stability and delivery
    • Peters EE, Ameri M, Wang X, et al. Erythropoietin-coated ZP-microneedle transdermal system: Preclinical formulation, stability, and delivery. Pharm Res 2012;29(6):1618-26
    • (2012) Pharm Res , vol.29 , Issue.6 , pp. 1618-1626
    • Peters, E.E.1    Ameri, M.2    Wang, X.3
  • 72
    • 78650323878 scopus 로고    scopus 로고
    • Layer-by-layer assembly of DNAand protein-containing films on microneedles for drug delivery to the skin
    • Saurer EM, Flessner RM, Sullivan SP, et al. Layer-by-layer assembly of DNAand protein-containing films on microneedles for drug delivery to the skin. Biomacromolecules 2010;11(11):3136-43
    • (2010) Biomacromolecules , vol.11 , Issue.11 , pp. 3136-3143
    • Saurer, E.M.1    Flessner, R.M.2    Sullivan, S.P.3
  • 73
    • 84882437359 scopus 로고    scopus 로고
    • Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-Triggered protein adsorption and release: Application to microneedles
    • van der Maaden K, Yu H, Sliedregt K, et al. Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-Triggered protein adsorption and release: Application to microneedles. J Mater Chem B 2013;1:4466-77
    • (2013) J Mater Chem B , vol.1 , pp. 4466-4477
    • Van Der Maaden, K.1    Yu, H.2    Sliedregt, K.3
  • 74
    • 79958187550 scopus 로고    scopus 로고
    • Electrically-Assisted delivery of an anionic protein across intact skin: Cathodal iontophoresis of biologically active ribonuclease T1
    • Dubey S, Kalia YN. Electrically-Assisted delivery of an anionic protein across intact skin: Cathodal iontophoresis of biologically active ribonuclease T1. J Control Release 2011;152(3):356-62
    • (2011) J Control Release , vol.152 , Issue.3 , pp. 356-362
    • Dubey, S.1    Kalia, Y.N.2
  • 75
    • 0033976976 scopus 로고    scopus 로고
    • Iontophoresis: Electrorepulsion and electroosmosis
    • Guy RH, Kalia YN, Delgado-Charro MB, et al. Iontophoresis: Electrorepulsion and electroosmosis. J Control Release 2000;64(1):129-32
    • (2000) J Control Release , vol.64 , Issue.1 , pp. 129-132
    • Guy, R.H.1    Kalia, Y.N.2    Delgado-Charro, M.B.3
  • 76
    • 0034528538 scopus 로고    scopus 로고
    • Transcutaneous immunization: A human vaccine delivery strategy using a patch
    • Glenn GM, Taylor DN, Li X, et al. Transcutaneous immunization: A human vaccine delivery strategy using a patch. Nat Med 2000;6(12):1403-6
    • (2000) Nat Med , vol.6 , Issue.12 , pp. 1403-1406
    • Glenn, G.M.1    Taylor, D.N.2    Li, X.3
  • 77
    • 35148889797 scopus 로고    scopus 로고
    • Exploiting lymphatic transport and complement activation in nanoparticle vaccines
    • Reddy ST, van der Vlies AJ, Simeoni E, et al. Exploiting lymphatic transport and complement activation in nanoparticle vaccines. Nat Biotechnol 2007;25(10):1159-64
    • (2007) Nat Biotechnol , vol.25 , Issue.10 , pp. 1159-1164
    • Reddy, S.T.1    Van Der Vlies, A.J.2    Simeoni, E.3
  • 78
    • 84875190294 scopus 로고    scopus 로고
    • Synthetic adjuvants for vaccine formulations: Phytol derivatives
    • Ghosh SK, Chowdhury RR. Synthetic adjuvants for vaccine formulations: Phytol derivatives. Expert Opin Drug Deliv 2013;10(4):437-50
    • (2013) Expert Opin Drug Deliv , vol.10 , Issue.4 , pp. 437-450
    • Ghosh, S.K.1    Chowdhury, R.R.2
  • 79
    • 0035158888 scopus 로고    scopus 로고
    • Epidermal powder immunization induces both cytotoxic T-lymphocyte and antibody responses to protein antigens of influenza and hepatitis B viruses
    • Chen D, Weis KF, Chu Q, et al. Epidermal powder immunization induces both cytotoxic T-lymphocyte and antibody responses to protein antigens of influenza and hepatitis B viruses. J Virol 2001;75(23):11630-40
    • (2001) J Virol , vol.75 , Issue.23 , pp. 11630-40
    • Chen, D.1    Weis, K.F.2    Chu, Q.3
  • 80
    • 79956061128 scopus 로고    scopus 로고
    • In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers
    • Vasan S, Hurley A, Schlesinger SJ, et al. In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers. PLoS One 2011;6(5):e19252
    • (2011) PLoS One , vol.6 , Issue.5
    • Vasan, S.1    Hurley, A.2    Schlesinger, S.J.3
  • 81
    • 84880512476 scopus 로고    scopus 로고
    • Measles vaccination using a microneedle patch
    • Edens C, Collins ML, Ayers J, et al. Measles vaccination using a microneedle patch. Vaccine 2013;31(34):3403-9
    • (2013) Vaccine , vol.31 , Issue.34 , pp. 3403-3409
    • Edens, C.1    Collins, M.L.2    Ayers, J.3
  • 82
    • 84880509930 scopus 로고    scopus 로고
    • Dose sparing and enhanced immunogenicity of inactivated rotavirus vaccine administered by skin vaccination using a microneedle patch
    • Moon S, Wang Y, Edens C, et al. Dose sparing and enhanced immunogenicity of inactivated rotavirus vaccine administered by skin vaccination using a microneedle patch. Vaccine 2013;31(34):3396-402
    • (2013) Vaccine , vol.31 , Issue.34 , pp. 3396-402
    • Moon, S.1    Wang, Y.2    Edens, C.3
  • 83
    • 84884688641 scopus 로고    scopus 로고
    • Long-Term protective immunity from an influenza virus-like particle vaccine administered with a microneedle patch
    • Quan FS, Kim YC, Song JM, et al. Long-Term protective immunity from an influenza virus-like particle vaccine administered with a microneedle patch. Clin Vaccine Immunol 2013;20(9):1433-9
    • (2013) Clin Vaccine Immunol , vol.20 , Issue.9 , pp. 1433-1439
    • Quan, F.S.1    Kim, Y.C.2    Song, J.M.3
  • 84
    • 76749169710 scopus 로고    scopus 로고
    • Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity
    • Kim Y-C, Quan F-S, Compans RW, et al. Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity. J Control Release 2010;142(2):187-95
    • (2010) J Control Release , vol.142 , Issue.2 , pp. 187-195
    • Kim, Y.-C.1    Quan, F.-S.2    Compans, R.W.3
  • 85
    • 77955417028 scopus 로고    scopus 로고
    • Dissolving polymer microneedle patches for influenza vaccination
    • Sullivan SP, Koutsonanos DG, del Pilar Martin M, et al. Dissolving polymer microneedle patches for influenza vaccination. Nat Med 2010;16(8):915-20
    • (2010) Nat Med , vol.16 , Issue.8 , pp. 915-920
    • Sullivan, S.P.1    Koutsonanos, D.G.2    Del Pilar Martin, M.3
  • 86
    • 78649802326 scopus 로고    scopus 로고
    • Improved DNA vaccination by skintargeted delivery using dry-coated densely-packed microprojection arrays
    • Chen X, Kask AS, Crichton ML, et al. Improved DNA vaccination by skintargeted delivery using dry-coated densely-packed microprojection arrays. J Control Release 2010;148(3):327-33
    • (2010) J Control Release , vol.148 , Issue.3 , pp. 327-333
    • Chen, X.1    Kask, A.S.2    Crichton, M.L.3
  • 87
    • 84875412118 scopus 로고    scopus 로고
    • Polymer multilayer tattooing for enhanced DNA vaccination
    • DeMuth PC, Min Y, Huang B, et al. Polymer multilayer tattooing for enhanced DNA vaccination. Nat Mater 2013;12(4):367-76
    • (2013) Nat Mater , vol.12 , Issue.4 , pp. 367-376
    • DeMuth, P.C.1    Min, Y.2    Huang, B.3
  • 88
    • 0034061329 scopus 로고    scopus 로고
    • Transdermal monitoring of glucose and other analytes using ultrasound
    • Kost J, Langer R, Mitragotri S, et al. Transdermal monitoring of glucose and other analytes using ultrasound. Nat Med 2000;6(3):347-50
    • (2000) Nat Med , vol.6 , Issue.3 , pp. 347-350
    • Kost, J.1    Langer, R.2    Mitragotri, S.3
  • 89
    • 84861187651 scopus 로고    scopus 로고
    • Towards blood free measurement of glucose and potassium in humans using reverse iontophoresis
    • McCormick C, Heath D, Connolly P. Towards blood free measurement of glucose and potassium in humans using reverse iontophoresis. Sensors Actuators B Chem 2012;166:593-600
    • (2012) Sensors Actuators B Chem , vol.166 , pp. 593-600
    • McCormick, C.1    Heath, D.2    Connolly, P.3
  • 90
    • 62449126447 scopus 로고    scopus 로고
    • Glucose sensors: A review of current and emerging technology
    • Oliver NS, Toumazou C, Cass AEG, et al. Glucose sensors: A review of current and emerging technology. Diabet Med 2009;26(3):197-210
    • (2009) Diabet Med , vol.26 , Issue.3 , pp. 197-210
    • Oliver, N.S.1    Toumazou, C.2    Cass, A.E.G.3
  • 91
    • 77956160937 scopus 로고    scopus 로고
    • Pilot studies of transdermal continuous glucose measurement in outpatient diabetic patients and in patients during and after cardiac surgery
    • Chuang H, Trieu M-Q, Hurley J, et al. Pilot studies of transdermal continuous glucose measurement in outpatient diabetic patients and in patients during and after cardiac surgery. J Diabetes Sci Technol (Online) 2008;2(4):595
    • (2008) J Diabetes Sci Technol (Online , vol.2 , Issue.4 , pp. 595
    • Chuang, H.1    Trieu, M.-Q.2    Hurley, J.3
  • 92
    • 77955902695 scopus 로고    scopus 로고
    • Noninvasive ultrasonic glucose sensing with large pigs (approximately 200 Pounds) using a lightweight cymbal transducer array and biosensors
    • Park E-J, Werner J, Beebe J, et al. Noninvasive ultrasonic glucose sensing with large pigs (approximately 200 Pounds) using a lightweight cymbal transducer array and biosensors. J Diabetes Sci Tech 2009;3(3):517-23
    • (2009) J Diabetes Sci Tech , vol.3 , Issue.3 , pp. 517-523
    • Park, E.-J.1    Werner, J.2    Beebe, J.3
  • 93
    • 79953282638 scopus 로고    scopus 로고
    • Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
    • Miller PR, Gittard SD, Edwards TL, et al. Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing. Biomicrofluidics 2011;5(1):013415
    • (2011) Biomicrofluidics , vol.5 , Issue.1 , pp. 013415
    • Miller, P.R.1    Gittard, S.D.2    Edwards, T.L.3
  • 94
    • 79954516154 scopus 로고    scopus 로고
    • Microneedle array-based carbon paste amperometric sensors and biosensors
    • Windmiller JR, Zhou N, Chuang M-C, et al. Microneedle array-based carbon paste amperometric sensors and biosensors. Analyst 2011;136(9):1846
    • (2011) Analyst , vol.136 , Issue.9 , pp. 1846
    • Windmiller, J.R.1    Zhou, N.2    Chuang, M.-C.3
  • 95
    • 84895460362 scopus 로고    scopus 로고
    • Microneedle electrodes toward an amperometric glucose-sensing smart patch
    • Epub ahead of print]
    • Invernale MA, Tang BC, York RL, et al. Microneedle electrodes toward an amperometric glucose-sensing smart patch. Adv Healthcare Mater 2013. [Epub ahead of print]
    • (2013) Adv Healthcare Mater
    • Invernale, M.A.1    Tang, B.C.2    York, R.L.3
  • 96
    • 84884817827 scopus 로고    scopus 로고
    • Early circulating biomarker detection using a wearable microprojection array skin patch
    • Coffey JW, Corrie SR, Kendall MAF. Early circulating biomarker detection using a wearable microprojection array skin patch. Biomaterials 2013;34(37):9572-83
    • (2013) Biomaterials , vol.34 , Issue.37 , pp. 9572-9583
    • Coffey, J.W.1    Corrie, S.R.2    Kendall, M.A.F.3
  • 97
    • 84865309584 scopus 로고    scopus 로고
    • A minimally invasive blood-extraction system: Elastic self-recovery actuator integrated with an ultrahigh-Aspect-ratio microneedle
    • Li CG, Lee K, Lee CY, et al. A minimally invasive blood-extraction system: Elastic self-recovery actuator integrated with an ultrahigh-Aspect-ratio microneedle. Adv Mater 2012;24(33):4583-6
    • (2012) Adv Mater , vol.24 , Issue.33 , pp. 4583-4586
    • Li, C.G.1    Lee, K.2    Lee, C.Y.3
  • 98
    • 84872609599 scopus 로고    scopus 로고
    • An optimized hollow microneedle for minimally invasive blood extraction
    • Li CG, Lee CY, Lee K, et al. An optimized hollow microneedle for minimally invasive blood extraction. Biomed Microdevices 2012;15(1):17-25
    • (2012) Biomed Microdevices , vol.15 , Issue.1 , pp. 17-25
    • Li, C.G.1    Lee, C.Y.2    Lee, K.3
  • 100
    • 84886034541 scopus 로고    scopus 로고
    • Transdermal and topical drug delivery today
    • In: Benson HAE Watkinson AC editors John Wiley Sons, Inc., Hoboken, NJ
    • Watkinson AC. Transdermal and topical drug delivery today. In: Benson HAE, Watkinson AC, editors, Transdermal and topical drug delivery. John Wiley Sons, Inc., Hoboken, NJ; 2012
    • (2012) Transdermal And Topical Drug Delivery
    • Watkinson, A.C.1
  • 101
    • 0003547433 scopus 로고    scopus 로고
    • Food and Drug Administration. 33rd edition. Available from
    • Food and Drug Administration. Approved drug products with therapeutic equivalence evaluations. 33rd edition. Available from: Http://www.fda.gov/ downloads/Drugs/ DevelopmentApprovalProcess/ UCM071436.pdf
    • Approved Drug Products With Therapeutic Equivalence Evaluations


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.