Integration-independent transgenic huntington disease fragment mouse models reveal distinct phenotypes and life span in vivo

Journal of Biological Chemistry

Volumn 290, Issue 31, 2015, Pages 19287-19306

  O'Brien, Robert ^a   DeGiacomo, Francesco ^a   Holcomb, Jennifer ^a   Bonner, Akilah ^a   Ring, Karen L ^a   Zhang, Ningzhe ^a   Zafar, Khan ^a   Weiss, Andreas ^b   Lager, Brenda ^c   Schilling, Birgit ^a   Gibson, Bradford W ^a   Chen, Sylvia ^a   Kwak, Seung ^c   Ellerby, Lisa M ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b EVOTEC AG   (Germany)

^c CHDI MANAGEMENT CHDI FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEURODEGENERATIVE DISEASES; PROTEOLYSIS;

DISEASE PROGRESSION; HUNTINGTON DISEASE; MOUSE MODELS; MUTANT HUNTINGTIN; NEUROTOXICITY; THERAPEUTIC TREATMENTS; TRANSGENIC MICE; TRANSGENICS;

MAMMALS;

CASPASE 2; CASPASE 6; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 86; HUNTINGTIN; POLYGLUTAMINE; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN 90; HSP86 PROTEIN, HUMAN; HTT PROTEIN, HUMAN; NERVE PROTEIN; STOP CODON;

AGE; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MODEL; EMBRYO; FEMALE; GENE LOCUS; HUNTINGTON CHOREA; IN VIVO STUDY; LIFESPAN; MALE; MASS SPECTROMETRY; MOUSE; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; SURVIVAL RATE; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT; ANIMAL; BRAIN; C57BL MOUSE; GENETICS; HEK293 CELL LINE; HUMAN; LONGEVITY; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; STOP CODON;

ANIMALS; BRAIN; CODON, NONSENSE; DISEASE MODELS, ANIMAL; FEMALE; HEK293 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HUNTINGTON DISEASE; LONGEVITY; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; PHENOTYPE; PROTEIN INTERACTION MAPPING; PROTEOLYSIS;

EID: 84940525612     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.623561     Document Type: Article

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